• Genomics & Informatics
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• v.5 no.3
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• pp.95-101
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• 2007

In this paper, we consider the variable selection methods in the Cox model when a large number of gene expression levels are involved with survival time. Deciding which genes are associated with survival time has been a challenging problem because of the large number of genes and relatively small sample size (n<

• Journal of Sasang Constitutional Medicine
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• v.21 no.1
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• pp.247-253
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• 2009

1. Objectives This study was designed to andyze the acute toxicity and safety of Yeoldahanso-tang 2. Methods We investigated the acute toxicity for water-extracted Yeoldahanso-tang. 25 male and 25 female mice were observed for 14 days after one day oral administration of Yeoldahanso-tang at the respective doses of 0(control group), 2560, 3200, 4000 and 5000 mg/kg. 3. Results We observed survival rates, general toxicity, change of body weight and autopsy. 4. Conclusions The data confirmed that Yeoldahanso-tang is free from the toxicity and safety problems in oral route respectively. Compared with the control group, we could not find any toxic alteration in all treated groups(2560, 3200, 4000 and 5000 mg/kg). In conclusion, LD50 of Yeoldahanso-tang was over 5000 mg/kg and it is very safe to mice.

• Nuclear Engineering and Technology
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• v.50 no.7
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• pp.1079-1087
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• 2018

There are many parameters that affect the natural circulation flow, such as height difference, heating power size, pipe diameter, system pressure and inlet temperature and so on. In general analysis the heating power is often regarded as a uniform distribution. The ANSYS-CFX numerical analysis software was used to analyze the flow heat transfer of supercritical water under different heating power distribution conditions. The distribution types of uniform, power increasing, power decreasing and sine function are investigated. Through the analysis, it can be concluded that different power distribution has a great influence on the flow of natural circulation if the total power of heating is constant. It was found that the peak flow of supercritical water natural circulation is maximal when the distribution of heating power is monotonically decreasing, minimal when it is monotonically increasing, and moderate at uniform or the sine type of heating. The simulation results further reveal the supercritical water under different heat transfer conditions on its flow characteristics. It can provide certain theory reference and system design for passive residual heat removal system about supercritical water.

• Horticulture, Environment, and Biotechnology : HEB
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• v.59 no.6
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• pp.835-845
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• 2018

We studied the role of ethylene control in regulating energy metabolism, antioxidant enzyme activity, and vase life of cut rose Rosa hybrida 'Carola'. Rose flowers at stage II were sprayed with one of the following solutions: water (control), $10{\mu}L\;L^{-1}$ 1-methylcyclopropene (1-MCP), or $0.5g\;L^{-1}$ 2-chloroethanephosphonic acid (ethephon). After harvest, ethylene production rate, respiration intensity, energy charge (EC), activities of energy metabolism-related and antioxidant enzymes, and malondialdehyde (MDA) content were measured. Results showed that 1-MCP enhanced the activities of superoxide dismutase, $H^+$-adenosine triphosphatase, $Ca^{2+}$-adenosine triphosphatase, succinic dehydrogenase, and cytochrome c oxidase, increased adenosine triphosphate (ATP) content, maintained high EC levels, inhibited respiration intensity, reduced peroxidase (POD) and polyphenol oxidase (PPO) activity and MDA accumulation, and prolonged vase life. Ethephon promoted ethylene production and respiration intensity, increased POD and PPO activity, reduced ATP content and EC levels, and accelerated senescence. Our results support a novel role for ethylene control in regulating senescence of 'Carola'.

• Animal Bioscience
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• v.34 no.3_spc
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• pp.457-462
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• 2021

Objective: The aim of this study was to investigate the effects of Enteromorpha powder supplementation on reproduction-related hormones and genes in the late laying period of Zi geese. Methods: A total of 312 (1-year-old) Zi geese with similar laying rate were randomly divided into 2 groups with 6 replicates each, each with 21 female geese and 5 male geese. The control group was fed with a basal diet and the test group was fed with a diet containing 3% Enteromorpha powder. The trial period lasted for 7 weeks. Results: Our results showed that the laying rate was improved in the test group at each week of trial (p<0.01), and the levels of estradiol in serum and prolactin in ovary were increased compared with the control group (p<0.05). Conclusion: Based on above results, Enteromorpha powder supplementation at 3% could promote reproductive performance during the late laying period of Zi geese.

• Current Optics and Photonics
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• v.5 no.6
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• pp.606-616
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• 2021

A photonic integrated interferometric imaging system possesses the characteristics of small-scale, low weight, low power consumption, and better image quality. It has potential application for replacing conventional large space telescopes. In this paper, the principle of photonic integrated interferometric imaging is investigated. A novel lenslet array arrangement and lenslet pairing approach are proposed, which are helpful in improving spatial frequency coverage. For the novel lenslet array arrangement, two short interference arms were evenly distributed between two adjacent long interference arms. Each lenslet in the array would be paired twice through the novel lenslet pairing approach. Moreover, the image reconstruction model for optical interferometric imaging based on compressed sensing was established. Image simulation results show that the peak signal to noise ratio (PSNR) of the reconstructed image based on compressive sensing is about 10 dB higher than that of the direct restored image. Meanwhile, the normalized mean square error (NMSE) of the direct restored image is approximately 0.38 higher than that of the reconstructed image. Structural similarity index measure (SSIM) of the reconstructed image based on compressed sensing is about 0.33 higher than that of the direct restored image. The increased spatial frequency coverage and image reconstruction approach jointly contribute to better image quality of the photonic integrated interferometric imaging system.

• KSII Transactions on Internet and Information Systems (TIIS)
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• v.16 no.10
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• pp.3419-3437
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• 2022

Anonymization technology is an important technology for privacy protection in the process of data release. Usually, before publishing data, the data publisher needs to use anonymization technology to anonymize the original data, and then publish the anonymized data. However, for data publishers who do not have or have less anonymized technical knowledge background, how to configure appropriate parameters for data with different characteristics has become a more difficult problem. In response to this problem, this paper adds a historical configuration scheme resource pool on the basis of the traditional anonymization process, and configuration parameters can be automatically recommended through the historical configuration scheme resource pool. On this basis, a privacy model hybrid recommendation algorithm for user satisfaction is formed. The algorithm includes a forward recommendation process and a reverse recommendation process, which can respectively perform data anonymization processing for users with different anonymization technical knowledge backgrounds. The privacy model hybrid recommendation algorithm for user satisfaction described in this paper is suitable for a wider population, providing a simpler, more efficient and automated solution for data anonymization, reducing data processing time and improving the quality of anonymized data, which enhances data protection capabilities.

• Structural Engineering and Mechanics
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• v.81 no.5
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• pp.539-550
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• 2022

A detailed experimental program was conducted to investigate the flexural behavior of ultra high performance concrete (UHPC) beams reinforced with high strength steel (HSS) rebars with a specified yield strength of 600 MPa via direct tensile test and monotonic four-point bending test. First, two sets of direct tensile test specimens, with the same reinforcement ratio but different yield strength of reinforcement, were fabricated and tested. Subsequently, six simply supported beams, including two plain UHPC beams and four reinforced UHPC beams, were prepared and tested under four-point bending load. The results showed that the balanced-reinforced UHPC beams reinforced with HSS rebars could improve the ultimate load-bearing capacity, deformation capacity, ductility properties, etc. more effectively owing to interaction between high strength of HSS rebar and strain-hardening characteristic of UHPC. In addition, the UHPC with steel rebars kept strain compatibility prior to the yielding of the steel rebar, further satisfied the plane-section assumption. Most importantly, the crack pattern of the UHPC beam reinforced with HSS rebars was prone to transform from single main crack failure corresponding to the normal-strength steel, to multiple main cracks failure under the condition of balanced-reinforced failure, which validated by the conclusion of direct tensile tests cooperated with acoustic emission (AE) source locating technique as well.

• Earthquakes and Structures
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• v.24 no.1
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• pp.65-79
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• 2023

A simplified analytical solution for seismic response of tunnel cross section in horizontally layered ground subjected to oblique incidence of SH wave is deduced in this paper. The proposed analytical solution consists of two main steps: free-field response in layered field and tunnel response. The free field responses of the layered ground are obtained by one-dimensional finite element method in time domain. The tunnel lining is treated as a thick-wall cylinder to calculate the tunnel response, which subject to free field stress. The analytical solutions are verified by comparing with the dynamic numerical results of two-dimensional ground-lining interaction analysis under earthquake in some common situations, which have a good agreement. Then, the appropriate range of the proposed analytical solution is analyzed, considering the height of the layered ground, the wavelength and incident angle of SH wave. Finally, by using the analytical solutions, the effects of the ground material, burial depth of the tunnel, and lining thickness and the slippage effect at the ground-lining interface on the seismic response of tunnels are investigated. The proposed solution could serve as a useful tool for seismic analysis and design of tunnels in layered ground.

• Steel and Composite Structures
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• v.47 no.1
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• pp.79-90
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• 2023

Nonlinear forced vibration properties of three-layered plates containing graphene platelets (GPL) filled skins and an auxetic core have been inquired within the present paper. Owning reduced weight as well as reduced stiffness, rectangle-shaped auxetic cores have been frequently made from novel techniques such as additive manufacturing. Here, the rectangle shape core is amplified via the graphene-filled layers knowing that the layers possess uniform and linear graphene gradations. The rectangle shape core has the equivalent material specifications pursuant to relative density value. The sandwich plate is formulated pursuant to Kirchhoff plate theory while a numerical trend has been represented to discretize the plate equations. Next, an analytical trend has been performed to establish the deflection-frequency plots. Large deflections, core density and GPL amplification have showed remarkable impacts on dynamic response of three-layered plates.