• 정보처리학회논문지C
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• 제9C권4호
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• pp.523-530
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• 2002

광대역 액세스 망에서 합류, 분배 지점에서의 효율을 고려한 PON(Passive Optical Network)의 설계는 중요한 관심거리가 되고 있다. PON 구조는 매우 간단하지만, 가입자들에서 발생하는 상향 트래픽 제어를 위해서는 매체 접근 제어 프로토콜이 필요하다. 본 논문에서는 여러 트래픽 클래스를 지원하는 ATM-PON을 사용하는 광대역 액세스 망을 위한 매체 접근 제어 프로토콜을 제시한다. 제안된 매체 접근 제어 프로토콜을 위해 G.983.1을 기반으로 하여 grant field 형식과 minislot 형식, 그리고 대역 할당 알고리즘을 제시하였다. 실험 결과 종래의 매체접근제어 프로토콜 보다 더 나은 서비스 품질을 보장받을 수 있음을 확인할 수 있었다.

• 사상체질의학회지
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• 제14권1호
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• pp.100-111
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• 2002

1. The Purpose of study An experimental study has done to examine the effect of defense on gastric mucosal damage of Jowesungcheong-tang. 2. The Material and Method of study Mice had intragastric injected with JST extract before indome thacin treatment which induces hemorrh age erosion artificially. General morphology, infiltrative cell in mucosa, the distribution of UEA-I, COX-1, MAC-1. ICAM, and Apoptotic cell were objected (Ahhreviation) JST :Jowesungcheong-tang, UEA-I : ulex europaeus agglutinin-I, COX-1: cyclooxyhenase-1, ICAM : intercellular adhesion molecule-1, GPE : Gastropathy elicitated mice 3. The results and Conclusions of study 1) The degree of hemorrhage erosion in GPE-group had increased conspicuously in gastric gland proper. JST -group were the same as normal 2) The noticeable increase of granular lecocytes and lymphocytes in GEP-group were seen, but in JST group, the configuration is decreased 3) The decrease of UEA-I positive reacted cells, COX-1, surface epithelial cells and the increase of MAC-l positive cells, ICAM-l positive cells had shown in GPE-group, but in JST-group UEA-I positive cells, COX-1 surface epithelial cells were in creased and MAC-1 positive cells, ICAM-l positive cells were decreased than GPE-group. 4) A number of apoptotic cells were distributed in hemorrhage erosion. The remarkable decrease of apoptotic cells were shown in JST-group.

• 한국통신학회논문지
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• 제28권1B호
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• pp.18-26
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• 2003

광대역 액세스 망에서 합류, 분배 지점에서의 효율을 고려한 PON(Passive Optical Network)의 설계는 중요한 관심거리가 되고 있다. PON 구조는 매우 간단하지만, 가입자들에서 발생하는 상향 트래픽 제어를 위해서는 매체 접근 제어 프로토콜이 필요하다 본 논문에서는 여러 트래픽 글래스를 지원하는 ATM-PON을 사용하는 광대역 액세스 망을 위한 Request-Counter MAC 프로토콜을 제시한다. 제안된 매체 접근 제어 프로토콜을 위해 ITU-TG 983을 기반으로 하여 Grant Field 형식과 Minislot 형식, 그리고 대역 할당 알고리즘을 제시하였다 실험 결과 종래의 매체 접근 제어 프로토콜보다 더 나은 서비스 품질을 보장받을 수 있음을 확인할 수 있었다.

• Journal of Periodontal and Implant Science
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• 제29권2호
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• pp.333-350
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• 1999

The modulation of leukocyte cell surface adhesion molecules may influence the development of cellular events that determine the course of the inflammatory process. Direct interaction between activated T cells and monocytes resulted in a large production of $IL-1{\beta}$ by monocytes. In this reactions, adhesion molecules play an important part, yet the role of them in Tmonocytes interaction remain unclear. This study was undertaken in an effort to elucidate, 1) the influence of 1.25(OH)$_2D_3-induced$ differentiation on the monocyte responsiveness to direct contact with T lymphocytes, and 2) the role of adhesion molecules on the T-monocyte direct interaction. Initially, I observed that direct contact of monocyte cell line THP-1 with stimulated fixed T cell line HuT78 markedly induces IL-1${\beta}$ production by THP-1. $IL-1{\beta}$ production was higher when THP-1 had been previously exposed to 1.25(OH)$_2D_3$ as compared to control, with ${\alpha}$- 1.25(OH)$_2D_3$ dose-dependent and exposure time-dependent manner. It was shown that 1.25(OH)$_2D_3$ also increased the expression of ${\beta}_2$ integrin adhesion receptor Mac-1(CD11b/CD18) dose- and timedependently, but did not increase the expression of human leukocyte antigen- D(HLA-D) and intercellular adhesion molecule-1(ICAM-1). The $IL-1{\beta}$ producing activity of THP-1 cells correlated well with the ability to induce the Mac-1 expression on THP-1 surface. Monoclonal antibody raised against relevant cell surface glycoproteins on THP-1 were tested for their ability to block the response of THP-1 to T cells. Antibody to Mac-1 only partially blocked $IL-1{\beta}$ production by THP-1, whereas antibodies to ICAM-1 and HLA-D did not. These data indicate that regulation of Mac-1 expression on THP-1 cells can alter the responsiveness of these cells to contact by activated T cells, however other unknown structures on the THP-1 cells may be involved in this process also.

• 한국동물위생학회지
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• 제41권3호
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• pp.171-177
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• 2018

Purified bee venom was collected from colonies of honeybees (Apis mellifera L.) using a bee venom collector under sterile conditions and then purified under strict laboratory conditions. Purified bee venom contained $63.9{\pm}5.4%$ melittin, $10.9{\pm}1.6%$ phospholipase A2, and $2.3{\pm}0.3%$ apamin. Purified bee venom has various anti-bacterial, anti-inflammatory and immunostimulating effects. In this study, we evaluated purified bee venom which are mammary gland cells, MAC-T cells are used to increase the synthesis of milk protein. Purified bee venom promoted the proliferation of MAC-T cells at concentrations below $1{\mu}g/mL$, but cytotoxicity at $10{\mu}g/mL$ and above. As a result of the increase in the synthesis of ${\beta}-casein$, a milk protein after treatment with MAC-T cells at a concentration of the bee venom without cytotoxicity, the ${\beta}-casein$ content in the cell culture was increased when treated at a concentration of 1 ng/mL or more. In addition, it was confirmed that purified bee venom significantly increased the expression of bovine ${\beta}-casein$ (bCSNB) mRNA, a ${\beta}-casein$ synthesis gene, at a concentration of 1 ng/mL or more. These results suggest that purified bee venom can be used to increase the production of livestock by ultimately increasing the expression of milk protein.

• 한국통신학회논문지
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• 제25권1A호
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• pp.132-141
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• 2000

본 논문에서는 트리 구조의 가입자망인 APON(ATM over Passive Optical Network)에서 멀티미디어 정보를 보다 효율적으로 제공하기 위한 매체 접근 제어 프로토콜을 제안하였다. 제안된 프로토콜은 사용자 측에서 발생한 원래의 트래픽 패턴을 손상시키지 않으면서 상향 데이터 흐름을 효과적으로 다중화할 수 있도록 하고, ATM 트래픽 클래스별 전송 품질(QoS)의 특성을 반영하였다. 이를 위하여 먼저 요구-허락형 전송 구조에서 다양한 요구 방식에 따른 성능을 분석하여, 각 트래픽 클래스에 적합한 요구 방식을 설정하고, 오버헤드를 최소화할 수 있는 전송 프레임 구조를 제안하였다. 또한 OLT의 셀 허락 분배 과정에서 ATM 클래스별로 각기 다른 우선 순위를 주어 셀 전송에 대한 허락을 스케줄링 한다. 제안한 허락 분배 알고리즘은 전송 지연과 CDV에 엄격한 성능을 요구하는 CBR/VBR 트래픽에 우선적으로 허락을 분배하고, ABR 트래픽은 최소 셀 전송률(MCR)을 보장하면서 이용 가능한 대역폭을 동적으로 사용하도록 하였으며, UBR 트래픽은 가장 낮은 우선 순위를 가지고 남은 대역을 사용하게 된다. 따라서 트래픽 속성을 변화시키지 않고 ATM 셀을 전달\ulcorner 가능하여 멀티미디어 전송에 있어 전송 품질(QoS)을 만족시킬 수 있다. 제안한 프로토콜에 대한 성능 평가를 위하여 평균 전송 지연 시간 및 CDV(Cell Delay Variation)등의 관점에서 시뮬레이션을 실시하고 성능 평가 결과를 기술하였다.

• Journal of information and communication convergence engineering
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• 제5권1호
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• pp.29-34
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• 2007

This paper proposes a MAC protocol for real-time VBR (rt-VBR) services in wireless ATM networks. The proposed protocol is characterized by a contention-based mechanism of the reservation request, a contention-free polling scheme for transferring the dynamic parameters, and a priority scheme of the slot allocation. The design objective of the proposed protocol is to guarantee the real-time constraint of rt-VBR traffic. The scheduling algorithm uses a priority scheme based on the maximum cell transfer delay parameter. The wireless terminal establishes an rt-VBR connection to the base station with a contention-based scheme. The base station scheduler allocates a dynamic parameter minislot to the wireless terminal for transferring the residual lifetime and the number of requesting slots as the dynamic parameters. Based on the received dynamic parameters, the scheduler allocates the uplink slots to the wireless terminal with the most stringent delay requirement. The simulation results show that the proposed protocol can guarantee the delay constraint of rt-VBR services along with its cell loss rate significantly reduced.

• 대한두경부종양학회지
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• 제34권2호
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• pp.35-38
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• 2018

Mucinous adenocarcinoma (MAC) is a rare malignant neoplasm that occasionally occurs in the large intestine (colon), followed by the pancreas, ovary, lung, prostate, and breast. It is characterized by large amounts of extracellular epithelial mucin that contains tumor cell nests. We herein present a unique case of MAC originating from minor salivary gland, the second to be reported in literature in South Korea. We report a case of MAC in the tongue considered to be developed from minor salivary gland with a review of literature.

• Journal of Animal Science and Technology
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• 제64권3호
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• pp.481-499
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• 2022

This study aims to determine the effects of D-methionine (D-Met) isomer and the methionine precursor 2-hydroxy-4-methylthiobutanoic acid i (HMBi) supplementation on milk protein synthesis on immortalized bovine mammary epithelial cell (MAC-T). MAC-T cells were seeded using 10-cm dishes and cultured in Dulbecco's modified Eagle's medium/F12 (DMEM/F12) basic medium. The basic medium of DMEM/F12 was replaced with the lactogenic DMEM/ F12 differentiation medium when 90% of MAC-T cells reached confluency. The best dosage at 0.6 mM of D-Met and HMBi and incubation time at 72 h were used uniformly for all treatments. Each treatment was replicated six times wherein treatments were randomly assigned in a 6-well plate. Cell, medium, and total protein were determined using a bicinchoninic acid protein assay kit. Genes, proteomics and metabolomics analyses were also done to determine the mechanism of the milk protein synthesis pathway. Data were analyzed by two-way analysis of variance (ANOVA) with supplement type and plate as fixed effects. The least significant difference test was used to evaluate the differences among treatments. The HMBi treatment group had the highest beta-casein and S6 kinase beta-1 (S6K1) mRNA gene expression levels. HMBi and D-Met treatments have higher gene expressions compared to the control group. In terms of medium protein content, HMBi had a higher medium protein quantity than the control although not significantly different from the D-Met group. HMBi supplementation stimulated the production of eukaryotic translation initiation factor 3 subunit protein essential for protein translation initiation resulting in higher medium protein synthesis in the HMBi group than in the control group. The protein pathway analysis results showed that the D-Met group stimulated fructose-galactose metabolism, glycolysis pathway, phosphoinositide 3 kinase, and pyruvate metabolism. The HMBi group stimulated the pentose phosphate and glycolysis pathways. Metabolite analysis revealed that the D-Met treatment group increased seven metabolites and decreased uridine monophosphate (UMP) production. HMBi supplementation increased the production of three metabolites and decreased UMP and N-acetyl-L-glutamate production. Taken together, D-Met and HMBi supplementation are effective in stimulating milk protein synthesis in MAC-T cells by genes, proteins, and metabolites stimulation linked to milk protein synthesis.

• Journal of Plant Biotechnology
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• 제38권4호
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• pp.285-292
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• 2011

식물 잎의 발달과정에서 heteroblasty는 외부 환경에 대한 식물의 형태적 적응 방법을 매우 잘 반영하며 이에 따른 변화는 기관의 최종 형태와 크기에 영향을 미친다. Heteroblasty를 나타내는 인자 중에서 leaf index는 단엽식물의 잎의 최종 모양과 크기를 나타내는 대표적인 인자이다. Leaf index는 결국 잎몸에서의 세포 증식과 세포 신장의 두 요인에 의해 결정된다. 비록 세포의 증식과 신장을 조절하는 유전자와 조절 기작들이 연구되고 있으나 큰 청사진을 제시하기에는 아직 미흡하다. 본 연구에서는 발달과정 중 잎의 leaf index 조절에 관여하는 유전자를 밝히고 그 조절 기작을 알아내기 위하여 애기장대 돌연변이체를 이용한 분자유전학적, 생리학적인 실험을 수행하였다. 잎과 잎 세포가 커지는 돌연변이체인 macrophylla (mac)를 선발하여 잎의 확장과정과 leaf index의 이상으로 인해 잎 기관의 모양뿐 만 아니라 heteroblasty에 변화가 발생했다는 사실을 밝혀냈다. 또한 이 돌연변이체는 기존에 알려진 ROTUNDIFOLIA3 (ROT3) 유전자의 점 돌연변이에 의해 일어났다고 판명되었고 mac/rot3-5로 명명되었다. 브라시노스테로이드 처리로 인해 ROT3 유전자의 발현이 음성 되먹임 저해를 받는 것으로 보아 ROT3 유전자가 브라시노스테로이드 생합성에 관여함을 제시하였다. 또한 암상태에서 ROT3 유전자의 발현이 증가하며, mac/rot3-5 돌연변이체가 야생형보다 암반응이 약하게 나타났다. 이러한 분석 결과를 토대로 본 논문은 ROT3 유전자가 잎의 확장과정에서 잎의 leaf index 조절과 고유한 heteroblasty의 정립에 중요한 역할을 수행하며, 브라시노스테로이드 호르몬의 조절을 통하여 음지회피성과 같은 환경조절반응을 수행하고 있다는 새로운 사실을 제시하였다.