• 한국소성가공학회:학술대회논문집
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• 한국소성가공학회 2005년도 추계학술대회 논문집
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• pp.231-234
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• 2005

The high temperature deformation behavior of AZ 31 Mg alloy was investigated by designing a back propagation neural network that uses a gradient descent-learning algorithm. A neural network modeling is an intelligent technique that can solve non-linear and complex problems by learning from the samples. Therefore, some experimental data have been firstly obtained from continuous compression tests performed on a thermo-mechanical simulator over a range of temperatures $(250-500^{\circ}C)$ with strain rates of $0.0001-100s^{-1}$ and true strains of 0.1 to 0.6. The inputs for neural network model are strain, strain rate, and temperature and the output is flow stress. It was found that the trained model could well predict the flow stress for some experimental data that have not been used in the training. Workability of a material can be evaluated by means of power dissipation map with respect to strain, strain rate and temperature. Power dissipation map was constructed using the flow stress predicted from the neural network model at finer Intervals of strain, strain rates and subsequently processing maps were developed for hot working processes for AZ 31 Mg alloy. The safe domains of hot working of AZ 31 Mg alloy were identified and validated through microstructural investigations.

• The Korean Journal of Physiology and Pharmacology
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• 제22권3호
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• pp.225-234
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• 2018

Adenosine is a naturally occurring breakdown product of adenosine triphosphate and plays an important role in different physiological and pathological conditions. Adenosine also serves as an important trigger in ischemic and remote preconditioning and its release may impart cardioprotection. Exogenous administration of adenosine in the form of adenosine preconditioning may also protect heart from ischemia-reperfusion injury. Endogenous release of adenosine during ischemic/remote preconditioning or exogenous adenosine during pharmacological preconditioning activates adenosine receptors to activate plethora of mechanisms, which either independently or in association with one another may confer cardioprotection during ischemia-reperfusion injury. These mechanisms include activation of $K_{ATP}$ channels, an increase in the levels of antioxidant enzymes, functional interaction with opioid receptors; increase in nitric oxide production; decrease in inflammation; activation of transient receptor potential vanilloid (TRPV) channels; activation of kinases such as protein kinase B (Akt), protein kinase C, tyrosine kinase, mitogen activated protein (MAP) kinases such as ERK 1/2, p38 MAP kinases and MAP kinase kinase (MEK 1) MMP. The present review discusses the role and mechanisms involved in adenosine preconditioning-induced cardioprotection.

• 통합자연과학논문집
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• 제10권2호
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• pp.85-94
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• 2017

Fibroblast growth factor receptor (FGFR) belongs to the family of receptor tyrosine kinase. They play important roles in cell proliferation, differentiation, development, migration, survival, wound healing, haematopoiesis and tumorigenesis. FGFRs are reported to cause several types of cancers in humans which make it an important drug target. In the current study, HQSAR analysis was performed on a series of recently reported 1H-Pyrazolo [3,4-b]pyridine derivatives as FGFR antagonists. The model was developed with Atom (A) and bond (B) connection (C), chirality (Ch), hydrogen (H) and donor/acceptor (DA) parameters and with different set of atom counts to improve the model. A reasonable HQSAR model ($q^2=0.701$, SDEP=0.654, NOC=5, $r^2=0.926$, SEE=0.325, BHL=71) was generated which showed good predictive ability. The contribution map depicted the atom contribution in inhibitory effect. A contribution map for the most active compound (compound 24) indicated that hydrogen and nitrogen atoms in the side chains of ring B as well as hydrogen atoms in the side chain of ring C and the nitrogen atom in the ring D contributed positively to the activity in inhibitory effect whereas, the lowest active compound (compound 04) showed negative contribution to inhibitory effect. Thus results of our study can provide insights in the designing potent and selective FGFR kinase inhibitors.

• Journal of Microbiology and Biotechnology
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• 제13권6호
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• pp.976-983
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• 2003

Seven Escherichia coli cells defective with aerobic growth were isolated by the insertion of ${\lambda}placMu53$, a hybrid bacteriophage of ${\lambda}$ and Mu, which created a transcriptional fusion to lacZY. These insertion mutant cells were tested on an XG ($5-bromo-4-chloro-3-indolyl-{\beta}-D-galactopyranoside$) medium for anaerobic expression of lacZ by fusion to a promoter. The chromosomal DNA from these strains were digested by EcoRI, and the EcoRI fragments that contained the fused gene and lacZ sequence were identified by Southern hybridization, using lacZ containing plasmid as a probe. The EcoRI fragment from each strain was cloned and sequenced. The sequence data were compared with the GenBank database. The mutated gene of three strains, CYT4, CYT5, and OS11, was found to be identical, and it was nrdAB that encoded ribonucleoside diphosphate reductase. The gene nrdAB was at min 50.5 on the Escherichia coli linkage map and 2,348,084 on the physical map, and is involved in hemAe-related reduction-oxidation reaction. OS6 and OS14 mutant strains had insertion at min 8.3 and the mutated gene was hemB. The hemB encodes 5-aminolevulinate dehydratase or porphobilinogen synthase. The OS3 mutant had insertion in cydB at min 16.6. The cydAB encodes cytochrome d oxidase. In the case of OS1, the fusion was made with sucA, the E1 component of ${\alpha}-ketoglutarate$ dehydrogenase.

• 통합자연과학논문집
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• 제12권4호
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• pp.133-141
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• 2019

Mesenchymal stem cells (MSCs) are known to differentiate into multiple lineages, making neurogenic differentiation an important target in the clinical field. In the present study, we induced the neurogenic differentiation of cells using histone deacetylase (HDAC) inhibitors and studied their mechanisms for further differentiation in vitro. We treated cells with the HDAC inhibitors, MS-275 and NaB; and found that the cells had neuron-like features such as distinct bipolar or multipolar morphologies with branched processes. The mRNA expressions encoding for NEFL, MAP2, TUJ1, OLIG2, and SYT was significantly increased following HDAC inhibitors treatment compared to without HDAC inhibitors; high protein levels of MAP2 and Tuj1 were detected by immunofluorescence staining. We examined the mechanisms of differentiation and found that the Wnt signaling pathway and downstream mitogen-activate protein kinase were involved in neurogenic differentiation of MSCs. Importantly, Wnt4, Wnt5a/b, and Wnt11 protein levels were highly increased after treatment with NaB; signals were activated through the regulation of Dvl2 and Dvl3. Interestingly, NaB treatment increased the levels of JNK and upregulated JNK phosphorylation. After MS-275 treatment, Wnt protein levels were decreased and GSK-3β was phosphorylated. In this cell, HDAC inhibitors controlled the non-canonical Wnt expression by activating JNK phosphorylation and the canonical Wnt signaling by targeting GSK-3β.

• 한국정보통신학회논문지
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• 제11권2호
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• pp.385-391
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• 2007

본 논문에서는 V-BLAST (Vertical-Bell-lab Layered Space Time)의 두 디코딩 과정인 ordering과 slicing에 사전 확률 (a priori probability)로 사용하기 위해서 반복 디코딩 (iterative decoding)을 사용한 MAP (Maximum A Posteriori) 디코더의 외부 정보 (extrinsic information)를 이용한 최적의 터보 부호화된 (Turbo Coded) V-BLAST 기법을 적용한 적응 변조 시스템 (adaptive modulation system)을 제시 후 성능을 관찰한다. 또한 적응 변조 시스템에서 간단하게 V-BLAST 시스템과 터보 부호화 (Turbo Coding) 기법이 결합된 기존의 터보 부호화된 V-BLAST 기법을 적용한 경우에 비하여 어느 정도 전송률 (throughput)향상이 있는가를 살펴본다. 실험결과, 적응 변조 시스템에서 최적의 터보 부호화된 V-BLAST 기법을 적용한 경우가 기존의 터보 부호화된 V-BLAST 기법을 적용한 경우에 비하여 전송률 성능이 우수함을 보였다. 특히, 실험 결과는 2.5 Mbps의 전송률에서 1.5 dB의 SNR 이득을 보인다.

• BMB Reports
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• 제46권12호
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• pp.617-622
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• 2013

Rac1 plays a key role in neurite outgrowth via reorganization of the actin cytoskeleton. The molecular mechanisms underlying Rac1-mediated actin dynamics in the cytosol and plasma membrane have been intensively studied, but the nuclear function of Rac1 in neurite outgrowth has not yet been addressed. Using subcellular fractionation and immunocytochemistry, we sought to explore the role of nuclear Rac1 in neurite outgrowth. bFGF, a strong agonist for neurite outgrowth in PC12 cells, stimulated the nuclear accumulation of an active form of Rac1. Rac1-PBR (Q) mutant, in which six basic residues in the polybasic region at the C-terminus were replaced by glutamine, didn't accumulate in the nucleus. In comparison with control cells, cells expressing this mutant form of Rac1 displayed a marked defect in extending neurites that was concomitant with reduced expression of MAP2 and MEK-1. These results suggest that Rac1 translocation to the nucleus functionally correlates with bFGF-induced neurite outgrowth.

• 한국측량학회지
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• 제9권1호
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• pp.83-96
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• 1991

본 연구는 최근 소축척 및 중축척지도 제작과 database 구축등의 활용분야에 효용성이 확대되고 있는 SPOT 위성영상의 3차원 위치결정에 대한 연구로서, 사진필름형태의 SPOT 위성영상에 대해 전처리 수준(level 1AP, 1B)에 따른 기하학적 특성과 정확도에 대해 분석하였다. 본 연구 결과, 전처리 수준에 따른 SPOT위성사진의 기하학적 특성과 각 전처리 수준의 외부표정요소에 대한 최적 다항식 형태 및 유의한 부가매개변수를 결정할 수 있었으며, level 1AP가 level 1B에 비해 기하학적 정밀도와 정화도가 양호하여 정밀한 3차원 위치결정과 지도제작에 적합함을 알 수 있었다.

• 한국산림과학회지
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• 제86권2호
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• pp.241-250
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• 1997

본 연구(硏究)는 수치(數値) 지형(地形) 해석법(解析法)에 의거 조림추천수종(造林推薦樹種)이 적지적소(適地適所)에 배치(配置)되도록 도면화(圖面化)하는 것을 목표(目標)로 현지(現地) 분포수종(分布樹種) 및 조림수종(造林樹種) 특성조사(特性調査)을 실시(實施)하여 알고리즘값을 설정(設定)하였다. 토양(土壤)은 토양조사(土壤調査)에 의거(依據) 토양도(土壤圖)를 작성(作成) 수치화(數値化)하여 사용(使用)하였고 평균표고(平均標高), 경사(傾斜), 방위(方位), 국소지형(局所地形)은 각각의 격자단위별(格子單位) 표고(標高)값을 가지고 계산식(計算式)을 적용(適用)하여 수치도(數値圖)를 작성(作成)하였다. 얻어진 결과(結果)를 요약(要約)하면 다음과 같다. 1. 개인별(個人用) 컴퓨터를 이용(利用)한 지형해석(地形解析) 및 수치도(數値圖) 중첩법(重疊法)에 의거 전북(全北) 무주군(茂朱郡) 일부지역(一部地域)(2,500ha)을 대상(對象)으로 토양(土壤) 및 임상조건(林相條件), 지형요인(地形要因)에 따라 분류(分類)할 수 있는 적지적수선정기법(適地適樹選定技法)을 개발(開發)하였다. 2. 연구(硏究) 대상지역(對象地域)에는 주로 갈색산림토양(褐色山林土壤)이 출현(出現)하고 소나무외 29개 수종(樹種)이 분포(分布)하였으며, 입지환경(立地環境) 및 토양조건(土壤條件)에 따라 수종별(樹種別)로 지위차이(地位差異)가 나타났다. 3. 본 연구(硏究)를 수행(遂行)하기 위하여 작성(作成)한 기본프로그램 (DTM, BAS)의 정확성을 알아보기 위하여 지형수치도(地形數値圖)의 평균표고(平均標高) 방위(方位)값과 현지(現地) 실측(實測)한 값사이의 오차율(誤差率)을 검증(檢證)한 결과(結果) 평균표고(平均標高) 및 방위(方位)값에서 모두 허용오차(許容誤差) 범위내(範圍內)인 5%미만(未滿)으로 나타나 개발(開發)된 프로그램의 유효성(有效性)이 입증(立證)되었다. 4. 적지적수도(適地適樹圖) 작성결과(作成結果) 가장 많은 면적(面積)을 차지하는 군(群)은 제 2군(R, $B_1$토양형(土壤型))으로 전체의 46%를 차지했으며, 산림(山林) 이외지역(以外地域)(L)이 23%, 제 6군($B_2$토양형(土壤型))은 13%로 나타났고, 제 5군은 7%, 제 4군은 5%, 기타 6%의 순으로 나타났다. 5. 조림수종군별(造林樹種群別) 관리방안(管理方案)은 제 1군의 비산림지역(非山林地域)을 제외(除外)하고 토양(土壤) 및 지형조건(地形條件)을 기준(基準)으로 하여 4개(個) 유형(類型)으로 분류(分類) 시행(提示)하였다.

• 한국수학교육학회지시리즈B:순수및응용수학
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• 제9권1호
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• pp.1-7
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• 2002

For A bounded subset G of a metric Space (X,d) and $\chi \in X$, let $f_{G}$ be the real-valued function on X defined by $f_{G}$($\chi$)=sup{$d (\chi, g)\in:G$}, and $F(G,\chi)$={$z \in X:sup_{g \in G}d(g,z)=sup_{g \in G}d(g,\chi)+d(\chi,z)$}. In this paper we discuss some properties of the map $f_G$ and of the set $ F(G, \chi)$ in convex metric spaces. A sufficient condition for an element of a convex metric space X to lie in $ F(G, \chi)$ is also given in this pope.