• 대한약침학회지
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• 제13권3호
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• pp.47-62
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• 2010

Objectives: Colitis is an inflammatory bowel disease characterized by colonic mucosal inflammation and chronic relapsing events represents. The purpose of this study is to evaluate effects of pharmacopuncture of anti-inflammatory herbal compound (AiC) applied to the different acupoints in the acute colitis induced by trinitrobenzenesulphonic acid (TNBS) intracolonic injection in rats. Methods: In Male Sprague - Dawley rats, weighing 250~400g, TNBS (5 mg/kg) was infused intrarectally through a silicon rubber catheter into the anus under isoflurane anaesthesia. Acupoints of LI4 (Hapkok), ST25 (Cheonchu), ST36 (Joksamni), and BL25 (Daejangsu) were intramuscularly injected by AiC, respectively (injection volume & times: 0.2 ml / acupoint, twice times on the 2nd & 3rd day). Expressions of cFos protein in the periaqueductal gray (PAG), locus coeruleus (LC), nucleus of solitary tract (Sol), and the 6th lumbar spinal cord (L6 s.c.) were observed at 24 hr after TNBS induced colitis by immunohistochemistry. Results: The expression of c-Fos protein in the L6 s.c., Sol, LC and PAG increased 24 hr after TNBS injection into colorectum as compared to normal and 50% ethanol treated group. AiC to LI4 inhibited the expression of c-Fos protein in Sol and PAG but not L6 s.c. and LC. AiC to ST36 showed significant inhibition the c-Fos expression in L6 s.c., Sol and PAG. AiC to ST25 only showed the effects in L6 s.c. and PAG. AiC to BL25 inhibited significantly the expression of c-Fos protein all over the areas. To investigate whether or not endogenous opioids are involved, intrathecal injection of naltrexone (30ug/30ul) was applied before the 2nd pharmacopuncture treatment 24 hr after TNBS-induced colitis in rat. Naltrexone reversed the inhibition of c-Fos protein expression in the spinal cord and brainstem. Conclusions: These data show that pharmacopuncture of Aic potently inhibits signal pathways ascending hypersensitivity of colorectum after TNBS induced colitis and depends on the endogenous opioids according to acupoints.

• 한방재활의학과학회지
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• 제23권4호
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• pp.213-223
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• 2013

Objectives Low back pain (LBP) is one of the most common reason for people in Korea to visit Korean medical institutions. To assess actual amounts of use in the treatment of LBP in Korean medicine and to provide objective base line data for policy decision making, research regarding the current state of LBP patients' treatment in Korean medical institutions are in need. Methods The current study was designed as a retrospective chart review to investigate descriptive characteristics of LBP patients. The clinical records of 304 patients who were hospitalized for the treatment of LBP in Korean rehabilitation medicine inpatient clinics of five different Korean medicine hospitals were analyzed. The percentage of patient characteristics such as sex, age, average duration of admission, insurance type, diagnosed LBP related disease code, and rates of interventions applied were assessed. Results 1. The female sex was significantly predominant among patients with LBP : 105 patients (34.5%) were male and 199 patients (65.5%) were female. Percentage of the patients' age appeared as followed : 76 people (25.0%) were in their 50s, 64 people (21.1%) were in their 40s, 51 people (16.8%) were in their 30s, 37 people (12.2%) were in their 60s, and 33 people (10.9%) were in their 70s. Approximately half of the total LBP patients investigated were older than 50. 2. The average duration of admission was 16.2 days. Approximately one third (30.3%) of the patients were hospitalized for 8 to 14 days. 3. Female patients tended to stay admitted in hospitals slightly longer than male patients. Elderly (age 60~79) patients stayed in hospitals longer (17.8 days) compared to younger (age 20~39) patients (13.5 days). 4. More than half of the patients (171 cases, 56.3%) had their hospital bills covered with automobile insurance. 40.1% (122 cases) of the patients had medical insurance to cover their hospital bills. The average duration of admission of patients who had automobile insurance was 14.2 days, while that of the patients who had medical insurance was 18.4 days. 5. "Sprain and strain of the lumbar spine and pelvis" was the most commonly used (195 cases, 64.1%) disease code in patients with LBP. Patients diagnosed as "lumbar and other intervertebral disc disorders with radiculopathy" required the longest admission duration (22.1 days). 6. Herbal medication was applied to all of the patients during admission. Acupuncture was applied to all of the patients except one case diagnosed as spinal stenosis. Physical therapy, cupping therapy, moxibustion therapy, chuna therapy, and pharmacopuncture therapy were applied to 94.7, 92.8, 85.2, 83.9, and 49.7% of the patients, respectively. 7. There were certain differences among Korean medicine hospitals in terms of the LBP patients' duration of admission, type of insurance, frequency of the disease code use, type of intervention applied. Conclusions It is thought that the current study can be used as reference data in assessing the current state of LBP treatment in Korean rehabilitation medicine and a basis for future research. Provided improvements of certain limitations of the current study in future researches, such data would act as better base line data in policy decision making.

• 대한핵의학회지
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• 제36권4호
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• pp.255-260
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• 2002

목적: SAPHO 증후군은 전흉벽의 골관절에 주로 위치하는 혈청학적 검사상 음성을 보이면서 다양한 피부증상을 동반하는 골관절 질환으로 질병의 특성에 대한 폭넓은 이해를 통하여 조기진단을 함으로써 불필요한 수술이나 장기간의 비효율적인 항생제 치료를 피하는 것이 임상적으로 중요점이라 할 수가 있겠다. 이에 저자들은 SAPHO 증후군으로 진단받은 환자에서 골신티그라피의 소견의 특징을 알아보고 유용성을 알아보고자 하였다. 대상 및 방법: 다발성 관절통과 반복적으로 재발되는 피부증상이 있어 임상적으로 SAPHO 증후군으로 진단 받은 5명의 환자(모두 남자, $22.8{\pm}4.75$세)를 대상으로 하였다. 모든 환자에서 저에너지 고해상도 조준기가 장착된 이중헤드 감마카메라(ECAM, Siemens, Germany)를 이용하여 전신영상을 얻었고, 2명의 환자에서는 척추 관절의 이상 유무를 확인하기 위하여 SPECT 영상을 얻었다. 골신티그라피상 섭취증가를 보이는 관절을 알아보고 호발빈도와 단순 X선과 관절 침범 유무를 진단하는 성능을 비교하였다. 결과: 골신티그라피상 모든 환자에서 이상소견을 보인 관절은 흉쇄골 관절, 천장골 관절, 수부의 소관절이었다. 흉쇄골 관절이상은 양측성이 3/5 (60%)이고 일측성이 2/5 (40%)로 관찰되었다. 천장골 관절에서는 양측성이 4/5 (80%) 이고 일측성이 1/5 (20%)로 관찰되었다. 척추 관절의 이상은 4/5 (80%)에서 관찰되었는데 이 가운데 요추 이상은 4명 모두에서 볼수가 있었고 흉추의 이상은 3명, 경추의 이상은 1명에서 보여 척추에서는 요추의 침범이 가장 많았다. 척추골 SPECT는 2명에서 시행되었는데 추체나 척추경 보다는 후관절에 이상을 초래함을 평면영상에 비하여 보다 상세히 알 수가 있었다. 결론: SAPHO 증후군은 피부증상과 함께 다양한 골관절을 침범하는 질환으로 골신티그라피를 시행함으로써 관절의 이상을 조기에 진단하여 불필요한 수술이나 장기간의 비효율적인 항생제 치료를 피하는데 도움이 될 것으로 사료된다.