• Proceedings of the CALSEC Conference
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• 2003.09a
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• pp.54-59
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• 2003

The information sharing is essential to make collaboration by participants in the collaboration environment. The sharing of the information is necessary to reduce time-to-market of new Product. In this paper, V2-model is proposed far supporting the sharing of the information on product development. V2-model supports collaborative product development in design and supply chain. Through viewpoints, V2-model supports 1) two-level structure that consist of private level and public level ,2) level-up process and 3) product development process. The public level information supports to share the product information on collaborative supply chain and design. The viewpoints in V2-model are divided into public viewpoints that point to the public level information and private viewpoints that point to the private level information. Private viewpoints are transformed into public viewpoints. The extended Topic Map has B-Topic, S-Topic and View for representing V2-model in this paper. The level-up process of V2-model is implemented through the merging of S-Topics. V2-model is implemented with washing machine model using extended Topic Maps. In this model, the public viewpoints and private viewpoints are represented and the level-up process, which transforms private viewpoints into public viewpoints, is implemented.

• Proceedings of the KIEE Conference
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• 2000.07c
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• pp.1850-1852
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• 2000

In this paper, new Partial Discharge (PD) detection technique using Pockels cell was proposed and considerable apparent chaotic characteristics were discussed. For this purpose, PD was generated from needle-plane electrode in air and detected by optical measuring system using Pockels cell, based on Mach-Zehnder interferometer, consisting of He-Ne laser, single mode optical fiber, 50/50 beam splitter and photo detector. A qualitative analysis was carried out by drawing Return map for the normalized time series of the detected PD signals. The results are as follows:(a) Fixed points, between 0.7 and 1.0, are appeared clearly in the right upper area of the return map as the increase in the number of obtained data.(b) Considerable periodicity have been remarked even though exact period and length can not be determined.(c) The self-similarity can be also observed inasmuch as the late paths do not follow the previous ones. Accordingly, exact quantitative analysis such as embedding dimension, fractal dimension, and Lyapunov exponents should be carried out for deducing the quantitative properties regarding PD phenomena.

• Journal of Microbiology and Biotechnology
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• v.26 no.6
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• pp.1124-1131
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• 2016

In this study, the global proteome of the IPEC-J2 cell line was evaluated using ultra-high performance liquid chromatography coupled to a quadrupole Q Exactive^™ Orbitrap mass spectrometer. Proteins were isolated from highly confluent IPEC-J2 cells in biological replicates and analyzed by label-free mass spectrometry prior to matching against a porcine genomic dataset. The results identified 1,517 proteins, accounting for 7.35% of all genes in the porcine genome. The highly abundant proteins detected, such as actin, annexin A2, and AHNAK nucleoprotein, are involved in structural integrity, signaling mechanisms, and cellular homeostasis. The high abundance of heat shock proteins indicated their significance in cellular defenses, barrier function, and gut homeostasis. Pathway analysis and annotation using the Kyoto Encyclopedia of Genes and Genomes database resulted in a putative protein network map of the regulation of immunological responses and structural integrity in the cell line. The comprehensive proteome analysis of IPEC-J2 cells provides fundamental insights into overall protein expression and pathway dynamics that might be useful in cell adhesion studies and immunological applications.

• Journal of the Korea Society of Computer and Information
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• v.22 no.8
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• pp.15-23
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• 2017

In this paper, the block reweighting and global offset initialization methods are proposed to complement the improved IRLMS algorithm which is the effective algorithm in registration based SBNUC algorithm. Proposed block weighting method reweights the error map whose abnormal data are excluded. The global offset initialization method compensates the global nonuniformity initially. The ordinary registration based SBNUC algorithm is hard to compensate global nonuniformity because of low scene motion. We employ the proposed methods to improved IRLMS algorithm, and apply it to real-world infrared raw image stream. The result shows that new implementation provides 3.5~4.0dB higher PSNR and convergence speed 1.5 faster then the improved IRLMS algorithm.

• The Pure and Applied Mathematics
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• v.5 no.1
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• pp.1-3
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• 1998

Let f : X longrightarrow Y be quasi-open. We show that: (1) If A $\subset$ X is open, f│A is quasi-open, (2) f : X longrightarrow f(X) is quasi-open. (3) And let $f_{\alpha}/,:X_{\alpha}$, longrightarrow $Y_{\alpha}$ be quasi-open. Then $\Pi f_{\alpha}, : \Pi X_{\alpha}$ longrightarrow $\Pi Y_{\alpha}$/ defined by {$x_{\alpha}$} longrightarrow {$f_{\alpha},({\chi}_{\alpha}$)}, is quasi-open. (4) Lastly, if $f_{i}: X_{i}$ longrightarrow Y are quasi-open, i = 1,2, then F: $X_1 \bigoplus X_2$ longrightarrow Y, defined by $F({\chi})=f_i({\chi})$, ${\chi} \in X_i$, is also quasi-open.

• Molecules and Cells
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• v.42 no.10
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• pp.702-710
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• 2019

Neuroinflammation is an important contributor to the pathogenesis of neurodegenerative disorders including Parkinson's disease (PD). We previously reported that our novel synthetic compound KMS99220 has a good pharmacokinetic profile, enters the brain, exerts neuroprotective effect, and inhibits $NF{\kappa}B$ activation. To further assess the utility of KMS99220 as a potential therapeutic agent for PD, we tested whether KMS99220 exerts an anti-inflammatory effect in vivo and examined the molecular mechanism mediating this phenomenon. In 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-treated mice, oral administration of KMS99220 attenuated microglial activation and decreased the levels of inducible nitric oxide synthase and interleukin 1 beta ($IL-1{\beta}$) in the nigrostriatal system. In lipopolysaccharide (LPS)-challenged BV-2 microglial cells, KMS99220 suppressed the production and expression of $IL-1{\beta}$. In the activated microglia, KMS99220 reduced the phosphorylation of $I{\kappa}B$ kinase, c-Jun N-terminal kinase, and p38 MAP kinase; this effect was mediated by heme oxygenase-1 (HO-1), as both gene silencing and pharmacological inhibition of HO-1 abolished the effect of KMS99220. KMS99220 induced nuclear translocation of the transcription factor Nrf2 and expression of the Nrf2 target genes including HO-1. Together with our earlier findings, our current results show that KMS99220 may be a potential therapeutic agent for neuroinflammation-related neurodegenerative diseases such as PD.

• The Journal of Korean Academy of Sensory Integration
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• v.14 no.1
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• pp.41-49
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• 2016

Objective : The purpose of this study was to investigate how undressing skill training based on Neuro-developmental treatment (NDT) approach effected on the midline orientation and protective reaction of children with cerebral palsy (CP). Methods : Two participants of this study were 3 years 5 months old boy and 4 years 5 months old girl, living in B city. They were medically diagnosed as cerebral palsy. Research design used in this study is AB design for a single subject research. There was no intervention on the baseline A phases, and functional activity based NDT was used undressing skill training during the B phases. Midline orientation was tested by Stepping subtest in MAP. Protective reaction was measured by Protective reaction subtest in QUEST. Results : In comparison with the baseline (A), midline orientation was improved above 2 standard deviations at intervention phase (B). and protective reaction was improved above averages in both hands. Conclusion : The study showed undressing skill training based on NDT approach that were effective for midline orientation of children with CP. Undressing skill training was one of the major functional activities. Thus, large studies are required to ensure the training effects.

• Korean Journal of Food Science and Technology
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• v.40 no.4
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• pp.406-411
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• 2008

This study was conducted to examine the quality enhancement of fermented soybean pastes (cheonggukjang) using microorganisms with high enzyme activities and proper experimental design. The microorganisms for soybean paste fermentation were selected from a specific area of Gyeonggi and were idenlified by 16S rDNA sequence analysis. To prepare the cheonggukjang, an optimum mixing ratio of selected microorganisms was determined using contour plots and numerical optimization methods. A total of 39 microorganisms were isolated from the soybean paste, consisting primarily of Bacillus subtilis and Bacillus licheniformis, and no mold was found. Three microorganisms showing high enzyme activities were selected and used to formulate an optimum mixing ratio for cheonggukjang preparation. Based on levels of amino-nitrogen, ammonium-nitrogen, antioxidant activity values, and sensory preference results, the optimum mixing ratio of 50% of Bacillus sp. SC-1 and 50% SC-3 was suggested for the manufacture of high quality of cheonggukjang.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.14 no.11
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• pp.5834-5840
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• 2013

Along with the development of high-speed, wired and wireless Internet technology, various harmful images in a form of photos and video clips have become prevalent these days. In this paper, we suggest a method of automatically detecting adult images by extracting woman's nipple areas which represent obscenity of the image. The suggested algorithm first segments skin color areas in the $YC_bC_r$ color space from input images and extracts nipple's candidate areas from the segmented skin areas through the suggested nipple map. We then select real nipple areas by using geometrical information and determines input images as harmful images if they contain nipples. Experimental results show that the suggested nipple map-based method effectively detects adult images.

• International Journal of Oral Biology
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• v.37 no.3
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• pp.137-145
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• 2012

Aggregatibacter actinomycetemcomitans is the most important etiologic agent of aggressive periodontitis and can interact with endothelial cells. Monocyte chemoattractant protein-1 (MCP-1) and interleukin-8 (IL-8) are chemokines, playing important roles in periodontal pathogenesis. In our current study, the effects of A. actinomycetemcomitans on the production of MCP-1 and IL-8 by human umbilical vein endothelial cells (HUVEC) were investigated. A. actinomycetemcomitans strongly induced the gene expression and protein release of both MCP-1 and IL-8 in a dose- and time-dependent manner. Dead A. actinomycetemcomitans cells were as effective as live bacteria in this induction. Treatment of HUVEC with cytochalasin D, an inhibitor of endocytosis, did not affect the mRNA up-regulation of MCP-1 and IL-8 by A. actinomycetemcomitans. However, genistein, an inhibitor of protein tyrosine kinases, substantially inhibited the MCP-1 and IL-8 production by A. actinomycetemcomitans, whereas pharmacological inhibition of each of three members of mitogen-activated protein (MAP) kinase family had little effect. Furthermore, gel shift assays showed that A. actinomycetemcomitans induces a biphasic activation (early at 1-2 h and late at 8-16 h) of nuclear factor-${\kappa}B$ (NF-${\kappa}B$) and an early brief activation (0.5-2 h) of activator protein-1 (AP-1). Activation of canonical NF-${\kappa}B$ pathway ($I{\kappa}B$ kinase activation and $I{\kappa}B-{\alpha}$ degradation) was also demonstrated in these experiments. Although lipopolysaccharide from A. actinomycetemcomitans also induced NF-${\kappa}B$ activation, this activation profile over time differed from that of live A. actinomycetemcomitans. These results suggest that the expression of MCP-1 and IL-8 is potently increased by A. actinomycetemcomitans in endothelial cells, and that the viability of A. actinomycetemcomitans and bacterial internalization are not required for this effect, whereas the activation of protein tyrosine kinase(s), NF-${\kappa}B$, and AP-1 appears to play important roles. The secretion of high levels of MCP-1 and IL-8 resulting from interactions of A. actinomycetemcomitans with endothelial cells may thus contribute to the pathogenesis of aggressive periodontitis.