• 제목/요약/키워드: M1 polarization

검색결과 647건 처리시간 0.026초

Modeling Polarized Dust Emission from Aligned Grains by Radiative Torques

  • Lee, Hyeseung;Lazarian, A.;Chepurnov, A.
    • 천문학회보
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    • 제39권1호
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    • pp.58.1-58.1
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    • 2014
  • We model the polarized dust emission from aligned grains by radiative torques in molecular clouds. We consider various models of molecular clouds and calculate the polarization spectrum from aligned grains by both internal and external radiation fields. We show that some polarization spectrum exhibits the bump at wavelengths ${\lambda}$ < $100{\mu}m$, which can be explained due to the polarized emission from a population of small grains aligned by internal radiation fields. Our polarization spectra can explain the anomalous spectra observed by Hildebrand et al, with the rising polarization toward short wavelengths

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Cigarette Smoke Extract-Treated Mouse Airway Epithelial Cells-Derived Exosomal LncRNA MEG3 Promotes M1 Macrophage Polarization and Pyroptosis in Chronic Obstructive Pulmonary Disease by Upregulating TREM-1 via m6A Methylation

  • Lijing Wang;Qiao Yu;Jian Xiao;Qiong Chen;Min Fang;Hongjun Zhao
    • IMMUNE NETWORK
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    • 제24권2호
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    • pp.3.1-3.23
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    • 2024
  • Cigarette smoke extract (CSE)-treated mouse airway epithelial cells (MAECs)-derived exosomes accelerate the progression of chronic obstructive pulmonary disease (COPD) by upregulating triggering receptor expressed on myeloid cells 1 (TREM-1); however, the specific mechanism remains unclear. We aimed to explore the potential mechanisms of CSE-treated MAECs-derived exosomes on M1 macrophage polarization and pyroptosis in COPD. In vitro, exosomes were extracted from CSE-treated MAECs, followed by co-culture with macrophages. In vivo, mice exposed to cigarette smoke (CS) to induce COPD, followed by injection or/and intranasal instillation with oe-TREM-1 lentivirus. Lung function and pathological changes were evaluated. CD68+ cell number and the levels of iNOS, TNF-α, IL-1β (M1 macrophage marker), and pyroptosis-related proteins (NOD-like receptor family pyrin domain containing 3, apoptosis-associated speck-like protein containing a caspase-1 recruitment domain, caspase-1, cleaved-caspase-1, gasdermin D [GSDMD], and GSDMD-N) were examined. The expression of maternally expressed gene 3 (MEG3), spleen focus forming virus proviral integration oncogene (SPI1), methyltransferase 3 (METTL3), and TREM-1 was detected and the binding relationships among them were verified. MEG3 increased N6-methyladenosine methylation of TREM-1 by recruiting SPI1 to activate METTL3. Overexpression of TREM-1 or METTL3 negated the alleviative effects of MEG3 inhibition on M1 polarization and pyroptosis. In mice exposed to CS, EXO-CSE further aggravated lung injury, M1 polarization, and pyroptosis, which were reversed by MEG3 inhibition. TREM-1 overexpression negated the palliative effects of MEG3 inhibition on COPD mouse lung injury. Collectively, CSE-treated MAECs-derived exosomal long non-coding RNA MEG3 may expedite M1 macrophage polarization and pyroptosis in COPD via the SPI1/METTL3/TREM-1 axis.

복합산화물 $(Ba Ca)TiO_3$-ZnO의 구조적 및 유전분극 특성 (The structural and dielectric polarization characteristics of composite oxide material in $(Ba Ca)TiO_3$-Zn)

  • 홍경진;임장섭;정우성;민용기;김용주;김태성
    • E2M - 전기 전자와 첨단 소재
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    • 제10권3호
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    • pp.239-246
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    • 1997
  • The ZnO is stabilize dielectric constant over a broad temperature range because its addition makes the relaxation time short. In this study, the composite oxide material (B $a_{0.85}$ $Ca_{0.15}$)Ti $O_{3}$ was mixed by ZnO additive material and the dielectric polarization characteristics was studied. The relative density was over 90[%] at all specimen in the structural characteristics. Among of the specimen, the relative density of (B $a_{0.85}$ $Ca_{0.15}$)Ti $O_{3}$ with ZnO (0.4mol) has a 95[%]. The grain size of composite oxide material with an increasing ZnO increased and it was 1.0[.mu.m]-1.22[.mu.m]. In the electrical characteristics, the charge and discharge current was increased by ZnO addition. The dielectric relaxation time was increased by space charge polarization at above 110[.deg. C] and the dielectric relaxation time was fixed by space charge polarization of para-dielectric layer at below 110[.deg. C]. The dielectric relaxation time was maximum when the grain size was small. The dielectric relaxation time is decreased with an additive material ZnO and interface polarization, existing void at the grain and grain boundary. The remnant polarization is increased and the coercive electric field is decreased by ZnO.

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Molecular imaging of polarized macrophages in tumors

  • Ran Ji Yoo;Yun-Sang Lee
    • 대한방사성의약품학회지
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    • 제7권1호
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    • pp.41-49
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    • 2021
  • Diversity and flexibility are two typical hallmarks of macrophages. Two types of macrophages, M1(classically activated macrophages) and M2(alternatively activated macrophages) exist at both ends of the commonly known macrophage polarization. M1 macrophages have inflammatory properties and are primarily responsible for defending against invading bacteria in our body. On the other hand, M2 macrophages are involved in anti-inflammatory responses and tissue remodeling. Polarized migration of macrophages is of increasing interest in regulating the initiation, generation, and resting phases of inflammatory diseases. In this review, it intend to discuss the properties and functions of tumor-associated macrophages based on polarized macrophages that affect inflammatory diseases. In addition, the purpose of this study is to investigate a molecular imaging approach that targets macrophages that affect tumor growth by controlling the polarization of macrophages that affect tumor diagnosis and treatment.

Dichromated Gelatin 홀로그램의 편광 특성과 편광분리 소자 응용 (Polarization property of dichromated gelatin hologram and it's application to holographic polarization separation element)

  • 이영락;임용석;곽종훈;최옥식;박진원;이윤우
    • 한국광학회지
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    • 제8권4호
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    • pp.260-266
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    • 1997
  • DCG(dichromated gelatin : 7.mu.m 두께) 필름을 이용하여 홀로그래픽 편광분리(Holographic Polarization Separation : HPS)소자를 설계 제작하였다. 제작한 HPS소자의 편광특성을 노출시간, 입사각, 편광각 등의 몇가지 물리적 변수들을 이용하여 조사하였다. 실험결과가 Kogelnik의 결합 파동이론에 기초한 이론적 결과와 잘 일치함을 알 수 있었다. 제작한 HPS소자는 633 nm 파장에서 편광 회절 강도비가 500:1(S편광:P편광)이상이였다. 또한 HPS소자의 광 스위치 및 자유공간 광 연결소자로서의 응용 가능성을 제시하였다.

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보일러용 STS 444재 용접부의 수소취성에 미치는습기의 영향 (Effect of Humidity on the Hydrogen Embrittlement of STS 444 Weld Zone for Boiler)

  • 임우조;최병일;윤병두
    • 수산해양교육연구
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    • 제18권1호
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    • pp.58-64
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    • 2006
  • In order to examine the effect of humidity on hydrogen embrittlement of STS 444 weld zone for boiler with dry and wet welding conditions, this paper was carried out the accelerated hydrogen osmosis test and the electrochemical Tafel polarization test. In 0.5M $H_2SO_4$ + 0.01M $As_20_3$ solution, this test is added to load of $1400kg/cm^2$ together with hydrogen osmosis by current of $50 {mA/cm^2}$ for 60 min.. The electrochemical Tafel polarization test was carried out in 0.5M $H_2SO_4$ + 0.01M $As_20_3$ solution. Therefore, the effect of humidity on hydrogen embrittlement of STS 444 was considered. The main results are as following: On the basis of hydrogen embrittlement mechanism, that is, integrated electrochemical polarization characteristics with the established mechanism of hydrogen embrittlement, the reduction rate of corrosion current density of weld zone in the wet weld condition is larger than in the dry condition. We can nondestructively predict the degree of hydrogen embrittlement of STS 444 weld zone for boiler through the reduction rate of electrochemical corrosion current density.

Self-starting vector phase conjugate laser oscillator in inverted Nd:YAG

  • Kim, D.H.;Udaiyan, D.;Green, R.P.M.;Crofts, G.J.;Damzen, M.J.
    • Journal of the Optical Society of Korea
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    • 제1권1호
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    • pp.41-43
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    • 1997
  • We report the operation of a self-adaptive vector phase conjugate laser (VPCL) oscillator which compensates intracavity polarization distortion and wavefront aberration simultaneously. The VPCL in Nd:YAG gain media produce an output with energy of 125mJ in a 20ns single-longitudinal-mode pulse at 10Hz, which is unaffected by intracavity polarization distortion.

Fe-Cr합금의 공식저항성 평가를 위하여 다양한 규격(KS D 0238, ASTM G 61, ISO 17475)에 따라 실시한 동전위 분극 시험과 임계공식온도 측정시험 (Evaluation on Resistance to Pitting Corrosion of Fe-Cr Alloys via Measurement of the Critical Pitting Temperature (CPT) and Potentiodynamic Polarization According to KS D 0238 (wet, dry), ASTM G 61 and ISO 17475 Standards)

  • 강수연;이재봉;김영호
    • 대한금속재료학회지
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    • 제47권10호
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    • pp.635-643
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    • 2009
  • The resistance to pitting corrosion of Fe-Cr alloys was evaluated by performing potentiodynamic polarization and critical pitting temperature (CPT) tests. For the potentiodynamic polarization tests, various standards were applied, i.e., KS D 0238 (wet, dry), ASTM G 61, and ISO 17475, showing different potentiodynamic polarization results including pitting potentials. ASTM G 61 and ISO 17475 standards presented relatively higher pitting potential while KS D 0238 (dry) indicated lower values than the others. Effects of surface roughness, scan rates, and exposure time to air before tests were also investigated. CPT tests were performed under two different applied potentials, 300 m$V_{SCE}$ and 200 m$V_{SCE}$ in deaerated 1 M NaCl aqueous solution. CPT values and the polarization test results showed a linear relationship.

Design of a Polarization Splitter Based on a Dual-core Hexagonal-shaped Photonic Crystal Fiber

  • Jegadeesan, Subramani;Dhamodaran, Muneeswaran;Azees, Maria;Murugan, Arunachalam
    • Current Optics and Photonics
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    • 제3권4호
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    • pp.304-310
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    • 2019
  • In this paper, a microstructured, hexagonal-shaped dual-core photonic crystal fiber (PCF) is proposed. The proposed structure has specific optical properties to obtain high birefringence and short coupling length, for different values of structural parameters varied over a wide range of wavelength. The properties are analyzed using a solid core of silica material. The proposed structure is implemented as a polarization splitter with splitting length of 1.9 mm and a splitting ratio of -34.988 dB, at a wavelength of 1550 nm. The obtained bandwidth in one band gap of about 81 nm. The numerical analysis ensures that the performance of the proposed polarization splitter is better than that of existing ones.

Lornoxicam & Tenoxicam Drugs as Green Corrosion Inhibitors for Carbon Steel in 1 M H2SO4 Solution

  • Fouda, A.S.;El-Defrawy, A.M.;El-Sherbeni, M.W.
    • Journal of Electrochemical Science and Technology
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    • 제4권2호
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    • pp.47-56
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    • 2013
  • Inhibition performance of Lornoxicam & Tenoxicam against corrosion of carbon steel in 1M $H_2SO_4$ solutions was investigated by weight loss, potentiodynamic polarization and electrochemical impedance spectroscopy (EIS) measurements. The inhibition efficiency increased with increasing inhibitor's concentration, but decreased with increase in temperature. Potentiodynamic polarization curves showed that, the inhibitors were of mixed type. The apparent activation energy ($E^*_a$) and other thermodynamic parameters for the corrosion process have also been calculated and discussed. The inhibition of carbon steel corrosion is due to the adsorption of the inhibitor molecules on the surface, which follows Temkin adsorption isotherm. The mechanism of inhibition was discussed in the light of the chemical structure of the undertaken inhibitors.