• 한국수정란이식학회지
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• 제30권4호
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• pp.305-313
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• 2015

Xenotransplantation of pig islet regarded as a good alternative to allotransplantation. However, cellular death mediated by hypoxia-reoxygenation injury after transplantation disturb success of this technique. In the present study, we produce transgenic pig expressing human heme oxygenase 1 (HO1) genes to overcome cellular death for improving efficiency of islet xenotransplantation. Particularly, Korean miniature pig breed, Micro-Pig, was used in the present study. Somatic cell nuclear transfer (SCNT) technique was used to produce the HO1 transgenic pig. Six alive transgenic piglets were produced and all the transgenic pigs were founded to have transgene in their genomic DNA and the gene was expressed in all tested organs. Also, in vitro cultured fibroblasts derived from the HO1 transgenic pig showed low reactive oxygen species level, improved cell viability and reduced apoptosis level.

• 터널과지하공간
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• 제25권3호
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• pp.244-254
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• 2015

모래와 자갈이 암반 위에 퇴적된 지층에서 터널의 윗부분이 지하수가 많은 모래자갈층을 통과하는 상황에서 터널을 시공하였다. 지상의 일부 곡선구간에 빌딩들도 있는 저심도 터널을 안전하게 시공하기 위하여 강도가 작고 지하수가 많은 터널천정부의 모래자갈이 터널 내로 낙하하는 유사현상(sand flow)을 예방해야 하였다. 이를 위하여 대구경강관다단그라우팅이나 제트그라우팅으로 터널주변 충적층을 굴착 전에 미리 보강한 후 터널을 시공하였다. 이와 같이 터널을 보강한 효과와 지상빌딩의 안전을 시공 중 계측을 통하여 확인하였다.

• 해양환경안전학회:학술대회논문집
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• 해양환경안전학회 2006년도 추계학술발표회
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• pp.65-69
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• 2006

물제트분사장치가 부착된 NACA-0021 익 주변의 흐름을 업자영상유속계를 이용하여 고찰하였다. $R_e=6.0261\times10^4$에서 영각 (a) 을 $0^{\circ}\sim35^{\circ}$로 변화시켜가며, 물제트분사 속도를 0[m/s], 9.2[m/s] 의 2 가지로 조절한 결과 익 후류영역에서는 박리 후 비정상적인 (unsteady) 재순환 재부착 영역이 형성되었으며, 박리영역의 폭이 콴다 효과 (Coanda effect)를 갖는 물제트분사로 인하여 최대 1/3만큼 감소하는 경향을 확인하였다. 물분사가 없는 조건에서의 박리는 영각(a) $17^{\circ}\sim18^{\circ}$부근에서 시작되는 것이 관측되었으나, 물제트분사를 시켰을 경우 $20^{\circ}\sim21^{\circ}$에서 박리가 시작되는 것을 유통관측을 통해 알 수 있었다. 유통계측을 통해 익의 후연부 (trailing edge) 에서 생성되었던 와 (vortex, eddy) 가 물제트분사로 인해 소멸되는 것을 알 수 있었고, 영각이 작고 물분사 유속이 빠를 수록 박리영역의 감소가 더욱 가속화됨을 알 수 있었다.

• 한국지구과학회지
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• 제31권4호
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• pp.322-334
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• 2010

최근 30년간(1979-2008년) 한반도 주변($32-36^{\circ}N$, $122-132^{\circ}E$)에서 태풍이 약화될 때 한국에서 나타나는 시공간적 강수 특징을 분석하였다. 약화 유형은 온대저기압으로 약화되는 태풍(Weakened to Extratropical Cyclone, WEC)과 열대성 저압부로 약화되는 태풍(Weakened to Tropical Depression, WTD)으로 구분하였다. WEC의 경우, 강수량은 전국에 걸쳐 골고루 분포하였으며 남해안에서 가장 많았다. WTD의 경우, 강수량은 남해안에서 가장 많았지만 중부 및 내륙지역은 적었다. 두 경우의 강수량 차이는 Region 2(전라남도, 경상남도, 경상북도 남동부 지역, 제주도)에서는 거의 없었으며, Region 1(중부지방, 전라북도, 경상북도 내륙)에서는 WTD보다 WEC일 때 강수량이 더 많았다. 태풍이 한반도로 접근 할 때 WEC의 경우 태풍의 북서쪽에는 상층의 발달된 잠재소용돌이도와 하층의 온도골이 위치하고 있었으며, 태풍의 북동쪽에는 상층 제트 및 강한 상층 발산역이 위치하였다. 이는 태풍 전면에 경압교란과 비단열 과정을 발달시켰고 이로 인해 강수영역이 넓게 형성된 것으로 추측되었다. 그러나 WTD의 경우에서는 강한 잠재소용돌이도나 온도골, 상층제트가 태풍 주변에 나타나지 않았으며, 이로 인해 강수영역이 좁게 형성되었다.

• Environmental Engineering Research
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• 제22권1호
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• pp.75-86
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• 2017

The aerosol content dynamics in a virtual system were investigated. The outcome was extended to monitor the mean concentration diffusion of aerosols in a predefined macro and micro scale. The data set used were wind data set from the automatic weather station; satellite data set from Total Ozone Mapping Spectrometer aerosol index and multi-angle imaging spectroradiometer; ground data set from Aerosol robotic network. The maximum speed of the macro scale (West Africa) was less than 4.4 m/s. This low speed enables the pollutants to acquire maximum range of about 15 km. The heterogeneous nature of aerosols layer in the West African atmosphere creates strange transport pattern caused by multiple refractivity. It is believed that the multiple refractive concepts inhibit aerosol optical depth data retrieval. It was also discovered that the build-up of the purported strange transport pattern with time has enormous potential to influence higher degrees of climatic change in the long term. Even when the African Easterly Jet drives the aerosols layer at about 10 m/s, the interacting layers of aerosols are compelled to mitigate its speed to about 4.2 m/s (macro scale level) and boost its speed to 30 m/s on the micro scale level. Mean concentration diffusion of aerosols was higher in the micro scale than the macro scale level. The minimum aerosol content dynamics for non-decaying, logarithmic decay and exponential decay particulates dispersion is given as 4, 1.4 and 0 respectively.

• 한국소음진동공학회:학술대회논문집
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• 한국소음진동공학회 2006년도 춘계학술대회논문집
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• pp.197-202
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• 2006

The low-altitude earth observation satellite is generally equipped with high performance camera as a main payload which is vulnerable to vibration environment. During the launch process of a satellite, the combustion and jet noise of launch vehicle produce severe acoustic environment and the acoustic loads induced may damage the critical equipments of the satellite including the camera. Therefore to predict and simulate the effect of the acoustic environment which the satellite has to sustain at the lift-off event is very important process to support the load-resistive design and test-qualification of components. Statistical Energy Analysis(SEA) has been widely used to estimate the vibro-acoustic responses of the structures and gives statistical but reliable results in the higher frequency region with less modeling efforts and calculation time than the standard FEA. In this study, SEA technique has been applied to a 3-Dimensional model of a low-altitude earth observation satellite to predict the acceleration responses on the structural components induced by the high level acoustic field in the launch vehicle fairing. In addition, the expected response on each critical component panel was calculated by the classical method in consideration of the mass loading and imposed sound pressure level, and then compared with SEA results.

• 한국추진공학회:학술대회논문집
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• 한국추진공학회 2008년 영문 학술대회
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• pp.195-201
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• 2008

In the jet engines on the aircrafts cruising at high altitude over 20 km and subsonic speed, the Reynolds number in terms of the compressor blades becomes very low. In such an operating condition with low Reynolds number, it is widely reported that total pressure loss of the air flow through the compressor cascades increases dramatically due to separation of the boundary layer and the secondary-flow. But the detail of flow mechanisms causes the total pressure loss has not been fully understood yet. In the present study, two series of numerical investigations were conducted to study the effects of Reynolds number on the aerodynamic characteristics of compressor cascades. At first, the incompressible flow fields in the two-dimensional compressor cascade composed of C4 airfoils were numerically simulated with various values of Reynolds number. Compared with the corresponding experimental data, the numerically estimated trend of total pressure loss as a function of Reynolds number showed good agreement with that of experiment. From the visualized numerical results, the thickness of boundary layer and wake were found to increase with the decrease of Reynolds number. Especially at very low Reynolds number, the separation of boundary layer and vortex shedding were observed. The other series, as the preparatory investigation, the flow fields in the transonic compressor, NASA Rotor 37, were simulated under the several conditions, which corresponded to the operation at sea level static and at 10 km of altitude with low density and temperature. It was found that, in the case of operation at high altitude, the separation region on the blade surface became lager, and that the radial and reverse flow around the trailing edge become stronger than those under sea level static condition.

• Korean Journal of Radiology
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• 제1권1호
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• pp.11-18
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• 2000

Objective: To evaluate the hydrodynamic changes occurring in cerebrospinal fluid (CSF) flow in cervical spinal stenosis using the spatial modulation of magnetization (SPAMM) technique. Materials and Methods: Using the SPAMM technique, 44 patients with cervical spinal stenosis and ten healthy volunteers were investigated. The degree of cervical spinal stenosis was rated as low-, intermediate-, or high-grade. Low-grade stenosis was defined as involving no effacement of the subarachnoid space, intermediate-grade as involving effacement of this space, and high-grade as involving effacement of this space, together with compressive myelopathy. The patterns of SPAMM stripes and CSF velocity were evaluated and compared between each type of spinal stenosis and normal spine. Results: Low-grade stenosis (n = 23) revealed displacement or discontinuity of stripes, while intermediate- (n = 10) and high-grade (n = 11) showed a continuous straight band at the stenotic segment. Among low-grade cases, 12 showed wave separation during the systolic phase. Peak systolic CSF velocity at C4-5 level in these cases was lower than in volunteers (p < .05), but jet-like CSF propulsion was maintained. Among intermediate-grade cases, peak systolic velocity at C1-2 level was lower than in the volunteer group, but the difference was not significant (p > .05). In high-grade stenosis, both diastolic and systolic velocities were significantly lower (p < .05). Conclusion: Various hydrodynamic changes occurring in CSF flow in cervical spinal stenosis were demonstrated by the SPAMM technique, and this may be a useful method for evaluating CSF hydrodynamic change in cervical spinal stenosis.

• 천문학회보
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• 제40권2호
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• pp.51.3-52
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• 2015

Gamma-Ray Bursts(GRBs) are the most violent event in the universe, whose detection rate is a few in a day. The spectral lag, which is commonly observed in the observed light curves of GRBs, is a difference in arrival times of the high-energy and low-energy photons. The relation between the spectral lag and the luminosity of the observed GRBs is shown to be anti-correlated in previous studies. In reported relations to date, the isotropic luminosity has been assumed. On the other hand, GRBs are likely to emit its energy through a beamed jet. In this study, we attempt to obtain the relation between the spectral lag and the collimation-corrected luminosity. We have calculated collimation-corrected luminosities and opening angles using the observed light curves taken from a database of Swift/BAT, XRT. We expect to increase its significance level by expanding a sample size compared with those previously analyzed.

• 한국지반공학회:학술대회논문집
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• 한국지반공학회 2010년도 춘계 학술발표회
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• pp.643-648
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• 2010

Waterjet is a very useful technology for rock excavation because of low level noise and vibration during breaking rocks. To accurately predict the volume and shape excavated by the waterjet, it is important to understand waterjet fracture mechanisms. There have been various theoretical assumptions and approaches in the literature. In this study, waterjet mechanisms are classified into three standards: a mechanism scale, theoretical assumption for a target material, and jet phase. In addition, through a waterjet experimental study for weathered and intact granitic rocks, a fracture shape is observed and analyzed on comparison with the previous mechanisms. As a result, best waterjet mechanisms are selected to explain the fracture pattern of the granitic rocks.