• 생물정신의학
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• 제30권1호
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• pp.24-30
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• 2023

Objectives Alzheimer's disease (AD) is the most common form of dementia in older adults, damaging the brain and resulting in impaired memory, thinking, and behavior. The identification of differentially expressed genes and related pathways among affected brain regions can provide more information on the mechanisms of AD. The aim of our study was to identify differentially expressed genes associated with AD and combined biomarkers among them to improve AD risk prediction accuracy. Methods Machine learning methods were used to compare the performance of the identified combined biomarkers. In this study, three publicly available gene expression datasets from the hippocampal brain region were used. Results We detected 31 significant common genes from two different microarray datasets using the limma package. Some of them belonged to 11 biological pathways. Combined biomarkers were identified in two microarray datasets and were evaluated in a different dataset. The performance of the predictive models using the combined biomarkers was superior to those of models using a single gene. When two genes were combined, the most predictive gene set in the evaluation dataset was ATR and PRKCB when linear discriminant analysis was applied. Conclusions Combined biomarkers showed good performance in predicting the risk of AD. The constructed predictive nomogram using combined biomarkers could easily be used by clinicians to identify high-risk individuals so that more efficient trials could be designed to reduce the incidence of AD.

• 한국분말재료학회지
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• 제30권3호
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• pp.210-216
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• 2023

In this study, machine learning models are proposed to predict the Vickers hardness of AlSi10Mg alloys fabricated by laser powder bed fusion (LPBF). A total of 113 utilizable datasets were collected from the literature. The hyperparameters of the machine-learning models were adjusted to select an accurate predictive model. The random forest regression (RFR) model showed the best performance compared to support vector regression, artificial neural networks, and k-nearest neighbors. The variable importance and prediction mechanisms of the RFR were discussed by Shapley additive explanation (SHAP). Aging time had the greatest influence on the Vickers hardness, followed by solution time, solution temperature, layer thickness, scan speed, power, aging temperature, average particle size, and hatching distance. Detailed prediction mechanisms for RFR are analyzed using SHAP dependence plots.

• Journal of the Korean Association of Oral and Maxillofacial Surgeons
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• 제49권3호
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• pp.135-141
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• 2023

Objectives: This study aimed to develop and validate machine learning (ML) models using H₂O-AutoML, an automated ML program, for predicting medication-related osteonecrosis of the jaw (MRONJ) in patients with osteoporosis undergoing tooth extraction or implantation. Patients and Methods: We conducted a retrospective chart review of 340 patients who visited Dankook University Dental Hospital between January 2019 and June 2022 who met the following inclusion criteria: female, age ≥55 years, osteoporosis treated with antiresorptive therapy, and recent dental extraction or implantation. We considered medication administration and duration, demographics, and systemic factors (age and medical history). Local factors, such as surgical method, number of operated teeth, and operation area, were also included. Six algorithms were used to generate the MRONJ prediction model. Results: Gradient boosting demonstrated the best diagnostic accuracy, with an area under the receiver operating characteristic curve (AUC) of 0.8283. Validation with the test dataset yielded a stable AUC of 0.7526. Variable importance analysis identified duration of medication as the most important variable, followed by age, number of teeth operated, and operation site. Conclusion: ML models can help predict MRONJ occurrence in patients with osteoporosis undergoing tooth extraction or implantation based on questionnaire data acquired at the first visit.

• Geomechanics and Engineering
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• 제31권3호
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• pp.265-279
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• 2022

Tunnel convergence prediction is essential for the safe construction and design of tunnels. This study proposes five machine learning models of deep neural network (DNN), K-nearest neighbors (KNN), Gaussian process regression (GPR), support vector regression (SVR), and decision trees (DT) to predict the convergence phenomenon during or shortly after the excavation of tunnels. In this respect, a database including 650 datasets (440 for training, 110 for validation, and 100 for test) was gathered from the previously constructed tunnels. In the database, 12 effective parameters on the tunnel convergence and a target of tunnel wall convergence were considered. Both 5-fold and hold-out cross validation methods were used to analyze the predicted outcomes in the ML models. Finally, the DNN method was proposed as the most robust model. Also, to assess each parameter's contribution to the prediction problem, the backward selection method was used. The results showed that the highest and lowest impact parameters for tunnel convergence are tunnel depth and tunnel width, respectively.

• Journal of Medicine and Life Science
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• 제20권4호
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• pp.141-157
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• 2023

Stroke is a leading cause of disability and death. The condition requires prompt diagnosis and treatment. The quality of care provided to patients with stroke can vary depending on the availability of medical resources, which in turn, can affect prognosis. Recently, there has been growing interest in using machine learning (ML) to support stroke diagnosis and treatment decisions based on large medical data sets. Current ML applications in stroke care can be divided into two categories: analysis of neuroimaging data and clinical information-based predictive models. Using ML to analyze neuroimaging data can increase the efficiency and accuracy of diagnoses. Commercial software that uses ML algorithms is already being used in the medical field. Additionally, the accuracy of predictive ML models is improving with the integration of radiomics and clinical data. is expected to be important for improving the quality of care for patients with stroke.

• Earthquakes and Structures
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• 제27권2호
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• pp.83-95
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• 2024

The prediction of seismic behavior of the existing building stock is one of the most impactful and complex problems faced by countries with frequent and intense seismic activities. Human lives can be threatened or lost, the economic life is disrupted and large amounts of monetary reparations can be potentially required. However, authorities at a regional or national level have limited resources at their disposal in order to allocate to preventative measures. Thus, in order to do so, it is essential for them to be able to rank a given population of structures according to their expected degree of damage in an earthquake. In this paper, the authors present a ranking approach, based on Machine Learning (ML) algorithms for pairwise comparisons, coupled with ad hoc ranking rules. The case study employed data from 404 reinforced concrete structures with various degrees of damage from the Athens 1999 earthquake. The two main components of our experiments pertain to the performance of the ML models and the success of the overall ranking process. The former was evaluated using the well-known respective metrics of Precision, Recall, F1-score, Accuracy and Area Under Curve (AUC). The performance of the overall ranking was evaluated using Kendall's tau distance and by viewing the problem as a classification into bins. The obtained results were promising, and were shown to outperform currently employed engineering practices. This demonstrated the capabilities and potential of these models in identifying the most vulnerable structures and, thus, mitigating the effects of earthquakes on society.

• 한국지하수토양환경학회지:지하수토양환경
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• 제21권3호
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• pp.21-34
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• 2016

In the present study, we applied various machine learning techniques comparatively for prediction of subsurface structures based on multiple secondary information (i.e., well-logging data). The machine learning techniques employed in this study are Naive Bayes classification (NB), artificial neural network (ANN), support vector machine (SVM) and logistic regression classification (LR). As an alternative model, conventional hidden Markov model (HMM) and modified hidden Markov model (mHMM) are used where additional information of transition probability between primary properties is incorporated in the predictions. In the comparisons, 16 boreholes consisted with four different materials are synthesized, which show directional non-stationarity in upward and downward directions. Futhermore, two types of the secondary information that is statistically related to each material are generated. From the comparative analysis with various case studies, the accuracies of the techniques become degenerated with inclusion of additive errors and small amount of the training data. For HMM predictions, the conventional HMM shows the similar accuracies with the models that does not relies on transition probability. However, the mHMM consistently shows the highest prediction accuracy among the test cases, which can be attributed to the consideration of geological nature in the training of the model.

• 한국지능시스템학회:학술대회논문집
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• 한국퍼지및지능시스템학회 2001년도 추계학술대회 학술발표 논문집
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• pp.275-278
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• 2001

In this paper, We evaluate the learning ability of non-monotonic DBM(Deterministic Boltzmann Machine) network through numerical simulations. The simulation results show that the proposed system has higher performance than monotonic DBM network model. Non-monotonic DBM network also show an interesting result that network itself adjusts the number of hidden layer neurons. DBM network can be realized with fewer components than other neural network models. These results enhance the utilization of non-monotonic neurons in the large scale integration of neuro-chips.

• Computers and Concrete
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• 제33권1호
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• pp.55-75
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• 2024

The present study introduces an optimum performance soft computing model for predicting the compressive strength of high-performance concrete (HPC) by comparing models based on conventional (kernel-based, covariance function-based, and tree-based), advanced machine (least square support vector machine-LSSVM and minimax probability machine regressor-MPMR), and deep (artificial neural network-ANN) learning approaches using a common database for the first time. A compressive strength database, having results of 1030 concrete samples, has been compiled from the literature and preprocessed. For the purpose of training, testing, and validation of soft computing models, 803, 101, and 101 data points have been selected arbitrarily from preprocessed data points, i.e., 1005. Thirteen performance metrics, including three new metrics, i.e., a20-index, index of agreement, and index of scatter, have been implemented for each model. The performance comparison reveals that the SVM (kernel-based), ET (tree-based), MPMR (advanced), and ANN (deep) models have achieved higher performance in predicting the compressive strength of HPC. From the overall analysis of performance, accuracy, Taylor plot, accuracy metric, regression error characteristics curve, Anderson-Darling, Wilcoxon, Uncertainty, and reliability, it has been observed that model CS4 based on the ensemble tree has been recognized as an optimum performance model with higher performance, i.e., a correlation coefficient of 0.9352, root mean square error of 5.76 MPa, and mean absolute error of 4.1069 MPa. The present study also reveals that multicollinearity affects the prediction accuracy of Gaussian process regression, decision tree, multilinear regression, and adaptive boosting regressor models, novel research in compressive strength prediction of HPC. The cosine sensitivity analysis reveals that the prediction of compressive strength of HPC is highly affected by cement content, fine aggregate, coarse aggregate, and water content.

• 한국재난정보학회 논문집
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• 제19권4호
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• pp.924-935
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• 2023

Purpose: The central aim of this study is to leverage machine learning techniques for the classification of Intrusion Detection System (IDS) data, with a specific focus on identifying the variables responsible for enhancing overall performance. Method: First, we classified 'R2L(Remote to Local)' and 'U2R (User to Root)' attacks in the NSL-KDD dataset, which are difficult to detect due to class imbalance, using seven machine learning models, including Logistic Regression (LR) and K-Nearest Neighbor (KNN). Next, we use the SHapley Additive exPlanation (SHAP) for two classification models that showed high performance, Random Forest (RF) and Light Gradient-Boosting Machine (LGBM), to check the importance of variables that affect classification for each model. Result: In the case of RF, the 'service' variable and in the case of LGBM, the 'dst_host_srv_count' variable were confirmed to be the most important variables. These pivotal variables serve as key factors capable of enhancing performance in the context of classification for each respective model. Conclusion: In conclusion, this paper successfully identifies the optimal models, RF and LGBM, for classifying 'R2L' and 'U2R' attacks, while elucidating the crucial variables associated with each selected model.