• Proceedings of the Korean Society for Noise and Vibration Engineering Conference
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• 2011.04a
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• pp.618-626
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• 2011

Recent development of related technologies and efficient utilization of the entire country for the purpose of railway construction, and plans are being accelerated. the railway noise has been improved by increasing the high speed railway station, and accelerating the existing trains. Nord2000 which is an overseas noise prediction equation could not be applied directly to the domestic railway vehicles. So the specific vehicles in the Nordic countries which is a similar specification to domestic trains should be selected. Nord2000's accuracy was compared to Schall03, CRN's. Prediction of Ground impedance and Roughness class were carried out at different. In this paper, the result of selected vehicles for Nord2000 was as follows. S-1aX2 was for express trains, N-$^*2c$-3b was for Mugunghwa, S-Pass/wood was for Saemaul, N-4a was for freight trains, N-3a was for subway, the calculation time for Nord2000 took longer than others, in addition, Ground absorption was indispensable to calculate a noise map for Nord2000. As a result, CRN's prediction noise levels at Wonju-si was closest to the measurements. However, the predicted noise levels of Nord2000 was the most accurate.

• Asian Pacific Journal of Cancer Prevention
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• v.15 no.1
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• pp.167-174
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• 2014

Tumor angiogenesis, growth and metastasis are three closely related processes. We therefore investigated the effects of barbigerone on all three in the B16F10 tumor model established in both zebrafish and mouse models, and explored underlying molecular mechanisms. In vitro, barbigerone inhibited B16F10 cell proliferation, survival, migration and invasion and suppressed human umbilical vascular endothelial cell migration, invasion and tube formation in concentration-dependent manners. In the transgenic zebrafish model, treatment with $10{\mu}M$ barbigerone remarkably inhibited angiogenesis and tumor-associated angiogenesis by reducing blood vessel development more than 90%. In vivo, barbigerone significantly suppressed angiogenesis as measured by H and E staining of matrigel plugs and CD31 staining of B16F10 melanoma tumors in C57BL/6 mice. Furthermore, it exhibited highly potent activity at inhibiting tumor growth and metastasis to the lung of B16F10 melanoma cells injected into C57BL/6 mice. Western blotting revealed that barbigerone inhibited phosphorylation of AKT, FAK and MAPK family members, including ERK, JNK, and p38 MAPKs, in B16F10 cells mainly through the MEK3/6/p38 MAPK signaling pathway. These findings suggested for the first time that barbigerone could inhibit tumor-angiogenesis, tumor growth and lung metastasis via downregulation of the MEK3/6/p38 MAPK signaling pathway. The findings support further investigation of barbigerone as a potential anti-cancer drug.

• The KIPS Transactions:PartB
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• v.15B no.1
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• pp.9-16
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• 2008

In this paper, we present an algorithm for synthesizing intermediate view image from a stereoscopic pair of images. An image of multiview is need for people in order to easily recognize 3D image. However, if many cameras are use for that, not only does system get more complicated but also transmission rating cause a big trouble. Hence, stereo images are photograph and issue on the sending side and algorithm to generate several intermediate view image is able to be use on the receiving side. The proposed method is based on disparity space image. First of all, disparity space image that is depicted by the gap of pixel followed by disparity of stereo image is generated. Disparity map is made by utilizing disparity space image for searching for optimal disparity path then eventual intermediate view image is generated after occlusion region which does not match is processed. Experimental results illustrate the performance of the proposed technique and we obtained a high quality image of more than 30 dB PSNR.

• Journal of Powder Materials
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• v.21 no.4
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• pp.277-285
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• 2014

The effects of processing parameters on the flow behavior and microstructures were investigated in hot compression of powder metallurgy (P/M) Ti-6Al-4V alloy. The alloy was fabricated by a blended elemental (B/E) approach and it exhibited lamellar ${\alpha}+{\beta}$ microstructure. The hot compression tests were performed in the range of temperature $800-1000^{\circ}C$ with $50^{\circ}C$ intervals, strain rate $10^{-4}-10s^{-1}$, and strain up to 0.5. At $800-950^{\circ}C$, continuous flow softening after a peak stress was observed with strain rates lower than $0.1s^{-1}$. At strain rates higher than $1s^{-1}$, rapid drop in flow stress with strain hardening or broad oscillations was recorded. The processing map of P/M Ti-6Al-4V was designed based on the compression test and revealed the peak efficiency at $850^{\circ}C$ and $0.001s^{-1}$. As the processing temperature increased, the volume fraction of ${\beta}$ phase was increased. In addition, below $950^{\circ}C$, the globularization of phase at the slower strain rate and kinking microstructures were found. Based on these data, the preferred working condition of the alloy may be in the range of $850-950^{\circ}C$ and strain rate of $0.001-0.01s^{-1}$.

• Korean Journal of Agricultural Science
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• v.43 no.3
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• pp.353-359
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• 2016

Soil organic carbon (SOC) retention has gradually gotten attention due to the need for mitigation of increased atmospheric carbon dioxide and the simultaneous increase in crop productivity. We estimated the statistical maximum value of soil organic carbon (SOC) fixed by clay content using the Korean detailed soil map database. Clay content is a major factor determining SOC of subsoil because it influences the vertical mobility and adsorption capacity of dissolved organic matter. We selected 1,912 soil data of B and C horizons from 13 soil series, Sangju, Jigog, Jungdong, Bonryang, Anryong, Banho, Baegsan, Daegog, Yeongog, Bugog, Weongog, Gopyeong, and Bancheon, mainly distributed in Korean upland. The ranges of SOC and clay content were $0-40g\;kg^{-1}$ and 0 - 60%, respectively. Soils having more than 25% clay content had much lower SOC in subsoil than topsoil, probably due to low vertical mobility of dissolved organic carbon. The statistical analysis of SOC storage potential of upland subsoil, performed using 90%, 95%, and 99% maximum values in cumulative SOC frequency distribution in a range of clay content, revealed that these results could be applicable to soils with 1% - 25% of clay content. The 90% SOC maximum values, closest to the inflection point, at 5%, 10%, 15%, and 25% of clay contents were $7g\;kg^{-1}$, $10g\;kg^{-1}$, $12g\;kg^{-1}$, and $13g\;kg^{-1}$, respectively. We expect that the statistical analysis of SOC maximum values for different clay contents could contribute to quantifying the soil carbon sink capacity of Korean upland soils.

• Journal of Plant Biotechnology
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• v.33 no.3
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• pp.153-160
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• 2006

Brassica rape is an important species used as a vegetable, oil, and fodder worldwide. It is related phylogenically to Arabidopsis thaliana, which has already been fully sequenced as a model plant. The 'Multinational Brassica Genome Project (MBGP)'was launched by the international Brassica community with the aim of sequencing the whole genome of B. rapa in 2003 on account of its value and the fact that it has the smallest genome among the diploid Brassica. The genome study was carried out not only to know the structure of genome but also to understand the function and the evolution of the genes comprehensively. There are two mapping populations, over 1,000 molecular markers and a genetic map, 2 BAC libraries, physical map, a 22 cDHA libraries as suitable genomic materials for examining the genome of B. rapa ssp. pekinensis Chinese cabbage. As the first step for whole genome analysis, 220,000 BAC-end sequences of the KBrH and KBrB BAC library are achieved by cooperation of six countries. The results of BAC-end sequence analysis will provide a clue in understanding the structure of the genome of Brassica rapa by analyzing the gene sequence, annotation and abundant repetitive DHA. The second stage involves sequencing of the genetically mapped seed BACs and identifying the overlapping BACs for complete genome sequencing. Currently, the second stage is comprises of process genetic anchoring using communal populations and maps to identify more than 1,000 seed BACs based on a BAC-to-BAC strategy. For the initial sequencing, 629 seed BACs corresponding to the minimum tiling path onto Arabidopsis genome were selected and fully sequenced. These BACs are now anchoring to the genetic map using the development of SSR markers. This information will be useful for identifying near BAC clones with the seed BAC on a genome map. From the BAC sequences, it is revealed that the Brassica rapa genome has extensive triplication of the DNA segment coupled with variable gene losses and rearrangements within the segments. This article introduces the current status and prospective of Korea Brassica Genome Project and the bioinformatics tools possessed in each national team. In the near future, data of the genome will contribute to improving Brassicas for their economic use as well as in understanding the evolutional process.

• BMB Reports
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• v.33 no.1
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• pp.92-95
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• 2000

The HIV-1 p24(202-221) sequence ETINNEEEWDRVHPV HAGP contains a B-cell epitope with the earliest immune response and the highest antibody titer against anti-mouse sera obtained by immunization with p24 antigens. A novel mouse monoclonal antibody (mAb) was generated against the immunodominant B-cell epitope of the HIV-1 p24 capsid protein, p24(202-221). BALB/c mice were immunized with the four branched multiple antigenic peptide (MAP) containing the HIV-1p24(202-221) sequence, and antibody-secreting hybridoma were produced by fusion of mouse splenocytes with P3X63Ag8.653, mouse myeloma cells. One clone which produced the antigen-specific mAb named KI-24 (Isotype IgG1, light chain: ${\kappa}$) was identified. mAb KI-24 was highly specific for both the p24(202-221) and p24 proteins when analyzed by ELISA and Western blotting. Since p24(202-221) also contains a cytotoxic T-lymphocyte epitope, this specfic peptide epitope and the monoclonal antibody with specific reactivity against the p24 protein and p24(202-221) can be used in peptide vaccine development and p24 antigen detection from HIV patients.

• Journal of the Korean Society of Environmental Restoration Technology
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• v.3 no.4
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• pp.33-42
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• 2000

This study is carried out to investigate plant community structure, actual vegetation map and flora for examining the relationship between naturally introduced vegetation and surrounding vegetation in Hamtae coal-mined spoil lands. According to the analysis of vegetation, surrounding vegetation was divided into five plant community groups : Pinus koraiensis community, Pinus densiflora - Quercus mongolica community, Q. mongolica - Deciduous broadleaved trees community, Betula schmidtii - B. davurica community, Larix leptolepis community. Robinia pseudo-acacia, which had been planted, was dominant species in coal-mined spoil lands. Young trees, which were naturally introduced, such as B. schmidtii, B. davurica etc., partially appeared with the high density($15{\sim}19ea/100m^2$) in coal-mined spoil lands. The flora of this area was listed as 54 taxa; 22 families, 42 genus, 50 species, 3 varieties and 1 forma. Especially Spodiopogon sibiricus, Miscanthus sinensis, Arundinella hirta, Artemisia capillaris, Artemisia iwayomogi and Youngia denticulata appeared with the high frequency. It is estimated that the proper way for harmonious and effective revegetation is to target B. schmidtii - B. davurica communities and to seed B. schmidtii - B. davurica mixing highly frequent herbaceous species.

• Journal of the Korean Chemical Society
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• v.37 no.5
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• pp.473-476
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• 1993

Dipropargyldiphenylmetane, $C_{19}H_{16}, crystallizes in a monoclinic space group $C2/_c$$ with a = 11304(3), b = 20.799(5), c = 6.622(2)${\AA}$, ${\beta} = 112.8(3)^{\circ}$, Z = 4, V = 1435.3${\AA}^3,\;F(000)\;=\;520,\;D_c\;=\;1.14g{\cdot}cm^{-3}$ and ${\mu}\;=\;0.32\;cm^{-1}$. The structure was solved by direct methods and all non-H atoms were identified in the E-map. The final refinement gave R = 0.055 from 1328 unique observed reflections with I $\geq$ -1.0 $\sigma(I).$ The molecule belongs to the point group $C_2$ of Symmetry by possessing the 2-fold axis which coincides witeh the crystallographic symmetry axis in the unit cell. The linear propargyl moiety is nearly $perpendicular(94.2)^{\circ}$ to the molecular plane of the benzene ring. The internal angle of methane carbon atoms in $108.1(1)^{\circ}$, bonding to the benzene and the propargyl moiety with the bond lengths of 1.530(2) and $1.560(2)\AA$, respectively. The shortest contant between the molecules is $3.538(2)\AA$ between C(9) and C(9) (-x, y, -1/2-z).

• IMMUNE NETWORK
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• v.11 no.6
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• pp.420-423
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• 2011

Since CKD-712 has been developed as an anti-inflammatory agent, we examined the effect of CKD-712 during TLR4 signaling. Using HEK293 cells expressing TLR4, CKD-712 was pre-treated 1 hr before LPS stimulation. Activation of NF-${\kappa}B$ was assessed by promoter assay. The activation of ERK, JNK, p38, IRF3 and Akt was measured by western blotting. CKD-712 inhibited the NF-${\kappa}B$ signaling triggered by LPS. The activation of ERK, JNK, p38 or IRF3 was not inhibited by CKD-712. On the contrary the activation of these molecules was augmented slightly. The activation of Akt with stimulation of LPS was also enhanced with CKD-712 pre-treatment at lower concentration, but was inhibited at higher concentration. We suggest that during TLR4 signaling CKD-712 inhibits NF-${\kappa}B$ activation. However, CKD-712 augmented the activation of Akt as well as Map kinases. Therefore, we suggest that CKD-712 might have a role as an immunomodulator.