• 한국융합학회논문지
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• 제10권2호
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• pp.41-48
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• 2019

본 연구는 HPMC (Hydroxypropyl methyl cellulose)의 점도와 겉보기 점도가 유탕면의 흡유량과 지방 소화율에 미치는 영향을 확인하고자 하였다. HPMC 상업용 소재의 점도와 밀가루 대체 농도가 증가함에 따라 흡유량 감소와 지방 소화 지연 효과가 나타났다. 한편, 동일한 겉보기 점도를 보이는 수준으로 밀가루 대신 HPMC를 대체하여 제조한 유탕면에서도 겉보기 점도가 같음에도 불구하고 HPMC 자체 점도 증가(높은 중합도를 갖는 시료)에 따른 흡유량 감소와 지방 소화 지연효과를 볼 수 있었다. 이상의 결과로부터, 유탕면의 흡유량 감소와 지방 소화 지연은 겉보기 점도가 동일하다 하더라도 HPMC 자체의 높은 점도가 더 주요한 영향을 주는 것을 확인할 수 있었다.

• Journal of Microbiology and Biotechnology
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• 제14권6호
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• pp.1217-1226
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• 2004

A psychrotrophic bacterial strain, Pseudomonas fluorescens BM07, synthesized unsaturated fatty acids (UFA) from fructose in response to lowering of growth temperature, and incorporated them into both polyhydroxyalkanoic acid (PHA) and membrane lipid. The blocking of PHA synthesis by adding 5 mM 2-bromooctanoic acid to the growth medium, containing 70 mM fructose, was found to be a useful means to profile the composition of membrane lipid by gas chromatography. As the growth temperature changed from 35 to $50^{\circ}C$, the total content of two UFA, 3-hydroxy-cis-5­dodecenoic acid ($C_{12:1}$) and 3-hydroxy-cis-7-tetradecenoic acid ($C_{14:1}$), in PHA increased from 31 to 44 $mol\%$. The growth at lower temperatures also led to an increase in the level of two major UFA, palmitoleic acid (C16:1 cis9) and cis-vaccenic acid (C18:1 cis11), in membrane lipid. A fraction of these membrane-lipid UFA was converted to their corresponding cyclopropane fatty acids (CFA). The CFA conversion was a function of culture time, exhibiting biphasic increase before and after entering the stationary phase. However, pH changes in growth media had no effect on the CFA conversion, which is contrary to the case of E. coli reported. The cells grown at $30^{\circ}C$ responded to a cold shock (lowering the medium temperature down to $10^{\circ}C$) by increasing the level of C16:1 cis9 and C 18: I cis II up to that of $10^{\circ}C$-grown control cells and concomitantly decreasing the relative level of cis-9,10­methylenehexadecanoic acid (the CFA converted from C16:1 cis9) from 14 to 8 $mol\%$, whereas the 10-grown cells exhibited little change in the lipid composition when exposed to a warmer environment of $30^{\circ}C$ for 12 h. Based on this one- way response, we suggest that this psychrotrophic strain responds more efficiently and sensitively to a cold shock than to a hot shock. It is also suggested that BM07 strain is a good producer of two unsaturated 3-hydroxyacids, $C_{12:1}\;and\;C_{141:1}$.

• 한국식품영양과학회지
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• 제36권10호
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• pp.1248-1256
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• 2007

본 연구에서는 선행연구에서 우량 콩나물로 선별된 이소 플라본을 다량 함유한 콩나물의 투여가 실험적으로 유발된 고지혈증 흰쥐의 지질대사에 미치는 효과를 조사하였다. 고지혈증은 SD계 흰쥐에 cholesterol 0.5%, lard 9.3%, sodium cholate 0.2%를 함유한 AIN standard식이에 의해 유발되었다. 실험군은 정상 대조군, 고지혈증 대조군, 고지혈증 유발식이에 1%, 5% 콩나물 분말, 또는 0.2% 대두 이소플라본 추출물 보충군으로 하였다. 실험식을 4주간 투여한 후 혈장 지질과 과산화물 수준, 간조직의 항산화효소 활성도, 혈장 항산화 영양소 수준을 측정하여 다음과 같은 결과를 얻었다. 콩나물 분말의 보충 투여는 고지혈증 동물의 식이효율$(0.33{\sim}0.34)$에 영향을 미치지 않았으며 고지혈증 쥐에서 혈장 중성지질의 저하 경향을 보였으며 총 콜레스테롤 농도의 유의적인 저하효과를 나타내었다. 또한 콩나물 분말 투여는 고지혈증 동물들에서 투여량에 관계없이 혈장과 간, 신장, 심장 등 조직 중의 지질과산화물 수준을 낮추는 경향을 보였으나 그 저하효과는 대두 이소플라본 추출물의 효과보다는 낮았다. Catalase와 glutathione peroxidase 등 항산화효소들의 활성도는 고이소플라본콩나물의 투여로 대조군에 비해 유의적이지는 않았지만 증가되는 경향을 나타냈으며 혈장의 vitamin A수준은 5% 콩나물 투여군에서 유의적으로 높았고 vitamin E 수준은 유의적인 차이가 없었다. 이상의 결과로부터 이소플라본이 풍부한 콩나물의 투여는 고지혈증 동물에서 혈중지질 개선효과가 대두 이소플라본 추출물의 효과와 유사하거나 더 높은 것으로 나타났으며, 유의적이지는 않았으나 조직중 지질과산화물생성을 억제하고 항산화영양소 수준을 높이는 경향을 나타내었다. 이와 같은 결과는 본 실험에서 사용한 콩나물 시료가 높은 이소플라본 함량 이외에도 식이섬유를 다량 함유하고 있으므로 섬유에 의한 부가적인 효과에 의한 것으로 추정되며 콩나물의 영양적 우수성을 일부 입증한 결과로 평가된다.

• 한방재활의학과학회지
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• 제19권4호
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• pp.59-78
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• 2009

Objective : This study was designed to examine the effects of stem bark extracts of Cornus walteri Wanger on the lipid lowering, anti-oxidative activity and concentration of proinflammatory cytokines in hyperlipidemic rat. Methods : Male rats weighing $195.21{\pm}5.85g$ fed high fat diet for 8 weeks and 40 rats(above 400 g) were divided into 4 groups. Each groups were divided into a control group and 3 experimental groups. We fed a control group of rats a basal diet and administered normal saline(100 mg/kg, 1 time/1 day) for 4 weeks. And we fed each experimental group of rats Basal diet and administered an extract of Cornus walteri Wanger(100 mg/kg, 200 mg/kg, 300 mg/kg, 1 time/1 day) for 4 weeks. At the end of the experiment, the rats were sacrificed to determine their chemical composition. We measured lipid of plasma and liver, concentration of proinflammatory cytokines, anti-oxidative activity and gene expression. Results : 1. Concentration of plasma free fatty acid, LDL-cholesterol showed a tendency to decrease in Cornus walteri Wanger ext. groups. Concentration of plasma triglyceride, total cholesterol showed a significantly decrement in all Cornus walteri Wanger ext. group than that of control group. HDL-cholesterol showed a significantly increment in the 300 mg/kg Cornus walteri Wanger ext. group. 2. Concentration of liver total cholesterol showed a tendence to decrease in Cornus walteri Wanger ext. groups. Concentration of triglyceride liver showed a significantly decrement in all Cornus walteri Wanger ext. group than that of control group. 3. Concentration of plasma and liver TBARS showed a tendence to decrease in Cornus walteri Wanger ext. groups. The values of GSH-Px, SOD and CAT activity showed a significantly increment in the 300 mg/kg Cornus walteri Wanger ext. group than that of control group. 4. The values of plasma AST and ALT activity showed no significantly different in all treatment groups. 5. Concentration of plasma $IL-1{\beta}$, IL-6 and $TNF-{\alpha}$ showed a tendency to decrease in the Cornus walteri Wanger ext. groups. However the concentration of IL-10 in the 200 and 300 mg/kg Cornus walteri Wanger ext. groups showed a significantly increment than that of control group. Concentration of liver $IL-1{\beta}$, $TNF-{\alpha}$ and IL-10 showed no significantly difference in all treatment groups. However concentration of IL-6 in the 200 and 300 mg/kg Cornus walteri Wanger ext. groups showed a significantly decrement than that of control group. 6. In the analysis of RT-PCR, gene expression of $TNF-{\alpha}$, Apo-B, Apo-E and leptin in the Cornus walteri Wanger ext. groups showed a lower expression than that of control group. 7. The ratio of $TNF-{\alpha}$, Apo-E and leptin expression per $\beta$-actin expression in the 200 and 300 mg/kg Cornus walteri Wanger ext. showed a significantly decrement than that of control group. The ratio of Apo-B expression per $\beta$-actin expression in the 300 mg/kg Cornus walteri Wanger ext. showed a significantly decrement than that of control group. Conclusions : According to above results, in lowering lipid effect, antioxidative activity and antiinflammatory effect, the Cornus walteri Wanger ext. gives positive effect.

• 한국식품과학회지
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• 제38권5호
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• pp.674-678
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• 2006

발아현미의 섭취에 의한 흰쥐의 비만억제 및 콜레스테롤 저하 효과를 조사하기 위하여 대조군, 백미군, 현미군, 발아현미군의 4가지 처리군으로 나누어 흰쥐에 고지방, 고콜레스테롤 식이를 공급하면서 5주간 사육후 효과를 비교하였다. 체중의 경우 모든 처리군에서 유의적인 차이를 나타내지 않았으나 발아현미군에서 5주 경과후의 체중에서 $471.2{\pm}17.8\;g$으로 가장 작은 값을 나타내었다. 체중증가량과 식이효율의 경우에도 발아현미군이 각각 $310.6{\pm}14.7\;g$과 $41.8{\pm}2.0%$로 유의적인 수준은 아니지만 가장 낮은 값을 나타내었다. 혈중 중성지질 및 콜레스테롤의 경우 발아 현미군은 5주 경과시 각각 $54.0{\pm}23.4\;mg/dL$, $64.8{\pm}14.7\;mg/dL$로 백미군, 현미군에 비해 크게 낮을 뿐만 아니라 부고환지방, 신장 지방 중량에서도 낮은 값을 나타내었다. 간의 총 지질과 총 콜레스테롤에서 발아현미군은 $216.3{\pm}35.7\;mg/g$ liver 와 $16.5{\pm}0.7\;mg/g$ liver로 기타 처리군에 비해 낮은 값을 나타내었으며, 변의 총 지질, 총 콜레스테롤, 중성지질에서도 각각 $165.0{\pm}22.2\;mg/g$ feces, $26.5{\pm}2.7\;mg/g$ feces, 3.4 mg/g feces로 기타 처리군에 비해 유의적으로 높은 값을 나타내었다.

• Archives of Pharmacal Research
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• 제27권11호
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• pp.1099-1105
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• 2004

The peroxisome proliferator-activated receptors (PPARs) are a primary regulator of lipid metabolism. Potency for activation of PPAR$\gamma$, one of a subfamily of PPARs, particularly mirrors glucose lowering activity. We prepared thiazolidinediones featuring benzoxazole moiety for subtype selective PPAR$\gamma$ activators. 5-[4-[2-(Benzoxazol-2-yl-alkylamino)ethoxy]benzyl]thiazolidine-2,4-diones have been prepared by Mitsunobu reaction of benzoxazolylalkylaminoethanol 8 and hydroxybenzylthiazolidinedione 6 and their activities were evaluated. Most compounds tested were identified as potent PPAR$\gamma$ agonists.

• 한국식품영양학회지
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• 제9권2호
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• pp.116-122
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• 1996

This study aimed at the effect of carbohydrate level on serum glucose and lipid in Korean female 300 NIDDM patients. Mostly NIDDM appears in 50-64 years. As carbohydrate level increased, nutrient intakes increased. Most carbohydrate intakes were polysaccharides. High carbohydrate diets made blood glucose level increased. But high carbohydrate-fiber diets result lowering effect on serum LDL /HDL-cholesterol ratio and triacylglycerides. In conclusion, NIDDM patients need regular exercise and total energy intake balance. High carbohydrate-fiber diets are recommendable.

• Asian-Australasian Journal of Animal Sciences
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• 제27권7호
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• pp.1057-1068
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• 2014

The major goals of the poultry industry are to increase the carcass yield and to reduce carcass fatness, mainly the abdominal fat pad. The increase in poultry meat consumption has guided the selection process toward fast-growing broilers with a reduced feed conversion ratio. Intensive selection has led to great improvements in economic traits such as body weight gain, feed efficiency, and breast yield to meet the demands of consumers, but modern commercial chickens exhibit excessive fat accumulation in the abdomen area. However, dietary composition and feeding strategies may offer practical and efficient solutions for reducing body fat deposition in modern poultry strains. Thus, the regulation of lipid metabolism to reduce the abdominal fat content based on dietary composition and feeding strategy, as well as elucidating their effects on the key enzymes associated with lipid metabolism, could facilitate the production of lean meat and help to understand the fat-lowering effects of diet and different feeding strategies.

• Food Science and Biotechnology
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• 제17권3호
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• pp.457-463
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• 2008

The effects of dietary supplementation of the unrefined rice bran oil from 'Suwon 415' pigmented black rice (BRBO) on cholesterol metabolism and cellular antioxidant status were investigated in hypercholesterolemic rats. The significant reduction of total cholesterol (TC) and low density lipoprotein cholesterol (LDL-C) concentrations was observed in the plasma of rats fed BRBO. BRBO also decreased plasma and hepatic oxidative stress as a result of increased levels of hepatic thiobarbituric acid reactive substances (TBARS) levels associated with the elevations of hepatic superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GSH-Px) activities together with increased plasma level of tocopherol. This study indicates that dietary BRBO supplement can leads to the improvement of overall cholesterol metabolism and antioxidant status even more effectively than 'Chuchung' white rice (WRBO). Consumption of BRBO may also protect the liver from oxidative damage caused by lipid peroxidation.

• 생약학회지
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• 제25권3호
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• pp.272-277
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• 1994

Meliae toosendan Fructus, the seed of Pagoda tree, Melia toosendan Sieb. et Zucc. (Meliaceae), has been used as a liver protective herbal drug in the Orient. Administration of seed oil to hyperlipedemic rats revealed the lipid lowering effects in serum and liver tissue without any toxicity in body weight increase and liver function.