• Journal of Physiology & Pathology in Korean Medicine
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• v.20 no.2
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• pp.494-497
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• 2006

A child with five delay, five ankylosis, five weakening needs to take herbal medicine for a long term. So safety, efficacy inspection for the long term usage of herbal medicine and mixed dose is needed because other medication or functional health foods, etc could be taken during this process. Operated liver function test before and after dosing herbal medicine to one hundred and sixty children who aided private oriental medicine located in Seoul, and measured the efficacy by comparing sleeping hours, morbidity, stamina, sanguineness, personality, digestion with the state before taking herbal medicine based on questionnaire done by the parents. Every children were under the limits, and there were no differences between boys and girls, and no notable differences according to family histories. There were positive results in efficacy inspection ordered as improvement in personality, stamina, sanguineness, decrease in morbidity, increase in appetite, digestion. No signs of disorder in liver function has been found during the dose of herbal medicine or simultaneous medicine, and shown promotion of health.

• The Journal of Korean Medicine
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• v.32 no.6
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• pp.112-116
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• 2011

Objectives: To inform the clinical features of drug-induced liver injury (DILI), and study traditional Korean medicine (TKM)-based strategies or therapeutics. Methods: A female patient with hepatitis after long term use of medication for cold symptoms was treated with Oriental therapies, after which the clinical outcome was evaluated by serum biochemical parameters and ultrasonography. Results: Clinical and biochemical levels were fluctuating during administration of cold medicine, but the patient completely recovered her health with herbal medicines. Conclusion: This case report would provide information about a typical DILI by western medicine followed by treatment with traditional Korean medicine.

• Proceedings of the Korean Environmental Health Society Conference
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• 2005.11a
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• pp.183-184
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• 2005

• Journal of Society of Preventive Korean Medicine
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• v.6 no.1
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• pp.129-139
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• 2002

This research purpose was to get urine and hair metal correlation by Spearman methods in subjects with long term intake of herbal medicine. And that result can help research for metal absorption mechanism in body. Subjects have been intake 1-124 months(7.55 months mean) in decoction and 1-60 months (1.27 months means) for some disease treatment in sampling point. 1) Metal concentrations in urine and hair of study subjects showed higher than WHO reference limits, especially 0.32-6.17% in urine and 11.69-26.95% in hair. 2) Metal concentration in urine correlated 0.37(p〈0.001) Cu to Cd, 0.37(p〈0.001) Pb to Cu, 0.29(p〈0.001) Pb to Cu, 0.29(p〈0.001) Pb to Cd, and 0.36(p〈0.001) Pb to Cu, -0.13(p〈0.05) Hg to Cu in hair. Also between urine and hair correlated 0.21(p〈0.001) Cd to Cd. 0.17(p〈0.01) Pb to Pb, -0.06 Cu to Hg, -0.01 Hg to Cu. These results showed that occur physical and chemical reaction among many metals in body, respectively. However, further study related this subjects will be need.

• Herbal Formula Science
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• v.19 no.2
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• pp.83-92
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• 2011

Objectives : This study was carried out to moniter microbial flora on freeze-dried herbal powder and identify isolated bacteria. Methods : We measured the total number of bacteria and fungi in 29 herbal powder which had made according to the guideline of KFDA. For the identification, we observed microscopic properties and carried out polymerase chain reaction(PCR). The purified DNA was analyzed by DNA sequencer. Results : Among the 29 herbal powders, the fungi were detected only one sample as unacceptable range of total aerobic bacteria. Isolated bacteria were identified as Bacillus cereus, B. subtilis, B. megaterium, B. licheniformis, Erwinia tasmaniensis, E. amylovora, and Pantoea agglomerans by 16S rDNA analysis. E. tasmaniensis was observed 20 herbal samples. Conclusions : According to above results, further studies for the effective sterilization of low herbal materials should be needed.

• The Journal of Internal Korean Medicine
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• v.40 no.5
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• pp.983-989
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• 2019

Objective: Many types of delayed adverse reactions, such as long-term numbness, occur after injecting contrast medium, but few clinical studies have reported effective treatments for these reactions. We report that herbal medicine can have a positive clinical effect in patients who have experienced long-term numbness after contrast medium injection. Method: A patient who had felt numbness in her head and whole limbs presented at Semyung University Korean Medicine hospital. Her numbness had first started 2 days after injection of contrast medium, and she had felt it constantly for almost 2 years. After admission at the hospital, she took "modified Samul-tang" herbal medicine (120 cc three times per day) from 29 January 2019 to 2 February 2019. We measured her numbness using a numeric rating scale (NRS) on 29 January and 2 February and we compared both scores to determine the degree of favorable and clinical effects of herbal medicine. Result: The NRS score for numbness was 5 for her head and limbs on the first day (29 January), but after 4 days (2 February), the NRS score decreased to 0 for her head and both arms and hands, and it decreased from 5 to 2 for both her legs and feet. Conclusion: Korean herbal medicine can have positive clinical effects on treating adverse reactions due to injection of contrast medium.

• The Journal of Internal Korean Medicine
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• v.23 no.2
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• pp.222-227
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• 2002

Although there are a few reports concerning the side effects and toxicity of herbal medicines, there has not yet been any report concerning their causes, mechanisms or prevention. We investigated the internal reports concerning the side effects and toxicity of herbal medicines. In the findings, liver disorder (hepatic injury) was found in 7 cases, kidney disorders (nephropathy) were found in 12 cases, heart disorders were found in 4 cases and mineral-caused diseases were found in 2 cases. Besides, we found the major cause of the side effects and toxicity was drug abuse, such as over-dosage and long term medication. So, we hope this report brings more attention to the safety and toxicity of herbal medicines.

• The Journal of Internal Korean Medicine
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• v.27 no.3
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• pp.572-578
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• 2006

Objectives : This study investigated whether taking herbal medicine over the long-term had any side effects of liver damage. Methods : We checked LFT levels of the 58 admitted patients. Results : When we compared admission LFT levels with discharge LFT levels, we found the levels of AST, ALT and LDH had decreased. This test showed statistically significant decrease. When we compared admission LFT levels with discharge LFT levels, we found the increases of discharge LFT levels fell within the standard deviation. When we compared admission LFT levels with discharge LFT levels, we found the levels of LFT did not increase as much as two standard deviations. Conclusions : According to the above results, taking herbal medicine over a long-term did not have any side effects of drug-induced liver damage.

• The Journal of Korean Medicine
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• v.34 no.4
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• pp.56-62
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• 2013

Objectives: Hepatocellular carcinoma patients have a poor prognosis and survival beyond 5 years is very rare in spite of western treatment. We report a case of long-term survival of a hepatocellular carcinoma patient treated by Korean medicine combined with western therapy. Methods: The treatment was provided from November 2004 to July 2012. Herbal medicine, acupuncture and moxibustion treatment were used as main treatment methods. We prescribed herbal medicines three times a day and performed acupuncture and moxibustion an average of 2-3 times a week. Clinical laboratory tests were performed each month and a CT scan was carried out 13 times during the treatment period. In order to evaluate the disease status, we checked the patient's abdominal circumference, weight change and subjective symptoms regularly. Results: During treatment, subjective symptoms of the patient and state of ascites due to hepatocellular carcinoma were relatively stable. The progress of hepatocellular carcinoma was gradual without worsening rapidly. Since the initial diagnosis with hepatocellular carcinoma, the patient survived for a further 7 years and 9 months treated by Korean medicine combined with western treatment. Conclusions: According to the above results, this case indicates that Korean medical treatment combined with western therapy for hepatocellular carcinoma patients has synergistic effects of prolonged survival, relief of symptoms and management of complications.

• The Journal of Korean Obstetrics and Gynecology
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• v.35 no.4
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• pp.57-76
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• 2022

Objectives: This review is aimed to figure out the effectiveness of herbal medicine for treating threatened abortion by analyzing randomized controlled trials. Methods: We searched relevant studies using seven databases including 4 domestic databases and 3 foreign databases. Data retrieval was conducted on May 18, 2022. and the papers published from January 1, 2018 to May 18, 2022 were included. The risk of bias was assessed by using Cochrane's risk of bias tool. Results: 182 studies were searched in domestic and foreign databases, and 9 studies were finally selected. Among 9 studies, the treatment group was treated with only oral herbal medicine in 4 studies and with combined treatment of herbal medicine and western medicine in 5 studies. On the other hand, the control group was treated with only western medicine. In all 9 studies, evaluation indexes in the treatment group showed more effectiveness than those of the control group, evaluation indexes were different for each study though. Conclusions: Herbal medicine was more effective for treating threatened abortion whether using it alone or combining with western medicine compared to using western medicine alone. Additional studies which include large number are needed to confirm long-term effectiveness and safety of herbal medicine treatment.