• Journal of Acupuncture Research
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• v.24 no.4
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• pp.167-181
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• 2007

Objectives: To evaluate expression of MIF mRNA, MIF, $TNF-{\alpha}$, $IL-6R-{\alpha}$, STAT-3, $NF-{\kappa}B$ p65, COX-2 and iNOS, MMP-9mRNA after injecting deer antler herbal acupuncture solution in a LPS rat model. Methods: The experiment was divided in category of the control group, RA group, and NA group. RA was induced in the mice via injecting 300ug/kg LPS. The deer antler herbal acupuncture solution 50ug/kg was applied on $ST_{35}$(犢鼻) and EX-LE201(內膝眼) for 19days from $3^{rd}$ day of RA inducement. Results: 1. In the deer antler herbal acupuncture solution treated RAW 264.7cell, the mRNA expression of cytokines, RA related inflammation factors, such as the MIF, COX- 2, iNOS, and MMP-g reduced concentration dependently. 2. In the deer antler herbal acupuncture treated mice's synovial membrane, decrease in the cell replication of synovial joint cells, regeneration of blood vessel, fibrosis and fibroblastic cells expansion were observed. 3. Positive reaction of RA-related cytokines MIF, $TNF-{\alpha}$, $IL-6R-{\alpha}$, STAT3, COX-2, iNOS, $NF-\;{\kappa}B$ p65, MMP-9 was reduced. Conclusion : On the basis of the results, it was concluded that deer antler herbal acupuncture extract has significant protecting ability against acute progressive RA by inhibiting the production of MIF, as a top in cytokines related to inflammation.

• Asian Pacific Journal of Cancer Prevention
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• v.17 no.4
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• pp.2185-2193
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• 2016

Background: The pathogenesis of sporadic colorectal cancer (CRC) is influenced by the patient genetic background and environmental factors. Based on prior understanding, these are classified in two major pathways of genetic instability. Microsatellite instability (MSI) and CPG island methylator phenotype (CIMP) are categorized as features of the hypermethylated prototype, and chromosomal instability (CIN) is known to be indicative of the non-hypermethylated category. Secreted frizzled related protein 2 (SFRP2), APC1A in WNT signaling pathway and the DNA repair gene, O6-methylguanine-DNA methyltransferase (MGMT), are frequently hypermethylated in colorectal cancer. Detection of methylated DNA as a biomarker by easy and inexpensive methods might improve the quality of life of patients with CRC via early detection of cancer or a precancerous condition. Aim: To evaluate the rate of SFRP2 and MGMT hypermethylation in both polyp tissue and serum of patients in south Iran as compared with matched control normal population corresponding samples. Materials and Methods: Methylation-specific PCR was used to detect hypermethylation in DNA extracted from 48 polypoid tissue samples and 25 healthy individuals. Results: Of total polyp samples, 89.5% had at least one promoter gene hypermethylation. The most frequent methylated locus was SFRP2 followed by MGMT-B (81.2 and 66.6 percent respectively). Serologic detection of hypermethylation was 95% sensitive as compared with polyp tissue. No hypermethylation was detected in normal tissue and serum and its detection in patients with polyps, especially of serrated type, was specific. Conclusions: Serologic investigation for detection of MGMT-B, SFRP2 hypermethylation could facilitate prioritization of high risk patients for colonoscopic polyp detection and excision.

• Korean Journal of Remote Sensing
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• v.40 no.2
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• pp.203-217
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• 2024

The Land Use, Land-Use Change and Forestry (LULUCF) sector of the National Greenhouse Gas Inventory is crucial for obtaining data on carbon sinks, necessitating accurate estimations. This study analyzes cases of countries applying the LULUCF sector at the Tier 3 level to propose enhanced methodologies for carbon sink estimation. In nations like Japan and Western Europe, satellite spatial information such as SPOT, Landsat, and Light Detection and Ranging (LiDAR)is used alongside national statistical data to estimate LULUCF. However, in Korea, the lack of land use change data and the absence of integrated management by category, measurement is predominantly conducted at the Tier 1 level, except for certain forest areas. In this study, Space-borne LiDAR Global Ecosystem Dynamics Investigation (GEDI) was used to calculate forest canopy heights based on Relative Height 100 (RH100) in the cities of Icheon, Gwangju, and Yeoju in Gyeonggi Province, Korea. These canopy heights were compared with the 1:5,000 scale forest maps used for the National Inventory Report in Korea. The GEDI data showed a maximum canopy height of 29.44 meters (m) in Gwangju, contrasting with the forest type maps that reported heights up to 34 m in Gwangju and parts of Icheon, and a minimum of 2 m in Icheon. Additionally, this study utilized Ordinary Least Squares(OLS)regression analysis to compare GEDI RH100 data with forest stand heights at the eup-myeon-dong level using ArcGIS, revealing Standard Deviations (SDs)ranging from -1.4 to 2.5, indicating significant regional variability. Areas where forest stand heights were higher than GEDI measurements showed greater variability, whereas locations with lower tree heights from forest type maps demonstrated lower SDs. The discrepancies between GEDI and actual measurements suggest the potential for improving height estimations through the application of high-resolution remote sensing techniques. To enhance future assessments of forest biomass and carbon storage at the Tier 3 level, high-resolution, reliable data are essential. These findings underscore the urgent need for integrating high-resolution, spatially explicit LiDAR data to enhance the accuracy of carbon sink calculations in Korea.

• Korean Journal of Environment and Ecology
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• v.34 no.1
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• pp.18-26
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• 2020

Echinosophora koreensis (Nakai) Nakai an endemic plant with limited distribution in some parts of the Korean Peninsula, is designated as "Endangered" species on the IUCN Red List. The species is under the threat of deterioration in nature due to various environmental changes causing loss of natural habitats. We investigated the distribution pattern and population structure of E. koreensis to serve as a basic reference for identifying the dynamics and persistence of natural populations of this species in the future. To determine the characteristics of the E. koreensis population, we laid two to three large plots sized 20m×30m on the ridgeline as the reference in Yanggu, Chuncheon, and Hongcheon and laid four to seven small quadrats sized 1m×1m on the transect. A total of 530 plots were laid, 10 each at 2m interval, to measure the number of the stems, the number of fruiting, height, and other factors. The collected distribution information was compared with the existing IUCN assessed categories by applying IUCN Red List ver 3.1 Criteria B. The average population density of the three surveyed areas was 3.47 stem/㎡; the density of each area was 3.95 stems/㎡ in Yanggu, 3.37 stems/㎡ in Chuncheon, and 2.87 stems/㎡ in Hongcheon. The number of fruiting per stem was 0.0038, indicating only 7 fruits out of 1,837 stems and that vegetative reproduction is likely to be more dominant than sexual reproduction. The distribution tendency of population density in the small plots in three surveyed areas showed that the density of E. koreensis tended to decrease toward the center of the forest with low crown openness and around the mountain ridge with high crown openness. It indicated that the quantity of light could be a very important factor for the growth of individuals of this species. The analysis of the heights of individuals present in the surveyed plots showed a range of 2.3 ~ 68.5cm and an average of 20.1cm. An analysis on the stage-structure of the E. koreensis population based on the sieve height found that the appearance frequency decreased with increasing height above 15 ~ 20cm and that the percentage of individuals lower than 10cm, which were presumed to be seedlings, was severely low, indicating a necessity of study on the population sustainability based on the monitored data. The occupied area calculated with the collected species distribution information was 200㎢, indicating the EN category according to the IUCN Red List Reference B.

• Asian-Australasian Journal of Animal Sciences
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• v.20 no.1
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• pp.12-18
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• 2007

The objective of the study was to compare ranking of Sahiwal bulls selected on the basis of highest lactation milk yield of their dams with their estimated breeding values (EBVs) using an animal model. Data on 23,761 lactation milk yield records of 5,936 cows from five main Livestock Experiment Stations in Punjab province of Pakistan (1964-2004) were used for the study. At present the young A.I bulls are required to be from A-category bull-dams. Dams were categorized as A, B, C and D if they had highest lactation milk yield of ${\geq}$2,700, 2,250-2,699, 1,800-2,249 and <1,800 litres, respectively. The EBVs for lactation milk yield were estimated for all the animals using an individual animal model having fixed effect of herd-year and season of calving and random effect of animal. Fixed effect of parity and random effect of permanent environment were incorporated when multiple lactation were used. There were 396 young bulls used for semen collection and A.I during 1973-2004. However, progeny with lactation yields recorded, were available only for 91 bulls and dams could be traced for only 63 bulls. Overall lactation milk yield averaged 1,440.8 kg. Milk yield was 10% heritable with repeatability of 39%. Ranking bulls on highest lactation milk yield of their dams, the in-vogue criteria of selecting bulls, had a rank correlation of 0.167 (p<0.190) with ranking based on EBVs from animal model analysis. Bulls' EBVs for all lactations had rank correlation of 0.716 (p<0.001) with EBVs based on first lactation milk yield and 0.766 (p<0.001) with average EBVs of dam and sire (pedigree index). Ranking of bulls on highest lactation yield of their dams has no association with their ranking based on animal model evaluation. Young Sahiwal bulls should be selected on the basis of pedigree index instead of highest lactation yield of dams. This can help improve the genetic potential of the breed accruing to conservation and development efforts.

• Journal of muscle and joint health
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• v.23 no.2
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• pp.95-104
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• 2016

Purpose: The purpose of this study was to examine body composition and dietary self-efficacy in nursing students. Methods: The study was a descriptive, correlational study with a convenience sample of 197 female nursing students. This study was conducted from April 1st to May 31th in 2015. SPSS 21.0 program was used for data analysis. Results: The average of body protein was $7.90{\pm}1.17kg$ and normal range was 33%. A BMI's average was $21.02{\pm}2.94kg/m^2$ and 62.9 fell into standard range. The average of dietary self-efficacy of subjects was $3.42{\pm}0.53$. The subjects performed intense physical activities during three or more days had higher body protein (F=5.89, p=.003), body minerals (F=6.15, p=.003) and body-efficacy (F=4.13, p=.017) but remarkably lower body fat (F=4.04, p=.019). There is no noticeable correlation of body composition with dietary self-efficacy. However, it is obvious that each category of body composition had a significant positive correlation. Conclusion: This study demonstrated that students who were inclined to overeat had higher body protein, body minerals, body fat, and BMI. Students performed intense physical activities had high body protein, body minerals, and dietary self-efficacy, whereas they had low body fat. Each entry between the body composition had a significant positive correlation.

• Journal of computational fluids engineering
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• v.19 no.4
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• pp.80-85
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• 2014

High-volume low-speed (HVLS) fans are one category of ceiling fan installed in large enclosings such as warehouses, large barns and health clubs in order to generate comfortable air circulation. As a rotary blade, aerodynamic performance of a HVLS fan is predominantly related to its airfoil(s), and the pitch and twist angles. This paper first, investigates the effects of airfoil on the performances of three different HVLS fans with NACA 5414, 6413 and 7415 airfoils. The fans have six untwisted blades with the diameter of 6 m and rotate at 60 RPM. The blades pitch angels are $12^{\circ}$, $12^{\circ}$ and $13^{\circ}$, respectively. The results are presented in the form of the aerodynamic forces and moments, volumetric flow rate and streamlines. Regarding the volumetric flow of air, the results show that the model with NACA 7415 has the best performance. Hence, two other HVLS fans with the same airfoil but, with four and five blades are studied in order to investigate the effects of number of blades. From the point of view of air circulation still the six-bladed fan is the best one; however, the five-bladed fan is more efficient in power consumption.

• The Mathematical Education
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• v.39 no.2
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• pp.151-166
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• 2000

The purpose of this study is to understand what two models of SOLO taxonomy and van Hiele theory suggest and find out what relation there is between the category system of the SOLO taxonomy and the thinking level of the van Hiele theory. The van Hiele theory describes in line of ranking level so that it may increase the teaching effects by putting together a class, which takes into consideration the students thoughts. The SOLO taxonomy focused on the response mode of the students rather than the thinking level or the developmental stage of them to pursuit the method that can describe the students understanding in depth quality-wise. Although the SOLO taxonomy and the van Hiele model seem to have different form and character from outside in terms of their goals, a closer examination reveals that the two stances have much in common and that the models are complementary. Although the van Hiele placed more focus on the thoughts, because the conclusion was based on the students responses, the van Hiele theory can be interpreted within the structure identified in the SOLO model. In this study, we have tried to understand how the response structure form the SOLO taxonomy and the thinking level of the van Hiele theory are related, based on the studies of Pegg and Davery1998). If you briefly look at them, there are following corresponding relation between the SOLO taxonomy and the van Hiele theory. a) The relational level(R) in iconic moe is van Hiele level 1. b) The multisturctural level(M$_2$) in the second cycle of concrete-symbolic mode is van Hiel level 2. c) The relation level(R$_2$) in the second cycle of concrete-symbolic mode is van Hiele level 3. d) The unistructural level(U$_2$) in the second cycle of formal mode is van Hiele level 4. e) The postformal mode is van Hiele levle 5. Though it would be difficult to conclude that these correspondences were perfectly done, if you look at their relation, you can see that the learning process of the students were not carried out uniformly. Therefore, by studying the students response structure, using the SOLO taxonomy, and identifying the learning cycle and understand the geometrical concept more in depth.

• The Journal of Internal Korean Medicine
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• v.41 no.5
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• pp.811-820
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• 2020

Objective: The aim of this study was to report the effectiveness of traditional Korean medicine treatment of a gait disturbance in a patient with idiopathic normal pressure hydrocephalus induced by secondary Parkinsonism. Methods: The patient was treated with Korean herbal medicine (Yukmijihwang-tang-gami), acupuncture, moxibustion, and rehabilitation exercise. The gait of the patient was evaluated by the 10 m Walk Test, Timed Up and Go (TUG) test, 360° turning test, Functional Ambulatory Category (FAC), and GAITRite. Results: After 20 days of traditional Korean medicine treatment, we observed improvement in the symptoms of the gait disturbance. Conclusion: Traditional Korean medicine treatment might be effective in the treatment of gait disturbance in patients with idiopathic normal pressure hydrocephalus induced by secondary Parkinsonism.

• Environmental Mutagens and Carcinogens
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• v.22 no.4
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• pp.259-265
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• 2002

Phthalate analogues are a plasticizer and solvent used in industry. Phthalates were reported to be a potential carcinogen classified in the category of suspected endocrine disruptors. Most common human exposure to these compounds may occur with contaminated food. They may migrate into food from plastic wrap or may enter food from general environmental contamination. Since these substances are not limited to the original products, and enter the environment, they have become widespread environmental pollutants, thus leading to a variety of phthalates that possibly threaten the public health. Concern about their use has been mounting. To screen and elucidate the endocrine disrupting activity and their mechanism of phthalate analogues, first of all, E-screen assay was performed in MCF7 human breast cancer cells with seven phthalate analogues. In this cell proliferation assay, only dibutyl phthalate (DBP) showed weak estrogenic activity. Also the yeast-based transcription assay to assess the interactions of DBP with the estrogen, androgen, and progesterone receptors was conducted. DBP in the concentration ranges from 10$^{-16}$ to 10$^{-11}$ M was active in the estrogen transcriptional assay, but it did not show the effect on $\beta$-galactosidase activity in the progesterone and androgen transcriptional assays. These data indicate that DBP shows estrogenic potential and can be classified as weak and/or suspected endocrine disrupting chemicals.