• 대한후두음성언어의학회지
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• 제28권2호
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• pp.144-147
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• 2017

Laryngeal neoplasm is the second most common malignancy of the upper aerodigestive tract. About 85% to 95% of laryngeal malignancies are squamous cell carcinoma that arises from the epithelial lining of the larynx. The exact cause of laryngeal neoplasm is unknown, but certain risk factors can affect the chances of developing it. Chronic inflammation is a mutagen factor confirmed in the carcinogenesis of various tumor. Inhalation injuries cause histopathologic damage to laryngeal mucosa and inflammation change. This long term inflammation may leads to the development of dysplasia and malignant transformation. Recently, we experienced a case of malignant transformation of laryngeal mucosa after inhalation injury patient 25 years ago. Herein, we reported this rare case and review the relevant literature.

• 대한핵의학회지
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• 제18권1호
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• pp.25-31
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• 1984

The effeciency of combined application of isotope scan and ultrasonography of thyroid was assessed in 91 patients with thyroid nodule. Malignancy rates were 35.5%, 18.8%, & 0% in solid, complex & cystic nodule group, respectively. No statistically significant co-relationship was found between isotope scan finding & ultrasonographic finding. Malignant nodules were found only in cold solid nodule group & cold complex nodule group, and rate of malignant nodule was different between them(45.8% in cold solid nodule group & 20.7% in cold complex nodule group). Difference between the rate of cystic change in benign & malignant nodule observed in our study(59.2% vs. 35.3%) was thought to explain at least partly the statistically different rate of malignant nodule in cold solid nodule & cold complex nodule group. No difference in the boundary condition, echogenicity & distribution of internal echo existed between benign nodule group &malignant nodule group.

• 대한두경부종양학회지
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• 제15권1호
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• pp.66-69
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• 1999

Background and Objectives: It is critical to distinguish benign from malignant thyroid nodule and to select a patient for surgery. Even though the U/S study dose not make great contribution to diagnose a malignant thyroid nodule, it is widely used in the evaluation of anatomic feature of thyroid. The authors tried to estimate the efficacy of the U/S study in preoperative diagnosis of malignant thyroid nodule. Materials and Method: At the department of General Surgery of Ajou University, 75 patients who were operated after diagnosis with thyroid nodule by U/S study between July 1996 to June 1997 were retrospectively analyzed. By comparing the U/S impression that implies malignant thyroid nodule to FNAC and post-operative pathologic results ware as follows. Results: 1) Absence of cystic change, presence of internal hypoechogenicity, lobulation, calcification, thick and irregular halo, and nodule more than 4cm in diameter on U/S were considered significant statistically for the diagnosis of malignancy(Chi-square test, p<0.05) 2) Presence of internal hypoechogenicity or thick and irregular halo has the validity in Logistic regression analysis. 3) FNAC was done in 65 case. 19 case were malignant, 11 case were suspicious and 46 patients were benign (sensitivity 52.6%, specificity 87%). 4) The findings of U/S which are hypoechogenic and thick and irregular halo show 82% sensitivity and 97% specificity. In combination with the findings of FNAC that imply benign or suspicious lesions, the sensitivity was 100% and the specificity was 97%. Conclusion: This study suggest that the hypoechogenicity and thick and irregular halo on U/S are important information for the diagnosis of thyroid malignancy which were considered benign or suspicious after FNAC.

• 대한세포병리학회지
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• 제2권2호
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• pp.73-78
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• 1991

A total of 362 bile samples from 104 patients with evidence of biliary tract obstruction were submitted for diagnostic cytology from January, 1989 to April, 1991. The patients were classified based on the obstructive cause, and the cytologic results were reviewed. 298 of the specimens were from patients with intrabiliary malignant structure, and 17 were from patients with extrabiliary malignant compression or benign biliary obstruction. Bile cytology was positive for carcinoma in 42 samples from patients with intrabiliary malignant stricture, and the diagnostic sensitivity was 14%. There were no false positive cases. We concluded that the cause of low sensitivity was degenerative change of cell due to prolonged sampling time. What is noteworthy was the high prevalence of Clonorchis sinensis eggs, being detected in 25 patients with intrabiliary malignancy, supporting the association between clonorchiasis and biliary tree malignancy.

• Journal of Chest Surgery
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• 제30권8호
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• pp.838-842
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• 1997

비정형 폐기관지 카시노이드(carcinoid)는 드문 폐 종양으로 기원이 신경호르몬 종양으로 사려되며 전형적인 카시노이드와 소세포암 사이의 중간 정도의 악성도를 나타내는 형태이다. 저자들은 무증상이며, 호르몬 생성을 보이지 않은 비정형 카시노이드를 수술치험 하였다. 환자는 49세 여자환자로 단순흉부촬영상 우연히 발견된 우하엽의 종괴를 주소로 내원하였다. 기관지 내시경하 조직검사에서 진단되어 우하엽 및 중엽 절제술과 종경동 임파선 박리술을 시행받고 술후 4주후에 방사선 치료를 받았다.

• Journal of Chest Surgery
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• 제24권5호
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• pp.498-504
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• 1991

Mucoepidermoid carcinoma arising in the tracheobronchial tree is an extremely rare tumor. Usually it remains as locally invasive neoplasm, although malignant change is described. Histologically, it is characterized by an admixture of vacuolated, mucus producing cells and sheets of epithelial cells with a cohesive pattern which resemble squamous cells. Its clinical and histopathological behaviors were reported as varying degrees of benign to extremely malignant. We had experienced two young patients with low-grade mucoepidermoid carcinoma of the right and left upper lobar bronchi. A 15-year-old man who had had intermittent hemoptysis for 1 year underwent right upper lobectomy. And the other 18-year-old man had suffered from obstructive pneumonitis for 6 months underwent left pneumonectomy. The postoperative courses were uneventful, and the bronchoscopy and chest CT which were done at 6 months later revealed no regional recurrence.

• Journal of Chest Surgery
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• 제21권5호
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• pp.941-947
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• 1988

The mucoepidermoid carcinoma of the bronchus is very rare neoplasm. The histological appearance is an intimate mixture of mucous-producing cell and epidermoid cell. The malignant potency of the tumor was determined by histologic pattern. Bronchoplasty techniques represent the ideal form of excisional therapy for benign endobronchial tumor as well as tumors of low-grade malignant potential, such as bronchial adenoma, and for repair of traumatic airway injuries and benign stricture and selected group of patients with carcinoma of the lung. We experienced a case of-low-grade mucoepidermoid carcinoma in a patient of 21-year old male who has been suffered from hemoptysis episodes for several years. The sleeve resection of left main bronchus and left lower lobectomy due to bronchiectatic change were carried out. The patient are being followed up without specific problem.

• Archives of Reconstructive Microsurgery
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• 제20권2호
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• pp.89-95
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• 2011

Purpose: The purpose of this study was to evaluate the clinical results of anterolateral thigh free flap on soft tissue defect following wide excision in malignant soft tissue tumor of lower extremities. Methods: Between February 2005 to April 2010, we followed up 19 cases who were undergoing anterolateral thigh free flap because of soft tissue defect following wide excision of malignant soft tissue tumor in lower extremity, including 9 cases were heel, 5 cases in foot, 3 cases in ankle, 2 cases in knee and leg. We observed that of implanted area's color, peripheral circulation at 3, 5, 7 days after operation and evaluated operating time, amount of hemorrhage, implanted skin necrosis, additional operations, complications. And we also evaluated the oncologic results, including local recurrence, metastasis, and morbidity. Results: Average operation time of wide excision and anterolateral thigh free flap was 7 hour 28 minutes. 18(94.7%) of total 19 cases showed successful engraftment, on the other hand, failure of engraftment due to complete necrosis of flap in 1 case. In 18 cases with successful engraftment, reoperation was performed in 4 cases. Among them, removal of hematoma and engraftment of flap after bleeding control was performed in 3 cases, because of insufficient circulation due to the hematoma. In the remaining 1 case, graft necrosis due to flap infection was checked, and grafted after combination of wound debridement and conservative treatment such as antibiotics therapy, also skin graft was performed at debrided skin defect area. Skin color change was mainly due to congestion with hematoma, flap was not observed global congestion or necrosis except 4 cases which shows partial necrosis on margin that treated with conservative therapy. Conclusions: Anterolateral thigh free flap could be recommended for reconstruction of soft tissue defect following wide excision of malignant soft tissue tumor in lower extremity.

• Journal of the Korean Association of Oral and Maxillofacial Surgeons
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• 제30권3호
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• pp.228-233
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• 2004

Summary: The malignant peripheral nerve sheath tumor(MPNST) is an aggressive neoplasm and can either arise independently or result from malignant change in preexisting neurofibromatosis (von Recklinghausen's disease). Its histologic characteristics remain controversial, but currently it is believed that the schwann cell is the origin of the peripheral nerve sheath tumors. MPNST is an uncommon neoplasm of the head and neck region, and its presentation in the oral cavity is quite rare. In this study, we report a patient with a rare case of a MPNST involving the maxilla. A case report: A 29-year-old female presented with a chief complaint of painless swelling with bleeding tendency on the left maxillary tuberosity area 2 months ago. Clinical examination showed a $5.0{\times}3.0cm^2$ sized, indurative swelling on the site. Conventional radiographs showed a relatively well-defined soft tissue mass involving the left maxillary sinus, and destruction of the anterior, posterolateral walls of the left maxillary sinus. Subtotal maxillectomy and split-thickness skin graft from thigh were undertaken. In histochemical and immunohistochemical studies, the specimen revealed positive reactivities to Vimentin and S-100 protein. Final diagnosis was made as MPNST.

• Radiation Oncology Journal
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• 제13권3호
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• pp.225-231
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• 1995

악성 섬유성 조직구종은 상악골부위에서는 매우 드물게 발생하는 악성 종양으로서, 두경부에 발생되는 예가 전체 악성 섬유성 조직구종의 $7{\%}$ 이며 이들 $7{\%}$ 중 $12{\%}$가 상악골에 발생한다고 한다. 상악골의 악성 섬유성 조직구종은 국소재발이나 원격전이가 $55{\%}$의 환자들에서 발생하며 평균 생존기간은 상악골, 하악골 및 구강연부조직의 악성 섬유성 조직구종에 관한 연구에서 30개월로 보고되었다. 상악골의 악성 섬유성 조직구종은 일차적으로 근치적 수술요법이 주 치료방법이다. 방사선치료에 관한 보고들은 대상환자들이 적어서 지금까지 체계적으로 보고되지 않았고, 증례보고에 의한 종양의 퇴행 또는 조직학적 변화가 발표된 바 있으며 일부 저자들은 수술후 방사선치료가 도움이 되지 않으므로 재발성 또는 수술 불가능한 경우에 시행하기를 권하기도 한다. 재발성 또는 전이성 악성 섬유성 조직구종 환자들에서 항암화학요법으로 $33{\%}$의 관해율을 보였다는 보고가 있다. 저자들은 상악골의 악성 섬유성 조직구종 1예를 경험하였기에 문헌고찰과 함께 보고하는 바이다.