• Asian Pacific Journal of Cancer Prevention
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• 제13권2호
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• pp.613-615
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• 2012

The aim of this study was to ana1yze T-cell lymphoma invasion and metastasis-inducing factor 1 (Tiam1) expression in 1ung cancer patients. A total of 204 patients with lung cancer tissue lesions were enrolled in the present study, along with 40 cases of normal lung tissue and 40 of normal fetal lung tissue. Tiam1 protein expression level was determined using intensity quantitative analysis, for comparison in lung cancer, metastatic, normal lung, and fetal lung tissue. The positive unit (PU) of Tiam1 was $13.5{\pm}5.42$ in lung cancer,$5.67{\pm}1.56$ in norma1 epithelial cells, and $5.89{\pm}1.45$ in fetal lung epithelial cells. The value in the lung cancer tissue was significantly higher than that in the normal lung tissue and the fetal lung tissue (P<0.01). The Tiam1 PU values with lymph node metastasis and without 1ymph node metastasis were $15.2{\pm}4.34$ and $12.5{\pm}4.23$, respectively, and the difference was statistically significant (P<0.05). The Tiam1 PU values in different tumor, nodes, metastasis (TNM) stages, III-IV period, and I-II phase were $14.7{\pm}4.14$ and $11.0{\pm}5.34$ (P<0.05). A correlation was found between Tiam1 expression and the age of patient, tumor size, tumor type, and tumor differentiation. Tiam1 protein expression in the lung tumor tissue is significantly higher than that in the normal lung tissue and fetal lung tissue. Tiam1 expression may be closely related to lung cancer development and metastasis.

• Tuberculosis and Respiratory Diseases
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• 제39권4호
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• pp.310-317
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• 1992

연구배경 : Angiotensin-converting enzyme (ACE)은 인체의 여러 조직 또는 혈청내에 존재하는 glycoprotein peptidyldipeptide hydrolase로써 여러 종류의 peptides에서 dipeptides를 떼어내는 역할을 담당한다. 이러한 ACE는 주로는 혈관 내피 세포에서 형성되며 인체에서는 폐에 가장 많은 모세혈관들이 존재하므로 ACE가 혈중에 존재하는 기질과 작용하는 곳 또한 폐의 모세 혈관내이다. 임상적으로 ACE는 유육종증의 진단 및 경과 관찰에 이용되며 기타 급성 또는 만성 폐질환에서 혈청 ACE 활성도가 감소된다는 사실이 보고되고 있다. 그러나 한 시점에서의 혈청 ACE 활성도는 폐손상의 유무 및 그 정도를 잘 반영한다고 볼 수는 없으나 시간 간격을 두고 차례대로 측정한 값은 예후와 관련이 있다고 알려져 있다. 이에 저자는 폐암환자를 대상으로 혈청내의 ACE 활성도를 측정하여 이들 환자에 있어서 향후 예후 예측의 지표로써의 가능성을 알아보고자 하였다. 방법 : 연구대상은 새로 진단된 폐암 환자로 하였고 대조군으로는 연구 대상군과 비슷한 연령군으로 하되 두군 모두에서 고혈압, 심장질환, 간질환, 신장 질환 그리고 폐암 이외의 기타 폐질환이 있는 사람은 제외시켰다. 연구대상군은 편평상피세포 폐암환자 19명, 선암폐암환자 13명, 소세포 폐암환자 9명 이었다. 결과 : 1) 편평상피세포 폐암환자의 혈청내 ACE 활성도는 $36.2{\pm}14.2$ U/L 이었고 선암 폐암환자는 $46.0{\pm}18.7$ U/L, 소세포 폐암환자는 $45.7{\pm}14.1$ U/L, 대조군은 $41.4{\pm}18.7$ U/L로 폐암환자의 ACE 활성도는 대조군과 차이가 없었으며 폐암의 세포형에 따라서도 차이가 없었고 폐암의 병기에 따라서도 ACE 활성도는 차이가 없었다. 2) 편평상피세포 폐암환자 4명과 선암 폐암환자 4명은 폐암의 치료로써 폐절제술을 받았으며 수술 전후 ACE 활성도는 편평세포 폐암환자가 수술전 $35.8{\pm}13.9$ U/L, 수술후 $12.5{\pm}3.9$ U/L로 의미있게 감소하였으며 선암 폐암환자에서는 각각 $47.1{\pm}5.9$ U/L, $15.0{\pm}3.9$ U/L로 수술후 의미있게 감소하였다. 3) 편평상피 세포 폐암환자중 3명과 선암 폐암환자 4명에 대하여 항암제를 투여받은 3개월에 걸쳐 측정한 ACE 활성도는 유의한 변화가 없었으며 임상적으로도 폐암의 호전은 없었다. 4) 소세포 폐암환자 9명은 3개월동안의 항암제 투여 중 임상적으로는 호전이 있었으나 혈청내 ACE 활성도는 의미있는 변화가 없었다. 결론 : 이상에서 폐정제술후 혈청내 ACE 활성도는 감소됨을 알 수 있었으나 폐암의 세포형, 병기, 임상적 호전과 혈청내 ACE 활성도는 연관이 없어 혈청 ACE 활성도는 폐암환자의 질병 경과 판정의 지표로써 부적합함을 알 수 있었다.

• 보건행정학회지
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• 제31권1호
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• pp.91-99
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• 2021

Background: The Korean government introduced National Cancer Control Program and strengthening national health insurance coverage for cancer patients. Although many positive effects have been observed, there are also many concerns about cancer management such as patient concentration or time-to-treatment. Thus, we investigated the association between the time-to-treatment and survival of cancer patients, and compared regional differences by time trend. Methods: The data used in this study were national health insurance claims data that included patients diagnosed with lung cancer and received surgical treatment between 2005 and 2015. We conducted survival analysis with Cox proportional hazard model for the association between time-to-treatment and survival in lung cancer. Additionally, we compared the regional differences for time-to-treatment by time trend. Results: A total of 842 lung cancer patients were included, and 52.3% of lung cancer patients received surgical treatment within 30 days. Patients who received surgical treatment after 31 days had higher 5-year or 1-year mortality compared to treatment within 30 days (5-year: hazard ratio [HR], 1.566; 1-year: HR, 1.555; p<0.05). There were some regional differences for time-to-treatment, but it was generally reduced after 2010. Conclusion: Delayed surgical treatment after diagnosis can negatively affect patient outcomes in cancer treatment. To improve cancer control strategies, there are needed to analyze the healthcare delivery system for cancer care considering the severity and types of cancer.

• Tuberculosis and Respiratory Diseases
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• 제81권1호
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• pp.29-41
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• 2018

Lung cancer is one of the most commonly diagnosed cancers and the leading cause of cancer-related deaths worldwide. Although progress in the treatment of advanced non-small cell lung cancer (NSCLC) has been made over the past decade, the 5-year survival rate in patients with lung cancer remains only 10%-20%. Obviously, new therapeutic options are required for patients with advanced NSCLC and unmet medical needs. Cancer immunotherapy is an evolving treatment modality that uses a patient's own immune systems to fight cancer. Theoretically, cancer immunotherapy can result in long-term cancer remission and may not cause the same side effects as chemotherapy and radiation. Immunooncology has become an important focus of basic research as well as clinical trials for the treatment of NSCLC. Immune checkpoint inhibitors are the most promising approach for cancer immunotherapy and they have become the standard of care for patients with advanced NSCLC. This review summarizes basic tumor immunology and the relevant clinical data on immunotherapeutic approaches, especially immune checkpoint inhibitors in NSCLC.

• Journal of Chest Surgery
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• 제27권5호
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• pp.364-373
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• 1994

Alpha 1-Proteinase inhibitor[PI] was known as a major protective enzyme against to excessive hydrolytic and proteolytic reaction. So, it was suggested that Alpha 1-PI may implicated in growth of bronchogenic cancer. This study was undertaken to investigate the role of Alpha 1-PI in local invasion of bronchogenic cancer. Three groups of patients were studied; Preliminary research group of 15 bronchogenic cancer patients, Main research group of 13 bronchogenic cancer patients and Normal control group of 10 nephrectomy donor. Serum Alpha 1-PI level was observed in each group of patients during pre-and postoperative days. Pre-operative serum Alpha 1-PI level in preliminary research group [329.2$\pm$14.21mg/dl]and main research group[406.2$\pm$39.30mg/dl] were higher than in normal control group[236.2$\pm$19.55mg/dl] significantly[p<0.005]. Serial Alpha 1-PI level in each group during pre-and postoperative days shows peaked at 3rd. postoperative day in preliminary and main research group, thereafter decreased gradually. Immunohistochemical study for Alpha 1-antitrypsin[A1AT] was carried out by ABC[avidin-biotin peroxidase complex] method using Alpha-1 antitrypsin DAKOR to tumor tissues of 13 lung cancer patients in main research group. 6 cases[46.2%, squamous cell ca.;5, adenocarcinoma;1] of above 13 cases show positive immunoreactivity for A1AT. In conclusion, alpha 1-PI and elastase are disclosed that have defined actions for lung cancer growing or spreading.

• Asian Pacific Journal of Cancer Prevention
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• 제15권22호
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• pp.9611-9614
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• 2014

Purpose: To investigate the clinical value in lung cancer of a combination of four serum tumor markers, haptoglobin (Hp), carcinoembryonic antigen (CEA), neuron specific enolase (NSE) as well as the cytokeratin 19 fragment (CYFRA21-1). Materials and Methods: Serum Hp (with immune-turbidimetric method), CEA, NSE, CYFRA21-1 (with chemiluminescence method) level were assessed in 193 patients with lung cancer, 87 patients with benign lung disease and 150 healthy controls. Differences of expression were compared among groups, and joint effects of these tumor markers for the diagnosis of lung cancer were analyzed. Results: Serum tumor marker levels in patients with lung cancer were obviously higher than those with benign lung disease and normal controls (p<0.01). The sensitivities of Hp, CEA, NSE and CYFRA21-1 were 43.5%, 40.9%, 23.3% and 41.5%, with specificities of 90.7%, 99.2%, 97.9% and 97.9%. Four tumor markers combined together could produce a positive detection rate of 85.0%, significantly higher than that of any single test. With squamous carcinomas, the positive detection rates with Hp and CYFRA21-1 were higher than that of other markers. In the adenocarcinoma case, the positive detection rate of CEA was higher than that of other markers. For small cell carcinomas, the positive detection rate of NSE was highest. The area under receiver operating characteristic curve ($AUC^{ROC}$) of Hp in squamous carcinoma (0.805) was higher than in adenocarcinoma (0.664) and small cell carcinoma (0.665). Conclusions: Hp can be used as a new serum tumor marker for lung cancer. Combination detection of Hp, CEA, NSE and CYFRA21-1 could significantly improve the sensitivity and specificity in diagnosis of lung cancer, and could be useful for pathological typing.

• 동서간호학연구지
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• 제16권1호
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• pp.1-10
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• 2010

Purpose: This study tested the effects of Nei-Guan acupressure on nausea, vomiting, and anorexia of lung cancer patients on chemotherapy. Methods: A nonequivalent control group pre-post test design was used to identify the effect of Nei-Guan acupressure on nausea, vomiting, and anorexia of lung cancer patients on chemotherapy. The participants were 60 patients who were admitted to a hospital for chemotherapy from February 1 to October 28, 2009. The patients were randomly assigned to the control group (n=30) or experimental group (n=30). The data were analyzed using Mann-Whitney test. Results: Nausea, vomiting, and anorexia were significantly decreased in the experiment group compared to the control group on the day of discharge from the hospital. However, the levels of nausea, vomiting, and anorexia between two groups were not statistically significant seven days after the discharge. Conclusions: Nei-Guan acupressure is effective in decreasing nausea, vomiting and anorexia of the patients with lung cancer on chemotherapy on the on the day of the discharge while the effectiveness is not certain 7 days after the discharge. Further study is needed to confirm these findings.

• Tuberculosis and Respiratory Diseases
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• 제79권2호
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• pp.58-69
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• 2016

Lung cancer causes the most cancer deaths in Korea. Although the smoking rate has begun to decrease, the prevalence of lung cancer is still increasing. We reviewed the national lung cancer registry data and the data published about lung cancer in Korea. In 2012, the crude incidence rate of lung cancer was 43.9 per 100,000. The age-standardized mortality rate of lung cancer was 19.8 per 100,000. The 5-year relative survival rate for lung cancer was 11.3% from 1993 to 1995 and increased to 21.9% in the period from 2008 to 2012. Lung cancer occurring in never-smokers was estimated to increase in Korea. Adenocarcinoma is steadily increasing in both women and men and has replaced squamous cell carcinoma as the most common type of lung cancer in Korea. In patients with adenocarcinoma, the frequency of EGFR mutations was 43% (range, 20%-56%), while that of the EMK4-ALK gene was less than 5%.

• Asian Pacific Journal of Cancer Prevention
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• 제13권1호
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• pp.301-304
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• 2012

Objective: To explore the associations of serum tumor associated material (TAM) with other common tumor markers like carcinoembryonic antigen (CEA), carbohydrate antigen 125 (CA125), carbohydrate antigen19-9 (CA19-9) and its clinical application in non-small cell lung cancer (NSCLC) patients. Methods: A total of 87 patients were enrolled into this study, all with histologically or cytologically confirmed NSCLC. With the method of chemical colorimetry, the level of TAM was determined and compared, while chemiluminescence was used to measure the levels of common tumor markers. Results: The level of TAM decreased after chemotherapy compared with before chemotherapy when CT or MRI scans showed disease control. Furthermore, it increased when disease progessed and there was no statistically significant difference in monitoring of TAM and common tumor markers (P>0.05). Conclusions: Detecting TAM in NSCLC patients has a higher sensitivity and specificity, so it can be used as an indicator for clinical monitoring of lung cancer chemotherapy.

• Asian Pacific Journal of Cancer Prevention
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• 제16권11호
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• pp.4711-4714
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• 2015

Background: The incidence of lung cancer increases with age. Approximately 50% of non-small cell lung cancer (NSCLC) patients are over 70 years old. Because of the increasing elderly population, treatment approaches in this age group continue to be studied similar to groups of young people. Materials and Methods: In the current study, 26 patients who underwent radical surgery and adjuvan chemoradiation at Ataturk Chest Diseases and Chest Surgery Training and Research Hospital were evaluated retrospectively. Results: Of 21 patients (81%) were male and the average age was 74.4. Lobectomy was performed in 18 cases, pneumonectomy in 3, sleeve lobectomy in 3 and bilobectomy in 2. There was no perioperative or early period mortality. Overall survival was 24.5 months. Conclusions: From our study, lung cancer surgery and adjuvant therapy can be performed safely with low morbidity in the elderly.