• Asian-Australasian Journal of Animal Sciences
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• 제9권5호
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• pp.533-538
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• 1996

The rate and extent of digestion of dietary carbohydrates has a tremendous impact on ruminal fermentation and the productivity of the animals. The objective of the study was to determine the dry matter (DM) and neutral detergent fiber (NDF) degradabilities and rate and extent of feed byproducts (cotton seed cake, wheat bran), legumes [berseem (Egyptian clover), lucern (Medicago sativa), cowpeas (Vigna sinensis)], grasses [maize (Zea mays), millet (Panicum miliaceum), sorghum (Sorghum vulgare)] and wheat straw in ruminally fistulated male buffalo calves. By using nylon bags, 10 grams sample was exposed to the ruminal fermentation for 0, 1, 2, 4, 6, 10, 16, 24, 36, 48 and 96 hours. Dry matter and NDF degradability was measured at 48 hours. Extent of DM and NDF disappearance was determined at each time point. Rates of disappearance of DM and NDF were determined by regressing the natural logarithm of the percentage of original DM and NDF remaining in the bags between 1 and 96 hours. The dry matter digestibility (DMD) of the feed byproducts (FBP) and legume forages when incubated in the rumen of male buffalo calves were greater (p < 0.05) than grasses. Extent of digestion followed similar pattern as DMD. Rate of DMD was higher in FBP than in legumes and was the lowest in the wheat straw. The NDF degradability (NDFD) of FBP, legumes and grasses did not differ, however, wheat straw had the lowest NDFD from all the feeds tested. The lowest NDFD of wheat straw may have been due to the depressing effect of lignin on fiber digestion. The FBP and legumes had higher (p < 0.05) rates and lower extents of NDF digestion than grasses.

• Structural Engineering and Mechanics
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• 제61권4호
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• pp.527-538
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• 2017

The evaluation of the loss-of-support conditions of frictional beam-to-column connections using simplified numerical models describing the transverse response of a portal-like structure is presented in this paper considering the effects of the seismic-hazard disaggregation. Real earthquake time histories selected from European Strong-motion Database (ESD) are used to show the effects of the seismic-hazard disaggregation on the beam loss-of-support conditions. Seismic events are classified according to different values of magnitudes, epicentral distances and soil conditions (stiff or soft soil) highlighting the importance of considering the characteristics of the seismic input in the assessment of the loss-of-support conditions of frictional beam-to-column connections. A rigid and an elastic model of a frame of a precast industrial building (2-DoF portal-like model) are presented and adopted to find the minimum required friction coefficient to avoid sliding. Then, the mean value of the minimum required friction coefficient with an epicentral distance bin of 10 km is calculated and fitted with a linear function depending on the logarithm of the epicentral distance. A complete parametric analysis varying the horizontal and vertical period of vibration of the structure is performed. Results show that the loss-of-support condition is strongly influenced by magnitude, epicentral distance and soil conditions determining the frequency content of the earthquake time histories and the correlation between the maxima of the horizontal and vertical components. Moreover, as expected, dynamic characteristics of the structure have also a strong influence. Finally, the effect of the column nonlinear behavior (i.e. formation of plastic hinges at the base) is analyzed showing that the connection and the column are a series system where the maximum force is limited by the element having the minimum strength. Two different longitudinal reinforcement ratios are analyzed demonstrating that the column strength variation changes the system response.

• Asian-Australasian Journal of Animal Sciences
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• 제33권4호
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• pp.670-677
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• 2020

Objective: Interleukin-6 (IL-6) is a T cell-derived B cell stimulating factor which plays an important role in inflammatory diseases. In this study, the pharmacokinetic properties of LMT-28 including physicochemical property, in vitro liver microsomal stability and an in vivo pharmacokinetic study using BALB/c mice were characterized. Methods: LMT-28 has been synthesized and is being developed as a novel therapeutic IL-6 inhibitor. The physicochemical properties and in vitro pharmacokinetic profiles such as liver microsomal stability and Madin-Darby canine kidney (MDCK) cell permeability assay were examined. For in vivo pharmacokinetic studies, pharmacokinetic parameters using BALB/c mice were calculated. Results: The logarithm of the partition coefficient value (LogP; 3.65) and the apparent permeability coefficient values (P_app; 9.7×10^-6 cm/s) showed that LMT-28 possesses a moderate-high cell permeability property across MDCK cell monolayers. The plasma protein binding rate of LMT-28 was 92.4% and mostly bound to serum albumin. The metabolic half-life (t_1/2) values of LMT-28 were 15.3 min for rat and 21.9 min for human at the concentration 1 μM. The area under the plasma drug concentration-time curve and C_max after oral administration (5 mg/kg) of LMT-28 were 302±209 h·ng/mL and 137±100 ng/mL, respectively. Conclusion: These data suggest that LMT-28 may have good physicochemical and pharmacokinetic properties and may be a novel oral drug candidate as the first synthetic IL-6 inhibitor to ameliorate mammalian inflammation.

• 한국음향학회지
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• 제35권1호
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• pp.49-54
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• 2016

본 논문에서는 커널 백피팅 알고리즘에 가중 ${\beta}$-지수승 최소평균제곱오차 추정방식(weighted ${\beta}$-order minimum mean square error: WbE)을 적용한 보컬음 분리 방식에 대해 제안한다. 음성 향상 방식에서, WbE는 진폭 성분 기반 MMSE(Minimum Mean Square Error) 추정방식, 로그 스펙트럼 진폭 기반 MMSE 추정방식 등과 같은 기존의 베이지안(Bayesian) 기반의 추정방식들 보다 객관적 및 주관적 측면에서 모두 보다 높은 성능을 나타내는 방식으로 잘 알려져 있다. 이에 본 논문에서는 기본적인 반복적 커널 백피팅 알고리즘에 WbE를 적용하여 음악 신호에서의 보컬음 분리 성능을 향상시키고자 하였다. 실험결과는 본 논문에서 제안한 방식이 기존의 분리 방식보다 분리 성능이 더 뛰어나다는 것을 보인다.

• 한국정보과학회논문지:데이타베이스
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• 제32권5호
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• pp.558-566
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• 2005

XML은 인터넷상에서 데이타를 표현하고 교환하기 위한 새로운 표준이다. 본 논문에서는, XML문서에 대한 경로-지향 질의어의 평가를 위한 새로운 접근법에 대하여 기술한다. 본 논문의 접근법에서는, 경로-지향 질의어의 평가속도를 개선하기 위해 경로서명을 이용하는 병렬 매치 인덱싱 구조의 제안과 함께 데이타베이스 안에 저장된 엘리먼트들의 경로서명들과 입력된 질의어의 경로서명 사이에 매치작업을 수행하기 위한 병렬 매치 알고리즘을 설계한다. 먼저, 병렬 매치 구조를 형성하기 위해서는 XML 문서상의 모든 경로서명들에 대한 이진 트라이를 구성한 다음 이들을 병렬 매치 인덱싱 구조로 변환한다. 경로-지향 질의어의 검색 연산을 수행하기 위해 병렬 매치 인덱싱 구조와 병렬 매치 알고리즘을 사용한다. 본 논문에서 제안한 방법에서 알고리즘의 시간 복잡도는 XML 문서내의 경로서명의 수에 대하여 로그값에 비례한다.

• 한국통신학회논문지
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• 제35권2C호
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• pp.148-154
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• 2010

본 연구에서는 무선 랜 표준안인 802.11n에서 채널 부호화 알고리즘으로 채택된 LDPC부호의 복호 알고리즘의 저복잡도에 대해 연구를 하였다. 샤논의 한계에 근접하기 위해서는 큰 블록 사이즈의 LDPC 부호어 길이와 많은 반복횟수를 요구한다. 이는 많은 계산량을 요구하며, 그리고 이에 따른 전력 소비량(power consumption)을 야기시키므로 본 논문에서는 세 가지 형태의 저복잡도 LDPC 복호 알고리즘을 제시한다. 첫째로 큰 블록 사이즈와 많은 반복 횟수는 많은 계산량과 전력 소모량을 요구하므로 성능 손실 없이 반복횟수를 줄일 수 있는 부분 병렬 방법을 이용한 복호 알고리즘, 둘째로 early stop 알고리즘에 대해 연구 하였고, 셋째로 비트 노드 계산과 체크 노드 계산 시 일정한 신뢰도 값보다 크면 다음 반복 시 계산을 하지 않는 early detection 알고리즘에 대해 연구 하였다.

• 정보처리학회논문지:소프트웨어 및 데이터공학
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• 제9권2호
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• pp.39-44
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• 2020

본 논문에서는 사전연산이 가능한 세션 키 쌍을 이용하여, 최소의 정보만을 노출하여 키 교환이 가능한 변형된 Diffie-Hellman 키 교환 프로토콜을 보인다. 기존 Diffie-Hellman 및 Diffie-Hellman 기반 기법들의 보안성인 이산대수문제를 변형하여 생성원이 노출되지 않도록 설계함으로써 전송되는 암호문에 대한 공격으로부터 향상된 보안성을 가진다. 제안하는 기법에 실제 값을 적용하여 알고리즘의 동작을 증명하고 기반이 되는 기존 알고리즘과의 수행시간과 안전성을 비교 분석하여, 키 교환 시점 연산량을 유지하며 두 기반 알고리즘 시간복잡도의 곱 이상으로 알고리즘의 안전성이 향상되었음을 보였다. 제안하는 알고리즘을 기반으로 보안성이 향상된 키 교환 환경을 제공할 수 있을 것으로 기대된다.

• Journal of Pharmaceutical Investigation
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• 제38권1호
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• pp.1-8
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• 2008

Planetary ball mill was used to decrease and control the particle size of excipients. The effects of the weight of sample and the revolution number of mill, and grinding time on the particle size of the ground sample were analyzed by response surface methodology. The optimum conditions for the milling of microcrystalline cellulose were 38.82 g of the weight of sample and 259 rpm of the revolution number of mill, and 45 minutes of grinding time. The predicted value of the particle size at the these conditions was $19.02{\mu}m$, of which the experimental value at the similar conditions was $18.68{\mu}m$. The tensile strength of tablets of single-component powders, such as microcrystalline cellulose, hydroxypropylmethyl cellulose and starch, binary mixtures and ground binary mixtures of these powder were measured at various relative densities. It was found that the logarithm of the tensile strength of the tablets was proportional to the relative density. A simple model, based upon Ryshkewitch-Duckworth equation that was originally proposed for porous materials, has been developed in order to predict the relationship between the tensile strength and relative density of ground binary tablets based on the properties of the constituent single-component powders. The validity of the model has been verified with experimental results for ground binary mixtures. It has demonstrated that this model can well predict the tensile strength of ground binary mixtures based upon the properties of single-component powders, such as true density, and the compositions. When the tensile strength of the mixture of microcrystalline cellulose hydroxypropylmethyl cellulose (90:10) and the ground mixture of them were compared, the tensile strength of the ground mixture decreased widely from 45.3 to 5.6% compared to the mixture in case the relative density of tablets was in the range of $0.7{\sim}0.9$. When the tensile strength of the mixture of microcrystalline cellulose starch (80:20) and the ground mixture of them were compared, the tensile strength of the ground mixture decreased widely from 31.0 to 11.6% compared to the mixture in case the relative density of tablets was in the range of $0.7{\sim}0.9$.

• Journal of Microbiology and Biotechnology
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• 제17권4호
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• pp.644-649
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• 2007

Response surface model was developed for predicting the growth rates of Salmonella enterica sv. Typhimurium in tryptic soy broth (TSB) medium as a function of combined effects of temperature, pH, and NaCl. The TSB containing six different concentrations of NaCl (0, 2, 4, 6, 8, and 10%) was adjusted to an initial of six different pH levels (pH 4, 5, 6, 7, 8, 9, and 10) and incubated at 10 or $20^{\circ}C$. In all experimental variables, the primary growth curves were well $(r^2=0.900\;to\;0.996)$ fitted to a Gompertz equation to obtain growth rates. The secondary response surface model for natural logarithm transformations of growth rates as a function of combined effects of temperature, pH, and NaCl was obtained by SAS's general linear analysis. The predicted growth rates of the S. Typhimurium were generally decreased by basic (9, 10) or acidic (5, 6) pH levels or increase of NaCl concentrations (0-8%). Response surface model was identified as an appropriate secondary model for growth rates on the basis of coefficient determination $(r^2=0.960)$, mean square error (MSE=0.022), bias factor $(B_f=1.023)$, and accuracy factor $(A_f=1.164)$. Therefore, the developed secondary model proved reliable predictions of the combined effect of temperature, NaCl, and pH on growth rates for S. Typhimurium in TSB medium.

• 대한디지털의료영상학회논문지
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• 제10권2호
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• pp.23-31
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• 2008

Computed radiography(CR) has been widely used in the field of diagnostic radiography since digital X-ray image was introduced. The imaging performance of CR system was studied by analyzing the digital image data of the CR images which are the outcomes of the whole imaging system composed of image plate(IP), laser digitizer, analoge-digital convertor, and a given image processing unit. In this study, we used a conventional CR system made by Agfa. From the flat field image of 150$\times$150 image pixels, signal-to-noise ratio(SNR) was calculated. SNR of the CR image increases in proportion to logarithm value of the X-ray exposure irradiated on the IP. SNR is less than about 6 at the exposure below 0.2mR and is more than 10 at the exposure above 0.54mR. In our study, most of images obtained by the smaller exposures less than 2.0mR can not be readable. In general, the minimum value of the SNR ranges from 3 to 5. We obtained modulation transfer function(MTF) by analyzing the bar pattern image which was made under conditions as follows: X-ray tube potential was 55kVp, the IP exposure was 0.54 mR, and the distance between X-ray source to IP was 2m, where bar pattern was located on the IP. MTF is 23% at 2.5lp/mm spatial frequency. Provided that the MTF of noise equivalent modulation is 10%, the CR system has the limiting spatial resolution of 3.2lp/mm. If the image sharpness is evaluated by the spatial frequency where MTF is 50%. the corresponding spatial frequency is 0.5$\sim$0.75lp/mm. MTFA(Modulation Transfer Function Area) is 1.0lp/mm. Compared with the Fuji CR whose MTFA is 1.1lp/mm, Agfa CR in this study shows almost same MTFA performance.