• 정보교육학회논문지
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• 제8권2호
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• pp.203-209
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• 2004

본 연구는 가상현실 언어인 VRML과 자바 애플릿을 이용하여 학습자(초등학교 고학년, 중학교 학생)에게 흥미를 줄 수 있는 향상된 학습 방법을 제공하고자 한다. 과학 교육의 현실적인 어려움을 극복하고자 VRML을 이용한 3차원 애니메이션 기능을 사용한다. 이를 통해, 우리 생활 속에 친숙한 기계 구조와 원리를 학습시키고 과학 학습의 흥미를 갖도록 한다. 앞으로 이와 같은 방법은 과학 교육의 효율성을 향상시키는데 널리 활용될 수 있다.

• 한국경영과학회지
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• 제40권2호
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• pp.63-77
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• 2015

The territorial air that our sovereignty is being applied to is divided into several zones and areas. In order to use and manage them effectively, these zones and areas have laws, regulations and rules. The number of airspaces (MOA : Military Operation Area) and Ranges that are used in the military are limited and many airbases are being used for training. Currently the central department manages some, and the rest are independent airbases. Therefore, efficient allocation is not performed and the result occurs where airspaces and ranges are allocated unnecessarily. This is increasing the workload of staff leading to unnecessary re-work. To slove problem, this study proposed models for allocating airspaces and ranges using goal programming with multi-objective functions of minimizing the deviations of the target values.

• 한국콘텐츠학회:학술대회논문집
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• 한국콘텐츠학회 2018년도 춘계 종합학술대회 논문집
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• pp.401-402
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• 2018

콘텐츠 큐레이션 서비스를 위해서 대용량 데이터를 학습하는 과정에서 발생하는 메모리부족 문제, 학습소요시간 문제 등을 해결하기 위한 "대용량 문서학습을 위한 동적학습 파이프라인 생성기술 중 빅데이터 마이닝을 위한 점진적 학습 모델" 기술이 필요하며, 본 논문에서 제안한 콘텐츠 큐레이션 서비스는 온라인상의 수많은 콘텐츠들 중 개인의 주관이나 관점에 따라 관련 콘텐츠들을 수집, 정리하고 편집하여 이용자와 관련이 있거나 좋아할 만한 콘텐츠를 제공하는 서비스이다. 본 논문에서 설계된 모아 큐레이션 서비스는 대용량의 문서를 학습함에 있어서 메모리 부족 문제, 학습 소요시간 문제 등을 해결하기 위해 학습데이터의 용량 제한이 없는 문서를 자유롭게 학습하고 부분적인 자질추가/변경 시에 변경요소만을 추가 반영할 수 있는 범용적이고 일반적인 분류기의 구조설계 방법 등을 제시하였다.

• Asian-Australasian Journal of Animal Sciences
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• 제30권4호
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• pp.462-469
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• 2017

Objective: The aim of this study is to identify genomic regions or genes controlling growth traits in pigs. Methods: Using a panel of 54,148 single nucleotide polymorphisms (SNPs), we performed a genome-wide Association (GWA) study in 562 pure Yorshire pigs with four growth traits: average daily gain from 30 kg to 100 kg or 115 kg, and days to 100 kg or 115 kg. Fixed and random model Circulating Probability Unification method was used to identify the associations between 54,148 SNPs and these four traits. SNP annotations were performed through the Sus scrofa data set from Ensembl. Bioinformatics analysis, including gene ontology analysis, pathway analysis and network analysis, was used to identify the candidate genes. Results: We detected 6 significant and 12 suggestive SNPs, and identified 9 candidate genes in close proximity to them (suppressor of glucose by autophagy [SOGA1], R-Spondin 2 [RSPO2], mitogen activated protein kinase kinase 6 [MAP2K6], phospholipase C beta 1 [PLCB1], rho GTPASE activating protein 24 [ARHGAP24], cytoplasmic polyadenylation element binding protein 4 [CPEB4], GLI family zinc finger 2 [GLI2], neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adaptor 2 [NYAP2], and zinc finger protein multitype 2 [ZFPM2]). Gene ontology analysis and literature mining indicated that the candidate genes are involved in bone, muscle, fat, and lung development. Pathway analysis revealed that PLCB1 and MAP2K6 participate in the gonadotropin signaling pathway and suggests that these two genes contribute to growth at the onset of puberty. Conclusion: Our results provide new clues for understanding the genetic mechanisms underlying growth traits, and may help improve these traits in future breeding programs.

• Journal of Applied Biological Chemistry
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• 제59권1호
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• pp.25-29
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• 2016

B형 간염 바이러스는 간경변증과 간세포암의 원인이 되는 간섬유화를 유발한다. 하지만 현재까지 그와 관련한 자세한 메커니즘은 밝혀지지 않았기에 본 연구에서 이를 알아보고자 하였다. 실험 결과, B형 간염 바이러스에서 발현되는 HBx 단백질에 의해 vimentin, fibronectin, slug, snail, NOX4가 증가되는 것을 확인하였다. NOX4에 의한 활성산소가 snail, slug 발현을 유도하고 섬유화 과정을 촉진할 수 있기 때문에 NOX4의 발현을 유도하는 HBx가 간섬유화를 조절, 유도하는 것을 확인하였다.

• 천문학회보
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• 제43권1호
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• pp.40.4-41
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• 2018

We introduce a coordinate catalog for photometry of the KMTNet Galactic bulge observation program and how to find the microlensing event candidates in the photometry result. Basically, the KMTNet bulge program is monitoring a total of 27 target fields (108 deg2) with four different cadences of 0.5, 1.0, 2.5, and 5.0 hours. In order to measure the stellar flux of each target, we made a 'observation coordinate catalog' by using the 'OGLE-III catalog' and 'DoPhot package'. The catalog contains approximately 0.3 billion stars in the bulge fields. We also search for a microlensing event candidates by means of the 'Event Finder algorithm' which calculates the restricted single-lens fitting (t0, teff, u0; u0 = 0 or 1) model. As a result, we found more than 2,000 microlensing event candidates per each year including about 700 events from the other survey groups such as OGLE and MOA. In this year, we will improve our current pipeline system, e.g. upgrading the catalog and applying real-time photometry.

• 한국항행학회논문지
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• 제13권6호
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• pp.998-1010
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• 2009

최근 지식환경의 변화에 따라 R&D 투자성과를 극대화하기 위한 기술개발 전략의 새로운 패러다임으로 개방형 기술혁신(Open Innovation)이 확산되고 있다. 국내에도 기술개발 비용의 증가, 제품수명의 단축 등으로 R&D 투자 효율성을 극대화하기 위한 기술개발 전략으로 개방형 기술혁신(Open Innovation)에 대한 관심이 고조되고 있지만 활용 실태 등에 대한 조사 발표는 미미한 실정이다. 본 사례연구는 기술 경영 관점에서 개방형 기술혁신이 신제품 개발에 적용되는 일련의 과정을 통하여 기업들이 개방형 기술혁신을 중요한 기술개발 전략의 일환으로 새롭게 실행하거나 강화하려고 할 때 어떤 점들을 고려하고 점검하고 준비해야 하는지에 대한 경영 실무적 측면에서 시사점을 제공해 준다고 할 것이다.

• Food Science and Biotechnology
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• 제16권6호
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• pp.884-888
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• 2007

The aim of this study was to analyze the antioxidant properties of different cultivars of grape skin extract in an in vitro system. The extracts were prepared from eight grape cultivars: 'Campbell Early' (CE), 'Kyoho' (K), 'New Kyoho' (NK), 'Muscat of Alexandria' (MOA), 'Seibel' (S), 'Morgen Schow' (MS), 'Gold Finger' (GF), and 'Meru' (M). The total phenolic acid contents were highest in MS and K. Resveratrol content was high in NK (50.88 mg/l g of coat), and quercetin content was significantly higher in K (0.68 mg/l g of coat) than in the other grape species (0.21-0.44 mg/l g of coat). The K and MS grape species, in which total phenol content was comparatively high (K: $24.15\;{\mu}g/mL$, MS: $25.52\;{\mu}g/mL$), also showed a high level of electron donating activity (K, 53%; MS, 59%). The hydrogen radical scavenging activity of M (50.36%) was significantly higher than the other grape species, including the S (50.21%), MS (49.43%), and K (49.06%) cultivars. Antioxidant activity varied depending on grape species, but overall it was highest in the MS and K cultivars.

• 한국건설순환자원학회논문집
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• 제11권3호
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• pp.210-217
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• 2023

Various performances of ultra-high performance concrete (UHPC) applied with microplastics and expanded polystyrene (EPS) beads were evaluated. CompressIve and flexural strength, performance after ignition, flow-down in fresh state, and effective bond strength were evaluated. Designed weight of the cement panel with these mixtures was calculated based on the flexural strength. As a result of the experiments, it was confirmed that the EPS could reduce the density of UHPC with largest range. By maximum addition of EPS beeds, the density of UHPC decreased to 1300 kg/m³, and the compressive and flexural strengths for this mixtures were in ranges of 20-30 MPa and 15-20 MPa, respectively. On the other hand, lightest cement panel could be designed with UHPC having a density ranges about 2.0 g/cm³.

• 동의생리병리학회지
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• 제17권6호
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• pp.1433-1440
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• 2003

This research was performed to investigate protective effect of Sophorae subprostratae Radix and each fractions against ischemic damage using PC12 cells. To observe the protective effect of Sophorae subprostratae Radix on ischemia damage, vibility and changes in activities of Superoxide dismutase (SOD), Glutathione Peroxidase (GPx), Catalase and Production of Malondialdehyde (MDA) were observed after treating PC12 cells with Sophorae subprostratae Radix during ischemic insult. Groups were divided into five groups: no treated (Normal), hypoxia chamber for 48hrs followed by 6h at normoxic chamber (H/R), Sop horae subprostratae Radix total phase treated group with H/R (Total), Sophorae subprostratae Radix water phase treated group with H/R (Water), Sophorae subprostratae Radix BuOH phase treated group with H/R (BuOH), Sophorae subprostratae Radix alkaloid phase treated group with H/R (Alkaloid). The results showed that (1) in hypoxiajreperfusion model using PC12 cell, the Sophorae subprostratae Radix has the protective effect against ischemia in the dose of 0.2 ㎍/㎖, 2 ㎍/㎖ and 20 ㎍/㎖, (2) Sophorae subprostratae Radix increased the activities of glutathione peroxidase and catalase. (3) the activity of Superoxide Diamutase(SOD) increased by ischemic damage, which might represent the self protection. This study suggests that Sophorae subprostratae Radix has neuroprotective effect against neuronal damage following hypoxiajreperfusion cell culture model using PC12 cell and dose dependency effects. In conclusion, Sophorae subprostratae Radix has protective effects against ischemic oxidative damage at the early stage of ischemia.