• The Transactions of the Korean Institute of Electrical Engineers D
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• v.49 no.8
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• pp.423-431
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• 2000

This paper presents a systematic approach to the input-output data-based fuzzy modeling for the complex and uncertain nonlinear systems, in which the conventional mathematical models may fail to give the satisfying results. To do this, we propose a new method that can yield a successful fuzzy model using a mGA hybrid schemes with a fine-tuning method. We also propose a new coding method fo chromosome for applying the mGA to the structure and parameter identifications of fuzzy model simultaneously. During mGA search, multi-purpose fitness function with a penalty process is proposed and adapted to guarantee the accurate and valid fuzzy modes. This coding scheme can effectively represent the zero-order Takagi-Sugeno fuzzy model. The proposed mGA hybrid schemes can coarsely optimize the structure and the parameters of the fuzzy inference system, and then fine tune the identified fuzzy model by using the gradient descent method. In order to demonstrate the superiority and efficiency of the proposed scheme, we finally show its applications to two nonlinear systems.

• Tunnel and Underground Space
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• v.11 no.3
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• pp.270-278
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• 2001

Two numerical methods such as DEM and FDM were adopted to analysis of rock slope stability, of which dimensions are about 150 m(length), 58 m(height), 70°dip, in Halla limestone mine. For this rock slope stability analysis, strength reduction method was used to calculate the safety factor of slope through numerical method. To keep the rock slope safely, it is proposed to reduce the height of the rock slope from 58 m to 45 m and to reduce the angle of the slope from 70°to 55°, too.

• Proceedings of the KSEG Conference
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• 2002.04a
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• pp.61-73
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• 2002

Daegok dam is Concrete Face Rockfill Dam(C.F.R.D) of which 52m height, 190m length, that construction in beneath 306, Chanjeon-Ri, Dudong-Myeon, Ulju-Gun, Ulsan Metrocity. Left slope excavation of spillway have related to Daegok dam construction are developing crack in Sta. No. 1~2, EL. 134~137m after 67.0mm rainfall from 2000. 7. 23. 13:00 to 7. 24. 04:00. Surface geological survey and slope stability investigation with stereographic projection method in order of slope stability establishment. Partial supplement excavation and SSL. P. C. Anchoring method is able to pre-stressing are think about unstable element after excavation. This slope stability establishment is very successfully completion.

• Proceedings of the Korean Geotechical Society Conference
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• 2009.03a
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• pp.123-131
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• 2009

The study decided the improvement depth of soft ground of deep mixing method through 2 and 3 dimension finite element method and following results were acquired. 1. 2 dimension analysis shows settlement 10% more estimated than 3 dimension analysis. 2. When the rate of replacement is under 5%, the settlement sharply increased. 3. The most economical design for the levee was decided 3.0m for width direction, 6.0m for length direction and 8.0m for improvement depth. 4. When the soft ground is developed through deep mixing method, the decision of improvement should be decided through 3 dimension analysis than 2 dimension analysis.

• Archives of Pharmacal Research
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• v.26 no.2
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• pp.173-181
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• 2003

A polymeric micelle drug delivery system was developed to enhance the solubility of poorly-water soluble drug, biphenyl dimethyl dicarboxylate, DDB. The block copolymers consisting of poly(D,L-lactide) (PLA) as the hydrophobic segment and methoxy poly(ethylene glycol) (mPEG) as the hydrophilic segment were synthesized and characterized by NMR, DSC and MALDI-TOF mass spectroscopy. The size of the polymeric micelles measured by dynamic light scattering showed a narrow monodisperse size distribution with the average diameter less than 50 nm. The MW of mPEG-PLA, 3000 (MW of mPEG, 2 K; MW of PLA, 1K), and the presence of hydrophilic and hydrophobic segments on the polymeric micelles were confirmed by MALDI-TOF mass spectroscopy and NMR, respectively. Polymeric micelle solutions of DDB were prepared by three different methods, i.e. the matrix method, emulsion method and dialysis method. In the matrix method, DDB solubility was reached to 13.29 mg/mL. The mPEG-PLA 2K-1K micelle system was compared with the poloxamer 407 micelle system for their critical micelle concentration, micelle size, solubilizing capacity, stability in dilution and physical state. DDB loaded-polymeric micelles prepared by the matrix method showed a significantly increased aqueous solubility (＞5000 fold over intrinsic solubility) and were found to be superior to the poloxamer 407 micelles as a drug carrier.

• The Journal of Korean Institute of Communications and Information Sciences
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• v.38C no.9
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• pp.740-745
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• 2013

This paper presents BER, FER performance comparison, especially on PHY mode of IEEE 802.15.4g and IEEE 802.11 under AWGN channel through a simulation, which is communication method using identical frequency bandwidth in M2M environment. This considers suitable communication method of required parameter. It is advantageous that FSK method is used in situations where the system require low complexity and inexpensive structure. And OFDM method is considered for system performance. Further, when the high throughput and various traffic characteristics of the system are required, it can be considered that the method of IEEE 802.11 OFDM PHY mode is used.

• Mass Spectrometry Letters
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• v.10 no.2
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• pp.56-60
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• 2019

Coptidis Rhizoma (CR) has been used widely in traditional medicine to treat common diseases. This study aimed to develop a high-sensitivity liquid chromatography-tandem mass (LC-MS) spectrometry method for the evaluation of the pharmacokinetics of a new natural product that contain CR extract with the main bioactive compound, berberine, at trace concentrations. Human plasma samples were pretreated with methanol by a protein precipitation method. Berberine was analyzed on a Kinetex C18 column ($2.1mm{\times}50mm$, $100{\AA}$, $1.7{\mu}m$) using a mobile phase of 10 mM ammonium formate/0.1% formic acid in water (A) and acetonitrile (B) (50:50, v/v) with a flow rate of 0.25 mL/min. The analyte was detected by using electrospray ionization in positive mode with multiple reaction monitoring (MRM). The method was sensitive, with a lower limit of quantification of 1 pg/mL, which has not been previously obtained. The method was validated (over the range of 1-50 pg/mL) and applied successfully for the pharmacokinetic study of human plasma samples.

• 제어로봇시스템학회:학술대회논문집
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• 1995.10a
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• pp.14-17
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• 1995

Various methods and techniques have been proposed for solving optimization problems; the methods have been applied to various practical problems. However the methods have demerits. The demerits which should be covered are, for example, falling into local minima, or, a slow convergence speed to optimal points. In this paper, Likelihood Search Method (L.S.M.) is proposed for searching for a global optimum systematically and effectively in a single framework, which is not a combination of different methods. The L.S.M. is a sort of a random search method (R.S.M.) and thus can get out of local minima. However exploitation of gradient information makes the L.S.M. superior in convergence speed to the commonly used R.S.M..

• Proceedings of the KSR Conference
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• 2005.05a
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• pp.562-567
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• 2005

F.C.M applied from Jin Jung Li to Yang Su Li(660m) in Puk Han River Bridge(1,414m) construction part is a construction method on the double-track construction which is the third section part of work, called Chung Ang Railroad Line(Deok-So${\sim}$Won-Ju). This method is the beginning application on Railroad Bridge. After completing upper slab structure, there are several following works such as setting up ballast, sleepers and laying long rails. So it is important to consider the properties of Railroad Bridge while designing the length of bridge and its single span. After the physical process study the shrinkage and creep of concrete, bending up by prestressing in general PSM bridge, relaxation of tendons as time goes by after post-tension, the conclusion of such a study is applied to the Puk-Han River Bridge in this construction field.

• Proceedings of the Korean Nuclear Society Conference
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• 1998.05b
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• pp.391-396
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• 1998

Modified product Consistency Test (M-PCT) has been developed as an alternative to other existing methods in determining the leachability of glass. M-PCT, the leaching method, is a hybrid of MCC-l and PCT, but can provide quicker sample preparation. Larger diameter glass sample (1.0-2.0 mm) than in the PCT method can be used so that the glass beads are more easily produced and cleaned. From the M-PCT, the total mass loss (ML) of glass, the normalized elemental release rate (NLi), pH value of leachate have been obtained. For some selected glasses in which leaching rates have been known, their chemical durablility have been tested using the M-PCT method. The results are compared to the literature data for the glasses. It is found that M-PCT method is reasonable and suitable in determining the leachability of Low and Intermediate level Radioactive Waste glass form, such as the pH, elemental loss and total mass loss.