• Proceedings of the Korea Information Processing Society Conference
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• 2008.05a
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• pp.331-334
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• 2008

현재 위피 저작도구는 위피 코드 작성의 편의성이 부족하고, 시각화를 배제한 문법 중심의 프로그래밍 도구가 대부분이다. 이로 인해 규모가 작은 위피 응용프로그램의 경우에도 직접 코딩해서 개발하고 있다. 따라서 위피 상위레벨(High level) 컴포넌트를 GUI 위젯(Widget)으로 시각화하고, 이를 모바일 레이아웃에 쉽게 적용한 후, 위피 코드로 렌더링(Rendering) 해주는 저작도구에 대한 연구가 필요하다. 본 논문에서는 위젯, 기본 위피 코드, 에뮬레이터 관리를 위해 W2PM(Widget and WIPI Platform Management)을 제안하고, 이를 시스템 기능 요구사항에 반영하여 GUI 위젯을 이용한 위피 저작도구를 설계한다. 제안한 도구는 개발자가 Look & Feel을 자유롭게 조정하고, 중.소규모의 위피 응용프로그램을 제작하는데 효율적이다.

• Ocean Systems Engineering
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• v.2 no.2
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• pp.99-113
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• 2012

Steel Catenary Risers (SCR) are the simplest and often the most economic solution compared to other riser types such as flexible pipe, riser towers, top tensioned risers, etc. The top of a SCR is connected to the host platform riser porch. The other end of the SCR connects to flowlines from subsea wells. The riser touchdown point (TDP), which is the location along the riser where contact with the sea floor first occurs, exhibits complex behaviors and often results in compression and fatigue related issues. Heave dynamic responses of semisubmersibles in extreme and operating sea states are crucial for feasibility of SCR application. Recent full field measurement results of a deep draft semisubmersible in Hurricane Gustav displayed the considerable discrepancies in heave responses characteristics between the measured and the simulated results. The adequacy and accuracy of the simulated results from recognized commercial software should be examined. This finding raised the awareness of shortcomings of current commercial software and potential risk in mega investment loss and environmental pollutions due to SCR failures. One main objective of this paper is to attempt to assess the importance and necessity of accounting for viscous effects during design and analysis by employing indicator of viscous parameter. Since viscous effects increase with nearly third power of significant wave height, thus newly increased metocean criteria per API in central Gulf of Mexico (GoM) and even more severe environmental conditions in Western Australia (WA) call for fundamental enhancements of the existing analysis tools to ensure reliable and robust design. Furthermore, another aim of this paper is to address the impacts of metocean criteria and design philosophy on semisubmersible hull sizing in WA and GoM.

• The Korean Journal of Physiology and Pharmacology
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• v.16 no.2
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• pp.79-89
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• 2012

We examine whether Phellodendron amurense (PA) and its major alkaloid compound, berberine (BER), improved memory defects caused by administering scopolamine in rats. Effects of PA and BER on the acetylcholinergic system and pro-inflammatory cytokines in the hippocampus were also investigated. Male rats were administered daily doses for 14 days of PA (100 and 200 mg/kg, i.p.) and BER (20 mg/kg, i.p.) 30 min before scopolamine injection (2 mg/kg, i.p.). Daily administration of PA and BER improved memory impairment as measured by the passive avoidance test and reduced the escape latency for finding the platform in the Morris water maze test. Administration of PA and BER significantly alleviated memory-associated decreases in cholinergic immunoreactivity and restored brain-derived neurotrophic factor and cAMP-response element-binding protein mRNA expression in the hippocampus. PA and BER also decreased significantly the expression of proinflammatory cytokines such as interleukin-$1{\beta}$, tumor necrosis factor-${\alpha}$ and cyclooxygenase-2 mRNA in the hippocampus. These results demonstrated that PA and BER had significant neuroprotective effects against neuronal impairment and memory dysfunction caused by scopolamine in rats. These results suggest that PA and BER may be useful as therapeutic agents for improving cognitive functioning by stimulating cholinergic enzyme activity and alleviating inflammatory responses.

• Biotechnology and Bioprocess Engineering:BBE
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• v.11 no.2
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• pp.173-177
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• 2006

In this study, a novel strategy was developed for the highly selective immobilization of proteins, using the polyhydroxyalkanoate (PHA) depolymerase substrate binding domain (SBD) as an active binding domain. In order to determine the appropriacy of this method for immunodiagnostic assays, the single-chain antibody (ScFv) against the hepatitis B virus (HBV) preS2 surface protein and the severe acute respiratory syndrome coronavirus (SARS-CoV) envelope protein (SCVe) were fused to the SBD, then directly immobilized on PH A-coated slides via microspotting. The fluorescence-labeled HBV antigen and the antibody against SCVe were then utilized to examine specific interactions on the PHA-coated surfaces. Fluorescence signals were detected only at the spotted positions, thereby indicating a high degree of affinity and selectivity for their corresponding antigens/antibodies. Furthermore, we detected small amounts of ScFv-SBD (2.7 ng/mL) and SCVe-SBD fusion proteins (0.6ng/mL). Therefore, this microarray platform technology, using PHA and SBD, appears generally appropriate for immunodiagnosis, with no special requirements with regard to synthetic or chemical modification of the biomolecules or the solid surface.

• Genomics & Informatics
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• v.8 no.3
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• pp.138-141
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• 2010

Together with single nucleotide polymorphism (SNP), copy number variations (CNV) are recognized to be the major component of human genetic diversity and used as a genetic marker in many disease association studies. Affymetrix Genome-wide SNP 5.0 is one of the commonly used SNP array platforms for SNP-GWAS as well as CNV analysis. However, there has been no report that validated the accuracy and reproducibility of CNVs identified by Affymetrix SNP array 5.0. In this study, we compared the characteristics of CNVs from the same set of genomic DNAs detected by three different array platforms; Affymetrix SNP array 5.0, Agilent 2X244K CNV array and NimbleGen 2.1M CNV array. In our analysis, Affymetrix SNP array 5.0 seems to detect CNVs in a reliable manner, which can be applied for association studies. However, for the purpose of defining CNVs in detail, Affymetrix Genome-wide SNP 5.0 might be relatively less ideal than NimbleGen 2.1M CNV array and Agilent 2X244K CNV array, which outperform Affymetrix array for defining the small-sized single copy variants. This result will help researchers to select a suitable array platform for CNV analysis.

• Bulletin of the Society of Naval Architects of Korea
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• v.26 no.2
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• pp.49-63
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• 1989

Wave drift forces which are small in magnitudes compared to the first order wave exciting forces can cause very large motion of a vessel in waves. In this paper a theoretical and experimental analysis is made of the mean and slowly varying wave dirft forces on the semi-submersible platform. Theoretical calculations are performed by using near field method with three dimensional diffraction theory and model tests are carried out in regular and irregular waves with a 1/60 semi model. Test results are compared with theoretical calculations and the mooring spring effects in the test are discussed.

• Proceedings of the Korean Vacuum Society Conference
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• 2013.02a
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• pp.589-589
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• 2013

열전재료는 제백효과(Seebeck effect)에 의해 폐열을 전기에너지로 변환시킬 수 있는 소재로서, 기존의 열전재료가 나노수준으로 크기가 줄어들 경우 양자제한효과에 의한 제백계수의 증가와 표면산란에 의한 열전도도 감소로 인해 벌크재료에 비해 높은 에너지변환효율을 가질 수 있을 것으로 기대되고 있다. 에너지 변환효율은 열전성능계수인 $ZT=S2{\sigma}T/k$로 정의되며 따라서 우수한 열전재료는 높은 제백계수 S와, 높은 전기전도도 ${\sigma}$ 및 낮은 열전도도 k를 갖는 재료여야 한다. 그러나 나노소재는 낮은 측정 신호와 측정소자준비가 어려워 기존 측정시스템으로는 원활한 측정이 어렵다. 특히 열전도도의 경우 나노소재 자체의 열전도 보다 나노소재 주변 구조에 의한 열전도가 큰 경우 정확한 열전도도 평가가 어렵다. 본 연구에서는 나노선의 열전물성을 평가하기 위해 MEMS기반 기술을 이용하여 열전물성 측정플랫폼(MEMS-based thermoelectric measurement platform, MTMP)을 개발하였다. 개발 된 MTMP는 얇은 Si nitride 브릿지들이 허공에 떠 있는 두 개의 아일랜드 형태의 멤브레인 구조를 지지하는 형태로 제작되었으며, 한 쪽 아일랜드구조 위에는 나노히터가 있어 두 아일랜드 구조 사이에 온도구배를 만들 수 있도록 제작되었다. 제작된 멤브레인을 이용하여 전기화학적인 방법으로 합성한 Bi-Te계 나노선의 S, ${\sigma}$ 그리고 k를 측정하였다. 측정결과 화학양론적 미세구조를 갖는 단결정 Bi2Te3 나노선은 300 K의 측정온도에서 $S=-57{\mu}V/K$, ${\sigma}=3.9{\times}10^5S/m$, k=2.0 W/m-K의 측정 값으로 ZT=0.19였다. 본 연구에서 개발한 MTMP는 나노선 뿐만 아니라 나노플레이트의 열전 측정에도 활용할 수 있는 구조로서 나노열전소재 측정에 널리 활용될 수 있다.

• Journal of Microbiology and Biotechnology
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• v.29 no.7
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• pp.1155-1164
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• 2019

Lichens contain diverse bioactive secondary metabolites with various chemical and biological properties, which have been widely studied. However, details of the inhibitory mechanisms of their secondary metabolites against influenza A virus (IAV) have not been documented. Here, we investigated the antiviral effect of lichen extracts, obtained from South Korea, against IAV in MDCK cells. Of the lichens tested, Nipponoparmelia laevior (LC24) exhibited the most potent inhibitory effect against IAV infection. LC24 extract significantly increased cell viability, and reduced apoptosis in IAV-infected cells. The LC24 extract also markedly reduced (~ 3.2 log-fold) IAV mRNA expression after 48 h of infection. To understand the antiviral mechanism of LC24 against IAV, proteomic (UPLC-$HDMS^E$) analysis was performed to compare proteome modulation in IAV-infected (V) vs. mock (M) and LC24+IAV (LCV) vs. V cells. Based on Ingenuity Pathway Analysis (IPA), LC24 inhibited IAV infection by modulating several antiviral-related genes and proteins (HSPA4, HSPA5, HSPA8, ANXA1, ANXA2, $HIF-1{\alpha}$, AKT1, MX1, HNRNPH1, HNRNPDL, PDIA3, and VCP) via different signaling pathways, including $HIF-1{\alpha}$ signaling, unfolded protein response, and interferon signaling. These molecules were identified as the specific biomarkers for controlling IAV in vitro and further confirmation of their potential against IAV in vivo is required. Our findings provide a platform for further studies on the application of lichen extracts against IAV.

• Current Applied Physics
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• v.18 no.11
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• pp.1255-1260
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• 2018

In this work, a green and simple one-pot route was developed for the synthesis of highly fluorescent aminofunctionalized graphene quantum dots (a-GQDs) via hydrothermal process without any further modification or surface passivation. We synthesized the a-GQDs using glucose as the carbon source and ammonium as a functionalizing agent without the use of a strong acid, oxidant, or other toxic chemical reagent. The as-obtained aGQDs have a uniform size of 3-4 nm, high contents of amino groups, and show a bright green emission with high quantum yield of 32.8%. Furthermore, the a-GQDs show effective fluorescence quenching for $Cu^{2+}$ ions which can serve as effective fluorescent probe for the detection of $Cu^{2+}$. The fluorescent probe using the obtained aGQDs exhibits high sensitivity and selectivity toward $Cu^{2+}$ with the limit of detection as low as 5.6 nM. The mechanism of the $Cu^{2+}$ induced fluorescence quenching of a-GQDs can be attributed to the electron transfer by the formation of metal complex between $Cu^{2+}$ and the amino groups on the surface of a-GQDs. These results suggest great potential for the simple and green synthesis of functionalized GQDs and a practical sensing platform for $Cu^{2+}$ detection in environmental and biological applications.

• Asia pacific journal of information systems
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• v.25 no.2
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• pp.337-355
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• 2015

The Internet has become one of the most important channels for people to communicate and for companies to implement their sales promotion activities, such as advertising. Marketing and advertising attempt to influence customers' attitude to persuade them to choose to buy the advertisers' products instead of the competitors'. With the different forms of online marketing, such as search engine marketing, email marketing, and mobile marketing, advertisers can find more effective strategies to attract the attention of more targeted audiences. With the emergence of the social web (web 2.0), a new platform was introduced called social networks. This paper presents the current work in internet marketing activities until web 2.0, and conducts a social network analysis to aid in data extraction. Marketing and advertising companies have understood the power of information for a very long time. The more knowledge these companies have on the demographics, consumer habits, and preferences of particular customer types, the more they can tailor their product offerings, and the more sales they can make. This paper aims to understand the internet marketing concepts as well as present challenges and work directions in internet marketing.