• Journal of The Korean Society of Integrative Medicine
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• v.7 no.2
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• pp.181-187
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• 2019

Purpose: The purpose of this study was to investigate the activity of respiratory muscle and lung capacity during deep breathing with electrical stimulation of the vagus nerve. Methods: This study was conducted on 30 healthy adults in their 20s. Subjects were randomly performed to deep breathing or deep breathing with vagus nerve electrical stimulation. All subjects' diaphragm and internal oblique muscle activity were measured during deep breathing by electromyography, and lung capacity was measured by spirometry immediately after beep breathing. In the vagus nerve stimulation method, the surface electrode was cut into the left ear and then electrically stimulated using a needle electric stimulator. Results: The activity of diaphragm was significantly increased in deep breathing with vagus nerve electrical stimulation than in deep breathing. However, lung capacity did not show any significant difference according to the condition. Conclusion: Vagus nerve electrical stimulation could induce diaphragm activity more than deep breathing alone. Deep breathing with vagus nerve electrical stimulation may enhance the activity of the respiratory muscles and is expected to be an effective treatment for the elderly or COPD patients with poor breathing ability.

• Journal of Physiology & Pathology in Korean Medicine
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• v.25 no.1
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• pp.55-64
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• 2011

The object of this study was to observe the effects of Scutellariae Radix (SR) aqueous extracts on lipopolysaccharide (LPS)-induced rat acute lung injury. Five different dosages of SR extracts were orally administered once a day for 28 days before LPS treatments, and then 5 hours after lipopolysaccharide treatment, all rats were sacrificed. 8 groups, each of 16 rats per group were used in the present study. Changes on the body weights, lung weights, pulmonary transcapillary albumin transit, arterial gas parameters (pH, $PaO_2$ and $PaCO_2$) bronchoalveolar lavage fluid (BALF) protein, lactate dehydrogenase (LDH) and proinflammatory cytokines tumor necrosis factor-${\alpha}$ (TNF-${\alpha}$), interleukin-1${\beta}$ (IL-1${\beta}$) contents, total cell numbers, neutrophil and alveolar macrophage ratios, lung malondialdehyde (MDA), myeloperoxidase (MPO), proinflammatory cytokine TNF-${\alpha}$ and IL-1${\beta}$ contents were observed with histopathology of the lung, changes on luminal surface of alveolus (LSA), thickness of alveolar septum, number of polymorphonuclear neutrophils (PMNs). The results were compared with a potent antioxidant ${\alpha}$-lipoic acid, 60 mg/kg, in which the effects on LPS-induced acute lung injury were already confirmed. The results obtained in this study suggest that over 125 mg/kg of SR extracts showed favorable effects on the LPS-induced acute lung injury, and 250 mg/kg of SR extracts resembling acute respiratory distress syndrome mediated by their antioxidant and anti-inflammatory effects and .as similar to ${\alpha}$-lipoic acid in the present study. Therefore, it is expected that SR will be showed favorable effects on the acute respiratory distress syndrome.

• Journal of the Korean Society of Physical Medicine
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• v.19 no.2
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• pp.91-98
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• 2024

PURPOSE: This study aimed to provide basic clinical data by investigating the impact of Activities of daily living-related dual-task intervention on lung function, balance, and Activities of daily living of stroke patients. METHODS: After sampling 40 stroke patients who met the selection criteria, this study randomly assigned 20 patients who received dual-task exercise intervention to the experimental group and 20 patients who received single exercise intervention to the control group by drawing lots. Next, the study pre-tested their lung function, balance, and activity of daily living. All interventions were conducted for 30 minutes, 3 times a week for 4 weeks, and when all interventions were completed after 4 weeks, lung function, balance, and activity of daily living were re-measured in the same way as the pre-test. RESULTS: In comparing changes in lung function, balance, and activity of daily living within each of the experimental and control groups, statistically significant improvement were found in the experimental group only (p < .01). Statistically significant improvement were also found in lung function, balance, and activities of daily living between the groups (p < .05) (p < .01). CONCLUSION: A statistically significant improvements were found in lung function, balance, and activities of daily living only in the experimental group and statistically significant differences were found between groups. Because they take arm exercises by maintaining balance in a standing position on a labile surface and through dual-task exercise such as folding a towel, moving a cup, and throwing and catching a ball, muscles related to lung function were stimulated and lung function and balance were improved. This helped activities of daily living to be improved. Thus, it is considered that dual-task exercise should be utilized for stroke patients' smooth everyday life.

• Asian Pacific Journal of Cancer Prevention
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• v.15 no.6
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• pp.2685-2688
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• 2014

Background: To explore the prevalence of lymphocyte subgroups $CD3^+$ $CD4^+$ and $CD3^+$ $CD8^+$ and their surface receptors NKG2D and NKG2A in patients with non-small cell lung cancer (NSCLC). Materials and Methods: A total of 40 patients with NSCLC were divided into different groups according to different clinical factors (TNM staging, pathological patterns and genders) for assessment of relations with $CD3^+$ $CD4^+$ and $CD3^+$ $CD8^+$ and the surface receptors NKG2D and NKG2A of T lymphocytes in peripheral blood by flow cytometry. Results: Patients in the advanced group had evidently lower levels of $CD3^+$ $CD4^+$ but markedly higher levels of $CD3^+$ $CD8^+$ in peripheral blood than those with early lesions (p<0.05). In addition, NSCLC patients in the advanced group had obviously higher $CD3^+$ $CD4^+$ NKG2D and $CD3^+$ $CD8^+$ NKG2A expression rates but lower $CD3^+$ $CD4^+$ NKG2A and $CD3^+$ $CD8^+$ NKG2D expression rates (p<0.05). However, there were no significant differences between NSCLC patients with different genders and pathological patterns in expression levels of lymphocyte subgroups $CD3^+$ $CD4^+$ and $CD3^+$ $CD8^+$ and their surface receptors NKG2D and NKG2A. Conclusions: Unbalanced expression of surface receptors NKG2D and NKG2A in $CD3^+$ $CD4^+$ and $CD3^+$ $CD8^+$ lymphocytes may be associated with a poor prognosis, greater malignancy and immunological evasion by advanced cancers, related to progression of lung cancer.

• Tuberculosis and Respiratory Diseases
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• v.63 no.1
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• pp.42-51
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• 2007

Background: TRAIL is a cytokine that selectively induces apoptosis in various cancer cell lines. Gefitinib is new targeted drug applied in lung cancer that selectively inhibits EGFR tyrosine kinase. However, lung cancers have shown an initial or acquired resistance to these drugs. This study examined the effect of IGF-1R and its blockade on enhancing the sensitivity of lung cancer cell lines to TRAIL and gefitinib. Methods: Two lung cancer cell lines were used in this study. NCI H460 is very sensitive to TRAIL and gefitinib. On the other hand, A549 shows moderate resistance to TRAIL and gefitinib. The IGF-1R blockade was performed using adenoviruses expressing the dominant negative IGF-1R and shRNA to IGF-1R and AG1024 (IGF-1R tyrosine kinase inhibitor). Results: The adenovirus expressing dominant negative IGF-1R(950st) induced the increased expression of defective IGF-1R on the lung cancer cell surface, and the adenovirus-shIGF-1R effectively decreased the level of IGF-1R expression on cell surface. The genetic blockade of IGF-1R by the adenovirus-dnIGF-1R and AG1024 increased the sensitivity of A549 cells to TRAIL. The reduction of IGF-1R by transduction with ad-shIGF-1R also increased the sensitivity of the A549 cells to gefitinib. Conclusion: The blockade of IGF-1R through various mechanisms increased the sensitivity of the lung cancer cell line that was resistant to TRAIL and gefitinib. However, further studies using other cell lines showing acquired resistance as well as in vivo animal experiments will be needed.

• Journal of Chest Surgery
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• v.32 no.2
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• pp.164-170
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• 1999

Background: The diffuse infiltrative lung disease often requires biopsy for its final diagnosis. Unlike the limited exposure that can be achieved through small thoracotomy incisions in open lung biopsy technique, the thoracoscopic approach allows visualization and biopsy of nearly entire surface of the lung without morbidity of large standard thoracotomy. The purpose of this study was to compare the diagnostic efficacy and operative safety of thoracoscopic lung biopsy(TLB) with open lung biopsy(OLB) in the diagnosis of diffuse infiltrative lung disease. Material and Method: From March 1993 to August 1997, 81 patients were referred for diagnostic lung biopsy. 51 of them underwent standard open lung biopsy and the remaining 30 patients underwent thoracoscopic lung biopsy. Result: Mean operative time was 63 minutes for TLB and 79 minutes for OLB (p=0.04). The volume of biopsy specimen was not different between two groups(TLB 7.8 cm3, OLB 6.9 cm3 : p=0.72) and the diagnostic accuracy of each methods was comparable (TLB 100%, OLB 96%). The duration of hospital stay was significantly less in TLB (TLB 13days, OLB 22days : p=0.01). The duration of parenteral narcotics administration was also less for TLB(TLB 2.5days, OLB 5.2days, p=0.05). Meanwhile, the duration of chest tube drainage, the frequency of parenteral narcotic injection were not significantly different between two groups. Complications occurred in 2 among the TLB patients (6.67%) and 4 among the OLB patients (7.84%). There was no operative mortality in both groups. Conclusion: We concluded that TLB is a good alternative procedure to OLB in the diagnosis of diffuse infiltrative lung disease with lower morbidity and comparable diagnostic accuracy.

• The Korean Journal of Physiology
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• v.5 no.2
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• pp.63-70
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• 1971

In an attempt to understand the possible effects of temperature and X-irradiation on the activities of surfactant in rabbits, the pulmonary surfactant from the rabbit was subjected to the incubation at $37^{\circ}C$ and X-irradiation with 900r in vitro, and activities of surfactant were measured at 10, 30, 60, and 90 minutes. Tension-area diagram of the lung extract was recorded automatically by the modified Langmuir-wilhelmy balance with a synchronized recording system designed in this Department. A comparison was made with the normal and the following results were obtained. 1) The maximal surface tension, minimal surface tension, width of the tension area diagram at the surface area of 40% and stability index of the normal rabbit lung extract were $31.6{\pm}3.11\;dynes/cm,\;8.2{\pm}0.56\;dynes/cm,\;21.4{\pm}4.40\;dynes/cm\;and\;1.12{\pm}0.22$,respectively. 2) In the $37^{\circ}C$ incubation group, maximal surface tension was similar to the normal value, while minimal surface tension was significantly lower and stability infer was markedly higher than the normal. 3) In the group where X-irradiation of 900r in vitro was applied, maximal surface tension did not differ greatly with the normal or the $37^{\circ}C$ incubation group. The minimal surface tension was significantly lower than the normal but comparing with the $37^{\circ}C$ incubation group, some decrease in minimal surface tension was noted. The width of the tension·area diagram at 40% and stability index in the irradiated group were significantly higher than the normal but a tendency of increase was noted comparing with the $37^{\circ}C$ incubation group.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.18 no.4
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• pp.624-631
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• 2017

This study aimed to identify the effect of the push-up plus exercise with sling on the muscle activity and lung function in adults with forward head posture over a period of 8 weeks. A total of 16 adults with forward head posture were recruited. The participants were divided into two groups : control (n-=8) and experimental (n=8). From July 6 until Aug 28, 2015, the participants were instructed to perform the knee push-up plus exercise and knee push-up plus using sling exercise three times a week to begin with and progressing to three sets of push-ups on each occasion after 8 weeks. The participants in both groups showed an increase in their craniovertebral angle (both groups p<0.001) and a decrease in their crania rotation angle (control p<0.05, experimental p<0.001). The participants in both groups showed a decrease in their trapezius activity (both groups p<0.001), an increase in their serratus anterior and lower trapezius muscle activity (both groups p<0.001), (and an increase in their) lung function (control group p<0.01, experimental group p<0.001). These findings show that push-up plus exercise improves posture and increases activation of lung function, while the push-up plus exercise in the sling is more effective in improving the forward head posture. The push-up plus exercise in the sling was more effective in improving the forward head posture, but there was no significant difference in the lung function between the two groups. Therefore, the push-up plus exercise in the sling is recommended as an exercise that is effective for the improvement of the posture and lung function of persons with forward head posture.

• Korean Journal of Environmental Biology
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• v.21 no.3
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• pp.297-302
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• 2003

This study was designed to determine whether selenium (Se) nutrition affects pulmonary glutathione peroxidase and alveolarization in the neonatal rat. Twenty-four female Sprague Dawley rats were bred and fed a semipurified Se-deficient (0.04 ppm, Se-) or a Se-adequate (0.5 ppm, Se+) diet through pregnancy and lactation. Pulmonary DNA synthesis was slightly higher in Se+ pups than in Se- pups on d 6 and d 9 of lactation, but significant difference was not found. As pulmonary alveolarization progressed, mean air space size decreased and internal surface area and lung volume increased. No difference in pulmonary alveolarization was found between Se- and Se+ pups by age. Pulmonary Se concentration was higher in Se+ pups than in Se- pups at all age. Glutathione peroxidase activity in lung tissur reflected Se status and was lower in Se- pups than in Se+ pups. In conclusion, selenium has no significant effect on alveolarization of neonatal lungs. but it is necessary for adequate supply of pulmonary antioxidant, glutathione peroxidase.

• Korean Journal of Veterinary Research
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• v.13 no.1
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• pp.63-66
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• 1973

A 16-year-old female Bengal tiger (Panthera tigris tigris) infected with Paragonimus kellicotti was described. Noticeable clinical symptom was not observed before death. At autopsy, numerous cysts were found on the pleural surface of the lung. The cysts were spherical, approximately 1.0 cm in diameter, bulge the pleura, and dark red-brown in color. Such cysts were also found in the deeper lung parenchyma, and usually contained adult flukes in pairs. Histopathologically, the cyst was lined with stratified squamous epithelium which arose from metaplasia of bronchial epithelium. Partial hyperplasia and necrotic foci accompanied with inflammatory cells were often observed in the squamous epithelium. The outer part of the cyst was consisted of fibrous connective tissue in which leukocytes were infiltrated. Catarrhal pneumonia was manifested in the adjacent lung tissues.