• Interdisciplinary Bio Central
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• 제1권1호
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• pp.3.1-3.6
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• 2009

Introduction: GTPases known as translation factor play a vital role as ribosomal subunit assembly chaperone. The bacterial Obg proteins ($Spo{\underline{0B}}$-associated ${\underline{G}}TP$-binding protein) belong to the subfamily of P-loop GTPase proteins and now it is considered as one of the new target for antibacterial drug. The majority of bacterial Obgs have been commonly found to be associated with ribosome, implying that these proteins may play a fundamental role in ribosome assembly or maturation. In addition, one of the experimental evidences suggested that Bacillus subtilis Obg (BsObg) protein binds to the L13 ribosomal protein (BsL13) which is known to be one of the early assembly proteins of the 50S ribosomal subunit in Escherichia coli. In order to investigate binding mode between the BsObg and the BsL13, protein-protein docking simulation was carried out after generating 3D structure of the BsL13 structure using homology modeling method. Materials and Methods: Homology model structure of BsL13 was generated using the EcL13 crystal structure as a template. Protein-protein docking of BsObg protein with ribosomal protein BsL13 was performed by DOT, a macro-molecular docking software, in order to predict a reasonable binding mode. The solvated energy minimization calculation of the docked conformation was carried out to refine the structure. Results and Discussion: The possible binding conformation of BsL13 along with activated Obg fold in BsObg was predicted by computational docking study. The final structure is obtained from the solvated energy minimization. From the analysis, three important H-bond interactions between the Obg fold and the L13 were detected: Obg:Tyr27-L13:Glu32, Obg:Asn76-L13:Glu139, and Obg:Ala136-L13:Glu142. The interaction between the BsObg and BsL13 structures were also analyzed by electrostatic potential calculations to examine the interface surfaces. From the results, the key residues for hydrogen bonding and hydrophobic interaction between the two proteins were predicted. Conclusion and Prospects: In this study, we have focused on the binding mode of the BsObg protein with the ribosomal BsL13 protein. The interaction between the activated Obg and target protein was investigated with protein-protein docking calculations. The binding pattern can be further used as a base for structure-based drug design to find a novel antibacterial drug.

• 가정간호학회지
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• 제7권1호
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• pp.58-72
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• 2000

This study was an attempt to encourage the development of a rehabilitation delivery system and programs as a substitute service for hospitalization on the case of car accident patients, such as hospital based home health care nursing services. Various substitute services for hospitalization are required to curtail the length of stay for inpatients who were hospitalized with car accident compensation insurance. It focused on developing an estimation an early discharge day for car accident inpatients based on detailed statements of treatment for 111 inpatients who were hospitalized at the General Hospital in 1997. This study had four specific purposes as follows. First. to find out the utilization of medical services. Second, to estimate the time of early discharge and income increasing effect based on early discharge for those patients. Third, to identify the factors affecting total medical expenditure and the length of stay for those inpatients. Forth, to figure out the need of utilizing home health care nursing service for accident patients. In order to analyze the length of stay and medical expenditure for inpatients who were hospitalized due to car accidents, the authors conducted micro- and macro-analysis of medical and medical expenditure records. Micro-analysis was done by nominal group discussion of 4 expertise with the critical criteria, such as a decrease in the amount of treatment after surgery, treatments, tests, drugs and changes in the test consistency, drug methods, vital signs, start of ROM exercise, doctor's order, patient's outside visiting ability, and stable conditions. In addition to identifying variables affecting medical expenditure, and the length of stay and income effect due to early discharge day, the data was analyzed with a multiple regression analysis and linear regression analysis model by SPSS-PC for windows and Excell program. Results of this study were as follows. First. the mean length of stay was 50.3 days. whereas the mean length of stay due to early discharge was 34.3 days at the hospital. The estimation of time of early discharge depended on the length of stay. The longer the length of stay, the longer the length of time of early discharge : for instance a length of stay under 10 days was estimated as correlating to a mean length of stay of 6.6 days and early discharge of 6.5. The mean length of stay was 217.4 days and the time of early discharge was 110.1 respectively. The mean medical expenditure per day was found to be 169.085 Won and the mean medical expenditure per day showed negative linear trends according to the length of stay at the hospital. The estimation results of the income effect due to being discharged 16 days early was around 2,244,000 won per bed. However. this sum does not represent the real benefits resulting from early discharge, but rather the income increasing amount without considering medical prime cost in the general hospital. Therefore, further analysis is required on the cost containments and benefits as turn over rate per bed as the medical prime costs. The length of stay was most significant and was positive to the total medical expenditure, as expected. Surgery and patient's residential area was also an important variable in explaining medical expenditure. The level of complications was the most significant variable in explaining the length of stay. There was a high level for need a home health care nursing service which further supports early discharge for accident patients. In addition, when the patient was discharged. they needed follow up care for complications suffered during the car accident. $86.8\%$ of discharged patients responded that they needed home health services after early discharge. From these research findings, the following suggestions have been drawn. Strategies on a health care delivery system must be developed in order to focus on the consumer's needs and being planned for 21 century health policy in Korea. Community based intermediate facilities or home health care should be developed for rehabilitation services as a substitute for hospitalization in order to shorten the length of stay would be. A hospital based home health care nursing service. it would be available immediately to utilize by patients who want rehabilitation services as a substitute for hospitalization with the cooperation of car insurance companies.

• 기록학연구
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• 제12호
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• pp.179-235
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• 2005

In this article, the task of evaluating the official documents that were created and issued by the Joseon Governor General office during the Japanese occupation period, with new perspectives based upon the Macro-Appraisal approaches developed by the Canadian scholars and personnel, will be attempted. Recently, the Canadian people and the authorities have been showing a tendency of evaluating the meaning and importance of a particular document with perspectives considering the historical situation and background conditions that gave birth to that document to be a more important factor, even than considering the quality and condition of that very document. Such approach requires the archivists to determine whether they should preserve a certain document or not based upon the meaning, functions and status of the entity that produced the document or the meaning of the documentation practice itself, rather than the actual document. With regard to the task of evaluating the official documents created and issued by the Joseon Governor General office and involved the city plans devised by the office back then, this author established total of 4 primary tasks that would prove crucial in the process of determining whether or not a particular theme, or event, or an ideology should be selected and documents involving those themes, events and ideologies should be preserved as important sources of information regarding the Korean history of the Japanese occupation period. Those four tasks are as follow: First, the archivists should study the current and past trends of historical researches. The archivists, who are usually not in the position of having comprehensive access to historical details, must consult the historians' studies and also the trends mirrored in such studies, in their efforts of selecting important historical events and themes. Second, the archivists should determine the level of importance of the officials who worked inside the Joseon Governor General office as they were the entities that produced the very documents. It is only natural to assume that the level of importance of a particular document must have been determined by the level of importance(in terms of official functions) of the official who authorized the document and ordered it to be released. Third, the archivists should be made well aware of the inner structure and official functions of the Joseon Governor General office, so that they can have more appropriate analyses. Fourth, in order to collect historically important documents that involved the Koreans(the Joseon people), the archivists should analyze not only the functions of the Joseon Governor General office in general but also certain areas of the Office's business in which the Japanese officials and the Koreans would have interacted with each other. The act of analyzing the documents only based upon their respective levels of apparent importance might lead the archivists to miss certain documents that reflected the Koreans' situation or were related to the general interest of the Korean people. This kind of evaluation should provide data that are required in appraising how well the Joseon Governor General office's function of devising city plans were documented back then, and how well they are preserved today, utilizing a comparative study involving the Joseon Governor General office's own evaluations of its documentations and the current status of documents that are in custody of the National Archive. The task would also end up proposing a specialized strategy of collecting data and documents that is direly needed in establishing a well-designed comprehensive archives. We should establish a plan regarding certain documents that were documented by the Joseon Governor General office but do not remain today, and devise a task model for the job of primary collecting that would take place in the future.

• 서비스연구
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• 제13권1호
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• pp.48-62
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• 2023

최근 K-POP 열풍에서 볼 수 있듯이 한국 음악 산업의 규모와 영향력은 더욱더 커지고 있다. 한국의 음원 시장에는 1년에 최소 6천 개의 음원이 공개되고 있지만 흥행했다고 말할 수 있는 음원은 많지 않다. 이에 흥행작을 만드는 요인이 무엇인지 밝히기 위한 많은 연구 및 시도가 이루어지고 있다. 음악의 상업적인 성공에는 음악의 질뿐만 아니라 미디어 노출이나 홍보와 같은 상업적인 요소 또한 중요한 역할을 담당한다. 최근 대중음악 산업에서는 인터넷 밈을 활용한 마케팅이 많이 나타나는데, 인터넷 밈이란 사람들 사이에서 확산되는 문화적 단위로 이미지나 동영상 등 다양한 형태로 확산되는 활동이나 트렌드라고 할 수 있다. 인터넷 환경과 디지털 커뮤니케이션 특성에 따라 다양한 밈의 형태로 콘텐츠들이 확대 재생산되고 있으며, 이는 소비자들에게 더 큰 반응을 일으킨다. 기존에 인터넷 밈현상은 자연적으로 발생해왔으나, 최근 마케팅 효과를 인지한 아티스트 측에서 마케팅의 요소로 활용하고 있다. 본 논문에서는 대중음악의 흥행 요인과 흥행의 관계에서 인터넷 밈의 매개효과를 분석하고, 이를 반영한 예측모델을 제안하였다. 분석 결과, '커버효과'와 '챌린지효과'의 매개효과가 있는 요인은 동일하게 나타났다. 내부 흥행요인 중에서는 '가수의 인지도', 'POP, 댄스, 발라드, 성인가요, 일렉트로니카' 장르에서 매개효과가 존재하였으며, 외부 흥행 요인 중에서는 '기획사 역량','음악 방송 프로그램 출연 횟수', '뉴스 기사 수'에서 매개효과가 나타났다. 커버효과와 챌린지효과를 반영한 예측 모형은 각각 F1-score가 0.6889, 0.7692로 나타났다. 본 연구는 실제 차트 데이터를 수집·분석하여 실무적으로 활용 가능한 상업적인 방향성을 제시하였으며, 대중음악의 여러 흥행 요인과 인터넷 밈의 매개효과가 존재한다는 것을 발견하였다는 점에서 의의를 갖는다.

• 벤처혁신연구
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• 제3권2호
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• pp.41-76
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• 2020

본 연구는 스마트팩토리 도입의도에 영향을 미치는 요인을 실증 분석을 통해 확인하였다. 4차산업혁명의 핵심분야인 스마트팩토리 도입에 있어서 어떤 요인이 중요하게 영향을 미치는가에 대한 연구이며, 아직까지 스마트팩토리 분야에서 기술 수용에 관한 연구가 부족한 상황에서 학술적 실무적 의의가 있다고 믿는다. 정보기술의 수용요인 연구에 설명력이 검증된 통합기술수용이론(UTAUT)을 기반으로 연구를 진행하였으며, UTAUT 이론의 4가지 독립변수인 성과기대, 노력기대, 사회적영향, 촉진조건에 추가로 스마트팩토리의 특성상 중요한 요인으로 예상되는 정부지원기대(Government Assistance Expectancy)를 독립변수에 추가하였다. 또한 스마트팩토리 기술수용의 기술적인 요인을 확인하고자 과업기술적합도(Task Technology Fit)변수 추가하여 스마트팩토리 도입의도에 미치는 영향관계를 실증 분석하였다. 또한 과업기술적합도의 선행변수인 과업특성(Task Characteristics)과 기술특성(Technology Characteristics)이 과업기술적합도에 어떠한 영향을 미치는지에 대한 분석도 진행하였다. 새로운 기술에 대한 신뢰(Trust)의 정도가 기술의 수용에 있어 매우 중요한 영향을 미칠 것으로 예상되어 신뢰를 매개변수로 추가하였다. 마지막으로 새로운 정보기술에 의한 혁신이 사용자에게 불가피하게 거부감을 야기할 수 있다는 선행연구들을 토대로 혁신저항(Innovation Resistance)을 조절역할을 하는 연구변수에 추가하여 실증적 검증을 진행하였다. 연구 결과 성과기대, 사회적 영향, 정부지원기대, 과업기술적합도는 스마트팩토리 도입의도에 정(+)의 영향을 미쳤다. 영향력의 크기는 정부지원기대(β=.487) > 과업기술적합도(β=.218) > 성과기대(β=.205) > 사회적영향(β=.204) 순으로 나타났다. 과업특성과 기술특성은 모두 과업기술적합도에 정(+)의 영향이 확인되었으며, 과업특성(β=.559)이 기술특성(β=.328)보다 과업기술적합도에 더 영향이 큰 것으로 나타났다. 신뢰에 대한 매개 효과 검정에서 6개 독립변수 각각과 스마트팩토리 도입의도 간에 신뢰의 통계적으로 유의미한 매개역할은 확인되지 않았다. 혁신저항의 조절효과 검정을 통해, 혁신저항이 정부지원기대와 스마트팩토리 도입의도 간 정(+)의 조절역할을 하는 것으로 나타났다. 즉 혁신저항이 크면 클수록 정부지원기대가 스마트팩토리 도입의도에 미치는 영향력이 혁신저항이 적은 경우보다 커지는 것으로 나타났다.