• Journal of Microbiology and Biotechnology
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• 제15권6호
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• pp.1408-1413
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• 2005

Elevated expression of carcinoembryonic antigen (CEA) has been implicated in various biological aspects of neoplasia such as tumor cell adhesion, metastasis, blocking of cellular immune mechanisms, and antiapoptosis function. Thus, the CEA could be an important target for anticancer therapy. In this study, we developed Tetrahymena group 1 intron-based trans-splicing ribozymes that can specifically target and replace CEA RNA. To this end, we first determined which regions of the CEA RNA were accessible to ribozymes by employing an RNA mapping strategy that was based on a trans-splicing ribozyme library. Next, we assessed the ribozyme activities by comparing the trans-splicing activities of several ribozymes that targeted different regions of the CEA RNA, and then the ribozyme that could target the most accessible site was observed to be the most active with high fidelity in vitro. Moreover, the specific trans-splicing ribozyme was found to react with and altered the target CEA transcripts in mammalian cells with high fidelity. These results suggest that the Tetrahymena ribozyme can be utilized to replace CEA RNAs in tumors with a new RNA-harboring anticancer activity, thereby hopefully reverting the malignant phenotype.

• Journal of Biosystems Engineering
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• 제32권5호
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• pp.332-338
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• 2007

Yield mapping is necessary for precision farming. An on-site rice weighing system for a head-feed combine was developed to measure the total weight of rice grain harvested while the combine was operated. A load cell system was used to monitor rice weights accumulated into the combine grain tank using a load cell. This method gave cumulative grain weight readings as a function of time. The system consisted of a load cell, two supporting brackets, and a computer-based data acquisition system. The weights measured with the system from two fields were compared with those obtained with a commercially available electronic balance. The response of the load cell to varying grain weights was linearly modeled, showing a coefficient of determination of 0.998 and a standard error of ${\pm}4.09kg$.

• 인지과학
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• 제10권1호
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• pp.45-55
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• 1999

본 논문은 사건/사타에 대한 공간적 인지가 수행되는 기본적인 방식을 규명하기 위해서는 그 사건/사태에 참여하는 참가자의 위치가 가장 주요한 요인임을 주장하고, 자연언어는 공간적 인지를 표현하기 위해 비교적 "단순한" 의미유형을 사용하고 있으며, 공간표현을 해석할 때 사건/사태 전체의 위치를 지정하는 것으로 해석하지 않고, 그 참가자로 표현된 논항(arguments)의 위치를 지정하는 것으로 해석한다는 것이다. 본 논문은 장소표현이 타동사의 두 논항의 위치를 지정하는 방식을 네 가지 유형의 노항지향성(argument orientations)으로 분류하여 기술하였고, 논항지향성을 통하여 영어를 포함한 자연언어의 장소표현이 관계(relations)의 집합에서 관계의 집합으로 사상하는 교차함수(intersecting functioins)로 해석되어야 한다는 의미해석상의 제약이 있음을 밝히고 있다.

• International Journal of Contents
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• 제2권2호
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• pp.10-16
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• 2006

In this paper, we propose a predictive resource metric region (RMR) based radio resource metric estimation (RRME) mechanism, which utilizes a resource metric mapping function (RMMF), both of which permit efficient inter-working between the physical layer and higher layers for envisaging multimedia service applications over a CDMA communication system platform. The RMR can provide the acceptable resource region where QoS and acceptable link quality can be guaranteed with an achievable resource margin to be utilized in terms of capacity margin, the degree of confidence (DCL) of user, second-order statistics of Eb/Io. With predicted capacity margin and variance, DCL can deliver decision parameters with which an adaptive QoS based admission control can perform well taking capacity and resource availability into account in a dynamic and predictive manner. Combined with advanced techniques such as adaptive modulation or rate control and power control, the proposed mechanism can adjust the conventional stringent link quality information efficiently, and deliver accurate information of the resource availability. Thus, these can guarantee the maximization of resource utilization of multimedia service applications.

• Journal of Communications and Networks
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• 제8권1호
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• pp.93-105
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• 2006

The domination of the Internet by TCP-based services has spawned many efforts to provide high network utilization with low loss and delay in a simple and scalable manner. Active queue management (AQM) algorithms attempt to achieve these goals by regulating queues at bottleneck links to provide useful feedback to TCP sources. While many AQM algorithms have been proposed, most suffer from instability, require careful configuration of nonintuitive control parameters, or are not practical because of slow response to dynamic traffic changes. In this paper, we propose a new AQM algorithm, hybrid random early detection (HRED), that combines the more effective elements of recent algorithms with a random early detection (RED) core. HRED maps instantaneous queue length to a drop probability, automatically adjusting the slope and intercept of the mapping function to account for changes in traffic load and to keep queue length within the desired operating range. We demonstrate that straightforward selection of HRED parameters results in stable operation under steady load and rapid adaptation to changes in load. Simulation and implementation tests confirm this stability, and indicate that overall performances of HRED are substantially better than those of earlier AQM algorithms. Finally, HRED control parameters provide several intuitive approaches to trading between required memory, queue stability, and response time.

• 대한전기학회:학술대회논문집
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• 대한전기학회 2006년도 춘계학술대회 논문집 전기설비전문위원
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• pp.83-85
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• 2006

변압기 및 GIS 설비 내의 부분방전(Partial Discharge: PD) 발생 시 과도 UHF 신호들이 발생하고 그 신호들은 탱크 안에서 공진한다. 한 개 이상의 PD소스가 존재하고 간섭을 포함 할 때, PD에서 발생하는 본 신호들을 정확히 분류 할 수 있는 능력은 진단의 수준을 높일 것이다. 고속 푸리에 변환(FFT)은 주파수변화가 많을 시에, 주요 주파수의 특징 구별이 어렵다. 즉 푸리에 변환 적용 시 noise의 불규칙적인 파형으로 원 신호와의 구분이 어렵다. 그래서 시간과 주파수영역 모두에서 좋은 해상도를 나타내는 웨이블릿을 사용하였다. 변압기 및 GIS 설비 탱크에서 다른 위치의 PD소스로부터 UHF신호들을 인지하는 것에 대하여 웨이블렷에 기초된 방법은, 단지 한 개의 UHF 센서로 신호를 받았을 경우에도 묘사되어진다. UHF PD신호들의 시간-주파수 특성은 웨이블릿 변환으로부터 설립되고, 신호의 에너지 분포 mapping의 의미로 제공되어 진다. 유사함수(similarity function)는 다양한 웨이블릿 계수분포 사이에서 유사성의 측정을 제공하기 위하여 정의된다. 실험으로 측정된 데이터를 통하여 다중부분방전의 유무를 판단하고자 한다.

• 대한원격탐사학회:학술대회논문집
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• 대한원격탐사학회 2006년도 Proceedings of ISRS 2006 PORSEC Volume I
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• pp.487-490
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• 2006

Ocean Color Monitor (OCM) onboard the Indian Remote Sensing Satellite IRS-P4 has been used to retrieve chlorophyll concentration in the Bay of Bengal and the Arabian Sea using a bio-optical algorithm. Cloud masking and atmospheric corrections have been performed before applying mapping function to derive chlorophyll concentration from IRS-P4 OCM data. We have retrieved chlorophyll concentration from OCM, and MODIS during the summer and winter season along the eastern and western coast of India at every 1 degree latitude at increasing distance (25, 50, 100, 150 and 200km) away from the coast as well as near river mouths for the period 2000-2003. We have also studied spatial and temporal dynamics of monthly MODIS Aqua (for period July 2002-April 2004). The seasonal dynamics of chlorophyll concentration over the Bay of Bengal and the Arabian Sea have been discussed using OCM and MODIS for both the coastal region and the open sea.

• 대한전기학회:학술대회논문집
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• 대한전기학회 2004년도 하계학술대회 논문집 D
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• pp.2209-2211
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• 2004

Unlike the wavelet neural network, since a mother wavelet layer of the self-recurrent wavelet neural network (SRWNN) is composed of self-feedback neurons, it has the ability to store past information of the wavelet. Therefore we propose the prediction method for the nonlinear chaotic time series model using a SRWNN. The SRWNN model is learned for the modeling of a function such that the inputs arc known values of the time series and the output is the value in the future. The parameters of the network are tuned to minimize the difference between the nonlinear mapping of the chaotic time series and the output of SRWNN using the gradient-descent method for the adaptive backpropagation algorithm. Through the computer simulations, we demonstrate the feasibility and the effectiveness of our method for the prediction of the logistic map and the Mackey-Glass delay-differential equation as a nonlinear chaotic time series.

• 전자공학회논문지SC
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• 제37권4호
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• pp.22-27
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• 2000

본 논문에서는 동적 다차원 웨이블릿 신경망을 제안한다. 웨이블릿 이론을 이용한 DMWNN은 근사화 대상함수를 유일하고 효과적으로 표현할 수 있으며, 추후에 사용할 수 있는 정보를 저장하는 능력을 가지고 있다. 따라서 DMWNN은 동적 매핑이 가능하고, 필요한 입력의 차원을 줄일 수 있는 장점이 있다. DMWNN은 대각 귀환신경망과 전방향 웨이블릿 신경망의 단점을 보완하여 설계하였다. 제안한 DMWNN의 우수성을 실험을 통해 검증하였다.

• Rapid Communication in Photoscience
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• 제2권2호
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• pp.56-59
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• 2013

Plant phytochromes, molecular light switches that regulate various aspects of plant growth and development, are known as autophosphorylating serine/threonine kinases. Although recent studies reveal that phytochrome autophosphorylation plays an important role in the regulation of phytochrome signaling through the control of phyA protein stability, the in vivo functional roles of phytochrome kinase activity in plant light signaling are largely unknown. Thus, it is necessary to investigate the detailed function of phytochrome as a protein kinase, which might include mapping of kinase domain on the phytochrome molecule, searching for substrates that could be phosphorylated by phyA, and in vivo functional analysis of the kinase activity with phytochrome mutants displaying reduced kinase activity. Our recent studies reveal that the kinase activity of phytochrome plays a positive role in plant light signaling. Therefore, we highlight the current knowledge about the functional roles of phytochrome kinase activity in the light signal transduction of plants, based on our recent results.