• The Korean Journal of Physiology and Pharmacology
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• 제8권5호
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• pp.253-257
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• 2004

Schwann cells play an important role in peripheral nerve regeneration. Upon neuronal injury, activated Schwann cells clean up the myelin debris by phagocytosis, and promote neuronal survival and axon outgrowth by secreting various neurotrophic factors. However, it is unclear how the nerve injury induces Schwann cell activation. Recently, it was reported that certain cytoplasmic molecules, which are secreted by cells undergoing necrotic cell death, induce immune cell activation via the toll-like receptors (TLRs). This suggests that the TLRs expressed on Schwann cells may recognize nerve damage by binding to the endogenous ligands secreted by the damaged nerve, thereby inducing Schwann cell activation. Accordingly, this study was undertaken to examine the expression and the function of the TLRs on primary Schwann cells and iSC, a rat Schwann cell line. The transcripts of TLR2, 3, 4, and 9 were detected on the primary Schwann cells as well as on iSC. The stimulation of iSC with poly (I : C), a synthetic ligand for the TLR3, induced the expression of $TNF-{\alpha}$ and RANTES. In addition, poly (I : C) stimulation induced the iNOS expression and nitric oxide secretion in iSC. These results suggest that the TLRs may be involved in the inflammatory activation of Schwann cells, which is observed during Wallerian degeneration after a peripheral nerve injury.

• 한국간담췌외과학회지
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• 제27권1호
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• pp.40-48
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• 2023

Backgrounds/Aims: Timing of resection for synchronous colorectal liver metastasis (CRLM) has been debated for decades. The aim of the present study was to assess the feasibility of simultaneous resection of CRLM in terms of major complications and develop a prediction model for safe resections. Methods: A retrospective single-center study of synchronous, resectable CRLM, operated between 2013 and 2021 was conducted. Upper limit of 95% confidence interval (CI) of major complications (≥ grade IIIA) was set at 40% as the safety threshold. Logistic regression was used to determine predictors of morbidity. Prediction model was internally validated by bootstrap estimates, Harrell's C-index, and correlation of predicted and observed estimates. Results: Ninety-two patients were operated. Of them, 41.3% had rectal cancers. Major hepatectomy (≥ 4 segments) was performed for 25 patients (27.2%). Major complications occurred in 20 patients (21.7%, 95% CI: 13.8%-31.5%). Predictors of complications were the presence of comorbidities and major hepatectomy (area under the ROC curve: 0.692). Unacceptable level of morbidity (≥ 40%) was encountered in patients with comorbidities who underwent major hepatectomy. Conclusions: Simultaneous bowel and CRLM resection appear to be safe. However, caution should be exercised when combining major liver resections with bowel resection in patients with comorbid conditions.

• 대한치위생과학회지
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• 제5권2호
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• pp.85-96
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• 2022

Background: This study was aimed at determining the relationship of the Dominance, Influence, Steadiness, and Conscientiousness (DISC) personality type with the major satisfactions and job preferences of dental hygiene and technician students. Methods: We enrolled 264 dental hygiene and technician students from a junior college in Chungcheong-do. A questionnaire survey was conducted to determine the DISC behavior type, major satisfaction level, and job preference of the participants. Statistical analyses were performed with the independent-samples t-test, one-way analysis of variance, and multiple regression. Results: Dental technician students had higher major satisfaction (p< .001) and preferred jobs with potential for growth (p= .020) or matching their vocation and interests (p= .013) compared to dental hygiene students. Factors influencing major satisfaction were grade (β= .160, p= .008) and a social personality type (β= .146, p= .070). Factors influencing preference for jobs with high growth potential were the personality type (β= .236, p= .001), grades (β= .157, p= .002), and major satisfaction (β= .429, p< .001). The conscientiousness personality type was conducive to preferencefor jobs with high growth potential. The steadiness personality type was conducive to preference for jobs aligned with vocation and interest (β= .249, p= .004). The conscientiousness personality type (β= .137, p= .041) and high major satisfaction (β= .193, p= .003) were conducive to preference for jobs with a satisfactory working environment. Conclusion: The results of this study could serve as a basis for customized career counseling and education programs according to personality types.

• 기본간호학회지
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• 제9권3호
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• pp.424-433
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• 2002

This study was done to compare death orientation scores for student nurses before and after studying a major. The participants were 130 student nurses before the major and 123 student nurses after the major at C university in Kwang Ju city. The data were gathered from March, 1998 to September, 2001 using a questionnaire. The data were analysed by Chi square test, t-test, ANOVA and Pearson correlation coefficients. The results of this study are summarized as follows ; 1 The mean scores for death orientation before and after the major were 57.8 and 60.2 respectively. The mean score of death orientation after the major tended to be higher than before but they were not significantly different. 2. There were significant differences in death orientation scores between the two groups before the major for 'physical function (F=3.83, p=.023)' and 'attending a lecture on spiritual nursing (F=2.58, p=.010)'. After the major there were significant difference for 'feeling of health (F=4.76, p= .001)'. 3. The death orientation scores before the major showed an inverse correlation with religiosity score (r=-.239, p=.006). After the major there was no correlation with religion.

• 대한불안의학회지
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• 제4권2호
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• pp.127-134
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• 2008

Objective : This study examined whether major depressive disorder patients with anxiety traits displayed abnormal electroencephalographic (EEG) alpha asymmetries. Methods : Resting EEG was recorded in 11 outpatients with major depressive disorder (6 of whom had a high anxiety trait while 5 exhibited a low anxiety trait) and 6 controls. Results : In contrast to the controls, within the major depressive disorder patient group, comorbid anxiety disorder showed alpha asymmetry indicative of less activation over right than over left temporal sites. Patients diagnosed with major depressive disorder but no anxiety disorder showed a reduced temporal alpha asymmetry, supporting the potential importance of evaluating anxiety in studies of regional brain activation, in depressed patients. Conclusion : These findings suggest that anxiety is associated with brain hypoactivation, especially with right temporal hypoactivation.

• 한국응급구조학회지
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• 제26권3호
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• pp.93-104
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• 2022

Purpose: This study examined the correlation between satisfaction with major, academic self-efficacy, and academic persistence with the general characteristics of students in a health-related field, to determine factors that affect academic persistence. Methods: The study was conducted on third- and fourth-grade health-field students at Daejion. The questionnaire consisted of a self-report, and a URL was sent by text message to students who agreed to participate after reading the purpose and necessity of the study. Results: Major satisfaction was 4.23 on average, academic self-efficacy was 4.15, and academic continuity was 4.25. Grade and school life satisfaction were the factors correlated with a significant difference in academic persistence. Significant positive correlations were seen between satisfaction with major (r=.637, p<.001) and academic self-efficacy (r=.563, p<.001); higher major satisfaction and academic self-efficacy led to higher academic persistence. Conclusion: A more systematic management approach needs to be conducted by developing active learning participation and applying customized counseling management and support programs by grade to improve the academic self-efficacy and academic persistence of students in health-related fields.

• 수산해양교육연구
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• 제22권4호
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• pp.477-489
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• 2010

This study tends to analyze the organizational factors of major curriculum of education department. For this, the education department's major curriculum of ten universities is analyzed in three levels. Subjects are analyzed for the high level, lesson plans for the middle level, and sub-topics for the low level. This study utilized the learning classified table of the Natioanl Research Foundation of Korea and the In-sil Chang's curriculum scope classified table. The results from the study are following. First, some subjects such as educational philosophy, educational psychology, life-long education take largest portions in the major curriculum of education department. Second. the history, the evaluation, and the definition and the scope of the education curriculum take greatest parts in the subject of education curriculum. It is expected that the findings of the study may provide the opportunities to introspect on the discussion and the organization of the educational directions and goals of education department.

• Communications for Statistical Applications and Methods
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• 제11권3호
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• pp.657-668
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• 2004

Permutation test has been applied for the QTL(quantitative trait loci) analysis and we selected a major locus. K -means clustering analysis, for the major DNA Marker mining of ILSTS035 microsatellite loci in Hanwoo chromosome 6, has been described. Finally, bootstrap testing method has been adapted to calculate confidence intervals and for finding major DNA Markers.

• The Journal of Korean Physical Therapy
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• 제13권2호
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• pp.265-272
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• 2001

The object of this thesis is to study the correlation between scoliosis and foot in a theoretical and empirical method. My research process was investigated for 34 students on the forward bending test, foot printer test, feedoscope test, X-ray test and so on. The main results of this study were as follows: 1. There was statistical significance on the correlation between foot length and spine length. 2. Scoliosis angle is the smallest on the pes plannus group and the biggest on the pes cavus group without statistical significance. 3. Left lumbar curve is the smallest, and right thoracic spine curve is the biggest on the left foot pattern group with statistical significance. 4. On the foot weightbearing groups, there was statistical significance both of between left and right foot groups. 5. There was no statistical significance on the t-test analysis between left foot area and right foot area according to scoliosis typology.

• The Journal of Korean Physical Therapy
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• 제13권2호
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• pp.325-333
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• 2001

The purpose of this study was to find out the effects of hallux valgus on the ankle plantarflexor and dorsiflexor peak torque, on the total work, on the average power, and on the Peak torque of plantarflexor to dorsiflexor ratio values. Isokinetic ankle plantarflexor and dorsiflexor strength was evaluated in 30 women(control: 15, hallux valgus: 15) by Cybex NORM System. Test data was gathered in the right ankle at a speed of 60/sec, 90/sec, 120/sec in the control group and the hallux valgus group. Statistical analysis was performed using SPSS 10.0 for windows software. Mean and standard deviations were measured and calculated for the General characterristic of subjects. A paired t-test was used to examine the differnces in the means for the ankle plantarflexor and dorsiflexor between two groups. Pearson coefficient correlation was used to examine the correlation of the hallux valgus and the peak torque. Analysis of variance indicated that isokinetic values of the control group were greater than the hallux valgus group(p<.05, p<.01).