• The Bulletin of The Korean Astronomical Society
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• v.39 no.2
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• pp.78.2-78.2
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• 2014

MIRIS (Multi-purpose Infrared Imaging System) is the primary payload on the Korean science and technology satellite, STSAT-3, which was launched on 2013 November 21. It is designed to observe the near-infrared sky with a $3.67^{\circ}{\times}3.67^{\circ}$ field of view and a $51.6^{{\prime}{\prime}}{\times}51.6^{{\prime}{\prime}}$ pixel resolution. Using two narrow-band filters at $1.88{\mu}m$ (Pa ${\alpha}$ line) and $1.84+1.92{\mu}m$ (Pa ${\alpha}$ dual continuum), the Paschen ${\alpha}$ Galactic plane survey has been carrying out, and the area for the Galactic longitude from $+280^{\circ}$ to $+100^{\circ}$ (with the width of $-3^{\circ}$ < b < $+3^{\circ}$) has been covered by 2014 August 31. In this contribution, we present the preliminary results of the MIRIS Paschen ${\alpha}$ emission maps and compare them with other wavelength maps such as $H{\alpha}$ and dust maps. Many of the Paschen ${\alpha}$ features have been detected along the plane, and some of them are weak or invisible in the $H{\alpha}$ map and coincide well with dense cloud regions.

• Experimental and Molecular Medicine
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• v.50 no.11
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• pp.7.1-7.12
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• 2018

Recent findings from The Cancer Genome Atlas project have provided a comprehensive map of genomic alterations that occur in hepatocellular carcinoma (HCC), including unexpected mutations in apolipoprotein B (APOB). We aimed to determine the clinical significance of this non-oncogenetic mutation in HCC. An Apob gene signature was derived from genes that differed between control mice and mice treated with siRNA specific for Apob (1.5-fold difference; P < 0.005). Human gene expression data were collected from four independent HCC cohorts (n = 941). A prediction model was constructed using Bayesian compound covariate prediction, and the robustness of the APOB gene signature was validated in HCC cohorts. The correlation of the APOB signature with previously validated gene signatures was performed, and network analysis was conducted using ingenuity pathway analysis. APOB inactivation was associated with poor prognosis when the APOB gene signature was applied in all human HCC cohorts. Poor prognosis with APOB inactivation was consistently observed through cross-validation with previously reported gene signatures (NCIP A, HS, high-recurrence SNUR, and high RS subtypes). Knowledge-based gene network analysis using genes that differed between low-APOB and high-APOB groups in all four cohorts revealed that low-APOB activity was associated with upregulation of oncogenic and metastatic regulators, such as HGF, MTIF, ERBB2, FOXM1, and CD44, and inhibition of tumor suppressors, such as TP53 and PTEN. In conclusion, APOB inactivation is associated with poor outcome in patients with HCC, and APOB may play a role in regulating multiple genes involved in HCC development.

• Transactions of the Korean Society of Mechanical Engineers B
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• v.35 no.3
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• pp.309-319
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• 2011

We experimentally investigated lifted propane jet flames diluted with nitrogen to obtain flame-stability maps based on heat-loss-induced self-excitation. We found that heat-loss-induced self-excitations are caused by conductive heat loss from premixed flame branches to trailing diffusion flames as well as soot radiation. The conductive-heat-loss-induced self-excitation at frequencies less than 0.1 Hz is explained well by a suggested mechanism, whereas the oscillation of the soot region induces a self-excitation of lift-off height of the order of 0.1 Hz. The suggested mechanism is also verified from additive experiments in a room at constant temperature and humidity. The heat-loss-induced self-excitation is explained by the Strouhal numbers as a function of the relevant parameters.

• Korean Journal of Agricultural and Forest Meteorology
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• v.10 no.4
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• pp.121-131
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• 2008

This study was conducted to delineate temporal and spatial patterns of potential risk of cold injury by combining the short-term cold hardiness of Campbell Early grapevine and the IPCC projected climate winter season minimum temperature at a landscape scale. Gridded data sets of daily maximum and minimum temperature with a 270m cell spacing ("High Definition Digital Temperature Map", HD-DTM) were prepared for the current climatological normal year (1971-2000) based on observations at the 56 Korea Meteorological Administration (KMA) stations using a geospatial interpolation scheme for correcting land surface effects (e.g., land use, topography, and elevation). The same procedure was applied to the official temperature projection dataset covering South Korea (under the auspices of the IPCC-SRES A2 and A1B scenarios) for 2071-2100. The dormancy depth model was run with the gridded datasets to estimate the geographical pattern of any changes in the short-term cold hardiness of Campbell Early across South Korea for the current and future normal years (1971-2000 and 2071-2100). We combined this result with the projected mean annual minimum temperature for each period to obtain the potential risk of cold injury. Results showed that both the land areas with the normal cold-hardiness (-150 and below for dormancy depth) and those with the sub-threshold temperature for freezing damage ($-15^{\circ}C$ and below) will decrease in 2071-2100, reducing the freezing risk. Although more land area will encounter less risk in the future, the land area with higher risk (>70%) will expand from 14% at the current normal year to 23 (A1B) ${\sim}5%$ (A2) in the future. Our method can be applied to other deciduous fruit trees for delineating geographical shift of cold-hardiness zone under the projected climate change in the future, thereby providing valuable information for adaptation strategy in fruit industry.

• KSCE Journal of Civil and Environmental Engineering Research
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• v.32 no.6B
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• pp.387-397
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• 2012

In this study, an ecological fragmentation improvement effect from different riverine ecobelt width was analyzed. The target river for this study is the Hongcheon river in Kangwondo. This section of 11 km among the Hongchenon river was reported to be seriously fragmented in the previous literatures. The Hongcheon river of 11 km was divided longitudinally into subsections of 1 km. The analysis through map and aerial photograph as well as field surveys were performed in 11 subsections(A-K). Using the fragmentation index, the connectivity fragmentation such as river bank, road, and land use and the ecological functional fragmentation were evaluated. The results showed that I-section has the highest fragmentation rate. The Hongcheon river in the present status without ecobelt was analyzed to has the fragmentation of 2nd rate from the mean fragmentation value of 11-subsections. Also, when the riverine ecobelt of 10 m-50 m was restored, the improvement effect of connectivity fragmentation was relatively small, while for the ecological fragmentation, the improvement effect of 12.4-25.1% was predicted. Also, the ecobelts of 10 m and 30 m were evaluated to have a relatively great improvement effect. Especially, for the ecobelt of 30m width, the fragmentation rate was mitigated form 2nd rate to 3rd rate.

• KSCE Journal of Civil and Environmental Engineering Research
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• v.31 no.1B
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• pp.29-36
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• 2011

Evapotranspiration (ET) from the various surfaces needs to be understood because it is a crucial hydrological factor to grasp interaction between the land surface and the atmosphere. A traditional way of estimating it, which is calculating it empirically using lysimeter and pan evaporation observations, has a limitation that the measurements represent only point values. However, these measurements cannot describe ET because it is easily affected by outer circumstances. Thus, remote sensing technology was applied to estimate spatial distribution of ET. In this study, we estimated major components of energy balance method (i.e. net radiation flux, soil heat flux, sensible heat flux, and latent heat flux) and ET as a map using Mapping Evapo-Transpiration with Internalized Calibration (METRIC) satellite-based image processing model. This model was run using Landsat imagery of Gyeongan watershed in Korea on Feb 1, 2003 and Sep 13, 2006. Basic statistical analyses were also conducted. The estimated mean daily ETs had respectively 22% and 11% of errors with pan evaporation data acquired from the Suwon Weather Station. This result represented similar distribution compared with previous studies and confirmed that the METRIC algorithm had high reliability in the watershed. In addition, ET distribution of each land use type was separately examined. As a result, it was identified that vegetation density had dominant impacts on distribution of ET. Seasonally, ET in a growing season represented significantly higher than in a dormant season due to more active transpiration. The ET maps will be useful to analyze how ET behaves along with the circumstantial conditions; land cover classification, vegetation density, elevation, topography.

• Journal of Broadcast Engineering
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• v.26 no.4
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• pp.429-440
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• 2021

With the recent development of deep convolutional neural network learning, deep learning techniques applied to single image super-resolution are showing good results. One of the existing deep learning-based super-resolution techniques is RDN(Residual Dense Network), in which the initial feature information is transmitted to the last layer using residual dense blocks, and subsequent layers are restored using input information of previous layers. However, if all hierarchical features are connected and learned and a large number of residual dense blocks are stacked, despite good performance, a large number of parameters and huge computational load are needed, so it takes a lot of time to learn a network and a slow processing speed, and it is not applicable to a mobile system. In this paper, we use the residual dense structure, which is a continuous memory structure that reuses previous information, and the residual dense channel attention block using the channel attention method that determines the importance according to the feature map of the image. We propose a method that can increase the depth to obtain a large receptive field and maintain a concise model at the same time. As a result of the experiment, the proposed network obtained PSNR as low as 0.205dB on average at 4× magnification compared to RDN, but about 1.8 times faster processing speed, about 10 times less number of parameters and about 1.74 times less computation.

• Journal of Acupuncture Research
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• v.22 no.3
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• pp.169-183
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• 2005

Objective : The purpose of this study was to investigate the anti-caner effect of cobrotoxin on the prostatic cancer cell line (PC-3).The goal of study is to ascertain whether cobrotoxin inhibits tile cell growth and cell cycle of PC-3, or the expression of relative genes and whether the regression of PC-3 cell growth is due to cell death or the expression of gene related to apoptosis. Methods : After the treatment of Pc-3 cells with cobrotoxin, we performed 형광현미경, MTT assay, Western blotting, Flow cytometry, PAGE electrophoresis and Surface plasmon resonance analysis to identify the cell viability, cell death, apoptosis, the changes of cell cycle and the related protein, Adk, MAP kinase. Results : 1. Compared with normal cell, the inhibition of cell growth reduced in proportion with the dose of cobrotoxin(0-16nM) in PC-3. 2. Cell viabilities of 0.1, 1, 4nM cobrotoxin treatment were decreased and those of 8, 16nM were decreased significantly. 3. S phase of cell cycle was decreased at the group of 1, 2, 4, 8, 16nM cobrotoxin, but M phase was increased at 0.1, 1, 2, 4, 8, 16nM cobrotoxin. 4. Cox-2 expression after cobrotoxin was peaked at 12hours and was decreased significantly after 6, 12, 24 hours. 5. The expression of Cdk4 was decreased dose-dependently at 1, 2, 4, 8nM cobrotoxin and was decreased siginificantly at 4, 8nM Cyclin D1 was decreased at 1, 2, 4, 8nM and Cycline E was not changed. Cycline B was decreased at 1, 2, 4, 8nM dose-dependently and was decreased siginificanlty at 2, 4, 8nM. 6. The expression of Akt was decreased at 1, 2, 4, 8nM dose-dependently and was decreased significantly at 2, 4, 8nM. 7. ERK was increased at 1, 2nM and decreased at 4, 8nM, p-ERK was increased at 1, 2, 4 nM, but decreased at 8nM. JNK and p-JNK were increased at 1, 4, 8 nM. p38 was increased at 2nM p-p38 was increased at lnM but decreased significantly at 2, 4, 8nM. 8. The nucli of normal cells were stained round and homogenous in DAPI staining, but those of PC-3 were stained condense and splitted. Apoptosis was increased dose-dependently at 2, 4, 8, 16nM and increased significantly at 2, 4, 8, 16nM. 9. Bax wasn`t changed at 1, 2, 4, 8nM and Bcl-2 was decreased significantly at 1, 2, 4, 8nM. Caspase 3 and 9 weren`t changed at 1, 2, 4nM but were decreased significantly at 8nM. Conclusions : These results indicate that cobrotoxin inhibits the growth of prostate Cancer cells, has anti-cancer effects by inducing apoptosis.

• Asian-Australasian Journal of Animal Sciences
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• v.24 no.12
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• pp.1660-1665
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• 2011

This study presents a linkage disequilibrium (LD) analysis and effective population size ($N_e$) for the entire Hanwoo Korean cattle genome, which is the first LD map and effective population size estimate ever calculated for this breed. A panel of 4,525 markers was used in the final LD analysis. The pairwise $r^2$ statistic of SNPs up to 50 Mb apart across the genome was estimated. A mean value of $r^2$ = 0.23 was observed in pairwise distances of <25 kb and dropped to 0.1 at 40 to 60 kb, which is similar to the average intermarker distance used in this study. The proportion of SNPs in useful LD ($r^2{\geq}0.25$) was 20% for the distance of 10 and 20 kb between SNPs. Analyses of past effective population size estimates based on direct estimates of recombination rates from SNP data demonstrated that a decline in effective population size to $N_e$ = 98.1 occurred up to three generations ago.

• Water for future
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• v.8 no.2
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• pp.30-40
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• 1975

Hydrogeological survey and geophysical prospecting have been carried out in Saudi Arabia for the purpose of finding groundwater in the soil and rock at the request of General trading company in Jeddah, Saudi Arabia. The surveyed area is located on $38^{\circ}-39^{\circ}$ 30' in longitude and $26^{\circ}-26^{\circ}$ 30' in latitude. The topography of this area is dominated by northwest southeast mountain range composed mostly of precambrian rocks and basalt of tertiary period. Geology is mainly composed of greenstone, granite, andesite, diorite rhyolite of pre-cambrian era and sandstone of cambrian period which are underlained by basalt and andesite of tertiary period and alluvium of quaternary unconformably. The instruments used in this investigation are TR-18B2 radioactivity unit which isjapanese patented and A.C. Terrameter, a resistivity meter manufactured by ABEM of Stockholm, Sweden. Radioactivity method has been conducted along the Alula-Khaybar road, totally 164Km by the car-borne. As a result of the above survey 16 places have been selected and these anomalies show 1.2N-1.6N compared to background of each area in intensity with width of 10-50m. Resistivity vertical profiling which made use of Schlumberger configuration method has been made over selected areas by radioactivity method to provide hydrogeological information for a water resources survey. The result of resistivity shows that good aquifers are located in the western part of surveyed area where sedimentary rock is distributed. The strata showing 10-50, ${\Omega}-m$ in resistivity are thought to be waterbearing layer. The variations in aquifer resistivity found, are thought to be due to verying clay content, which could be related to aquifer yield. It has proved impossible to detect small salinity variation in the buried aquifer by geophysics. As a result of resistivity prospecting 10 places are recommended to be drilled at the anomalies as shown attached map. yields from the proposed holes have been estimated approximately from $20m^3$ to $200m^3$ per day. Prior to drilling for groundwater, test boring using ${\c}4"$ should be drilled in order to obtain more reliable hydrogeological information for the construction of perfect wells.ells.