• Journal of Veterinary Clinics
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• v.29 no.3
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• pp.203-206
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• 2012

Treatment for heart failure is directed to reduce atrial volume overload by diuretic agents, to lessen ventricular pressure overload by vasodilatory agents and to increase myocardial performance through inotropic agents. Of those cardiac therapeutics, diuretic agents are the most important to control heart failure in dogs, although long-term use often causes detrimental side-effects such as acute renal failure and electrolyte abnormalities. Thus, this study was designed to find a new diuretic agent from medicinal herbs which has better diuretic effect and less unfavorable complications in dogs. In a preliminary study performed with 5 normal healthy dogs, the extract from Akebia quinata Decaisne showed mild to moderate diuretic effect (0.3-0.5 potency of furosemide 2 mg/kg) and minimal changes in serum chemistry and electrolyte. Although the study population was not large enough and study period was not sufficient enough, this study found a good alternative diuretic agent which can replace or reduce the use of furosemide in dogs with heart failure.

• Journal of Korean Society on Water Environment
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• v.35 no.1
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• pp.43-54
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• 2019

The objective of this study was to assess the effect of policies on water quality management based on the changes in pollutants and water quality in Special Water Preservation Area (SWPA) of Lake Paldang watershed from 1990 to 2016. The population, total sewage and flow rate of wastewater in SWPA continuously increased from 1990 to 2016, while the location of new facilities for industrial and livestock facilities has been restricted. However, unlike the buffer zone in which industrial and livestock facilities were continuously reduced after implementing of TMDL, it was found that the effect of land-use regulations on industrial and livestock facilities in SWPA were mitigated by the increase in the size of large facilities. Since 1999 when the emission standard of public sewage treatment plants (STP) was changed, the water quality of Lake Paldang has increased despite the increase of pollutant source. Since emission standard of STP changed in 2012 (BOD 5 mg/L, TP 0.2 mg/L), BOD concentration in Lake Paldang has also improved to the level of water quality in the early 1990s where as TP concentration has remained at its lowest since 1990. BOD and TP average discharge concentration of 43 STP (${\geq}500m^3/day$) in 2016 have been maintained $1.7{\pm}0.7mg/L$ and $0.06{\pm}0.02mg/L$ respectively. While the discharged load of STP in SWPA was decreased by the concentration management, the contribution rate to the total discharged load of non-point pollutants increased to 70 % in 2015, and the contribution rate to the point discharged load of individual treatment facilities increased to 80 %.

• Journal of Ecology and Environment
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• v.46 no.4
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• pp.324-333
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• 2022

Background: The Korean scarlet dwarf, Nannophya koreana Bae (Odonata: Libellulidae), is anendangered dragonfly with an increasing risk of extinction owing to rapid climate changes and human activities. To prevent extinction, the N. koreana population and their habitat should be protected. Therefore, suitable habitat evaluation is important to build the N. koreana restoration project. The habitat suitability index model (HSI) has been widely used for habitat evaluation in diverse organisms. Results: To build a suitable HSI model for N. koreana, 16 factors were examined by seven experienced researchers. A field survey for N. koreana observed sites and spatial analysis were conducted to improve the model. Five factors were finally selected by this procedure (crown density, open water surface, water depth, pioneer plant cover, and type of water source). Finally, the N. koreana HSI model was generated with the five adjusted factors based on interview, field survey, and spatial analysis. This model was validated by a current N. koreana habitat in 2021. With this model, 46 sites in Uljin-gun, Korea, were surveyed for N. koreana habitats; five sites were identified as core habitats and seven as potential core habitats. Conclusions: This model will serve as a strong foundation for the N. koreana restoration project and as a reference for future studies on N. koreana and other endangered insect populations. Further analysis and long-term data will improve the efficacy of this model and restore endangered wildlife.

• Journal of Genetic Medicine
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• v.20 no.2
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• pp.60-69
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• 2023

Purpose: Despite enzyme replacement therapy (ERT) and/or allogeneic hematopoietic stem cell transplantation, individuals with mucopolysaccharidosis (MPS) I or II often experience significant growth deficiencies. This study aimed to assess the safety and efficacy of recombinant human growth hormone (hGH) treatment in children diagnosed with MPS I or II. Materials and Methods: A total of nine pediatric patients-four with MPS I and five with MPS II-underwent treatment with ERT and hGH at Samsung Medical Center. Results: The mean hGH dose administered was 0.26±0.03 mg/kg/week. In the MPS I group, three patients showed an increase in height Z-score from -4.09±0.83 to -3.68±0.43 after 1 year of hGH treatment, and to -3.10±0.72 by the end of the hGH regimen. In the MPS II group, while the height Z-score of four patients decreased according to standard growth charts, it improved from 1.61±1.79 to 2.71±1.68 based on the disease-specific growth chart through hGH treatment. Two patients discontinued hGH treatment due to lack of efficacy after 22 and 6 months each of treatment, respectively. No new-onset neurological symptoms or necessity for prosthetic or orthopedic surgery were reported during hGH treatment. Conclusion: This study provides insights into the impact of hGH on MPS patients, demonstrating its potential to reverse growth deceleration in some cases. Further research is needed to explore the long-term effects of hGH on changes in body composition, muscle strength, and bone health in this population.

• Journal of Korean Academy of Rural Health Nursing
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• v.19 no.1
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• pp.55-65
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• 2024

Purpose: This study was intended to gain an in-depth understanding of and explored the experiences and meanings of participating in care services among community-dwelling older adults. Methods: A focus group interview approach was adopted. Twenty older adults were interviewed from November to December 2021 using semi-structured interview questions. The data was analyzed using thematic analysis. Results: Three main themes and seven sub-themes emerged for the elderly people living alone. One main theme was "ambivalence of elderly care services," the second was "desperate need for care services," and the third was "positive changes and expectations experienced with care services." For the elderly people living with their families, two main themes and four sub-themes were identified. One main theme was "care services met within the family system," the second was "needs for care services outside the family system." Conclusion: We aim to provide a basis for strengthening the quality of elderly community care services in the mid- to long-term and establish a system of close linkages between necessary services by understanding the needs of elderly people who live alone or with their families.

• Korean Journal of Environment and Ecology
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• v.36 no.2
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• pp.177-201
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• 2022

Following the adoption of the global plant conservation strategies at the Conference of the Parties for Biodiversity Conservation, diligent actions to achieve each targets are actively carried out. In particular, the need for ecological conservation research to achieve targets 2 and 7 of GSPC-2020 has increased. The priority taxa to accomplish the objectives of GSPC-2020 are rare and endemic plants. In particular, endemic plants with limited distribution in specific regions are evaluated to face a high risk of extinction. To address the necessity to preserve endemic plants, we investigated the distribution of Prunus choreiana H. T. Im, a Korean endemic plant. After that, we examined the vegetational environment of the habitat of P. choreiana and evaluated its population structure. The productivity of its fruits and the effects of pollinators on fruit production were evaluated as well. The fruiting ratio was calculated based on the number of flowers produced. Lastly, we observed the annual growth characteristics of P. choreiana. The habitats of P. choreiana did not show a specific type of vegetation. All of them were located in a limestone area of Gangwon-do in the central Korean Peninsula and occupied a site where the coverage of the tree layer and the sub-tree layer was not high or did not exist. The population structure of P. choreiana contained a high proportion of mature plants capable of producing fruits and a low proportion of seedlings and Juvenile plants. We found that the production of fruits required pollinators and was affected by the performance of each plant. Although P. choreiana produces many flowers, only a maximum of 20% and only 2-6% on average bear fruits. These flowering characteristics may be due to pollinators' low abundance and activity during the flowering season (between mid-March and early April), suggesting that many flowers are needed to attract more pollinators. We rarely observed the re-establishment of seedlings in the population of P. choreiana. Despite that, we predict the population to persist owing to its long lifespan and periodic production of numerous fruits. However, if the tree layer and sub-tree layer in competing status with P. choreiana increase their crown density, they are expected to inhibit the growth of P. choreiana and affect the risk of its extinction. Therefore, the current changes in the vegetational environment of the habitats are expected to decrease the number and extent of P. choreiana in the long term. The results of this study may serve as primary and important data necessary for the achievement of GSPC-2020 objectives.

• Journal of the Korean Society of Marine Environment & Safety
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• v.22 no.2
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• pp.160-166
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• 2016

Crew fatigue has been recognized as a major cause of maritime accidents. Systematic study on crew fatigue has a direct impact on the human factor, but the various measures being taken to prevent human error account for most of the causes of marine accidents situation are still insufficient. In this study, 128 people who have a variety of career and job types boarded the T/S Hanbada were analyzed the changes of fatigue during the 87-days a Maritime Silk Road Sailing Expedition. Crew fatigue was measured by period of time onboard classified as mental, physiological and physical changes through survey responses and individual interviews of nurses. Also, it was identified the fatigue factor through quantitative statistical analysis. As a result of repeated measures analysis of variance for the changes of fatigue in position and gender criteria in accordance with boarded period, the position-specific analysis was that Professor Rating group has appeared to feel more mental and physical fatigue than the student population. Also, the results of fatigability about the sex-specific analysis have been found that women feel more physical fatigue than men.

• Journal of the Korean Geographical Society
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• v.40 no.6 s.111
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• pp.730-747
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• 2005

This study examines relationships between climatic factors and spatial-temporal patterns and recent changes of tropical night phenomenon(TN) occurring through nighttime stages in South Korea. Frequencies of daily TN at different times of night are extracted from long term(1973-2004) 6 hourly nighttime(9PM and 3AM) temperature and daily minimum temperature data at 61 weather stations. Temporally, the occurrences of TN are more pronounced in the evening(9PM) and during the Changma Break period(late July - early August). Spatially, the TNs in the evening frequently occur in the urbanized inland cities at low latitudes due to urban heat islands, whereas the TNs in the middle of night(3AM) or at dawn frequently appeared along the coastal areas within 30km from ocean due to the thermal inertia of ocean. By contrast, the evening(dawn) TN is not seen in the highlands whose elevation is greater than 800m(300m) along the Taebaek and Sobaek mountain ridges due to temperature lapse rates with height Correlation and multivariate regression analyses reveal that the impacts of human or physical climatic factors, such as latitude, elevation, proximity to ocean, and population density, are diverse on the frequencies of TN according to nighttime stages. Recent temporal changes of the late Changma period and intensified urbanization during the 1990s have increased the occurances of TN in urban areas. Therefore, strategies to mitigate the increasing urban TN should be prepared in the near future.

• Health Policy and Management
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• v.27 no.2
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• pp.167-176
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• 2017

Background: This study aimed to analyze the impact of community health care resources on the place of death of older adults with dementia compared to those with cancer in South Korea, using public administrative big data. Methods: Based on a literature review, we selected person- and community-level variables that can affect older people's decisions about where to die. Data on place-of-death and person-level attributes were obtained from the 2013 death certification micro data from Statistics Korea. Data on the population and economic and health care resources in the community where the older deceased resided were obtained from various open public administrative big data including databases on the local tax and resident population statistics, health care resources and infrastructure statistics, and long-term care (LTC) insurance statistics. Community-level data were linked to the death certificate micro data through the town (si-gun-gu) code of the residence of the deceased. Multi-level logistic regression models were used to simultaneously estimate the impacts of community as well as individual-level factors on the place of death. Results: In both the dementia (76.1%) and cancer (87.1%) decedent groups, most older people died in the hospital. Among the older deceased with dementia, hospital death was less likely to occur when the older person resided in a community with a higher supply of LTC facility beds, but hospital death was more likely to occur in communities with a higher supply of LTC hospital beds. Similarly, among the cancer group, the likelihood of a hospital death was significantly lower in communities with a higher supply of LTC facility beds, but was higher in communities with a higher supply of acute care hospital beds. As for individual-level factors, being female and having no spouse were associated with the likelihood of hospital death among older people with dementia. Conclusion: More than three in four older people with dementia die in the hospital, while home is reported to be the place of death preferred by Koreans. To decrease this gap, an increase in the supply of end-of-life (EOL) care at home and in community-based service settings is necessary. EOL care should also be incorporated as an essential part of LTC. Changes in the perception of EOL care by older people and their families are also critical in their decisions about the place of death, and should be supported by public education and other related non-medical, social approaches.

• Tuberculosis and Respiratory Diseases
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• v.59 no.6
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• pp.619-624
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• 2005

Background : The drug resistance rate in tuberculosis patients with history of chemotherapy is an important indicator of for evaluation of appropriateness of treatment regimens and compliance of patients. This study examined the long-term changes in the drug resistance rates among TB patients failed in treatment or reactivated. Methods : The results of drug susceptibility testing data from patients registered in health centers from 1981 to 2004 were analyzed. Results : The rate of resistance to isoniazid decreased from 90% to 20%, and the resistance to ethambutol decreased from 45% to 6%. The rate of resistance to rifampicin varied from 13% to 28% and the resistance to pyrazinamide was 5% to 10%. Multidrug resistance was about 2-3% lower than any rifampicin resistance rates. The second-line drug resistance was ranged from 1% to 3%. There was no difference between patients' genders. Patient numbers per 100,000 population increased with age. The regional distribution was even at 4-6 patients per 100,000 population, and drug resistance rates were significantly lower in big city areas than in small towns and rural areas. Conclusion : The rates of resistance of Mycobacterium tuberculosis isolated from TB patients with history of chemotherapy to isoniazid, rifampin, ethambutol, and isoniazid plus rifampin were significantly decreased during over two decades.