• Journal of the Korea Institute of Information and Communication Engineering
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• v.13 no.9
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• pp.1837-1844
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• 2009

In this paper, the circuit of 2 variable ternary adder and multiplier circuit using current mode CMOS are implemented. The presented ternary adder circuit and multiplier circuit using current mode CMOS are driven the voltage levels. We show the characteristics of operation for these circuits simulated by HSpice. These circuits are simulated under $0.18{\mu}m$ CMOS standard technology, $5{\mu}A$ unit current in $0.54{\mu}m/0.18{\mu}m$ ratio of NMOS length and width, and $0.54{\mu}m/0.18{\mu}m$ ratio of PMOS length and width, and 2.5V VDD voltage, MOS model Level 47 using HSpice. The simulation results show the satisfying current characteristics. The simulation results of current mode ternary adder circuit and multiplier circuit show the propagation delay time $1.2{\mu}s$, operating speed 300KHz, and consumer power 1.08mW.

• Microbiology and Biotechnology Letters
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• v.26 no.6
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• pp.507-514
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• 1998

The strain K-54, the best producer of fibrinolytic enzyme, was isolated from Korean traditional food Chung Guk Jang and identified as Bacillus subtilis. Fibrinolytic enzyme was purified and characterized, and its molecular weight was determined. The fibrinolytic enzyme activity was increased about 66.9 times via purification with recovery yield of 10.1%. The optimum pH and temperature of this enzyme were 11 and $65^{\circ}C$. The enzyme was stable within a pH range 8-12 and unstable at 9$0^{\circ}C$. The molecular weight was estimated to be 29,000 dalton in the form of monomer with no other subunit. The isoelectric point was calculated 8.67. N-terminal sequence was identified Ala-Gly-Ser-Val-Pro-Try-Gly-Ser. Km value of the enzyme for $\alpha$-casein was calculated to be 0.31 (3.1 mg/$m\ell$). The enzyme activity highly inhibited by PMSF at 1 nM.

• Journal of Environmental Science International
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• v.27 no.10
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• pp.925-931
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• 2018

The characteristics of $PM_{10}$, $PM_{2.5}$ and Ratio($PM_{2.5}/PM_{10}$) of 11 urban air monitoring stations in Gyeongnam were analyzed for the last 3 years('15~'17). The average of the all stations was $PM_{10}\;45{\mu}g/m^3$, $PM_{2.5}\;24{\mu}g/m^3$ and Ratio 0.54, and annual reduction rates were $PM_{10}-2.9%$, $PM_{2.5}-2.7%$ and Ratio -1.2%, respectively. The seasonal characteristics of $PM_{10}$ were spring $54{\mu}g/m^3$ > winter $48{\mu}g/m^3$ > summer/autumn $40{\mu}g/m^3$, $PM_{2.5}$ were spring/winter $26{\mu}g/m^3$ > summer 23 > autumn $22{\mu}g/m^3$ and Ratio were summer 0.56 > winter 0.55 > autumn 0.54 > spring 0.51, respectively. The hourly characteristics of $PM_{10}$ were $11{\mu}g/m^3$ higher than 09:00~12:00 at 03:00~06:00, $PM_{2.5}$ were $6{\mu}g/m^3$ higher than 09:00~12:00 at 17:00~18:00 and Ratio were 0.07 higher than 04:00~06:00 at 19:00. By site, the highest concentration of $PM_{10}$ was YJ site $53{\mu}g/m^3$ and $PM_{2.5}$ was HW site $28{\mu}g/m^3$. And Ratio at HD site showed the largest reduction from '15 0.62 to '17 0.52.

• Kyungpook Mathematical Journal
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• v.54 no.4
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• pp.607-617
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• 2014

Let S = C(r,m), the finite cyclic semigroup with index r and period m. Each subsemigroup of S is cyclic if and only if either r = 1; r = 2; or r = 3 with m odd. For $r{\neq}1$, the maximum value of the minimum number of elements in a (minimal) generating set of a subsemigroup of S is 1 if r = 3 and m is odd; 2 if r = 3 and m is even; (r-1)/2 if r is odd and unequal to 3; and r/2 if r is even. The number of cyclic subsemigroups of S is $r-1+{\tau}(m)$. Formulas are also given for the number of 2-generated subsemigroups of S and the total number of subsemigroups of S. The minimal generating sets of subsemigroups of S are characterized, and the problem of counting them is analyzed.

• Clinical and Experimental Pediatrics
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• v.54 no.6
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• pp.241-245
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• 2011

Tuberous sclerosis complex (TSC) is a genetic multisystem disorder that results from mutations in the TSC1 or TSC2 genes, and is associated with hamartomas in several organs, including subependymal giant cell tumors. The neurological manifestations of TSC are particularly challenging and include infantile spasms, intractable epilepsy, cognitive disabilities, and autism. The TSC1- and TSC2-encoded proteins modulate cell function via the mammalian target of rapamycin (mTOR) signaling cascade, and are key factors in the regulation of cell growth and proliferation. The mTOR pathway provides an intersection for an intricate network of protein cascades that respond to cellular nutrition, energy levels, and growth factor stimulation. In the brain, TSC1 and TSC2 have been implicated in cell body size, dendritic arborization, axonal outgrowth and targeting, neuronal migration, cortical lamination, and spine formation. The mTOR pathway represents a logical candidate for drug targeting, because mTOR regulates multiple cellular functions that may contribute to epileptogenesis, including protein synthesis, cell growth and proliferation, and synaptic plasticity. Antagonism of the mTOR pathway with rapamycin and related compounds may provide new therapeutic options for TSC patients.

• Communications of the Korean Institute of Information Scientists and Engineers
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• v.28 no.9
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• pp.44-54
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• 2010

• East Asian mathematical journal
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• v.12 no.1
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• pp.47-54
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• 1996

• Journal of Veterinary Science
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• v.22 no.4
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• pp.54.1-54.13
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• 2021

Background: Hypoxia causes oxidative stress and affects cardiovascular function and the programming of cardiovascular disease. Melatonin promotes antioxidant enzymes such as superoxide dismutase, glutathione reductase, glutathione peroxidase, and catalase. Objectives: This study aims to investigate the correlation between melatonin and hypoxia induction in cardiomyocytes differentiation. Methods: Mouse embryonic stem cells (mESCs) were induced to myocardial differentiation. To demonstrate the influence of melatonin under hypoxia, mESC was pretreated with melatonin and then cultured in hypoxic condition. The cardiac beating ratio of the mESC-derived cardiomyocytes, mRNA and protein expression levels were investigated. Results: Under hypoxic condition, the mRNA expression of cardiac-lineage markers (Brachyury, Tbx20, and cTn1) and melatonin receptor (Mtnr1a) was reduced. The mRNA expression of cTn1 and the beating ratio of mESCs increased when melatonin was treated simultaneously with hypoxia, compared to when only exposed to hypoxia. Hypoxia-inducible factor (HIF)-1α protein decreased with melatonin treatment under hypoxia, and Mtnr1a mRNA expression increased. When the cells were exposed to hypoxia with melatonin treatment, the protein expressions of phospho-extracellular signal-related kinase (p-ERK) and Bcl-2-associated X proteins (Bax) decreased, however, the levels of phospho-protein kinase B (p-Akt), phosphatidylinositol 3-kinase (PI3K), B-cell lymphoma 2 (Bcl-2) proteins, and antioxidant enzymes including Cu/Zn-SOD, Mn-SOD, and catalase were increased. Competitive melatonin receptor antagonist luzindole blocked the melatonin-induced effects. Conclusions: This study demonstrates that hypoxia inhibits cardiomyocytes differentiation and melatonin partially mitigates the adverse effect of hypoxia in myocardial differentiation by regulating apoptosis and oxidative stress through the p-AKT and PI3K pathway.

• Proceedings of the Korean Magnestics Society Conference
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• 2007.05a
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• pp.54.1-54.1
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• 2007

• Proceedings of the Materials Research Society of Korea Conference
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• 1998.08a
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• pp.54.3-54
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• 1998