• Journal of the Korea Institute of Information Security & Cryptology
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• v.19 no.2
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• pp.63-74
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• 2009

In 2005, Wang et al. discovered devastating collision attacks on the main hash functions from the MD4 family. After the discovery of Wang, many analysis results on the security of existing hash-based cryptographic schemes are presented. At CRYPTO'07, Fouque, Leurent and Nguyen presented full key-recovery attacks on HMAC/NMAC-MD4 and NMAC-MD5[4]. Such attacks are based on collision attacks on the underlying hash function, and the most expensive stage is the recovery of the outer key. At EUROCRYPT'08, Wang, Ohta and Kunihiro presented improved outer key recovery attack on HMAC/NMAC-MD4, by using a new near collision path with a high probability[2]. This improves the complexity of the full key-recovery attack on HMAC/NMAC-MD4 which proposed by Fouque, Leurent and Nguyen at CRYPTO'07: The MAC queries decreases from $2^{88}$ to $2^{72}$, and the number of MD4 computations decreases from $2^{95}$ to $2^{77}$. In this paper, we propose improved outer key-recovery attack on HMAC/NMAC-MD4 with $2^{77.1246}$ MAC queries and $2^{37}$ MD4 computations, by using divide and conquer paradigm.

• BMB Reports
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• v.50 no.2
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• pp.55-57
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• 2017

Toll-like receptor 4 (TLR4) together with MD2, one of the key pattern recognition receptors for a pathogen-associated molecular pattern, activates innate immunity by recognizing lipopolysaccharide (LPS) of Gram-negative bacteria. Although LBP and CD14 catalyze LPS transfer to the TLR4/MD2 complex, the detail mechanisms underlying this dynamic LPS transfer remain elusive. Using negative-stain electron microscopy, we visualized the dynamic intermediate complexes during LPS transfer-LBP/LPS micelles and ternary CD14/LBP/LPS micelle complexes. We also reconstituted the entire cascade of LPS transfer to TLR4/MD2 in a total internal reflection fluorescence (TIRF) microscope for a single molecule fluorescence analysis. These analyses reveal longitudinal LBP binding to the surface of LPS micelles and multi-round binding/unbinding of CD14 to single LBP/LPS micelles via key charged residues on LBP and CD14. Finally, we reveal that a single LPS molecule bound to CD14 is transferred to TLR4/MD2 in a TLR4-dependent manner. These discoveries, which clarify the molecular mechanism of dynamic LPS transfer to TLR4/MD2 via LBP and CD14, provide novel insights into the initiation of innate immune responses.

• Korean Journal of Human Ecology
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• v.24 no.3
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• pp.437-449
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• 2015

The purpose of this study was to investigate the quality characteristics of Dangmyon(starch vermicelli) prepared with mulberry leaves powder. Mulberry leaves powder was added in ratios (w/w) of 0% (CON), 0.5% (MD1), 1.0% (MD2), 1.5% (MD3). and 2.0%(MD4), and then proximate compositions, physicochemical properties, RVA, SEM, texture and sensory evaluations of the Dangmyon were measured. MD1~MD4 samples showed higher contents of moisture, crude lipid, crude protein and crude ash as well as pH compared to control (p<0.001). In terms of color, lightness (L), yellowness (b), and redness (a) decreased as the mulberry leaves powder increased. The results of RVA properties analysis on all samples showed that control had the highest. With regard to the texture of Dangmyon samples, the scores of hardness, adhesiceness, gumminess, chewiness, resilience of CON was significantly higher than the samples MD1~MD4 (p<0.001), but the scores of springiness, cohesiveness was not significantly among samples. The result of observation on the cross section of Dangmyon added with mulberry leaves powder showed that number, size of cavity more increase compared to the control. In sensory evaluation, the scores of appearance, flavor, taste and overall preference for MD3 were significantly higher than the samples (CON, MD1, MD2, and MD4). From the findings, this study suggests that 1.5% addition of mulberry leaves powder was effective for preparation of Dangmyon in the aspects of the consumer acceptability.

• Journal of Korean Society for Quality Management
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• v.50 no.4
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• pp.735-749
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• 2022

Purpose: The purpose of this study is to investigate whether the Management Discussion and Analysis (MD&A) has an impact on auditors' audit efforts. MD&A is a means of disclosure that provides information about a company from the management's perspective in financial reporting. The MD&A is a standardized format of nonfinancial information that can be useful for the stake-holders. The auditors have incentives to utilize the nonfinancial information contained in the MD&A for their decision-making. We posit that the MD&A disclosure quality is associated with the level of audit efforts. Methods: We hand-collect the disclosure data from the Financial Supervisory Service of Korea (the Korean SEC). Results: By employing two measures of audit efforts, we document evidence that the quality of MD&A is associated with both audit hours and audit fees. Conclusion: It implies that the auditors perform intensive audit work for companies with high-quality disclosure of MD&A. The study contributes to the literature by providing the first approach to examine the association between the MD&A disclosure and audit efforts.

• Journal of Information Technology Services
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• v.22 no.4
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• pp.21-35
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• 2023

Software as Medical Devices (SaMD) is a growing category of medical devices that are composed of software to perform one or more medical purposes. SaMD is less likely to cause physical harm compared to conventional medical devices, particularly medical electrical equipments, and may be more vulnerable to privacy issues. This difference was acknowledged and resulted in introducing new regulation guidance specifically for cybersecurity of SaMD. It guides stakeholders of SaMD what to consider in what context in terms of cybersecurity. This study examines the current guidance of how cybersecurity is considered for SaMD by analyzing current medical device standards, then suggest which concept or details beyond current medical device standards may be applicable through analysis of international standards documents published for software in general.

• Molecules and Cells
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• v.24 no.1
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• pp.119-124
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• 2007

TLR4 together with CD14 and MD-2 forms a pattern recognition receptor that plays an initiating role in the innate immune response to Gram-negative bacteria. Here, we employed the surface plasmon resonance technique to investigate the kinetics of binding of LPS to recombinant CD14, MD-2 and TLR4 proteins produced in insect cells. The dissociation constants ($K_D$) of LPS for immobilized CD14 and MD-2 were $8.7{\mu}m$, and $2.3{\mu}m$, respectively. The association rate constant ($K_{on}$) of LPS for MD-2 was $5.61{\times}10^3M^{-1}S^{-1}$, and the dissociation rate constant ($K_{off}$) was $1.28{\times}10^2S^{-1}$, revealing slow association and fast dissociation with an affinity constant $K_D$ of $2.33{\times}10^6M$ at $25^{\circ}C$. These affinities are consistent with the current view that CD14 conveys LPS to the TLR4/MD-2 complex.

• Journal of Dairy Science and Biotechnology
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• v.32 no.2
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• pp.147-156
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• 2014

The aim of this study was to investigate the physiological characteristics and anti-obesity effects of E. faecalis MD366 isolated from raw milk. E. faecalis MD366 inhibited lipase activity ($65.0{\pm}0.9%$) and differentiation of 3T3-L1 adipocytes ($27.4{\pm}1.4%$) at a concentration of $100{\mu}g/mL$ ($10^8CFU/g$ E. faecalis MD366). The optimum growth temperature of E. faecalis MD366 was $37^{\circ}C$. Among 16 tested antibiotics, E. faecalis MD366 demonstrated the highest sensitivity to novobiocin and the highest resistance to neomycin, kanamycin, and vancomycin. The strain also showed high acid phosphatase activity. Moreover, E. faecalis was relatively tolerant to bile juice and acid, and displayed high resistance to Escherichia coli, Salmonella Typhimurium, and Staphylococcus aureus (80.4%, 60.2%, and 65.4%, respectively). These results demonstrate that E. faecalis MD366 can be potentially used as a probiotic with anti-obesity effects.

• Advances in pediatric surgery
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• v.1 no.1
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• pp.33-39
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• 1995

The incidence of Meckel's diverticulum(MD) in general population has been assessed as 2 percent. The major complications of MD are bleeding, perforation, and intestinal obstruction. In spite that the complication rate of Meckel's diverticulum is relatively high(about 4.2% during a lifetime), the preoperative diagnostic rate of complicated MD is very low. Authors investigated the clinical characteristics of complicated MD to improve the diagnostic rate. 16 patients with complicated Meckel's diverticulum who were operated upon at the Department of Pediatric Surgery, Seoul National University Children's Hospital from June 1985 to December 1993 were reviewed. Among the 16 patients with complicated MD, 12 patients(75%) were under 2 year-old and male were predominant(88%). The most common complication was bleeding patients with bleeding MD (8 cases) were diagnosed preoperatively as MD. 8 patients with other complications(perforation : 4 cases, obstruction : 4 cases) could not be suspected as complicated MD except one patient who had previous history of melena. These patients were diagnosed after exploratory laparotomy under the various impression other than MD. Among 12 patients with ulcer related complications such as bleeding and perforation, heterotopic gastric mucosa was found in 11 patients. In conclusion, in any children with unexplained acute abdomen, especially under 2 years old, complicated MD must be included in differential diagnosis. In children with obscure lower gastrointestinal bleeding, $^{99m}Tc$-pertechnetate scintigraphy is a useful diagnostic tool to rule out bleeding MD.

• Proceedings of the Korea Institutes of Information Security and Cryptology Conference
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• 1995.11a
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• pp.126-137
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• 1995

VDM-SL(Vienna Development Method - Specification Language)은 다양한 표준들의 정확한 기술을 위해 제시되고 있는 형식규격어의 하나로서 특히 보안표준의 표현에 적합한 형식규격어이다. 이러한 VDM-SL을 사용하여 보안표준의 표현 및 실행코드 생성의 정확성과 편리성을 제공하기 위한 다양한 도구들이 개발되고 있으며 이들 중 IFAD VDM-SL Toolbox는 가장 많은 기능을 구진 도구이다. 본 논문에서는 IFAD WDM-SL Toolbox를 이용해 해쉬알고리즘의 하나인 MD4 Message Digest Algorithm을 형식적 표현기법으로 나타내고 이를 바탕으로 참조구현 코드를 C++로 생성하는 방법을 설명한다. 또한 형식적 표현기법과 IFAD VDM-SL Toolbox를 이용해 생성된 참조구현코드의 실행 결과를 MD4의 테스트 벡터 (test vector)를 이용하여 RSA사에서 구현한 MD4 알고리즘과 비교 분석하여 형식적 표현기법을 이용하여 생성된 코드의 활용성에 대해 설명하고자 한다.

• Microbiology and Biotechnology Letters
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• v.20 no.4
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• pp.377-383
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• 1992

Seven strains of Bacillus thuringiensis were isolated from soil in Korea and characterized. The isolates were named HL-8, 10, 12, 13, 14, 15 and 16 which produced parasporal crystals and endospores in their cells. The biochemical characteristics of the seven isolates were only minor different in specific chracteristics to the known serotypes of Bacillus thuringiensis. The number of the plasmid DNA elements from the isolates were studied. The computerized molecular weights of the six plasmid elements in the HL-8 and HL-lO strains were from 3.01 to 15.1 Md, four plasmid elements in the HL-12 were from 5.4 to 21.9 Md, four plasmid elements in HL-13 were from 5.1 to 20 Md, three plasmid elements in HL-15 were from 3.4 to 11.3 Md and three plasmid elements in the HL-16 were from 2.4 to 20.1 Md. The seven isolates showed resistances to ampicillin, bacitracin, cephalothin, methicillin and penicillin G. The strains of HL-8, HL-lO, HL12, HL-14, HL-15 and HL-16 showed lethalities against Culex pipiens 3rd instar larvae. The HL8 and 14 strains showed 100% lethality to the larvae within 48 hours. HL-13 strain did not have toxicity against the larvae.