• Title/Summary/Keyword: Lon

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Effect of Bile Salt on the Pharmacokinetics of Bretylium in the Rat (I) - Increased Lipophiiicity of Bretylium by Ion-Pair Complexation with Taurodeoxycholate -

  • Shim, Chang-Koo;Chung, Suk-Jae;Lee, Jeong-Uk;Lee, Min-Hwa;Kim, Shin-Keun
    • Archives of Pharmacal Research
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    • v.9 no.2
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    • pp.111-114
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    • 1986
  • Bretylium tosylate is a quaternary ammonium compound used for the treatment of ventricular fibrilation in humans. It is advantageous to other cationic compound in the study of biliary excretion in that negligible amount is bound to plasma protein and metabolite is not likely is to be formed. Some researchers reported that the formation of ion-pair complex caused to increase the lipothilicity of cationic compound. The partition of bretylium between water and organic phase was increased with the addition of sodium taurodeoxycholate. Also sensitive gas chromatographical assay procedure using flame ionization detector was studied. This procedure can detect as low as 0.1 mg/ml using 0.1 ml biological sample, but contamination by previous injection is the major problem of this method.

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A Study on the Development of Hybrid Micro Power Sources for the IMT2000 (IMT2000을 위한 혼성마이크로 동력원 개발에 관한 연구)

  • Kim il-Song;Youn Myung-Joong;Kim Jung-Han;Ju Hun
    • The Transactions of the Korean Institute of Power Electronics
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    • v.10 no.2
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    • pp.203-210
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    • 2005
  • A study on the hybrid micro power source for the IMT2000 application has been presented. The hybrid micro power source is composed of solar cell, super-capacitor and battery. To compensate for the pulse loader of the IMT2000 application, the super-capacitor is connected through the lithium-lon battery to absorb the pulse discharge current. The solar cell provides the additional current to compensate for the depleted current and it is controlled to operate at the maximum power point voltage. A novel maximum power point tracking method is presented to operate at the pulse discharge load conditions and verified to have superior tracking performance through experiment. The controller design for the hybrid micro power source has been presented and verified through experiment.

Assessment of Risk in Wireless-Wired Network Based Control of Indoor Air Quality (IAQ) in Subway Stations (유무선 네트워크기반 지하철역사 공기질 제어의 위험성 평가)

  • Choi, Gi Heung
    • Journal of the Korean Society of Safety
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    • v.29 no.1
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    • pp.1-6
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    • 2014
  • With increasing number of citizen using subway stations everyday, safety, health and comfort of passengers and occupants became an important social issue. Considering the fact that various physical variables and pollutants are related to indoor air quality (IAQ) which may cause health problem, IAQ need to be closely monitored and controlled in multiple locations in subway stations. This study is a continuation of the previous studies and delay induced in wireless-wired network is experimentally evaluated and the risk involved is assessed. In doing that, a key parameter is identified to be the network delay in different network media. Application of information-theoretic measure to assess the risk in network delay is then discussed. The idea is based on the general principles of engineering design and their applications to quantification of uncertainty in network delay. Experimental results show that more risk is involved in wireless data communication. Efficient and fast conversion of transmission data in both LonWorks/IP server and ZL converter is also noted.

Basic Study for Development of Denitrogenation Process by lon Exchange I. Batch Experiment (이온교환법에 의한 탈질소공정개발의 기초연구 I. 회분식 실험)

  • Chae, Yong-Gon;Lee, Dong-Hwan;Kim, Jang-II;Yoon, Tae-Kyung;Ju, Chang-Sik;Lee, Min-Gyu
    • Journal of Life Science
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    • v.7 no.2
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    • pp.73-78
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    • 1997
  • Ion exchange performence to remove nitrate in water studied using commercially available strong vase anin exchange resin of $Cl^{-}$ type in the batch reactors. Anion exchange resin was more effective than activated carbon or zeolite. With large resin amount or high temperature or low initial concentration, nitrate removal characteristics for a typical gel-type resin was increased. The curves showed the generally accepted selectivity sequence as ${SO_4}^{2-}>{No_3}^->NO_{2-}>{HCO_3}^-$.

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EIA 709.1 프로토콜 기반의 원격에서 응용 프로그램을 구동시킬 수 있는 홈 자동화 제어기 개발

  • 이창은;박준희;손영성;문경덕
    • Proceedings of the Korean Information Science Society Conference
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    • 2002.10c
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    • pp.703-705
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    • 2002
  • 본 논문에서는 홈 자동화 네트워크의 대표적으로 자리잡고 있는 론웍스(Lonworks) 시스템의 하드웨어 플랫폼인 뉴론칩(Neuron) 기반의 노드를 대신하는 새로운 구조를 갖는 홈 자동화 제어기를 제안한다. 기존의 론웍스 해답(Solution)은 8비트 프로세서인 뉴론칩을 모든 노드들이 중앙처리장치로 사용하므로 고성능의 처리를 필요로 하는 응용 프로그램은 구현할 수 없었다. 또한 뉴런C(Neuron C) 언어를 사용하여 응용 프로그램을 개발하므로 C 언어에서 파생된 언어인 뉴런C 언어를 새롭게 배워야 하는 번거로운 점을 가지고 있으며, 뉴런C 컴파일러(Compiler)를 비롯한 LonMaker 등의 고가의 개발 장비를 구비해야 하므로 개발자로 하여금 개발비용에 대한 부담이 컸다. 이에 본 논문에서는 처리능력이 뛰어나며 저전력 특성을 갖춘 스트롱암(SA1110)칩을 메인 프로세서로 사용한 홈 자동화 제어기인 ECONICS를 개발했다. 이 ECONICS는 홈 제어 네트워크를 구성하기 위해 통신 하드웨어 및 ANSI 표준 프로토콜인 EIA709.1 통신 프로토콜 스택을 가지고 있다. 제안된 홈 자동화 제어기를 통하여 기존의 론웍스 노드에서 구현하기 힘든 다양하고 복잡한 응용프로그램을 구현할 수 있게 되었고, 제안된 홈 자동화 제어기의 상업적 유용성을 증명하기 위해 기존의 론웍스 노드들과의 호환성을 확인하였으며 개발자로 하여금 기존의 C 언어를 통하여 응용프로그램을 개발하게 함으로써 추후 홈 자동화 제어기로써 파급효과가 클 것이다.

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Morphological Characterization of small, dumpy, and long Phenotypes in Caenorhabditis elegans

  • Cho, Joshua Young;Choi, Tae-Woo;Kim, Seung Hyun;Ahnn, Joohong;Lee, Sun-Kyung
    • Molecules and Cells
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    • v.44 no.3
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    • pp.160-167
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    • 2021
  • The determinant factors of an organism's size during animal development have been explored from various angles but remain partially understood. In Caenorhabditis elegans, many genes affecting cuticle structure, cell growth, and proliferation have been identified to regulate the worm's overall morphology, including body size. While various mutations in those genes directly result in changes in the morphological phenotypes, there is still a need for established, clear, and distinct standards to determine the apparent abnormality in a worm's size and shape. In this study, we measured the body length, body width, terminal bulb length, and head size of mutant worms with reported Dumpy (Dpy), Small (Sma) or Long (Lon) phenotypes by plotting and comparing their respective ratios of various parameters. These results show that the Sma phenotypes are proportionally smaller overall with mild stoutness, and Dpy phenotypes are significantly stouter and have disproportionally small head size. This study provides a standard platform for determining morphological phenotypes designating and annotating mutants that exhibit body shape variations, defining the morphological phenotype of previously unexamined mutants.

A study on the type of Bi(肥) and Su(痩) of Body in 'Yellow Emperior's Nei-Ching' (${\ll}$내경(內徑)${\gg}$을 중심(中心) 한 체형(體型)의 비수(肥痩)에 대(對)한 고찰(考察))

  • Chun, Tae Kang;Hong, Won Sik
    • Journal of Korean Medical classics
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    • v.6
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    • pp.176-188
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    • 1993
  • After studing on the type of Bi(肥) and Su(痩) of Body in 'Yellow Emperior's Nei-Ching', I reached the following conclusions; 1. The specific charactor of bi(肥) and su(痩) were explained in table 1. 2. The specific charactor of gi(脂), ko(膏) and youk(肉) were explaned in table 2. 3. Obserbing the type of bi(肥) and su(痩) by the view of YinYang(陰陽), bi(肥) belongs to Yin(陰) and su(痩) belongs to Yang(陽). Also the each of bi(肥) and su(痩) could obserbed by the view of YinYang(陰陽). The type of su(痩) easily becomes to yanghea(陽虛) because chi(氣) easely becomes to exhaust also easely becomes to yinhea(陰虛) because blood(血) easely becomes to exhaust. So the outer of body is cold, the inner of body is hot. The type of bi(肥) easely causes YinYang(陰陽) to exceed because blood(血) easely becomes to black and turbid(血黑以濁), chi(氣) easely becomes to rough and slow(氣澁以遲). So the outer of body is hot, the iner of body is cold 4. Obserbing the type of bi(肥) and su(痩) by the view of viscera, in view of upper and lower(上下觀點) su(痩) is yang(陽) so heart and lung belongs to su(痩) bi(肥) is yin(陰) so liver and kidney belongs In bi(肥). in view of inner and outer(內外觀點) su(痩) is inner(內) so heart 3I1d liver belongs In su(痩) bi(肥) is outer(外) so lung and kidney belongs to bi(肥). 5. Obserbing the type of bi(肥) and su(痩) by the view of body constitution(體質), partially body constitution was divided into gi(脂), ko(膏) and youk(肉), entirely there was OhtaeinLon(五態人論) and four constitutional medicine(四象醫學) I thing that taeyangin(太陽人) and soyangin(少陽人) belong to su(痩), taeyinin(太陰人) and soyinin(少陰人) belong to bi(肥).

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Microbe Adhesion and Organic Removal from Synthetic Wastewater Treatment using Polypropylene Media Modified by Ion-Assisted Reactions (이온 보조 반응에 의하여 활성화된 폴리프로필렌 담체를 이용만 합성폐수 처리시 미생물 부착 및 유기물의 제거)

  • Seon, Yong-Ho;Han, Sung;Koh, Seok-Keun
    • KSBB Journal
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    • v.17 no.3
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    • pp.235-240
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    • 2002
  • The surface of polypropylene was modified by 1 keV $Ar^+$ ion beam in an $O_2$ environment in order to enhance wettability. Contact angle of deionized water on modified polypropylene was reduced from $78^{\circ}$to $22^{\circ}$. The enhanced wettability is originated from newly formed functional groups such as ether, carbonyl, and carbonyl groups. During immersion in deionized water, the enhanced wettability has remained nearly same. After washing in water, the hydrophilic functional groups on the polymer surface have been very stable. The modified polypropylene was adopted as bio-film media to remove organics in synthetic wastewater. Microbe adhesion on the polypropylene surface was improved due to the newly formed hydrophilic groups.

Simultaneous Saccharification and Extractive Fermentation for Lactic Acid Production (동시당화 및 추출발효에 의한 Lactic Acid 생산)

  • 공창범;우창호;최실호;윤현희
    • KSBB Journal
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    • v.14 no.2
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    • pp.212-219
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    • 1999
  • lactic acid production from cellulose by simultaneous saccharification and fermentation(SSF) was studied. The SSF using cellulase enzyme Cytolase CL and Lactobacillus delbrueckii was strongly inhibited by the end product(lactic acid). An ion-exchange resin(RA-400) was used for in-situ product removal during SSF. The sorption capacity of the resin was 200mg/g-resin. The simple SSF and the extractive SSF resulted in lactic acid concentrations of 30.4g/L and 32.0g/L, respectively, at the initial substrate concentration of 50g/L. A model was developed to simulate the extractive SSF. The lactic acid conversion for the initial substrate of 100g/L was estimated to be improved from 60% to 09% by in-situ product removal. The experimentally determined kinectic parameters were pH dependent, and fitted as empirical expressions to establish their values at different pH's. Lactic acid productivity was predicted to be maximum at pH 4.5-5.0.

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Long-Term Follow-Up Clinical Courses of Cerebellar Hemangioblastoma in von Hippel-Lindau Disease : Two Case Reports and a Literature Review

  • Lee, Seung-Hwan;Park, Bong-Jin;Kim, Tae-Sung;Um, Young-Jin
    • Journal of Korean Neurosurgical Society
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    • v.48 no.3
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    • pp.263-267
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    • 2010
  • Although cerebellar hemangioblastomas are histopathologically benign, they yield a degree of malignant clinical behavior in long-term follow-up. We present two cases of long-term progression of renal cell carcinoma, which had been diagnosed as renal cysts during treatment for cerebellar hemangioblastoma. A 14-year-old male with von Hippel-Lindau disease was admitted for a cerebellar hemangioblastoma with multiple spinal hemangioblastomas and a renal cyst. After primary total resection of the cerebellar hemangioblastoma, the patient required two further surgeries after 111 and 209 months for a recurrent cerebellar hemangioblastoma. Furthermore, he underwent radical nephrectomy as his renal cyst had progressed to renal cell carcinoma 209 months after initial diagnosis. A 26-year-old male presented with multiple cerebellar hemangioblastomas associated with von Hippel-Lindau disease and accompanied by multiple spinal hemangioblastomas and multiple cystic lesions in the liver, kidney, and pancreas. He underwent primary resect'lon of the cerebellar hemangioblastoma in association with craniospinal radiation for multiple intracranial/spinal masses. Unexpectedly, a malignant glioma developed 83 months after discovery of the cerebellar hemangioblastoma. At the same time, renal cell carcinoma, which had developed from an initial renal cyst, was diagnosed, and a radical nephrectomy was performed. In the view of long term clinical course, cerebellar hemangioblastoma associated with von Hipple-Lindau disease may redevelop even after primary total resection. In addition, associated lesions such as renal cysts may also progress to malignancy after the passing of a sufficient length of time.