• The Korean Journal of Physiology and Pharmacology
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• 제23권6호
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• pp.427-448
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• 2019

Nociceptin/orphanin FQ (N/OFQ) and its receptor, nociceptin opioid peptide (NOP) receptor, are localized in brain areas implicated in depression including the amygdala, bed nucleus of the stria terminalis, habenula, and monoaminergic nuclei in the brain stem. N/OFQ inhibits neuronal excitability of monoaminergic neurons and monoamine release from their terminals by activation of G protein-coupled inwardly rectifying $K^+$ channels and inhibition of voltage sensitive calcium channels, respectively. Therefore, NOP receptor antagonists have been proposed as a potential antidepressant. Indeed, mounting evidence shows that NOP receptor antagonists have antidepressant-like effects in various preclinical animal models of depression, and recent clinical studies again confirmed the idea that blockade of NOP receptor signaling could provide a novel strategy for the treatment of depression. In this review, we describe the pharmacological effects of N/OFQ in relation to depression and explore the possible mechanism of NOP receptor antagonists as potential antidepressants.

• 아태비즈니스연구
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• 제11권1호
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• pp.93-114
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• 2020

Purpose -The purpose of this study is to analyze how the accreditation system affect the selection of business strategies in social enterprises, which create social value rather than maximize profits. Design/methodology/approach - This study collected survey data from 40 accredited and 53 non-accredited social enterprises. This research employs a Fuzzy-set/qualitative comparative analysis to compare the combinations of factors that affect a social enterprise's performance Findings - The results show that for accredited enterprises organizational capabilities are significantly more important than networking capabilities, whereas for non-accredited enterprises internal communication, governance capacities and networking competencies are most important capabilities to improving their social performance. And also The accreditation systems for social enterprises would entice social enterprise away from business strategies based on with local society, which is differentiated with commonly accepted social enterprise model. Research implications or Originality - This research suggests that the accreditation system for social enterprises should be redesigned for enticing social enterprises in Korea to be more localized to meet local needs in terms of positive changes of local society.

• Molecules and Cells
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• 제44권12호
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• pp.861-878
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• 2021

The human genome contains many retroviral elements called human endogenous retroviruses (HERVs), resulting from the integration of retroviruses throughout evolution. HERVs once were considered inactive junk because they are not replication-competent, primarily localized in the heterochromatin, and silenced by methylation. But HERVs are now clearly shown to actively regulate gene expression in various physiological and pathological conditions such as developmental processes, immune regulation, cancers, autoimmune diseases, and neurological disorders. Recent studies report that HERVs are activated in patients suffering from coronavirus disease 2019 (COVID-19), the current pandemic caused by SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2) infection. In this review, we describe internal and external factors that influence HERV activities. We also present evidence showing the gene regulatory activity of HERV LTRs (long terminal repeats) in model organisms such as mice, rats, zebrafish, and invertebrate models of worms and flies. Finally, we discuss several molecular and cellular pathways involving various transcription factors and receptors, through which HERVs affect downstream cellular and physiological events such as epigenetic modifications, calcium influx, protein phosphorylation, and cytokine release. Understanding how HERVs participate in various physiological and pathological processes will help develop a strategy to generate effective therapeutic approaches targeting HERVs.

• 소성∙가공
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• 제32권5호
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• pp.276-286
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• 2023

The field of sheet metal forming using press technology has become essential in modern mass production systems. Draw bead is often used to enhance formability. However, optimal draw bead design often requires excessive time and cost due to iterative experimentation and sometimes results in some defects. Given these challenges, there is a need to enhance formability by introducing segmented blank holders without draw beads. In this paper, the feasibility of a localized holding strategy using segmented blank holders is evaluated without the use of draw beads. The possibility for improving the formability was evaluated by utilizing a combination of the forming limit diagram and the wrinkle pattern-based defect indicators. Artificial neural networks were used for predicting defect indicators corresponding to arbitrary input holding forces and the NSGA-II optimization algorithm is used to find optimum blank holder forces yielding better defect indicators than the original process with drawbeads. Using optimum holding forces obtained from the proposed procedure, the stamping process with the segmented blank holders can yield better formability than the conventional process with drawbeads.

• Journal of Microbiology and Biotechnology
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• 제33권2호
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• pp.242-250
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• 2023

Comparative gene identification-58 (CGI-58) is an activating protein of triacylglycerol (TAG) lipase. It has a variety of catalytic activities whereby it may play different roles in diverse organisms. In this study, a homolog of CGI-58 in Phaeodactylum tricornutum (PtCGI-58) was identified. PtCGI-58 was localized in mitochondria by GFP fusion protein analysis, which is different from the reported subcellular localization of CGI-58 in animals and plants. Respectively, PtCGI-58 overexpression resulted in increased neutral lipid content and TAG accumulation by 42-46% and 21-32%. Likewise, it also increased the relative content of eicosapentaenoic acid (EPA), and in particular, the EPA content in TAGs almost doubled. Transcript levels of genes involved in de novo fatty acid synthesis and mitochondrial β-oxidation were significantly upregulated in PtCGI-58 overexpression strains compared with wild-type cells. Our findings suggest that PtCGI-58 may mediate the breakdown of lipids in mitochondria and the recycling of acyl chains derived from mitochondrial β-oxidation into TAG biosynthesis. Moreover, this study potentially illuminates new functions for CGI-58 in lipid homeostasis and provides a strategy to enrich EPA in algal TAGs.

• Journal of Gastric Cancer
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• 제20권3호
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• pp.233-244
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• 2020

Purpose: For unresectable or initially metastatic gastric cancer, conversion surgery (CVS), after systemic chemotherapy, has received attention as a treatment strategy. This study evaluated the prognostic value of ypTNM stage and the oncologic outcomes in patients receiving CVS. Materials and Methods: A retrospective review of clinicopathologic findings and oncologic outcomes of 116 patients who underwent CVS with curative intent, after combination chemotherapy, between January 2000 and December 2015, has been reported here. Results: Twenty-six patients (22.4%) underwent combined resection of another organ and 12 patients received para-aortic lymphadenectomy (10.3%). Pathologic complete remission (CR) was confirmed in 11 cases (9.5%). The median overall survival (OS) and disease-free survival (DFS) times were 35.0 and 21.3 months, respectively. In multivariate analysis, ypTNM stage was the sole independent prognostic factor for DFS (P=0.042). Tumors invading an adjacent organ or involving distant lymph nodes showed better survival than those with peritoneal seeding or solid organ metastasis (P=0.084). Kaplan-Meier curves showed that the 3-year OS rate of patients with pathologic CR and those with CR of the primary tumor but residual node metastasis was 81.8% and 80.0%, respectively. OS was 65.8% for stage 1 patients, 49.8% for those at stage 2, and 36.3% for those at stage 3. Conclusions: The ypTNM staging is a significant prognostic factor in patients who underwent CVS for localized unresectable or stage IV gastric cancers. Patients with locally advanced but unresectable lesions or with tumors with distant nodal metastasis may be good candidates for CVS.

• 한국건설관리학회:학술대회논문집
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• 한국건설관리학회 2004년도 제5회 정기학술발표대회 논문집
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• pp.442-446
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• 2004

현재 정부의 주요 국정과제는 국토의 균형 있는 발전과 지방분권화 정책이다. 건교부를 포함한 타 부처에서는 이를 위해 많은 전략들을 수립하고 있다. 그러나 현재 국내 건설기술의 경우는 수도권에 집중되어있어 지역특성화가 이루어지고 있지 못한 실정이다. 건설 기술의 지역특성화가 이루어지지 못하면 지방산업경제의 경쟁력이 떨어지고 지방산업 경제의 낙후는 국가 경쟁력을 상실시켜 결국은 국가 경제력도 상실될 것이다. 따라서 건설기술의 지역특성을 맞추어 발전시키는 전략수립이 필요하고 전략을 수립하기에 앞서 지역 특성을 나타내는 건설기술의 도출이 필요하다. 본 연구의 의의는 지역특성화의 의미와 국내외 지역특성화 현황을 통해 알아보고 국가 정책방향과 설문을 통한 기술 수요조사, 기술역량을 조사하여 지역별 특성을 내포하는 건설기술을 도출함으로써 지역별 건설기술 발전을 위한 기초 자료를 확보했다는데 있다.

• 스마트미디어저널
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• 제4권4호
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• pp.93-100
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• 2015

현재 국내 출판계의 전자책과 앱북 시장은 장르문학인 소설과 웹툰 분야의 매출이 전체의 80%에 이르는 특정분야 매출 편중 현상이 두드러지게 나타나는 상황이다. E-book에서 진화한 앱북은 오프라인에서 주로 판매되는 종이책과는 달리 가독성과 구매의 편리함이 강점이지만 일반화되기에는 대중적 전파력에 있어 시일이 걸린다는 점이 단점으로 작용하기도 한다. 그러한 상황 속에서도 국내 전자책 시장의 매출은 가파르게 성장하고 있으며 현재는 장르문학에 국한되지 않고 출판콘텐츠 분야에서 다양한 실험적 도전이 시행되고 있는 단계라고 할 수 있다. 본 연구는 부산관광콘텐츠를 기반으로 한 최초의 지역콘텐츠 소재 앱북의 기획과 개발과정을 통해 향후 웹 모바일 플랫폼으로서 관광 앱북을 개발하고 기존의 단순한 정보만을 제공하는 앱북의 단점들을 보완하여 유료다운로드를 통한 구매로 이어지는 지속적 사용이 가능한 여행 앱북의 활용 전략을 제안하고자 한다.

• 한국전산구조공학회:학술대회논문집
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• 한국전산구조공학회 2007년도 정기 학술대회 논문집
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• pp.62-67
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• 2007

The research team for the virtual construction development was established with the support of Korea Ministry of Construction and Transportation, and KICTEP (Korea Institute of Construction and Transportation Technology Evaluation and Planning). Its aims are to develop system that is to improve productivity & quality, to create a higher value-added business, and to cultivate international competitiveness in the construction industry. The virtual construction system is a design, engineering, and construction management information system that allows the project participants to effectively share the information throughout the construction life cycle with the support of 3D and design information. To achieve this, the research team focuses on developing several systems. First, the team focuses on developing for the pre-planning, the structural engineering, MEP, and the 3D based estimation system. Second, they focus on developing a simulation system for the construction process planning and feasibility study with help of the virtual reality technologies. Third, they focus on developing the CPLM (Construction Project Life-cycle Management) system for managing construction project data, and the decision support system that makes the collaboration among the project participants based on 3D technologies and information. We also focus on developing the SDAI (Standard Data Access Interface), the localized guideline for 3D design, and a training program. In addition, we focus on developing the undeveloped area of the commercial system and building an environment that can support the communication and collaboration in the construction life-cycle rather than developing the existing and commercialized system.

• The Korean Journal of Physiology and Pharmacology
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• 제22권3호
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• pp.331-341
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• 2018

The aim of the present study was to examine the effects of preemptive analgesia on the development of trigeminal neuropathic pain. For this purpose, mechanical allodynia was evaluated in male Sprague-Dawley rats using chronic constriction injury of the infraorbital nerve (CCI-ION) and perineural application of 2% QX-314 to the infraorbital nerve. CCI-ION produced severe mechanical allodynia, which was maintained until postoperative day (POD) 30. An immediate single application of 2% QX-314 to the infraorbital nerve following CCI-ION significantly reduced neuropathic mechanical allodynia. Immediate double application of QX-314 produced a greater attenuation of mechanical allodynia than a single application of QX-314. Immediate double application of 2% QX-314 reduced the CCI-ION-induced upregulation of GFAP and p-p38 expression in the trigeminal ganglion. The upregulated p-p38 expression was co-localized with NeuN, a neuronal cell marker. We also investigated the role of voltage-gated sodium channels (Navs) in the antinociception produced by preemptive application of QX-314 through analysis of the changes in Nav expression in the trigeminal ganglion following CCI-ION. Preemptive application of QX-314 significantly reduced the upregulation of Nav1.3, 1.7, and 1.9 produced by CCI-ION. These results suggest that long-lasting blockade of the transmission of pain signaling inhibits the development of neuropathic pain through the regulation of Nav isoform expression in the trigeminal ganglion. Importantly, these results provide a potential preemptive therapeutic strategy for the treatment of neuropathic pain after nerve injury.