• Food Science and Biotechnology
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• v.17 no.6
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• pp.1254-1260
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• 2008

The aim of the present study was to prepare nanosample of fucoidan using lecithin as encapsulated material and to investigate the anticancer and immunomodulatory activity of nanoparticle in vitro. The nanoparticles have been characterized by dynamic light scattering (DLS) and transmission electron microscopy (TEM). Confocal microscopy confirmed the internalization of the fucoidan conjugates into the immune cells. The uptake of nanoparticles was confirmed with confocal microscopy demonstrating their localization in the cells. The anticancer activity was increased over 5-10% in different cancer cells of fucoidan nanoparticle as compare with fucoidan. The human B and T cells growth and the secretion of interleukin-6 and tumor necrosis factor-a from B cell were also improved by fucoidan nanoparticle because of the rapid absorption of nanoparticle into the cells as compare to fucoidan. At 0.6 mg/mL concentrations, the fucoidan nanoparticle showed better activity than 1.0 mg/mL concentration in T cell growth because the cells reached their saturation capacity. When the fucoidan was encapsulated in lecithin, its anticancer as well as its immunomodulatory activity proved to be superior from that of itself in pure form.

• Development and Reproduction
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• v.22 no.4
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• pp.331-339
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• 2018

NUCB2/nesfatin-1 is first known to be expressed in the hypothalamus while controlling appetite and energy metabolism. However, recent studies have shown that NUCB2/nesfatin-1 was expressed in the various organs as well as the hypothalamus. Our previous reports also demonstrated that NUCB2/nesfatin-1 was expressed in the ovary, testis, pituitary gland, lung, kidney, and stomach of fetal and adult mice. However, the role of NUCB2/nesfatin-1 in mouse fetus remains unknown. Thus, the aim of this study was to investigate whether NUCB2/nestatin-1 is expressed in mouse fetus at the developmental stage in which organogenesis begins. To do this, we performed in situ hybridization (ISH) and immunohistochemistry (IHC) staining to examine the distribution of NUCB2 mRNA and nesfatin-1 protein in the mouse fetal organs during early developmental stages, especially at embryonic day (E) 10.5. As a result of ISH, NUCB2 mRNA positive signals were more frequent in the liver, but there were relatively few positive signals in heart. On the other hand, no positive signals were detected in other organs. These ISH results were validated by IHC staining and qRT-PCR analysis. Expression of nesfatin-1 protein detected by IHC staining was similar to that of NUCB2 mRNA detected by ISH in the liver and heart. In addition, the levels of NUCB2 mRNA expression analyzed by qRT-PCR were significantly increased in the liver and heart compared to other organs of the mouse fetus at E13.5, whereas its level was extensively decreased in the liver, but increased in the lung, stomach, and kidney of the mouse fetus at E17.5. These results suggest that NUCB2/nesfatin-1 may play an important role in liver and heart development and physiological functions in the developmental process of mouse fetus. Further studies are needed on the function of NUCB2/nesfatin-1, which is highly expressed in the various organs, including liver and heart during mouse development.

• Journal of Convergence for Information Technology
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• v.8 no.6
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• pp.43-48
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• 2018

An etchant capable of forming a circuit in an FTO film that can replace ITO, which depends on full imports, was prepared. The etching solution is composed of 1 to 30% by weight of fluoride, 1 to 20% by weight of acid, 0.5 to 5% by weight of surfactant, 5 to 20% by weight of solvent, 0.5 to 10% by weight of corrosion inhibitor and the balance of water. This etchant can be etched using a dry film, thereby reducing the cost, and is free from bubbles and residue of the etchant. The characteristics of the etchant were etched in a time of 2 minute with a 100 nm thick FTO, and the etchant temperature was maintained at $50^{\circ}C$. An undercut of -0.00364% was obtained when put into a 2 minute etching solution. No harmful substances such as Cd, Pb, Hg and Cr components were measured. The use of FTO in Korea where rare earths do not exist can achieve localization and import substitution effect.

• The Journal of the Convergence on Culture Technology
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• v.5 no.1
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• pp.1-12
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• 2019

Even though Korea has lost its important modern era due to Japanese colonialism, it is in the rank of advanced nation today. It is common to think that there was no creative and innovative design activity because it was highly constrained by design activities. Is there no creative idea or innovative design in this period of design activity? As a result of analyzing the various products of modern design left in the question, I was able to find a new and unique Innovation in 10 fields. In other words, today, we can confirm that we have utilized innovative strategies in the field of design such as brand family, new sign system, modernism style, localization, star marketing, one source multi use, private brand, nature friendly, fusion and parody strategy.

• Journal of the Korea Institute of Information Security & Cryptology
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• v.15 no.5
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• pp.93-103
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• 2005

In this paper, we propose a RST resistant robust logo embedding technique for multimedia copyright protection Geometric manipulations are challenging attacks in that they do not introduce the quality degradation very much but make the detection process very complex and difficult. Watermark embedding in the normalized image directly suffers from smoothing effect due to the interpolation during the image normalization. This can be avoided by estimating the transform parameters using an image normalization technique, instead of embedding in the normalized image. Conventional RST resistant schemes that use full frame transform suffer from the absence of effective perceptual masking methods. Thus, we adopt $8\times8$ block DCT and calculate masking using a spatio-frequency localization of the $8\times8$ block DCT coefficients. Simulation results show that the proposed algorithm is robust against various signal processing techniques, compression and geometrical manipulations.

• Korean Chemical Engineering Research
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• v.60 no.2
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• pp.255-259
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• 2022

Solar membrane steam generation is a very promising technology that can harvest purified water from seawater or wastewater during the current danger of running out of pure water. However, solar Membrane steam generation had direct contact with water, making it difficult to increase the efficient amount of evaporation. Here, we propose solar membrane steam generator composed of polydimethylsiloxane (PDMS) and graphene oxide (GO) and improved evaporation through wettability control in part throughout the water-absorbing membrane. Wettability control has shown significant improvements in thermal localization and temperature rise in the area of heat exchange with sunlight. The evaporator has an evaporation rate of 1.54 kg m^-2 h^-1 under 1 sun irradiation. The results showed that Solar membrane steam evaporation can effectively harvest pure water through an increase in evaporation.

• Journal of the Korean Institute of Electrical and Electronic Material Engineers
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• v.35 no.3
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• pp.232-240
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• 2022

A variable vacuum capacitor (VVC), which is a variable element, is used to match impedance in plasma that changes with various impedance values, and its use is expanding with the rapid growth of the semiconductor business. Since VVCs have to secure insulation performance and vary capacitance within a compact size, electrode design and manufacturing are very important; thus, various technologies such as part design and manufacturing technology and vacuum brazing technology are required. In this study, based on the model of an advanced foreign company that is widely used for impedance matching in the manufacture of semiconductors and displays, a VVC that can realize the same performance was developed. The electrode part was designed, the consistency was confirmed through analysis, and the precision of capacitance was improved by designing a cup-type electrode to secure the concentricity of the electrode. As a result of the evaluation, all requirements was satisfied. We believe that self-development will be possible if satisfactory responses are received through evaluation by VVC consumers in the future.

• Korean Journal of Audiology
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• v.24 no.3
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• pp.119-126
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• 2020

Background and Objectives: In distracting listening conditions, individuals need to pay extra attention to selectively listen to the target sounds. To investigate the amount of listening effort required in reverberating and noisy backgrounds, a semantic mismatch was examined. Subjects and Methods: Electroencephalography was performed in 18 voluntary healthy participants using a 64-channel system to obtain N400 latencies. They were asked to listen to sounds and see letters in 2 reverberated×2 noisy paradigms (i.e., Q-0 ms, Q-2000 ms, 3 dB-0 ms, and 3 dB-2000 ms). With auditory-visual pairings, the participants were required to answer whether the auditory primes and letter targets did or did not match. Results: Q-0 ms revealed the shortest N400 latency, whereas the latency was significantly increased at 3 dB-2000 ms. Further, Q-2000 ms showed approximately a 47 ms delayed latency compared to 3 dB-0 ms. Interestingly, the presence of reverberation significantly increased N400 latencies. Under the distracting conditions, both noise and reverberation involved stronger frontal activation. Conclusions: The current distracting listening conditions could interrupt the semantic mismatch processing in the brain. The presence of reverberation, specifically a 2000 ms delay, necessitates additional mental effort, as evidenced in the delayed N400 latency and the involvement of the frontal sources in this study.

• Journal of Audiology & Otology
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• v.24 no.3
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• pp.119-126
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• 2020

Background and Objectives: In distracting listening conditions, individuals need to pay extra attention to selectively listen to the target sounds. To investigate the amount of listening effort required in reverberating and noisy backgrounds, a semantic mismatch was examined. Subjects and Methods: Electroencephalography was performed in 18 voluntary healthy participants using a 64-channel system to obtain N400 latencies. They were asked to listen to sounds and see letters in 2 reverberated×2 noisy paradigms (i.e., Q-0 ms, Q-2000 ms, 3 dB-0 ms, and 3 dB-2000 ms). With auditory-visual pairings, the participants were required to answer whether the auditory primes and letter targets did or did not match. Results: Q-0 ms revealed the shortest N400 latency, whereas the latency was significantly increased at 3 dB-2000 ms. Further, Q-2000 ms showed approximately a 47 ms delayed latency compared to 3 dB-0 ms. Interestingly, the presence of reverberation significantly increased N400 latencies. Under the distracting conditions, both noise and reverberation involved stronger frontal activation. Conclusions: The current distracting listening conditions could interrupt the semantic mismatch processing in the brain. The presence of reverberation, specifically a 2000 ms delay, necessitates additional mental effort, as evidenced in the delayed N400 latency and the involvement of the frontal sources in this study.

• Journal of the Korea Society of Computer and Information
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• v.27 no.12
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• pp.121-129
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• 2022

the Naval Combat Management System(CMS) has been installed and used in various ships since its localization, and has been developed by continuously introducing the latest technology. Recently, surface ship CMS have applied server virtualization and desktop virtualization(Virtual Desktop Infra, VDI) technologies among virtualization technologies to increase system stability and limitations on the limited space and weight of ships. On the other hand, submarine CMS do not have virtualization technology applied, so there are limitations in space and weight limitations and CMS efficiency improvement. To this end, this paper proposes a next-generation submarine CMS using Docker-based server virtualization. Through performance analysis between the processor of the existing CMS and the processor to which Docker-based server virtualization was applied, it was confirmed that the method proposed in this paper is applicable to the next-generation submarine CMS.