• 제목/요약/키워드: Localized Obesity

검색결과 28건 처리시간 0.022초

고등학생에서 체질량지수에 따른 비만에 대한 인식과 생활습관의 차이에 관한 조사 (A Study on Awareness and Knowledge of Obesity, Life Style, and Eating Habits According to Body Mass Index in High School Students)

  • 김미정;최광해;이경수
    • Clinical and Experimental Pediatrics
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    • 제45권12호
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    • pp.1491-1496
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    • 2002
  • 목 적: 남녀 고등학생들의 비만에 대한 인식도를 알아보고 그리고 비만에 대한 지식 정도와 실제 생활과의 연관관계 등을 조사하여 비만의 예방과 치료 방향 설정에 도움을 주고자 시행하였다. 방 법 : 연구 대상은 대구광역시 북구에 위치한 고등학교 1, 2학년 남녀 각각 882명, 668명 총 1,550명을 대상으로 설문지 조사를 시행하였으며 이중 성실하게 응답한 1514명을 본 연구의 대상으로 하였다. 설문지는 무기명으로, 본인이 직접 기입하도록 하였다. 성별 연령에 따른 체질량지수가 85 백분위수 이하를 1군(정상 체중군), 85-95 백분위수를 2군(비만 위험군), 95 백분위수 이상을 3군(비만군)으로 나누어 비교 분석하였다. 결 과 : 1) 비만에 대한 인식도 : 비만에 대한 인식정도는 남학생의 경우 심각한 질병으로 인식하는 경우가 1군에서 30.6%, 2군에서 37.4%, 3군에서 48.4%로 정상 체중군보다 비만군에서 비만을 질병으로 인식하는 경우가 통계학적으로 유의하게 높았으며(P=0.00), 여학생에서는 비만을 매우 심각한 질병으로 인식하는 경우가 1군에서 8%, 2군에서 15.8%, 3군에서 14.3%이었고, 심각한 질병으로 인식하는 경우가 1군에서 44.4%, 2군에서 55.3%, 3군에서 57.1%이었고, 각 군간의 비만에 대한 인식정도는 차이가 없었다(P=0.332). 2) 비만에 대한 지식 : 비만 지식에 대한 점수는 1군에서 남학생이 9.68, 여학생이 10.42이었으며, 2군에서는 남학생이 10.06, 여학생이 11.38이었으며, 3군에서는 남학생이 10.11, 여학생이 10.57이었다. 각 군간의 비만에 대한 지식은 남녀 모두 유의한 차이를 보이지 않았다. 3) 건강한 식습관과 비만에 대한 지식과의 상관관계 : 건전한 식습관과 비만에 대한 지식과의 상관관계는 남, 여학생 모두에서 통계학적으로 유의한 차이는 없었다. 4) 규칙적인 운동 습관 : 남학생의 경우 규칙적인 운동을 하는 경우가 1군, 2군, 3군에서 각각 38.7%, 36.7%, 34.9%로 통계학적 유의성은 없었고(P=0.795), 여학생 역시 각각 14.5%, 12.8%, 30.8%로 통계학적 유의성은 없었다. 5) 규칙적인 운동 유무와 비만에 대한 지식과의 관련성 : 남학생의 경우 규칙적인 운동을 하는 경우가 9.98점, 규칙적인 운동을 하지 않는 경우가 9.64점이었고, 여학생은 규칙적인 운동을 하는 경우가 10.73점, 규칙적인 운동을 하지 않는 경우가 10.50점으로 규칙적인 운동 유무와 비만에 대한 지식 정도는 남녀 모두 통계학적으로 유의한 차이가 없었다. 결 론 : 비록 일부 지역의 고등학생을 대상으로 한조사이나 고등학생들의 비만의 심각성에 대한 인식과 운동과 식습관의 관련성을 분석하는 의의가 있다. 고등학생들이 비만의 심각성에 대해서는 어느 정도 인식하고 있으나, 정상 체중 학생과 비만 학생사이에 비만에 대한 지식의 차이가 없었으며, 비만에 대한 지식정도와 건강한 식습관이나 규칙적인 운동의 유무와는 관련성이 없었다.

조위승청탕(調胃升淸湯)의 알코올 및 열수(熱水) 추출물이 지방세포 대사에 미치는 영향 (Effects of Chowiseungcheng-tang Extracts on the Preadipocytes Proliferation in 3T3-L1 cell line, Lipolysis of Adipocytes in rat, and Localized Fat Accumulation by extraction methods)

  • 이재은;김병우;임태진;김동희;권기록
    • 대한약침학회지
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    • 제11권1호
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    • pp.127-141
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    • 2008
  • Objectives : The purpose of this study is to investigate the effects of Chowiseungcheng-tang extracts on the preadipocytes proliferation in 3T3-L1 cell line, lipolysis of adipocytes in rat's epididymal adipocytes and localized fat accumulation of porcine by extraction methods(alcohol and water). Methods : Diminish preadipocytes proliferation and promote lipolysis of adipocytes do primary role to reduce obesity. So, we used 3T3-L1 mouse embryo fibroblasts(preadipocytes) and rat epididymal adipocytes from Sprague-Dawley rats to investigate the effects of Chowiseungcheng-tang extracts on the preadipocytes proliferation, lipolysis of adipocytes. They were treated with 0.01, 0.1, $1.0mg/m{\ell}$ Chowiseungcheng-tang alcohol and water extracts. And for the purpose of investigating the effects of Chowiseungcheng-tang alcohol and water extracts on the localized fat accumulation, we injected 0.1, 1.0, $10.0mg/m{\ell}$ Chowiseungcheng-tang extracts to porcine fat tissues and observed histological changes of them. Results : Following results were obtained from the preadipocytes proliferation and lipolysis of adipocytes and histological investigation of fat tissues. 1. Chowiseungcheng-tang extracts suppressed preadipocytes proliferation on the high dosage(especially $1.0mg/m{\ell}$), and especially alcohol extracts had better effects. 2. The alcohol extracts of Chowiseungcheng-tang decreased the activity of glycerol-3-phosphate dehydrogenase (GPDH) on the concentrations of 0.1, $1.0mg/m{\ell}$. Alcohol extracts had better effects than water extracts. 3. Chowiseungcheng-tang extracts increased lipolysis of adipocytes on the concentrations of 0.1, $1.0mg/m{\ell}$, and especially on the concentration of $1.0mg/m{\ell}$ alcohol extract of Chowiseungcheng-tang had better effect. 4. The water extract of Chowiseungcheng-tang had significant activity to the destruction of porcine fat cell membranes only on the concentration of $10.0mg/m{\ell}$, but alcohol extracts of Chowiseungcheng-tang had it on all concentrations. Conclusions : The alcohol extracts of Chowiseungcheng-tang had much better effects on the preadipoeytes proliferaton, lipolysis of adipocytes and localized fat accumulation than water extracts.

Bee Venom과 Sweet Bee Venom이 지방세포 대사에 미치는 영향 (The effects of Bee Venom and Sweet Bee Venom to the preadipocyte proliferation and lipolysis of adipocyte, localized fat accumulation)

  • 김민기;이시형;신조영;김강산;조남근;임태진;권기록
    • 대한약침학회지
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    • 제10권3호
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    • pp.5-19
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    • 2007
  • Objectives The purpose of this study was to investigate the effects of Bee Venom and Sweet Bee Venom to the primary cultured preadipocyte, adipocytes, and localized fat tissue. Methods Decreased preadipocyte proliferation and decreased lipogenesis are mechanisms to reduce obesity. So, preadipocytes and adipocytes were performed on cell cultures using Sprague-Dawley Rats and treated with 0.01-1mg/ml Bee Venom and Sweet Bee Venom. And porcine skin including fat tissue after treated Bee Venom and Sweet Bee Venom according to the dosage dependent variation are investigated the histologic changes after injection of these Pharmacopuncture. Result Following results were obtained from the preadipocyte proliferation and lipolysis of adipocyte and histologic investigation of fat tissue. 1. Bee Venom and Sweet Bee Venom showed the effect of decreased preadipocyte proliferation depend on concentration. 2. Bee Venom and Sweet Bee Venom showed the effect of decreased the activity of glycerol-3-phosphate dehydrogenase(GPDH) significantly. 3. Bee Venom was not showed the effect of lipolysis, but Sweet Bee Venom was increased in low dosage and decreased in high dosage. 4. Investigated the histologic changes in porcine fat tissue after treated Bee Venom and Sweet Bee Venom, we knew that these Pharmacopuncture was activated nonspecific lysis of cell membranes depend on concentration. Conclusion These results suggest that Bee Venom and Sweet Bee Venom efficiently induces decreased proliferation of preadipocyte and lipolysis in adipose tissue.

전기자극이 체성분에 미치는 효과 (The Effect of Electrical Stimulation of Body Composition in Obese Person)

  • 김용성;방상분
    • 대한임상전기생리학회지
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    • 제2권3호
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    • pp.13-24
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    • 2004
  • The purpose of this study is to reveal the effect of electrical stimulation of body composition in obese person. Subjects were 30s to 40s aged healthy workers(2004. 3. 8~4. 17) in the S general Hospital in Suwon and they were brought to manage obesity. Subjects were divided into control group(Female<0.85, Male<0.90) and study group(Female>0.85, Male>0.90) by WHR(waist-hip ratio) that is measured by Automatic body composition analyzer(InBody 3.0). And we divided the study group with randomized methods into group A(n=8) and group B(n=8). Then we compared and analyzed the change of muscle mass, body fat, abdominal girth, WHR, BMI(body mass index) after application of electrical stimulation, three times a week, for 30 minutes in each session with 50 Hz of pulse frequency, $20\;{\mu}s$ or $250\;{\mu}s$ of pulse duration. There was statistically meaningful decrement of body fat(p<0.05) and abdominal girth(p<0.05) but not of body weight, muscle mass, WHR and BMI in the control group after application of electrical stimulation with 50 Hz, $20\;{\mu}s$. There were meaningful change of abdominal girth(p<0.05), WHR(p<0.05) and BMI(p<0.05), but not of body weight, muscle mass and body fat after application of electrical stimulation with 50 Hz, $20\;{\mu}s$ in group A. We applied electrical stimulation with 50 Hz, $250\;{\mu}s$ in group B, then there were meaningful change of body weight(p<0.05), body fat(p<0.01), abdominal girth(p<0.01), WHR(p<0.05) and BMI(p<0.01) but not of muscle mass only. Consequently, the pulse duration is the main parameter of electrical stimulation that affect the body composition of obese person in this study and if we combined the diet control to reduce blood components we could have better result. So it would be more effective to manage localized obesity(in abdomen, thigh, upper arm, etc.) if you apply electrical stimulation considering the pulse duration.

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마황약침(麻黃藥鍼)이 지방세포 대사에 미치는 영향 (The Effect of Ephedrae Herba Pharmacopuncture on Adipocyte Metabolism)

  • 정종진;김병우
    • 대한한방내과학회지
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    • 제29권1호
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    • pp.80-89
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    • 2008
  • Objectives : This study was carried out to investigate the effects of Ephedrae Herba pharmacopuncture (EHP) on the adipogenesis in 3T3-L1 cells, lipolysis in rat epididymal adipocytes and histological changes in porcine adipose tissue. Methods : Inhibition of preadipocyte differentiation and/or stimulation of lipolysis play important roles in reducing obesity. 3T3-L1 preadipocytes were differentiated with adipogenic reagents by incubating for 3 days in the absence or presence of EHP ranging from 0.01 to 1.0 $mg/m{\ell}$. The effect of EHP on adipogenesis was examined by measuring glycerol-3-phosphate dehydrogenase (GPDH) activity and by oil red O staining. Mature adipocytes from rat epididymal fat pad were incubated with EHP ranging from 0.01 to 1.0 $mg/m{\ell}$ for 3 days. The effect of EHP on lipolysis was examined by measuring free glycerol released. Fat tissue from porcine skin was injected with EHP ranging from 0.1 to 10.0 $mg/m{\ell}$ to examine the effect of EHP on histological changes under light microscopy. Results : The following results were obtained from present study on adipogenesis of preadipocytes, lipolysis of adipocytes and histological changes in fat tissue. Proliferation of preadipocytes was significantly inhibited by EHP at the concentration of 1.0 $mg/m{\ell}$. Lipolysis of adipocytes was increased by EHP at the concentration of 0.1, 1.0 $mg/m{\ell}$. Porcine fat tissues were widely injured by EHP at the concentration of 10.0 $mg/m{\ell}$. Conclusions : From the above results, EHP efficiently induces inhibition of preadipocytes proliferation, lipolysis of adipocytes and histologic injury in fat tissues. Therefore, EHP may be useful to treat localized obesity.

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An Essential Role of the N-Terminal Region of ACSL1 in Linking Free Fatty Acids to Mitochondrial β-Oxidation in C2C12 Myotubes

  • Nan, Jinyan;Lee, Ji Seon;Lee, Seung-Ah;Lee, Dong-Sup;Park, Kyong Soo;Chung, Sung Soo
    • Molecules and Cells
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    • 제44권9호
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    • pp.637-646
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    • 2021
  • Free fatty acids are converted to acyl-CoA by long-chain acyl-CoA synthetases (ACSLs) before entering into metabolic pathways for lipid biosynthesis or degradation. ACSL family members have highly conserved amino acid sequences except for their N-terminal regions. Several reports have shown that ACSL1, among the ACSLs, is located in mitochondria and mainly leads fatty acids to the β-oxidation pathway in various cell types. In this study, we investigated how ACSL1 was localized in mitochondria and whether ACSL1 overexpression affected fatty acid oxidation (FAO) rates in C2C12 myotubes. We generated an ACSL1 mutant in which the N-terminal 100 amino acids were deleted and compared its localization and function with those of the ACSL1 wild type. We found that ACSL1 adjoined the outer membrane of mitochondria through interaction of its N-terminal region with carnitine palmitoyltransferase-1b (CPT1b) in C2C12 myotubes. In addition, overexpressed ACSL1, but not the ACSL1 mutant, increased FAO, and ameliorated palmitate-induced insulin resistance in C2C12 myotubes. These results suggested that targeting of ACSL1 to mitochondria is essential in increasing FAO in myotubes, which can reduce insulin resistance in obesity and related metabolic disorders.

흰쥐의 발정주기동안 난소내 Leptin 및 Leptin 수용체 발현의 주기적 변화에 관한 연구 (Study on the Cyclic Change of Leptin and Its Receptor Expression during the Estrous Cycle of Rat)

  • 김명신;양현원;권혁찬;김세광;조동체;윤용달
    • 한국발생생물학회지:발생과생식
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    • 제6권2호
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    • pp.123-129
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    • 2002
  • 비만유전자 산물인 leptin은 비만뿐만 아니라 여성의 생식 생리와 관련이 있는 것으로 보이나, 아직 이러한 leptin이 난소에 직접적으로 작용하는지 정확하게 밝혀지지 않고 있다. 따라서 본 연구에서는 흰쥐 난소에서 leptin과 leptin 수용체의 발현을 면역조직화학방법으로 확인하고 발정주기에 따른 leptin과 leptin 수용체의 발현 양상을 RT-PCR 방법으로 조사하고자 하였다. 면역조직화학적 염색방법 결과 흰쥐 난소내에서 leptin은 협막세포와 폐쇄 난포의 일부 과립세포에 염색되었고, leptin 수용체는 협막세포, 간질세포와 난포강이 형성되지 않은 난포의 난자에 염색되었다. 특히 폐쇄 난포에서는 leptin과 leptin 수용체가 정상 난포에 비해 강하게 염색되었다. 흰쥐의 발정주기 동안 혈청내 estradiol, progesterone leptin의 농도는 ELISA 방법으로 측정하였고, 난소내 leptin과 leptin 수용체의 mRNA 발현 양상은 RT-PCR 방법으로 조사하였다. 혈중 leptin 농도를 측정한 결과 estrous 시기에 비하여 metestrous 시기에 유의하게 증가하였고, 이 시기에 progesterone 농도가 함께 증가하는 것을 관찰할 수 있었다. Leptin mRNA는 모든 발정주기에서 발현되지 않았지만 leptin 수용체 mRNA는 diestrous 시기를 제외한 다른 발정주기에 모두 발현되었다. 이러한 결과는 leptin이 흰쥐 난소의 기능을 조절하는데 직접적으로 관여할 수 있다는 것을 제시하고 있다.

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추출방식에 따른 방풍통성산(防風通聖散)이 지방세포 대사에 미치는 영향 (The Effect of Bangpungtongsung-san Extracts on Adipocyte Metabolism)

  • 이상민;김병우;임태진;김동희;권기록
    • 대한약침학회지
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    • 제11권1호
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    • pp.163-176
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    • 2008
  • Objective : The purpose of this study is to investigate the effects of Bangpungtongsung-san extracts on the preadipocytes proliferation, of 3T3-L1 cell line. lipolysis of adipocytes in rat's epididymis and localized fat accumulation of porcine by extraction methods(alcohol and water). Methods : Diminish 3T3-L1 proliferation and lipogenesis do primary role to reduce obesity. So, 3T3-L1 preadipocyte and adipocytes were performed on cell cultures, and using Sprague-Dawley rats for the lipogenesis, and treated with 0.01-$1mg/m{\ell}$ Bangpungtongsung-san Extracts depend on concentrations. Porcine skin including fat tissue after treated Bangpungtongsung-san Extracts by means of the dosage dependent variation are investigated the histologic changes after injection of these extracts. Results : Following results were obtained from the 3T3-L1 preadipocyte proliferation and lipolysis of adipocyte in rats and histologic investigation of fat tissue. 1. Bangpungtongsung-san extracts were showed the effect of decreased preadipocyte proliferation on the high dosage($1.0mg/m{\ell}$). 2. Bangpungtongsung-san extracts were showed the effect of decreased the activity of glycerol-3-phosphate dehydrogenase(GPDH) on the high dosage($1.0mg/m{\ell}$) and Specially, alcohol extract of Bangpungtongsung-san was clear as time goes by high concentration. 3. Bangpungtongsung-san extracts were showed tries to compare the effect of lipolysis, alcohol extract of Bangpungtongsung-san on the high dosage($1.0mg/m{\ell}$) was observed the effect is higher than water extract. 4. Investigated the histological changes in porcine fat tissue after treated Bangpungtongsung-san extracts, we knew that water extract of Bangpungtongsung-san was showed the effect of lipolysis on the high dosage($10.0mg/m{\ell}$) and alcohol extract of Bangpungtongsung-san was showed significant activity to the lysis of cell membranes in all concentration. Conclusion : These results suggest that Bangpungtongsung-san efficiently induces diminish proliferation of preadipocyte and lipolysis in adipose tissue.