• Journal of Microbiology and Biotechnology
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• v.5 no.3
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• pp.154-157
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• 1995

MRK-22, an inhibitor of aminopeptidase M was isolated from the culture broth of Streptomyces sp. SL20209. The structure of MRK-22 was defined to be 3-amino-2-hydroxy-5-methylhexanoyl-valyl-valine, des-$Asp^4$-amastatin, by spectroscopic analysis and this was also confirmed by solid phase synthesis of the inhibitor. The molecular formula and weight of MRK-22 were $C_17H_33N_3O_5$ and MW 359($M^+$), respectively, and its $IC_50$ value against hog kidney AP-M was 0.79 $\mu$ g/ml.

• Journal of The Korean Astronomical Society
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• v.41 no.2
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• pp.17-22
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• 2008

We present an analysis of the soft X-ray emission of MRK 841 to investigate its long-term variation. The light variation of MRK 841 for three different energy bands of soft, medium, and hard values were studied. The maximum variability with a factor of 5 for about two years was confirmed at all three different bands. The light curves exhibit a gradual variation of brightness. In addition to a gradual variation, the short- term or micro variation was also confirmed with a factor of about two for all three different bands. The light variation of each band did not exhibit a correlation between them, but the flare event is strongest in the soft band. The hardness ratio for hard and soft bands shows irregular variation but there was no correlation between them. It was confirmed that there is a gradual decrease of the photon index. Results of our analysis are discussed within the framework of the accretion disk phenomenon.

• Journal of Korea Trade
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• v.26 no.4
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• pp.1-22
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• 2022

Purpose - This paper empirically investigates the effect of a rise in the global value chain (GVC) on the industry-level efficiency of resource allocation (based on plant-level inefficiency measures) in Korea, with a focus on various channels through which a rise in the GVC can increase competition among firms and thus induce resources to be allocated more efficiently across firms. Design/methodology - We empirically investigate the relationship between the industry-specific importance of GVC and the industry-level allocative inefficiency that is measured as the dispersion of the plant-level marginal revenue of capital (MRK) as in Hsieh and Klenow's (2009) influential model. We compute MRK dispersion for industries sorted by various characteristics that are closely related to firm/industry sensitivity to the GVC. In other words, we compute the average industry-level MRK dispersion for industries sorted by industry-specific importance of GVC and compute the difference between the two groups of industries (higher vs. lower than the median GVC); we also calculate the difference between industries sorted by industry-specific export (import) intensity. This is our difference-in-difference estimate of the MRK dispersion associated with the GVC for the export (import)-intensive industry versus the non-export (non-import)-intensive industry. This difference-in-difference estimate of the MRK dispersion conditional vs. unconditional on firm-level productivity is then calculated further (triple-difference estimate). Findings - A rise in GVC is associated with a decrease in the MRK dispersion in the export-intensive industry compared to the non-export-intensive industry. The same is true for industries that rely heavily on imports versus those that do not (i.e., import intensive vs. non-intensive). Furthermore, the reduction in the MRK dispersion in the export-intensive industry associated with an increase in the GVC is disproportionately greater for high-productivity firms. In contrast, the negative relationship between GVC and MRK dispersion in the import-intensive industry is disproportionately smaller for high-productivity firms. Originality/value - Existing studies focus on the relationship between GVC and aggregate output, exports, and imports at the country level. We investigate detailed firm/industry-level mechanisms that determine the relationship between GVC, trade, and productivity. Using the plant-level data in South Korea, we investigate how GVC is related to the cross-firm MRK dispersion, an important measure of allocative inefficiency, based on Hsieh and Klenow's (2009) influential economic theory. This is the first study to provide plant-level evidence of how GVC affects MRK dispersion. Furthermore, we examine how the relationship between GVC and MRK-dispersion varies across export intensity, import intensity, and firm-level productivity, providing insight into how GVC can affect firms' exposure to competition in the global market differently depending on market conditions and thus generate trade-related productivity gains.

• Journal of Korean Ophthalmic Optics Society
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• v.19 no.1
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• pp.105-109
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• 2014

Purpose: To compare the change of visual acuity and NIBUT after watching smart-phone in 1 hour under low intensity of illumination. Methods: 50 subjects (male 22, female 28) aged 20's years old ($20.7{\pm}2.4$ years) who do not have eye disease and have a good eye condition were participated for this study. Objective refraction, corrected distance visual acuity and NIBUT were measured before and after watching smart-phone (Galaxy 2, Samsung, KOREA) under low intensity of illumination (0 lx.) Objective refraction was carried out using auto-chart project (CP-1000, Dongyang, Korea), phoropter (VT-20, Dongyang, Korea) and auto refractor-keratometer (MRK-3100, Huvitz, Korea). Results: Refractive error was changed from $-3.20{\pm}2.00$ D to $-3.38{\pm}2.00$ D (p=0.006) and corrected distance visual acuity was changed from $0.93{\pm}0.08$ to $0.91{\pm}0.10$ (p=0.000) and NIBUT was changed from $10.48{\pm}7.00$ seconds to $10.29{\pm}6.47$ seconds (p=0.761) before and after watching smart-phone under low intensity of illumination. Conclusions: Continuous watching smart-phone under low intensity of illumination lead to temporal change of distance visual acuity and suitable rest may reduce the influence of distance visual acuity and tear safety.