• 대한불안의학회지
• /
• 제10권2호
• /
• pp.143-150
• /
• 2014

Objective : The subgenual cingulate cortex, a part of default-mode network, has been known to playa key role in the pathophysiology of depression. The previous studies have reported abnormal functional connectivity between the subgenual cingulate cortex and other brain regions in the patients with depression. The goal of this shldy was to explore the resting-state functional connectivity of the subgenual cingulate cortex between the patients with depression and healthy subjects. Methods : Twenty patients with major depression and age- and sex-matched 20 healthy subjects underwent 5-minute resting state fMRI scans. The functional connectivity map in each subject was acquired using seed-based correlation analysis with the seed located in the subgenual cingulate cortex (Talairach coordinates; x=-10, y=5, z=-10). The functional connectivity maps were calculated using AFNI and compared between the patient and healthy subject group via two-sample T-test using 3dttest++ in AFNI package. Results : Functional connectivity was decreased between the subgenual cingulate cortex and both sides of fusiform gyrus in depressed subjects. Connectivity was also decreased between the subgenual cingulate cortex and the left cerebellum in the patient group. There was no correlation between the severity of depression and the degree of functional connectivity between the subgenual cingulate cortex and the regions showing decreased functional connectivity. Conclusion : Decreased resting-state functional connectivity between the subgenual cingulate cortex and both sides of fusiform gyrus, and decreased connectivity between the subgenual cingulate cortex and the left cerebellum found in the patients with major depression in comparison to the healthy subjects might be related to abnormal emotional and cognitive processing of depressed patients.

• 아동학회지
• /
• 제31권4호
• /
• pp.1-14
• /
• 2010

The purpose of this study was to investigate the relationship between depression, colleagues/ supervisor's emotional support and burnout experienced by teachers in kindergartens and childcare centers. The subjects were 195 teachers who worked in kindergartens or childcare centers in Daegu and Gyeongbuk Province. Questionnaires, which required self-report by teachers, were used to investigate depression, colleagues/supervisor's emotional support and burnout. The data collected were analyzed by means of paired t-test, Pearson's correlation, simple regression, hierarchial regression, using SPSS Win 15.0. The results are as follows. (1) The emotional support from colleagues was significantly higher than from that provided by the supervisor. Moreover, teachers' depression levels were positively associated with burnout. (2) Colleagues' emotional support operated as major determining factor with the effect that burnout decreased as colleagues' emotional support levels increased. There were observable interactional effects between depression and the emotional support provided by colleagues' to colleagues experiencing burnout. (3) The supervisor's emotional support operated as a major factor with the effect that burnout decreased with a rise in the levels of a supervisor's emotional support. No interactional effects were observed between depression and supervisor's emotional to colleagues dealing with burnout.

• 한국보건간호학회지
• /
• 제19권2호
• /
• pp.305-315
• /
• 2005

Purpose: The purpose of this study was to investigate the relationships among depression, sleep patterns and health promoting behavior in female college students. Methods: The subjects of this study consisted of 350 college students. The data was collected through self-administered questionnaires from November to December of 2004. The data was analyzed via the SPSS computer program by using descriptive statistics, t-tests, ANOVA and Pearson's correlation coefficients. Results: There are significant differences and impacts on depression according to the amount of coffee consumed, the time spent on computer and the amount of smoke inhaled. Sleep patterns differ depending on one's college major, the time spent on computer, and the amount of smoke inhaled. Health promotion behavior was shown to be significantly different according to the living style, college major and how much TV was watched The mean scores for depression, sleep patterns, health promoting behavior were 1.45 (on a 3 points scale), 2.71 (on a 4 points scale), and 3.03 (on a 5 point scale), respectively. There was a significant positive correlation between sleep patterns and health promoting behavior, and there was negative correlation between depression and health promoting behavior, and between depression and sleep patterns in college students. Conclusion: The findings of this study give useful information to create further studies on intervention programs related to health promoting behavior for college female students.

• Journal of Nutrition and Health
• /
• 제54권2호
• /
• pp.152-164
• /
• 2021

Purpose: This study aimed to examine the association between depression and eating behavior factors in Korean adults. Methods: Study subjects were selected (n = 5,103) from the participants of the 7th Korea National Health and Nutrition Examination Survey 2018 and divided into depression (men, 59; women, 162) and normal groups (men, 2,083; women, 2,799). Subjects with a Patient Health Questionnaire 9 score ≥ 10 (out of 27 points) were defined as having depression. Results: A higher prevalence of depression was observed in both men and women who were unemployed (p < 0.001, p = 0.008), had lower income (both p < 0.001), poorer subjective health (both p < 0.001), and poor food safety (both p < 0.001). The prevalence of depression was higher in women with lower education levels (p = 0.008), who were unmarried (p = 0.010), smokers (p < 0.001), and in a one-person household (p = 0.001). Obese men showed a higher prevalence of depression (p = 0.009). Men who were eating alone or skipping lunch had a high prevalence of depression (p = 0.009), while women who were eating breakfast (p = 0.012), lunch (p = 0.001), and dinner (p = 0.010) alone had a high prevalence of depression. The relationship analysis between men and women according to dietary habits using logistic regression showed that, in women, after variable adjustment, skipping lunch (odds ratio [OR], 2.677; 95% confidence interval [CI], 1.090-6.574), meal frequency of 2 times per day (OR, 1.658; 95% CI, 1.084-2.536), and lunch frequency of 3-4 times per week (OR, 3.143; 95% CI, 1.725-5.728) were significantly associated with a higher prevalence of depression. Conclusion: Depression in women was not only affected by more sociodemographic variables but also associated with decreased frequency of lunch and dinner, especially with skipping lunch.

• 우울조울병
• /
• 제9권2호
• /
• pp.57-63
• /
• 2011

Objectives : This study aimed to investigate the prevalence and risk factors of depression within two weeks after stroke. Methods : A total of 362 stroke patients were recruited. Depression (major and minor depressive disorders) was diagnosed by applying DSM-IV criteria. Data on socio-demographic characteristics (age, gender, education, marital state, living state, religion, occupation, income, life event, and social support), stroke severity (NIHSS), disability (BI), stroke hemisphere and location, vascular risk and disease, and previous history of stroke and depression were obtained. Results : Depression was present in 90 (24.9%) patients: major depression 29 (8%) and minor depression 61 (16.9%) patients. In the univariate analyses, depression was associated with older age, higher number of stressful life event, poorer social support, severe disability, anterior stroke location, previous history of stroke and depression. In the multivariate analyses, depression was independently associated with higher number of stressful life events and poorer social support. Conclusion : Depression was common and was determined by premorbid levels of stress and social support in stroke patients at acute stage. More intensive psychiatric care and intervention is needed for the high risk group.

• 한국농촌간호학회지
• /
• 제6권2호
• /
• pp.69-77
• /
• 2011

Purpose: This study was done to identify the current status of research on depression in married immigrant women and to suggest directions for future nursing research. Method: Sixteen articles for the period between 2001 and 2010 were selected by key words such as "Married Immigrant Women" and "Depression" from the databases (RISS4U et al). Results: Twelve of the research reports were related to correlations and 4 were related to interventions. Depression level was measured using BDI or CES-D. Depression levels were as follows: 20-30% reported major depression and less than 10%, severe depression. Factors which influenced depression included: socio-demographic factors, and family, economic, psychological and situational characteristics. Psychological treatment prevailed in the intervention research, for example, art therapy, and horticultural therapy. In 2 papers significant improvement in the state of depression among participants in the intervention group were reported. Conclusion: The next phase of nursing research related to married immigrant women is to reconsider the importance of the concept of depression to reexamine research methods and directions.

• 생물정신의학
• /
• 제13권1호
• /
• pp.11-18
• /
• 2006

Depressive disorder is one of well-known major public health problems in Korea. The socioeconomic burden of depression is growing bigger and bigger. Therefore, the Korean government decided to establish the clinical research center for depression for better care of patients with depression. One of the major task of the center is the development of Korean clinical practice guideline for depressive disorders. This guideline should reflect the clinical situation in Korea and meet Korean physicians' needs. In addition, it should be feasible and easy to use. We reviewed the present status of the guideline development in Korea and other countries, and introduces the scope, method, and goals of Korean clinical practice guideline for depression.

• Bioinformatics and Biosystems
• /
• 제1권2호
• /
• pp.134-138
• /
• 2006

우울증은 가장 유병율이 높은 '기분 장애'(mood disorder)의 일종으로, 약 20%의 인구가 일생동안 우울증 증상을 한번쯤 경험한다. 이러한 우울증은 크게 '우울 장애'(major depressive disorder)와 '양극성 장애'(bipolar disorder)로 구분된다. 환자의 질병 분류에 따라 사용되는 약과 의학적 처방이 다르기 때문에, 우울증 환자의 빠르고 정확한 진단 및 분류는 매우 중요하다. 기존의 다면성 인성검사(MMPI)와 같은 통계적인 방법이 우울증 환자의 진단을 위해 사용돼 왔으나, 장시간의 집중력을 요구하기 때문에 집중력 저하의 특징을 보이는 우울증 환자들에게 적용하는데 어려움이 있다. 이 논문에서는 이러한 문제를 해결하고자, 빠른 측정이 가능하고 측정동안 집중력을 요하지 않는 EEC 데이터의 분석을 통해 우울증 환자의 분류를 시도하였다. EEG 채널 간 정보 흐름에서의 비선형성과 근사 엔트로피(approximate entropy)의 크기를 속성(attribute)으로 사용하여 데이터 마이닝 기법 중 의사 결정 트리(decision tree)와 가능성 기반 서포트 벡터머신(possibilistic support vector machines) 통해 분석을 수행하였다. 30명의 주요 우울장애환자와 24명의 양극성 장애 환자를 통해 위의 분석을 수행한 결과 의사 결정 트리의 경우 85.19% 의 정확도를 가지며 분류해냈고, 가능성 기반 서포트 벡터머신의 경우 77.78%의 정확도를 보여줬다. 본 연구는 가능성 기반 서포트 벡터 머신 분석이 우울증 환자는 진단하고 분류하는데 유용하게 적용될 수 있는 가능성을 제시하고 있다.

• 동의신경정신과학회지
• /
• 제34권4호
• /
• pp.453-461
• /
• 2023

Objectives: Major depressive disorder is a severe disease that is associated with suicidal ideation and behavior. In this case, Korean medicine psychotherapy and Korean medicine treatment were used to treat an adolescent patient with major depressive disorder. Methods: The Beck Depression Inventory, Reynolds Suicidal Ideation Questionnaire, and Crisis Triage Rating Scale were used as psychological evaluation scales. Korean medicine psychotherapy focuses on Giungoroen-therapy and IiGyeungByunQi-therapy and Korean medicine treatment combined with acupuncture, moxa, and herbal medicine. Results: Comparison before and after treatment showed improvement in clinical symptoms, Beck Depression Inventory, Reynolds Suicidal Ideation Questionnaire, and Crisis Triage Rating Scale. Conclusions: As a result of applying Korean medicine, psychotherapy and Korean medicine treatment reduces to an adolescent patient with major depressive disorder, depression, suicidal thoughts, and suicidal behavior.

• 동의신경정신과학회지
• /
• 제33권4호
• /
• pp.389-400
• /
• 2022

Objectives: Depression is a highly prevalent disease, and the market for antidepressant drugs continues to grow at a steady rate. Although current antidepressants are reported to be effective, because of their low remission rate and side effects, new antidepressants are needed. The use of Banhahubak-tang (BHT) to treat the symptoms of depression is supported by experimental evidence. The proposed study will evaluate the efficacy and safety of BHT in treating depression. Methods: A randomized, waitlist-controlled, parallel clinical trial will be conducted to assess the efficacy of BHT in depression. A total of 84 participants with depression will be randomized into the intervention group or waitlist-control group at a 1:1 ratio. Patients in the intervention group will be administered BHT three times a day for four weeks and followed up for four more weeks after therapy completion. Patients in the waitlist-control group will undergo the same intervention and follow-up after a four-week waiting period. The primary outcome is change in the Korean version of the Hamilton Depression Rating Scale (K-HDRS) scores for major depressive disorders after four weeks. The secondary outcomes include scores on the K-HDRS, Korean Symptom Check List 95 (KSCL-95), Insomnia Severity Index (ISI), State-Trait Anxiety Inventory-Korean version (STAI-K), State-Trait Anger Expression Inventory-Korean version (STAXI-K), and the Instrument on Pattern Identifications for Depression and EuroQol-5 Dimension (EQ-5D). Conclusions: This trial will provide high-quality clinical evidence of the efficacy and safety of BHT in the management of depression.