• Journal of Life Science
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• v.24 no.11
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• pp.1180-1186
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• 2014

Autophagy, the lysosomal degradation pathway, is an intracellular recycling system that is necessary for the metabolic benefits of exercise and for producing lasting beneficial effects of exercise in various diseases. However, the most recent studies have only examined the effect of a single bout of exercise or resistance exercise on autophagic responses. To determine the differential effects of acute and chronic exercise on the expression of autophagy-related genes in D. melanogaster, white-eyed mutant D. melanogaster were assigned randomly to four groups: control, acute exercise, 2 hr chronic exercise, and 3 hr chronic exercise. The flies were exercised using a mechanized platform known as the Power Tower. Our results revealed that a single bout of exercise resulted in increased mRNA levels of the Atg8a gene (~20%, p<0.05). However, Atg1 and Atg6 mRNA expression were not induced by acute exercise. Transcript levels of Atg6 (~29%, p<0.05) related to the nucleation of autophagosomes were significantly induced by 2 hr of chronic exercise. However, this chronic exercise was not enough to increase Atg1 and Atg8a mRNA expression. On the other hand, 3 hr of exercise for 7 days significantly increased Atg1, Atg6, and Atg8a gene expression-about 57%, 37%, and 71%, respectively (p<0.05). These results suggest that a single bout of exercise is not enough to induce full activation of selected autophagy-related genes in D. melanogaster. Our results demonstrated that chronic regular exercise induced autophagy-related gene expression, suggesting that chronic regular exercise training might be required to activate autophagic responses important for producing beneficial effects of exercise in various diseases.

• Journal of the Korean Society for Aeronautical & Space Sciences
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• v.44 no.9
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• pp.796-805
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• 2016

As a part of the first stage in the helicopter flight simulator development, this study numerically evaluates handling qualities of the dynamics model. The flight dynamics model was generated using public information for AS365 N2, the target aircraft of the simulator. The flight simulator is under development as a pilot training and research tool for firefighting missions. The assessment of the model intends to validate general characteristics and suitability before the model is enhanced with flight test data. The evaluation is based on the ADS-33E-PRF(Aeroautical Design Standard Performance Specification Handling Qualities Requirement) criteria, with consideration of category of the aircraft, missions, and environment. The numerical operations follow required or recommended procedures of flight test for compliance demonstration. Evaluation results are evaluated according to the rating specified in maneuverability ADS-33E-PRF. Results have identified to provide a satisfactory platform for flight dynamic model in the general helicopter simulator generated based on the RotorLibFDM, and can be used as a base for basic training and research.

• Journal of the Korean Electrochemical Society
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• v.16 no.1
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• pp.46-51
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• 2013

In order to monitor in situ electrochemical reaction we prepared the gold microshells on silica microspheres of $2{\mu}m$ in diameter which were able to not only work as electrodes but also surface enhanced Raman scattering (SERS) active substrates. Previously reported gold microshell using polystyrene as core material have a few serious problems, mostly coming from solubility in organic solvent, nonuniform distribution in size and toxicity of the polystyrene. Here we prepared silica core-gold microshell to obtain a strong SERS active platform benefitting from the physicochemical stability, uniformity and non-toxicity of silica. Varying the concentration of 3-aminopropyl triethoxysilane (APTES), the surfaces of silica beads were modified and the optimal condition was determined to be 1% APTES that made the SERS activity of gold microshell strongest. The gold microshells as made were characterized by homemade Micro-Raman system spectrometer, Field-Emission Scanning Electron Microscope.

• Bulletin of the Society of Naval Architects of Korea
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• v.26 no.2
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• pp.32-40
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• 1989

Dynamic ship positioning(DP) system is used to keep the position and heading of a ship, or a floating platform, above a pre-selected site on the seabed by using thrusters. This paper presents a control system based on filtering technique and optimal control theory. The planar motions of a vessel are assumed to consist of low frequency(LF) component and high frequency(HF) one. The former is mainly due to thrusters, current, wind and second order wave forces, while the latter is mainly due to first order oscillatory component of the wave force. Furthermore position measurement signals include the noise. By means of self-tuning filter and Kalman filter techniques, LF motion estimates and HF ones are seperately achieved from the position measurements of the vessel. The estimated LF motions are used as input to the feedback loops. The total thruster power is minimized using the Linear Quadratic Gaussian control theory. The performance of the vessel with the DP system is investigated by computer simulation.

• Toxicological Research
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• v.34 no.3
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• pp.267-279
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• 2018

Neurolathyrism is a neurodegenerative disorder characterized by spastic paraplegia resulting from the excessive consumption of Lathyrus sativus (Grass pea). ${\beta}$-N-Oxalyl-L-${\alpha},{\beta}$-diaminopropionic acid (L-ODAP) is the primary neurotoxic component in this pea. The present study attempted to evaluate the proteome-wide alterations in chick brain 2 hr and 4 hr post L-ODAP treatment. Proteomic analysis of chick brain homogenates revealed several proteins involved in cytoskeletal structure, signaling, cellular metabolism, free radical scavenging, oxidative stress and neurodegenerative disorders were initially up-regulated at 2 hr and later recovered to normal levels by 4 hr. Since L-ODAP mediated neurotoxicity is mainly by excitotoxicity and oxidative stress related dysfunctions, this study further evaluated the role of L-ODAP in apoptosis in vitro using human neuroblastoma cell line, IMR-32. The in vitro studies carried out at $200{\mu}M$ L-ODAP for 4 hr indicate minimal intracellular ROS generation and alteration of mitochondrial membrane potential though not leading to apoptotic cell death. L-ODAP at low concentrations can be explored as a stimulator of various reactive oxygen species (ROS) mediated cell signaling pathways not detrimental to cells. Insights from our study may provide a platform to explore the beneficial side of L-ODAP at lower concentrations. This study is of significance especially in view of the Government of India lifting the ban on cultivation of low toxin Lathyrus varieties and consumption of this lentil.

• Journal of Information Processing Systems
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• v.8 no.2
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• pp.347-358
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• 2012

Recently, security researches have been processed on the method to cover a broader range of hacking attacks at the low level in the perspective of hardware. This system security applies not only to individuals' computer systems but also to cloud environments. "Cloud" concerns operations on the web. Therefore it is exposed to a lot of risks and the security of its spaces where data is stored is vulnerable. Accordingly, in order to reduce threat factors to security, the TCG proposed a highly reliable platform based on a semiconductor-chip, the TPM. However, there have been no technologies up to date that enables a real-time visual monitoring of the security status of a PC that is operated based on the TPM. And the TPB has provided the function in a visual method to monitor system status and resources only for the system behavior of a single host. Therefore, this paper will propose a m-TMS (Mobile Trusted Monitoring System) that monitors the trusted state of a computing environment in which a TPM chip-based TPB is mounted and the current status of its system resources in a mobile device environment resulting from the development of network service technology. The m-TMS is provided to users so that system resources of CPU, RAM, and process, which are the monitoring objects in a computer system, may be monitored. Moreover, converting and detouring single entities like a PC or target addresses, which are attack pattern methods that pose a threat to the computer system security, are combined. The branch instruction trace function is monitored using a BiT Profiling tool through which processes attacked or those suspected of being attacked may be traced, thereby enabling users to actively respond.

• The Journal of the Korea institute of electronic communication sciences
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• v.14 no.1
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• pp.225-234
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• 2019

By using the Triboelectric nanogenerators, known as TENG, we can take advantages of high conversion efficiency and continuous power output even with small vibrating energy sources. Nonlinear energy extraction techniques for Triboelectric vibration energy harvesting usually requires synchronized active electronic switches in most electronic interface circuits. This study presents a nonlinear energy harvesting with high energy conversion efficiency to harvest and save energies from human active motions. Moreover, the proposed design can harvest and store energy from sway motions around different directions on a horizontal plane efficiently. Finally, we conducted a comparative analysis of a multi-mode energy storage board developed by a silicon-based piezoelectricity and a transparent TENG cell. As a result, the experiment showed power generation of about 49.2mW/count from theses multi-fully harvesting source with provision of stable energy storages.

• Journal of Sensor Science and Technology
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• v.20 no.5
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• pp.311-316
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• 2011

Monitoring the carbon dioxide concentration in arterial blood is vital for the evaluation and prevention of pulmonary disease. Yet, domestic pure arterial blood carbon dioxide sensor technologies are not being developed, instead all sensors are imported. In this paper, we develop a real time monitoring system for arterial blood partial pressure of carbon dioxide($pCO_2$) gas from the wrist by using a carbon micro-heater. The micro-heater was fabricated with a thickness of 0.3 ${\mu}m$ in order to collect the carbon dioxide under the skin. The micro-heater has been designed to perform temperature compensation in order to prevent damage to the skin. Two clinical trials of the system were undertaken. As a result, we demonstrated that a portable, transcutaneous carbon dioxide analysis($TcpCO_2$) device produced domestically is possible. In addition, this system reduced the analysis time significantly. Carbon films could reduce the unit price of these sensors by replacing the gold film used in foreign models. Also, we developed a real time monitoring system which can be used with optical biosensors for medical diagnostics as well as gas sensors for environmental monitoring.

• Korean Journal of Applied Biomechanics
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• v.13 no.2
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• pp.161-173
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• 2003

This study was performed to investigate the kinematic and kinetic differences between functional walking shoe(FWS) and general sports shoe(GSS). The subjects for this study were 4 male adults who had the walking pattern of rearfoot strike with normal feet. The movement of one lower leg was measured using force platform and 3 video cameras while the subjects walked at the velocity of 2/1.5 m/s. The findings of this study were as follows 1. The angle of lower leg-ground and angle of knee with FWS was greater than with GSS at the moment of strike the floor and the moment of second peak ground reaction force. The decreasing rate of angle of ankle was smaller in FWS from the strike phase to the second peak ground reaction force. These mean upright walking and round walking along the shoe surface. 2. The maximal Increased angle of Achilles tendon and the minimal decreased angle of rearfoot were smaller in FWS very significantly(p<0.001). Thus FWS prevent the excessive pronation of ankle and have good of rear-foot control. 3. The vortical ground reaction force and the rate of it to the BW were smaller in FWS statistically(p<0.001). The loading rate was smaller in FWS, too, and thess represent the reduction of load on ankle joint and prevention of injuries on it.

• Fire Science and Engineering
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• v.19 no.1 s.57
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• pp.80-86
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• 2005

In this study effects of the natural wind and the forced smoke ejection by operating the exhaust fan are studied numerically to examine the flow characteristics of the smoke and heat generated from a fire on the platform of an underground subway station. Three different situations, including 1) the case with no natural wind and no exhaust fan operation, 2) the case with natural wind but no exhaust fan operation and 3) the case with no natural wind but exhaust fan operation, are considered for the numerical analyses. The numerical results show that the natural wind causes a rapid spread of the fire along the tunnel resulting in rapid spread of the smoke and heat over the platform which affects the escape. The operation of the exhaust fan also results in the rapid spread of smoke and heat over the platform, but the time required for reaching the safe escaping height of the smoke layer with the exhaust fan operation is much longer than that without the exhaust fan operation. The numerical results also show that the required capacity of the exhaust fan becomes larger when the effect of the natural wind is included.