• Microbiology and Biotechnology Letters
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• v.45 no.4
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• pp.299-304
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• 2017

Biogenic amines such as histamine, tyramine, cadaverine, and putrescine may have detrimental effects on consumers' health; therefore, they must be considered hazardous substances in foods. In recent years, the application of microorganisms that can degrade biogenic amines has become an emerging method for reducing the amount of these amines in foods. Primarily, Bacillus sp. BCNU 9171 was isolated from Doenjang, a Korean traditional fermented soybean paste. The inhibitory effects of the cell-free supernatant (CFS) of Bacillus sp. BCNU 9171 on biogenic amine production by 4 amine-positive food pathogenic bacteria were investigated using high performance liquid chromatography (HPLC). Our results showed that 4 different CFS concentrations-10% [1 ml CFS + 9 ml histidine decarboxylase broth (HDB)], 25% (2.5 ml CFS + 7.5 ml HDB), 50% (5 ml CFS + 5 ml HDB), and 75% (7.5 ml CFS + 2.5 ml HDB)-reduced the biogenic amine production up to 87% compared with that of the control without CFS. These results suggested that it is advisable to use Bacillus sp. strain BCNU 9171 as a starter organism for the manufacture of fermented foods and to ensure food safety since it prevents the accumulation of high amounts of biogenic amines in fermented foods by amine-positive bacteria.

• Journal of the Microelectronics and Packaging Society
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• v.18 no.4
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• pp.19-25
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• 2011

The size reduction of the semiconductor chip and the improvement of the electrical performance have been enabled through the introduction of the Cu/Low-K process in modern electronic industries. However, Cu/Low-K has a disadvantage of the physical properties that is weaker than materials used for existing semiconductor manufacture process. It causes many problems in chip manufacturing and package processes. Especially, the delamination between the Cu layer and the low-K dielectric layer is a main defect after the temperature cycles. Since the Cu/Low-K layer is located on the top of the pad of the flip chip, the stress on the flip chip affects the Cu/Low-K layer directly. Therefore, it is needed to improve the underfill process or materials. Especially, it becomes very important to select the underfill to decrease the stress at the flip-chip and to protect the solder bump. We have solved the delamination problem in a 90 nm Cu/Low-K flip-chip package after the temperature cycle by selecting an appropriate underfill.

• Journal of the Institute of Electronics and Information Engineers
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• v.51 no.3
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• pp.194-201
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• 2014

This paper is able to be solved by improving degradation in multi-path environment by adjust beam pattern angle through modifying pulse phase of each antennas by using TRM (Transmitter Receiver Module). Beam Scanning Array Antenna, which is transmitter/receiver that improves degradation in multi-path environment without any signal distortion, is designed and manufactured. Beam Scanning Array Antenna should be able to send/receive signal at the antenna's longitudinal part without distortion and should not influences other systems. Also, it should include target detecting ability by beam steering.Dispersion characteristic of Beam Scanning Antenna, which is designed, is analysed by using fidelity, and steering and radar resolution performance is verified by using $1cm{\times}1cm$ sized target. To manufacture Beam Scanning Array Antenna, control board and GUI, which is able to control Vivaldi Antenna for IR-UWB, Tri-Band Wilkinson power divider, and TRM (Transmitter Receiver Module), is designed. Throughout this research, developed Beam Scanning UWB Array Antenna system is adoptable for radar application field. and time domain analysis techniques by using network analyser made the antenna characteristics analysis for setting up antenna more accurate. In addition, it makes beam width checking without difficulties.

• Toxicological Research
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• v.20 no.3
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• pp.195-203
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• 2004

4-Tert-Octylphenol (OP) is a surfactant additive widely used in the manufacture of a variety of detergents and plastic products. OP can disrupt endocrine function in humans and animals. This study was carried out to obtain toxicokinetic parameters of OP in male Sprague-Dawley (SD) rats. Male rats were administered with OP by single oral application of 200 mg/kg body weight. Blood, urine and tissues samples were taken at several time intervals after administration. Analysis of samples for OP was performed by column-switching high performance liquid chromatography (HPLC). In addition, we exam-ined tissue distribution and accumulation of OP after single oral application of 50, 100, and 200 mg/kg, single intravenous injection of 1, 5 and 10 mg/kg or daily application of 50 mg/kg for 14 consecutive days. After single oral administration of 200 mg/kg, Cmax of 213 $\pm$ 123 ng/ml was reached within the first 1.3 hr (Tmax) in the plasma. AUC was calculated for 1,333$\pm$484 ngㆍhr/ml. The final elimination half-life of plasma was longer than that of urine, but urinary clearance was lower than oral. A very small fraction of OP (Fe < 0.0017%) was excreted in urine within 24 hr. These results indicated that the major excretion route of OP was not urine. The mean maximal tissue distribution of OP was obserbed at 6 hr after treatment and slowly decreased time-dependently. High OP concentrations were detected in fat at 24 hr. The OP in fat was slowly released with longer elimination half-life and lower clearance than that of other tissues. OP was not accumulated in the liver following single oral application but 14-day oral treatments resulted in two-fold accumulation. It was probably due to the saturation of detoxification pathways. On the other hand, the mRNA expression of cytochrome P450 isoforms except CYP2C11 was not affected by OP at any dose. The expression of CYP2C11 mRNA decreased in a dose-dependent manner. This result suggests that OP changes expression of the male-specific cytochrome P450 isoforms in rat liver, and these changes are closely related to the toxic and estrogenic effect of OP.

• The Journal of Korean Institute of Electromagnetic Engineering and Science
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• v.28 no.4
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• pp.318-327
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• 2017

It is essential for the near-field receiving measurement to make beam pattern and check the performance of a active phased array antenna system. Also, we could obtain compensation value for mono-pulse function through the near-field receive test, however, if the radar has many frequency channel, the test would take long time and hard effort. So it is needed that frequency channels are selected for measurement and calculates the values for other frequency channels to improve efficiency in development and manufacture. In this case, the phase variations in sum and del channels would be checked. The phase measurement includes un-linear characteristic because of wrapping effect. Generally, radars have similar path length in sum and del channel, but if a radar has a electrical length gap between sum and del channel, errors could occur by phase's wrapping effect. In this paper, the interpolation method's error caused by electrical length gap is checked and the effective method for frequency channel selection to avoid wrapping effect is introduced.

• Journal of Acupuncture Research
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• v.32 no.3
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• pp.127-133
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• 2015

Objectives : Previous studies have shown that the amount of melittin, the main active ingredient in bee venom pharmacopuncture, tends to decrease substantially with time during pharmacopuncture manufacture. This study aimed to assess whether the stability of bee venom pharmacopuncture improved with pharmacopuncture additives. Methods : Components were measured using high performance liquid chromatography. Acute toxicity and antigenicity tests by subcutaneous and venous routes were conducted at Korea Pharmaceutical Test & Research Institute and mortality, adverse reactions, and body weight changes were assessed. Results : Stability tests using additives revealed that bee venom without additives was most stable. Bee venom pharmacopuncture without additives was further tested for toxicity in subcutaneous and venous administration in mice and no changes pertaining to toxicity were found over the testing period. Conclusions : Bee venom pharmacopuncture without additives was found to be most stable, and further, it did not show toxicity or antigenicity in subcutaneous and venous administration in mice.

• Journal of Advanced Navigation Technology
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• v.22 no.5
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• pp.442-448
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• 2018

In this paper, a microstrip antenna for LTE / LTE-A is designed and fabricated for a broadband mobile communication system. The proposed antenna is designed to have the characteristics of using FR-4 (er = 4.3), size of $40mm{\times}50mm$, and LTE / LTE-A frequency bands of 2.3 GHz and 2.5 GHz. 2014, and the simulation result shows that the gain is 2.391 dBi at 2.3 GHz and 2.566 dBi at 2.5 GHz. The S-parameter also showed a result of less than -10 dB (WSWR 2: 1) in the desired frequency band. The broadband mobile communication antenna has been miniaturized, high performance, and light weight, and an excellent and low cost system is continuously being developed, and a broadband mobile communication system is used by many people. Since LTE / LTE-A technology has been proposed according to the development of system and demand, it is expected that many users will design and manufacture antennas satisfying the above conditions and apply the applied technology.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.21 no.4
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• pp.437-445
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• 2020

Smoke grenades are the primary means of protection used by tanks to disrupt enemy detection systems. Such smoke grenades are a critical factor that determines the survival of tanks in the engagement of ground weapon systems, but it can only be used once. Owing to its destructive property, the performance and safety of the smoke grenade cannot be confirmed prior to use. Therefore, the reliability of smoke grenades can be evaluated through various tests during the storage period. This paper presents the results of estimating the reliability and shelf life of IR screening smoke grenade launchers based on the result of the Ammunition Stockpile Reliability Program conducted in 2019. Among the smoke grenade launcher lots currently stored, 16 lots and samples were selected for each year of manufacture and tested. The reliability and shelf life were estimated by examining the number of defects and the change in quality characteristics of each test item. The results of this study can be used to assess the reliability of the smoke grenade launchers and to improve the quality of manufacturing sites.

• Journal of Korean Society of Environmental Engineers
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• v.36 no.1
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• pp.7-12
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• 2014

The adsorption characteristics of Pb(II) and Cu(II) by the manganese oxide-coated activated carbon (MOAC) were investigated by series of batch experiments. MOAC was prepared by three types of manufacturing methods such as chemical precipitation method (CP), hydrothermal method (HT) and supercritical method (SC). Pseudo-second-order and Langmuir models adequately described kinetics and isotherm of Pb(II) and Cu(II) adsorption on the experimented adsorbents. These results indicated that heavy metal ions were chemically adsorbed onto uniform monolayered adsorption sites. The coating of manganese oxide enhanced the adsorption capacities of AC. And adsorption capacities of Pb(II) and Cu(II) were significantly affected by the manufacturing method of MOAC. The highest adsorption performance was obtained by using SC, followed by HT and CP, which is caused from high uniformity and amount of manganese oxide coated onto AC induced by high temperature and pressure. These results show that MOAC can be used as an effective adsorbent to remediate heavy metal contaminated environment.

• Journal of the Korean Wood Science and Technology
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• v.42 no.6
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• pp.691-699
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• 2014

In order to improve the dimensional stability and durability of wood, this study attempted to impregnate bismuth (Bi) - tin (Sn) alloy metal with low melting temperature into solid woods of three species such as radiata pine, red oak and white oak, and investigated to determine an optimum condition of manufacturing the metal alloy-wood composites with natural wood grains. These Bi-Sn alloys were chosen for this study because they were harmless to human and melting at low temperatures. The composites resulted in high dimensional stability and low thickness swelling, and also showed much improved performance such as high bending strength, high hardness, high electric conductivity, and high thermal conductivity as floor materials. A proper impregnating condition of all specimens was determined as 10 minutes of the preliminary vacuum time, and $185^{\circ}C$ of the heating temperature. The proper processing condition for radiata pine wood was 2.5 minutes of the pressuring time at the pressure of $10kgf/cm^2$. For red oak wood, 10 minutes of the pressuring time at the pressure of $30kgf/cm^2$ were the proper condition. The proper manufacture conditions for white oak wood was determined as 10 minutes of the pressuring time at the pressure of $50kgf/cm^2$.