• Tuberculosis and Respiratory Diseases
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• 제69권5호
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• pp.375-380
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• 2010

Lymphoid interstitial pneumonia (LIP) is a rare benign lymphoproliferative interstitial lung disease. LIP has been associated with autoimmune disorders, HIV, viral infections, and so on. Once underlying systemic diseases have been excluded, a diagnosis of idiopathic LIP can be made. Although 6 cases of pathologically confirmed LIP have occurred in Korea, thus far none has been associated with primary Sjogren's syndrome. A 44-year-old man was admitted to hospital due to a dry cough and dypsnea on exertion that had been ongoing for 2 months. A chest radiography showed multiple and variable-sized cystic lesions, on both lungs and both interstitial infiltration and consolidation in both lower lung fields. Tests for autoantibody showed positive results of anti-nuclear antibody and anti-Ro/La antibody. The patient underwent a video assisted thoracoscopic surgery biopsy and pathologically confirmed LIP. We report the first known case of LIP-associated with primary Sjogren's syndrome in Korea.

• IMMUNE NETWORK
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• 제12권6호
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• pp.296-300
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• 2012

Silica nanoparticles, which are applicable in many industrial fields, have been reported to induce cellular changes such as cytotoxicity in various cells and fibrosis in lungs. Because the immune system is the primary targeting organ reacting to internalized exogenous nanoparticles, we tried to figure out the immunostimulatory effect of silica nanoparticles in macrophages using differently sized silica nanoparticles. Using U937 cells we assessed cytotoxicity by CCK-8 assay, ROS generation by CM-$H_2DCFDA$, intracellular $Ca^{{+}{+}}$ levels by staining with Fluo4-AM and IL-8 production by ELISA. At non-toxic concentration, the intracellular $Ca^{{+}{+}}$ level has increased immediately after exposure to 15 nm particles, not to larger particles. ROS generation was detected significantly in response to 15 nm particles. However, all three different sizes of silica nanoparticles induced IL-8 production. 15 nm silica nanoparticles are more stimulatory than larger particles in cytotoxicity, intracellular $Ca^{{+}{+}}$ increase and ROS generation. But IL-8 production was induced to same levels with 50 or 100 nm particles. Therefore, IL-8 production induced by silica nanoparticles may be dependent on other mechanisms rather than intracellular $Ca^{{+}{+}}$ increase and ROS generation.

• 한국통신학회논문지
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• 제37권6C호
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• pp.520-526
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• 2012

폐질환은 대부분 흡연과 대기 오염으로 발병하며 한 번 손상된 폐는 기능 회복이 어려워 생명 연장의 위험 질환이며 현대인의 6대 질병 중 하나로 사회적 관심이 증대되고 있다. 따라서 평소 흡연을 하지 말며 폐 기능 강화를 위한 행위를 행해야 호흡기 질환으로 고통 받는 경우의 수를 줄일 수 있을 것으로 여겨진다. 본 논문에서는 귀의 혈 자리가 인체 장기와 연계되어 있다는 이혈요법을 적용하여 폐와 상응하는 귀의 혈 자리를 자극했을 때 실제 폐 기능 강화에 도움이 되는지를 음성 분석 기술에 의해 규명하는 방법을 제안하고자 한다. 이를 위해 우선 인체가 폐에 미치는 영향을 분석하기 위한 선행 연구로 흡연 전/후의 음성 변화를 고찰하고자 한다. 이를 기반으로 폐와 상응하는 이혈점을 자극하기 전과 후의 음성 특징 차이를 분석하여 폐의 이혈점 자극이 실제 폐 기능 향상에 도움이 되는지를 수치적, 정량적으로 규명해 내고자 한다.

• 혜화의학회지
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• 제16권2호
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• pp.87-98
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• 2007

Generally, mind-body medicine is the field of studying neurose or diseases induced to body by psychological cause in a broad sense. It is said that, by definition, the medicine means the field of medicine with psychosomatic disease as its main object of research, and that it aims at utilizing the study of the relationship between mind and diseases to diagnoses and therapy of many physical diseases. Oriental medicine, the mind is classified into 'O-shin'(五神, five minds) and 'Chil-chung'(七情, seven mental states). O-shin are related to the five viscera each other. The liver contains the soul, the heart does the mind, the spleen does the consciousness, the lungs do the spirit and the kidneys do the will Chil-chung are seven mental states such as joy(喜), rage(怒), anxiety(憂), thinking(思), sorrow(悲), fear(恐) and horror(驚). If these Chil-chung are excessive, they induce physical diseases by hurting the five viscera as well as they cause mental problems. In oriental medicine, five mental is a concept for understanding of man's mental structure. Spirit and body is inseparable relation in oriental medicine. Function of spirit and body is regarded as one in oriental medical physiology. Spirit is the essence of a function which an organism reveal, and it is regarded in the same with life. For this reason, identification spirit with life is special feature of oriental medicine.

• Environmental Analysis Health and Toxicology
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• 제31권
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• pp.13.1-13.4
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• 2016

An analysis of patients and fatalities due to exposure to polyhexamethylene guanidine (PHMG) shows that PHMG causes mainly lung diseases such as pulmonary fibrosis. However, no research on the other organs has been conducted on this matter yet. So, an in-depth discussion on toxicological techniques is needed to determine whether or not PHMG is toxic to organs other than just the lungs. For the test of target organ toxicity by PHMG exposure, a toxicokinetic study must first be conducted. However, measurement method for PHMG injected into the body has not yet been established because it is not easy to analyze polymer PHMG, so related base studies on analytical technique for PHMG including radio-labeling chemistry must come first. Moreover, research on exposure-biomarker and effect-biomarker must also be conducted, primarily related to clinical application. Several limitations seem to be expected to apply the biomarker study to the patient because much time has passed after exposure to the humidifier disinfectant. It is why a more comprehensive toxicological researches must be introduced to the causality for the victims.

• BMB Reports
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• 제36권1호
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• pp.49-59
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• 2003

Platelet-derived growth factor (PDGF) is a critical regulator of mesenchymal cell migration and proliferation. The vital functions of PDGFs for angiogenesis, as well as development of kidney, brain, cardiovascular system and pulmonary alveoli during embryogenesis, have been well demonstrated by gene knock-out approaches. Clinical studies reveal that aberrant expression of PDGF and its receptor is often associated with a variety of disorders including atherosclerosis, fibroproliferative diseases of lungs, kidneys and joints, and neoplasia. PDGF contributes to cancer development and progression by both autocrine and paracrine signaling mechanisms. In this review article, important features of the PDGF isoforms and their cell surface receptor subunits are discussed, with regards to signal transduction, PDGF-isoform specific cellular response, and involvement in angiogenesis, and tumorstromal interactions.

• Journal of Chest Surgery
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• 제12권1호
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• pp.1-8
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• 1979

Pulmonary aspergillosis is being recognized with increasing frequency in recent years and the-rising incidence of this infection parallels certain medical advances in antibiotics, chemotherapeutic and immunosuppressive therapy. The cavities of lungs resulting from tuberculosis, histoplasmosis or neoplasm are apt, to be infected by one of the species of the genus Aspergillus and eventually mycetomas are formed within the cavities. Authors have experienced 6 cases of pulmonary aspergillosis forming mycetoma in Dept. of Thoracic Surgery, Catholic Medical Center from Aug. 1976 to Feb. 1979. Hemoptysis or blood tinged sputum, the predominant symptom, occurred in all cases. All patients underwent pulmonary resection, 1 pneumonectomy, 3 lobectomies, 1 lobectomy with segmental resection and 1 segmental resection and survived well without death or complication. Primary aspergillosis was in 2 cases and underlying diseases were present in 4 cases: 3 pulmonary tuberculosis, 1 bronchiectasis. The common diagnostic study of intracavitary mycetoma was the posterioanterior chest roentgenogram; in cavities suspected of being diseased or in doubtful cases, tomography was most available to find fungus ball with air-meniscus shadow.

• 한국응용약물학회:학술대회논문집
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• 한국응용약물학회 1996년도 춘계학술대회
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• pp.45-52
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• 1996

In ancient times, respiration's perceived purpose was only to cool the blood, and nasal mucus was thought to be a discharge from the brain. Later it was demonstrated that fluids cannot travel from the brain to the nose. It appears that credit for pointing out the medical significance of bronchial secretions and the biological value of the exocrine function of the lungs belongs to Laennec. He described the “chronic idiopathic pituitous catarrh” known today as bronchorrhea, which is characterized by paroxysms of expectoration. The importance of all this is that airway secretions, and their alterations, became one of the cardinal signs of many respiratory diseases (1).

• Journal of Chest Surgery
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• 제27권4호
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• pp.287-291
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• 1994

Spontaneous pneumothorax is an accumulation of air in the pleural space with collapse of the lungs in the absence of external chest trauma. In this clinical study were analyzed of 369 cases of spontaneous pneumothorax experienced at the department of Thoracic and Cardiovascular Surgery, College of Medicine, Chosun University during from January, 1986 to December, 1992.The peak incidence of age was in 3rd decade and more predominantly in male than women [5:1]. Pulmonary tuberculosis was most common etiologic condition and frequently symptoms were dyspnea and chest pain. The site of pneumothorax was Rt.in 48%, Lt.in 45% and both in 7%. The common accompanied diseases were hydrothorax, pyothorax and hemothorax. In 166 cases [45%] were treated by closed thoracostomy only, in 43 cases [12%] were treated by closed thoracostomy & chemical pleurodesis with Tetracycline and in 145 cases [39%] were treated by open thoracotomy. The most serious complication, one case of pulmonary edema, was developed after closed thoracostomy and fatal.

• Journal of Chest Surgery
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• 제37권10호
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• pp.876-879
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• 2004

일반적으로 폐질환과 심장 질환이 동시에 발견되었을 때 동시 수술은 술자가 고려해야 되는 사항이 많다. 59세 여자 환자가 우중엽절제술과 이중판막 재치환술과 삼첨판막륜성형술을 동시에 시행 받았다. 동시 수술은 폐와 심장의 병변을 일거에 해소하면서 2차적으로 시행해야 하는 폐절제술 또는 심장수술에 따르는 위험성을 피할 수 있는 장점이 있으며 안전하게 시행할 수 있는 술식이다.