• Title/Summary/Keyword: MAP3K16

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Quantitative Assessment Technology of Small Animal Myocardial Infarction PET Image Using Gaussian Mixture Model (다중가우시안혼합모델을 이용한 소동물 심근경색 PET 영상의 정량적 평가 기술)

  • Woo, Sang-Keun;Lee, Yong-Jin;Lee, Won-Ho;Kim, Min-Hwan;Park, Ji-Ae;Kim, Jin-Su;Kim, Jong-Guk;Kang, Joo-Hyun;Ji, Young-Hoon;Choi, Chang-Woon;Lim, Sang-Moo;Kim, Kyeong-Min
    • Progress in Medical Physics
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    • v.22 no.1
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    • pp.42-51
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    • 2011
  • Nuclear medicine images (SPECT, PET) were widely used tool for assessment of myocardial viability and perfusion. However it had difficult to define accurate myocardial infarct region. The purpose of this study was to investigate methodological approach for automatic measurement of rat myocardial infarct size using polar map with adaptive threshold. Rat myocardial infarction model was induced by ligation of the left circumflex artery. PET images were obtained after intravenous injection of 37 MBq $^{18}F$-FDG. After 60 min uptake, each animal was scanned for 20 min with ECG gating. PET data were reconstructed using ordered subset expectation maximization (OSEM) 2D. To automatically make the myocardial contour and generate polar map, we used QGS software (Cedars-Sinai Medical Center). The reference infarct size was defined by infarction area percentage of the total left myocardium using TTC staining. We used three threshold methods (predefined threshold, Otsu and Multi Gaussian mixture model; MGMM). Predefined threshold method was commonly used in other studies. We applied threshold value form 10% to 90% in step of 10%. Otsu algorithm calculated threshold with the maximum between class variance. MGMM method estimated the distribution of image intensity using multiple Gaussian mixture models (MGMM2, ${\cdots}$ MGMM5) and calculated adaptive threshold. The infarct size in polar map was calculated as the percentage of lower threshold area in polar map from the total polar map area. The measured infarct size using different threshold methods was evaluated by comparison with reference infarct size. The mean difference between with polar map defect size by predefined thresholds (20%, 30%, and 40%) and reference infarct size were $7.04{\pm}3.44%$, $3.87{\pm}2.09%$ and $2.15{\pm}2.07%$, respectively. Otsu verse reference infarct size was $3.56{\pm}4.16%$. MGMM methods verse reference infarct size was $2.29{\pm}1.94%$. The predefined threshold (30%) showed the smallest mean difference with reference infarct size. However, MGMM was more accurate than predefined threshold in under 10% reference infarct size case (MGMM: 0.006%, predefined threshold: 0.59%). In this study, we was to evaluate myocardial infarct size in polar map using multiple Gaussian mixture model. MGMM method was provide adaptive threshold in each subject and will be a useful for automatic measurement of infarct size.

Hybrid Sensor Calibration Scheme for Mobile Crowdsensing-Based City-Scale Environmental Measurements

  • Son, Seung-Chul;Lee, Byung-Tak;Ko, Seok Kap;Kang, Kyungran
    • ETRI Journal
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    • v.38 no.3
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    • pp.551-559
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    • 2016
  • In this paper, we propose a hybrid sensor calibration scheme for mobile crowdsensing applications. As the number of newly produced mobile devices containing embedded sensors continues to rise, the potential to use mobile devices as a sensor data source increases. However, because mobile device sensors are generally of a lower performance and cost than dedicated sensors, sensor calibration is crucial. To enable more accurate measurements of natural phenomena through the use of mobile device sensors, we propose a hybrid sensor calibration scheme for such sensors; the scheme makes use of mobile device sensors and existing sensing infrastructure, such as weather stations, to obtain dense data. Simulation results show that the proposed scheme supports low mean square errors. As a practical application of our proposed scheme, we built a temperature map of a city using six mobile phone sensors and six reference sensors. Thanks to the mobility of the sensors and the proposed scheme, our map presents more detailed information than infrastructure-based measurements.

3-D Object Recognition and Restoration Independent of the Translation and Rotation Using an Ultrasonic Sensor Array (초음파센서 배열을 이용한 이동과 회전에 무관한 3차원 물체인식과 복원)

  • Cho, Hyun-Chul;Lee, Kee-Seong;SaGong, Geon
    • Proceedings of the KIEE Conference
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    • 1996.07b
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    • pp.1237-1239
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    • 1996
  • 3-D object recognition and restoration independent of the translation and rotation using an ultrasonic sensor array, neural networks and invariant moment are presented. Using invariant moment vectors on the acquired $16{\times}8$ pixel data, 3-D objects can be classified by SOFM(Self Organizing Feature Map) neural networks. Invariant moment vectors kept constant independent of the translation and rotation. The experiment result shows the suggested method can be applied to the environment recognition.

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Effect of Non-Perforated Breathable Films on the Quality and Shelf Life of Paprika during MA Storage in Simulated Long Distance Export Condition (비천공 Breathable필름이 장거리 모의 수출 조건에서 파프리카의 MA 저장중 품질과 저장수명에 미치는 영향)

  • Choi, In-Lee;Yoo, Tae-Jong;Kim, Il-Seop;Lee, Yong-Beom;Kang, Ho-Min
    • Journal of Bio-Environment Control
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    • v.20 no.2
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    • pp.150-155
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    • 2011
  • The aim of this study was investigated long distance export condition of paprika from Korea to Canada, and evaluated the effect of non-perforated breathable films on the storability of paprika during MA storage in the simulated long distance export condition. The long distance export condition of paprika from Korea to Canada was $7{\pm}1^{\circ}C$ and RH 90% during shipping for 20 days, and then the temperature of that was increased to $13^{\circ}C$ for 3 hours during transferring from refrigerated container to storage room in Canada, and decreased $3{\sim}4^{\circ}C$ for 3 days before distributing to local markets. The temperature and relative humidity of local markets was $16^{\circ}C$ and 60%, respectively. The packing material treatments were non-packing, as control, perforated film (6 mm diameter hole, $18holes/m^2$), and 3 kind of laser treated non-perforated films (oxygen transmission rate was 5,000, 20,000 and 100,000 $cc/m^2{\cdot}day{\cdot}atm$). Under the simulated long distance export condition; $7^{\circ}C$ and RH 90% for 15 days and then $20^{\circ}C$ and RH 55% for 7 days, the fresh weight loss of paprika was less than 1% in 3 kind of laser treated non-perforated film treatments but was more than 4% in control and perforated film treatment that showed severe deterioration of visual quality after 20 days of storage. The atmosphere of paprika packages was changed 5% oxygen and 15% carbon dioxide in 5,000 $cc/m^2{\cdot}day{\cdot}atm$ treatment, and 16% oxygen and 4~5% carbon dioxide in 20,000 $cc/m^2{\cdot}day{\cdot}atm$ treatment during room temperature storage after cold storage for 15 days. A carbon dioxide concentration of these 2 treatments was exceeded the optimal MA and CA condition. There was no significant difference in ethylene concentration among 3 kind of laser treated non-perforated film treatments. A paprika packed with 100,000 $cc/m^2{\cdot}day{\cdot}atm$ non-perforated film showed the highest visual quality under the simulated long distance export condition. However, the firmness and soluble solids did not show any significant difference among 3 kind of laser treated non-perforated film treatments. Therefore, we may suggest that 100,000 $cc/m^2{\cdot}day{\cdot}atm$ laser treated non-perforated film was the proper film for MAP of paprika under long distance export condition that was $7{\pm}1^{\circ}C$ and RH 90% for 15 days, and then $20^{\circ}C$ and RH 55% for 7 days.

A Multi-layered Prioritization Scheme for Emerging IT Technologies for Constructing a National Technology Road Map

  • Oh, Kyong-Joo;Kim, Nam-Gyu;Kim, Wan-Ki
    • Journal of Information Technology Applications and Management
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    • v.16 no.3
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    • pp.29-43
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    • 2009
  • The advancement of emerging technologies can create more national value, and this motivates many nations to invest their resources in the emerging technologies. However, due to limited financial and human resources, even a wealthy nation cannot afford to randomly invest its resource in all profitable technologies. Therefore, cautious appraisal and prioritization of the competitive technologies should be conducted first, and then concentrated investment should be done for only the selected technologies. In this study, we propose a quantitative criterion for prioritizing the targeted electronic device technologies. The prioritization scheme devised in this study consists of a growth layer, a profitability layer, a vitality layer, and an influence layer. The proposed model forecasts the most promising technologies by applying the revised version of the Analytic Hierarchy Process (AHP). We performed empirical experiments on 12 emerging electronic device technologies to analyze the practical applicability of our study. The experimental data was obtained from 70 experts in high-tech industry as a part of the 2004 Prioritization and Selection project that was carried out in South Korea. As a result, the proposed scheme was able to present the most promising areas for investment in the field of electronic device technology.

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An Agro-ecological Land Suitability Analysis Using GIS For Oil Palm Plantation in Southern Thailand

  • Dansagoonpon, Sutat;Tripathi, Nitin K;Borne, Frederic;Clemente, Roberto S.
    • Proceedings of the KSRS Conference
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    • 2003.11a
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    • pp.970-972
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    • 2003
  • Due to rapid increase in the demand of Natural Rubber (NR) few years ago, NR price sore very higher. The rubber plantation in Thailand expanded very fast to non traditional areas with the result Thai become the biggest NR exporting country in the world. However, the average yield is still lower compared to experimental yield of RRIT (Rubber Research Institute of Thailand) or just 60 % (RRIT, 1998). This is due to many of new rubber planting areas, which are not suitable. The Thai Ministry of Agriculture and Cooperatives thus has set 'The complete cycle development strategies for natural rubber' in the medium-term measures by reducing the rubber planting areas by 300,000 rai (1 rai = 0.16ha) through replanting with oil palm. The aim of this study is to find out land having lowest potential for rubber production (R3) but highest for oil palm production (P1). Find areas which are unsuitable for rubber and can be replaced by oil palm in order to get a better agricultural production. The study was applied upon Krabi province, Thailand. Crops requirement, degree of limitation to crops growth, climatic data, crops yield, soil map, topographic map etc., were used to evaluate land potential for both rubber and oil palm production according to FAO framework (Sys, 1992). An Agro-ecological suitability map for rubber and oil palm were produced. This was done by mean of GIS. The database was generated and guide map for the decision makers in view of suitable crop substitution was prepared.

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Assessment of Trophic State for Yongdam Reservoir Using Satellite Imagery Data (인공위성 영상자료를 이용한 용담호의 영양상태 평가)

  • Kim, Tae Geun
    • Journal of Environmental Impact Assessment
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    • v.15 no.2
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    • pp.121-127
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    • 2006
  • The conventional water quality measurements by point sampling provide only site specific temporal water quality information but not the synoptic geographic coverage of water quality distribution. To circumvent these limitations in temporal and spatial measurements, the use of remote sensing is increasingly involved in the water quality monitoring research. In other to assess a trophic state of Yongdam reservoir using satellite imagery data, I obtained Landsat ETM data and water quality data on 16th September and 18th October 2001. The approach involved acquisition of water quality samples from boats at 33 sites on 16th September and 30 sites on 18th October 2001, simultaneous with Landsat-7 satellite overpass. The correlation coefficients between the DN values of the imagery and the concentrations of chlorophyll-a were analyzed. The visible bands(band 1,2,3) and near infrared band(band 4) data of September image showed the correlation coefficient values higher than 0.9. The October image showed the correlation coefficient values about 0.7 due to the atmospheric effect and low variation of chlorophyll-a concentration. Regression models between the chrophyll-a concentration and DN values of the Landsat imagery data have been developed for each image. The regression model was determined based on the spectral characteristics of chlorophyll, so the green band(band 2) and near infrared band(band 4) were selected to generate a trophic state map. The coefficient of determination(R2) of the regression model for 16th September was 0.95 and that of the regression model for 18th October was 0.55. According to the trophic state map made based on Aizaki's TSI and chlorophyll-a concentration, the trophic state of Yongdam reservoir was mostly eutrophic state during this study.

Barbigerone Inhibits Tumor Angiogenesis, Growth and Metastasis in Melanoma

  • Yang, Jian-Hong;Hu, Jia;Wan, Li;Chen, Li-Juan
    • Asian Pacific Journal of Cancer Prevention
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    • v.15 no.1
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    • pp.167-174
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    • 2014
  • Tumor angiogenesis, growth and metastasis are three closely related processes. We therefore investigated the effects of barbigerone on all three in the B16F10 tumor model established in both zebrafish and mouse models, and explored underlying molecular mechanisms. In vitro, barbigerone inhibited B16F10 cell proliferation, survival, migration and invasion and suppressed human umbilical vascular endothelial cell migration, invasion and tube formation in concentration-dependent manners. In the transgenic zebrafish model, treatment with $10{\mu}M$ barbigerone remarkably inhibited angiogenesis and tumor-associated angiogenesis by reducing blood vessel development more than 90%. In vivo, barbigerone significantly suppressed angiogenesis as measured by H and E staining of matrigel plugs and CD31 staining of B16F10 melanoma tumors in C57BL/6 mice. Furthermore, it exhibited highly potent activity at inhibiting tumor growth and metastasis to the lung of B16F10 melanoma cells injected into C57BL/6 mice. Western blotting revealed that barbigerone inhibited phosphorylation of AKT, FAK and MAPK family members, including ERK, JNK, and p38 MAPKs, in B16F10 cells mainly through the MEK3/6/p38 MAPK signaling pathway. These findings suggested for the first time that barbigerone could inhibit tumor-angiogenesis, tumor growth and lung metastasis via downregulation of the MEK3/6/p38 MAPK signaling pathway. The findings support further investigation of barbigerone as a potential anti-cancer drug.

Ear Recognition by Major Axis and Complex Vector Manipulation

  • Su, Ching-Liang
    • KSII Transactions on Internet and Information Systems (TIIS)
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    • v.11 no.3
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    • pp.1650-1669
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    • 2017
  • In this study, each pixel in an ear is used as a centroid to generate a cake. Subsequently the major axis length of this cake is computed and obtained. This obtained major axis length serves as a feature to recognize an ear. Later, the ear hole is used as a centroid and a 16-circle template is generated to extract the major axis lengths of the ear. The 16-circle template extracted signals are used to recognize an ear. In the next step, a ring-to-line mapping technique is used to map these major axis lengths to several straight-line signals. Next, the complex plane vector computing technique is used to determine the similarity of these major axis lengths, whereby a solution to the image-rotating problem is achieved. The aforementioned extracted signals are also compared to the ones that are extracted from its neighboring pixels, whereby solving the image-shifting problem. The algorithm developed in this study can precisely identify an ear image by solving the image rotation and image shifting problems.

Hierarchical 3D modeling using disparity-motion relationship and feature points (변이-움직임 관계와 특징점을 이용한 계층적 3차원 모델링)

  • Lee, Ho-Geun;Han, Gyu-Pil;Ha, Yeong-Ho
    • Journal of the Institute of Electronics Engineers of Korea SP
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    • v.39 no.1
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    • pp.9-16
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    • 2002
  • This paper proposes a new 3D modeling technique using disparity-motion relationship and feature points. To generate the 3D model from real scene, generally, we need to compute depth of model vertices from the dense correspondence map over whole images. It takes much time and is also very difficult to get accurate depth. To improve such problems, in this paper, we only need to find the correspondence of some feature points to generate a 3D model of object without dense correspondence map. The proposed method consists of three parts, which are the extraction of object, the extraction of feature points, and the hierarchical 3D modeling using classified feature points. It has characteristics of low complexity and is effective to synthesize images with virtual view and to express the smoothness of Plain regions and the sharpness of edges.