• Title/Summary/Keyword: Mammalian cell

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Role and Action Mechanism of Secretory phospholipase $A_2$ in Macrophage Activation

  • Baek, Suk-Hwan
    • Proceedings of the PSK Conference
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    • 2002.10a
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    • pp.179-180
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    • 2002
  • The phospholipase $A_2$($PLA_2$) family represents a diverse group of enzymes that hydrolyze sn-2 fatty acid from the cell membrane. Several mammalian cytosolic $PLA_2$ and secretory $PLA_2$(s$PLA_2$) have been characterized and classified into different families. At present, 12 distinct sPLA$_2$s have been identified in mammals and classified into different groups, depending on their primary structures as characterized by the number and position of cysteine residues. (omitted)

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Biological Roles of Alternative Autophagy

  • Shimizu, Shigeomi
    • Molecules and Cells
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    • v.41 no.1
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    • pp.50-54
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    • 2018
  • Atg5 and Atg7 have long been considered as essential molecules for autophagy. However, we found that cells lacking these molecules still form autophagic vacuoles and perform autophagic protein degradation when subjected to certain stressors. During this unconventional autophagy pathway, autophagosomes appeared to be generated in a Rab9-dependent manner by the fusion of vesicles derived from the trans-Golgi and late endosomes. Therefore, mammalian autophagy can occur via at least two different pathways; the Atg5/Atg7-dependent conventional pathway and an Atg5/Atg7-independent alternative pathway.

Germ Cell Degeneration during Mammalian Spermatogenesis (포유류의 정자형성과정 중 생식세포의 변화)

  • 김종민
    • Proceedings of the KSAR Conference
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    • 2001.10a
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    • pp.11-13
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    • 2001
  • 사람을 포함한 포유류의 정자형성과정은 시상하부에서 분비된 생식소자극호르몬 방출호르몬 (gonadotropin releasing hormone)의 영향 하에 뇌하수체에서 합성 분비되는 난포자극호르몬 (follicle stimulating hormone; FSH) 과 황체화호르몬 (luteinizing hormone; LH)에 의해서 조절된다. LH의 라이디히 세포 (Leydig cells) 자극으로 인한 testosterone 의 합성분비가 성체(adult)의 정자형성과정과 그 유지(maintenance)에 매우 결정적이다. 반면, FSH는 미성숙 개체의 정소에서 일어나는 예비적 정자형성과정에 있어 중요한 역할을 하며, 성체에서도 질적인 면에서의 정자형성과정에 관여하는 것으로 사려된다. 그러므로, 시상하부-뇌하수체-정소의 축(axis)을 이루는 어느 한 성분에서라도 이상이 생기면 정자의 형성과정은 치명적인 영향을 받을 수 있다. (중략)

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Sialylated oligosaccharide analyses using high-performance liquid chromatography with a fluorescence detector

  • Cho, Due-Hyeon;Ryu, Chang-Soo;Park, Jee-Hun;Kim, Ha-Hyung
    • Proceedings of the PSK Conference
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    • 2003.04a
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    • pp.316.1-316.1
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    • 2003
  • N-acetylneuraminic acid is one of the major derivatives of sialic acid. is widely distributed in mammalian cells as the ${\alpha}$2-3- or ${\alpha}$2-6-linked nonreducing terminal residue of oligosaccharide chains of glycoconjugates, and plays important structural and functional roles at the cell membrane surface. The analysis of sialylated glycoproteins is an important part of glycoprotein characterization, especially because sialylation or desialylation in oligosaccharides often causes dramatic changes in the function of glycoproteins. (omitted)

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