• Journal of Yeungnam Medical Science
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• 제1권1호
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• pp.49-58
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• 1984

폐결핵 환자의 객담으로 부터 비정형항산균의 배균여부를 규명하기 위하여 세균학적 시험 및 임상적 조사를 시행하여 다음과 같은 결론을 얻었다. 1. 객담 334예에서 항산균 103주 (30.8%)를 분리 배양하였다. 2. 분리배양된 항산균주에서 비정형항산균으로 감별된 균주는 10주(9.7%)이며 인형결핵균주는 93주(90.3%)이였다. 3. 감별된 비저형항산균주는 Runyon군별로는 암착색균군, 광비발색균군이 각각 3주 (30.0%)씩이며 신속발육균군이 4주(40.0%)였으며 광발색균군은 분리되지 않았다. 4. 생물학석 성상 및 생화학적 특성시험 양상에 의해 암착색균군 3주 중 2주는 Mycobacterium scrofulaceum, 1주는 Mycobacterium szulgai로, 광비발색균 3주 중 2주는 Mycobacterium avium complex, 1주는 Mycobacterium terrae로 동정되였으며, 신속발육균주 4주중 3주는 Mycobacterium fortuitum, 1주는 Mycobacterium chelonei로 등정되었다. 5. 항결핵제에 대한 시험관내 약제감수성검사에서 INH, SM에서는 10주가 전부 내성을 나타내었으며, EB, TH, 및 CS의 저농도인 10mcg, 50mcg, 및 40mcg에서 완전내성을 나타내었다. 그리고 EB, TH, 및 RFP의 고농도인 20mcg, 및 100mcg,에서 감수성을 나타내었다. 6. 비정형항산균이 배균된 환자의 X-선소견 및 임상적 소견 조사에서는 인형결핵균 감성으로 인한 폐결핵 환자의 증상에 비해 경하지 않는 것으로 사료되었으며 장기간 항결핵제의 투여치로 되어 왔으나 대부분 호전되지 않았다.

• 천문학회지
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• 제34권3호
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• pp.129-135
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• 2001

We report results from an analysis of the X-ray archival data on MCG-2-58-22 obtained with Ginga, ROSAT and ASCA. By analyzing both short- and long-term light curves, we find clear time variations, ranging widely from, $\~10^3$ s to more than several years, in the X-ray energy range 0.1 - 10 keV. In addition, a flare is detected in 1991, overlaid on a gradual, secular flux decrease from 1979 to 1993; this flare has a time scale of about 1 year, and the X-ray flux increased by at least a factor of 3. The implications of these observational results are discussed in terms of accretion flow dynamics near a supermassive black hole.

• Progress in Superconductivity
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• 제12권2호
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• pp.124-128
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• 2011

We have developed a high-$T_C$ SQUID magnetometer system to measure magnetocardiograms of laboratory rats. White noise of the measurement system was about 50 fT/$Hz^{1/2}$ when measured in a magnetically shielded box. We optimized the measurement position to obtain clear MCG wave from rat's small heart by using grid measurements. With the optimization, the MCG signal was successfully detected with the peak amplitude of about 50 pT. We could observe well defined P-, QRS-, and T-wave from the rat MCG. The results suggest that the developed system has a strong potential to monitor the progress of heart disease model using laboratory rat.

• Mycobiology
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• 제42권2호
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• pp.147-151
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• 2014

We investigated the diversity of the foliar endophytes of Korean ginseng. Endophytic fungi were isolated from healthy leaves of mountain-cultivated ginseng (MCG) and field-cultivated ginseng (FCG) at 4 sites in Chungbuk Province. A total of 24 species of fungal endophytes were identified using molecular approaches. Additionally, the diversity of these endophytic fungi was compared between MCG and FCG. The major isolated endophytes were Edenia gomezpompae and Gibberella moniliformis in the MCG and FCG samples, respectively. The results suggest that ginseng endophytes have different community structures in different environments, and this understanding may prove useful in ginseng cultivation.

• 약학회지
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• 제23권3_4호
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• pp.147-152
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• 1979

Experiments were carried out to investigate for the interaction between FAD solution and synthetic resin containers made of polyvinylchloride(PVC), polyethylene(PE), and polycarbonate(PC), and for the effect of glycyrrhizine or malic acid on stabilization of FAD in aqueous solution by accelerated stability analysis. Analysis of FAD was determined by means of spectrometer and by separating by paper chromatography and metal ions were detected by atomic absorption spectrophotometer, which were extracted from containers by means of Food and Additive Regulation Standard. The thermal decomposition of FAD in aqueous solution was pseudo first order reaction and it was inhibited by adding glycyrrhizine or malic into the solution. PVC, PE and PC containers accelerated the decomposition of FAD in solution. It is assumed that bivalent heavy metals in resin containers may catalize the hydrolysis of FAD. The metals detected from the containers were Ca, Zn, Cu, Fe, Pb and Cd. And the total amounts of detected metals from PVC were 6.2mcg/cm$^{2}$, PE, 5.5mcg/cm$^{2}$, and PC, 2.7mcg/cm$^{2}$ which were proportional to the rate constant of FAD decomposition in aqueous solution.

• Journal of Pharmaceutical Investigation
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• 제14권4호
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• pp.189-194
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• 1984

The present study was undertaken to evaluate the relative bioavailability of doxycycline hyclate and doxycycline-L-methylenelysine, a new synthetic derivative of doxycycline. Single doses, equivalent to 100mg of doxycycline hyclate, were administered orally to 10 healthy male volunteers. Serum concentrations were determined periodically over 12 hrs. by microbiological assay. Peak serum concentrations were reached within 4 hrs. Doxycycline hyclate $(1.38mcg.ml^{-1})$ gave 1.66 tines higher concentration than doxycycline-L-methylenelysine $(0.38mcg.\;ml^{-1})$. And the areas under the serum concentrationtime curves 0 to 12 hrs were $8.38mcg.hr.ml^{-1}$ (doxycycline hyclate) and $5.56mg\;hr.ml^{-1}$(doxycycline).

• 천문학회지
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• 제38권3호
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• pp.339-344
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• 2005

We present analysis results of the energy spectra of MCG-2-58-22 associated with occasional flares which appear in a long-term X-ray light curve. We measure an intrinsic power-law slope of this object to be ${\Gamma}=1.74{\pm}0.02$ in the energy range of ${\sim}1-5keV$ and find that this slope is little affected by flares. We confirm that there exists a broad excess emission above 5 keV to the power-law continuum. The excess emission is less variable compared with a flux variation of flare and tends to be relatively weak during flares. A soft X-ray spectrum is also found to change, implying the presence of a variable soft component. We discuss the implications of these spectral variations.

• 한국전기전자재료학회:학술대회논문집
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• 한국전기전자재료학회 2004년도 추계학술대회 논문집 Vol.17
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• pp.444-447
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• 2004

A heart diagnosis system adopts hundreds of Superconducting Quantum Interface Device(SQUID) sensors for precision MCG(Magnetocardiogram) or MEG(Magnetoencephalogram) signal acquisitions. This system requires correct and real-time data acquisition from the sensors in a required sampling interval, i.e., 1 mili-second. This paper presents our hardware design and test results, to acquire data from 256 channel analog signal with 1-ksample/sec speed, using 12-bit 8-channel ADC devices, SPI interfaces, parallel interfaces, and 8-bit microprocessors. We chose to implement parallel data transfer between microprocessors as an effective way of achieving such data collection. Our result concludes that the data collection can be done in 250 ${\mu}sec$ time-interval.

• 한국정보통신학회:학술대회논문집
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• 한국정보통신학회 2016년도 추계학술대회
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• pp.281-282
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• 2016

심장에 의해 발생된 전류는 단지 전위뿐만 아니라 자기장을 생성한다. 이 논문은 양자 간섭 장치(SQUID) 시스템의 초전도 61 채널의 심자도(MCG) 시스템의 파라미터를 이용하여 신경회로망 알고리즘으로 심장 질환의 진단을 위한 분석을 수행하였고, 질환 진단에 사용 가능한 결과를 얻었다.

• 한국식품영양과학회지
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• 제45권6호
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• pp.789-796
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• 2016

본 연구에서 고당식이로 비알코올성 지방간을 유도한 마우스의 체중 변화는 대조군보다 백미군, 혼합잡곡군, 항비만혼합잡곡군에서 체중증가율이 낮았고 간 무게 또한 유의적으로 감소했으며, 간 내 조직학적 지방구 수와 크기가 감소한 것을 관찰할 수 있었다. 혈청 지질 수치 역시 개선 효과를 보였는데 모든 실험군이 대조군보다 중성지방, 총콜레스테롤 및 저밀도 콜레스테롤의 농도가 감소하였고, 혈청 고밀도 콜레스테롤은 모두 증가하였다. 간 조직 내 지질합성 및 지방산 침투와 관련 유전자 인자에서 대조군보다 SREBP-1c mRNA 유전자 발현 수준은 백미군, 혼합잡곡군 및 항비만혼합잡곡군에서, ACC 및 FAS mRNA 유전자 발현 수준은 혼합잡곡군과 항비만혼합잡곡군에서, SCD-1 mRNA 유전자 발현 수준은 항비만혼합잡곡군에서 감소하였다. CD36 및 $PPAR-{\gamma}$ mRNA 유전자 발현 수준 또한 대조군보다 백미군, 혼합잡곡군, 항비만혼합잡곡군에서 감소하였다. 간 내 ${\beta}$산화로 지방축적 억제와 관련된 유전자 인자인 $PPAR-{\alpha}$ 및 CPT-1 mRNA 유전자 발현 수준은 대조군보다 혼합잡곡군, 항비만혼합잡곡군에서 증가하였다. 본 실험 결과를 종합해 볼 때 고당식이로 비알코올성 지방간질환을 유도한 마우스에서 백미군, 혼합잡곡군 및 항비만혼합잡곡군 모두 지질 대사 개선 효과가 나타났으며 항비만혼합잡곡군이 가장 효과적이었다.