• 대한수의학회지
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• 제50권3호
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• pp.171-177
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• 2010

The purpose of this study was to evaluate the osteogenic capacity of water extract of danshen (Salvia miltiorrhiza Bunge). We have established in rat critical-sized calvarial defect model using the combination with collagen scaffold and danshen hydrophilic extract. All rats were extinguished at 8 weeks after bone graft surgery, and the bone regeneration ability of bone grafting sides was evaluated by plain radiography and micro-CT. These results revealed water extract of danshen had the potential to promote osteogenesis especially continuous oral administration with local treatment compared to one-shot local treatment. This compound may provide a new alternative agent for growth factors to promote bone healing and bone regeneration. In conclusion, these results suggest that danshen hydrophilic extract have the potential to promote osteogenesis in bone defects. Further studies about fusion technology with salvianolic acid B, peptides, growth factors, and scaffolds using of the combination of tissue engineering, cell engineering and mechanical engineering are needed.

• Asian Pacific Journal of Cancer Prevention
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• 제14권9호
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• pp.5127-5131
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• 2013

Background: 5-fluoro-uracil (FU) is a common agent in postoperative chemoradiation in gastric adenocarcinoma. However, FU is not well tolerated in a significant proportion of patients. Capecitabine (CA) is an orally administered fluoropyrimidine carbamate which is preferentially converted to active 5-FU and is one of the agents used instead of FU in such cases. We compared the toxicity, local and distant control and survival rates with FU or oral CA during the course of concurrent radiotherapy to assess the role of CA used instead of FU. Materials and Methods: We conducted an analysis of survival, disease control and toxicity data in 46 patients treated with postoperative chemoradiation following total or subtotal gastrectomy for gastric adenocarcinoma with either FU or CA between January 2008 and December 2012. Results: Median follow-up was 19 months (range: 3-59), median survival time was 23 ({\pm}6.08) months and 1-3 years overall survival (OS) rates were 64.9-39% for all patients. Compared with the CA regimen, the incidence of treatment interruption was higher with FU (p=0.023), but no significant differences were seen in local control (p=0.510), distant recurrences (p=0.721) and survival rates (p=0.866) among patients. Conclusions: Concurrent CA with radiotherapy seems to be a more tolerable and an equally effective regimen for the postoperative treatment of gastric adenocarcinoma when compared to FU.

• Bulletin of the Korean Chemical Society
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• 제33권11호
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• pp.3539-3543
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• 2012

Butacaine sulfate is an ester of p-aminobenzoic acid which has been widely used as a local anaesthetic and it is a long standing agent particularly for spinal anaesthesia. For this reason, a kinetic study of oxidation of butacaine sulfate by sodium N-chlorobenzenesulfonamide (chloramine-B or CAB) has been carried out in $HClO_4$ medium at 303 K in order to explore this redox system mechanistic chemistry. The rate shows a first-order dependence on both $[CAB]_o$, and $[substrate]_o$, and a fractional-order dependence on acid concentration. Decrease of dielectric constant of the medium, by adding methanol, increases the rate of the reaction. Variation of ionic strength and addition of benzenesulfonamide or NaCl have no significant effect on the rate. The reaction was studied at different temperatures and the activation parameters have been evaluated. The stoichiometry of the reaction has been found to be 1:2 and the oxidation products have been identified by spectral analysis. The observed results have been explained by plausible mechanism and the related rate law has been deduced.

• 대한두개안면성형외과학회지
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• 제12권2호
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• pp.129-131
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• 2011

Purpose: The purpose of this report is to present a case of persistent parotid fistula treated successfully with preoperative botulinum toxin type A injection into the parotid parenchyma, followed by fistulectomy. Methods: A 72-year-old female patient presented to the hospital with a 5-month history of clear, watery discharge from a tiny opening on the left cheek, which increased during food intake. A chemistry test of the fluid revealed an high amylase level. An ultrasonography of left parotid gland showed a $1.13{\times}0.6cm$ sized fistula. After demarcating the left parotid gland with assistance of ultrasonography, a total 40 units of botulinum toxin type A (Botox, Allergan, Irvine, CA) was injected into 4 subdivisions of the left parotid gland. The clear serous discharge ceased completely on the 5th day after botulinum toxin injection. On the 7th day, a fistulectomy was performed under the local anesthesia. Results: The parotid fistula healed completely without complications. During the 6-month follow up period, there was no discharge from the cheek. Conclusion: On the basis of our experience with type A botulinum toxin as a local anticholinergic agent in treating parotid fistula, preoperative botulinum toxin A injection seems to be very useful to prevent recurrence after fistulectomy.

• 공학논문집
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• 제6권2호
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• pp.11-22
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• 2004

분산제약조건만족문제(Distributed CSP)는 변수와 제약 조건들이 다수의 에이전트에 분산되어 있는 제약조건만족문제를 말한다. 이 개념은 인공지능 분야의 다양한 문제들에게 폭 넓게 적용 할 수 있으며 또한 이와 유사하게, 에이전트 행동들의 일치된 조합을 찾기 위한 멀티에이전트 시스템의 다양한 응용 문제들(분산 자원할당문제, 분산 스케줄링문제, 분산 번역업무 등)이 모두 분산 제약조건만족문제에 속한다고 할 수 있다. 분산제약조건만족문제는다수의 자율적으로 동작하는 에이전트들의 상호작용과 그들 간의 협조에 의해 모든 에이전트들이 갖고 있는 변수들의 값과 그들 간에 존재하는 제약 조건들이 일치(consistency)하는 값을 효율적으로 찾기 위한 양질의 알고리즘 개발에 관한 연구 분야로서 최근에 와서는 멀티에이전트 시스템을 이용하여 분산 제약조건만족문제를 해결하기 위한 효율적인 알고리즘 개발에 관한 연구가 활발하게 진행되고 있다. 이 논문에서는 비동기/병행적인 탐색 과정에서 모든 에이전트들이 그들의 시험적인 값들을 조건에 일치하는 값으로 변경하기 위해 각 에이전트의 우선순위를 동적으로 변경할 수 있게 함으로써 불 일치된 변수의 값을 탐색이 진행되는 동안에도 수정이 가능하도록 하여, 기존 비 동기 되돌림알고리즘의 개선 대상인 되돌림(backtracking)의 효율성을 크게 향상시킬 수 있는 멀티에이전트의 동적 우선순위탐색 알고리즘을 제안하였다.

• 한국정보과학회논문지:소프트웨어및응용
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• 제30권9호
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• pp.843-849
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• 2003

웹 이용 마이닝은 거대한 웹 로그들을 이용하여 웹 사용자의 이용 패턴을 분석하는 데이타 마이닝 기술이다. 이러한 웹 이용 마이닝 기술을 사용하기 위해서는 전처리 과정 중의 사용자와 세션을 정확하게 구분해야 하는데, 표준 웹 로그 형식의 로그 파일만으로는 완전히 구분할 수 없다. 사용자와 세션을 구분하기 위해서는 로컬캐시, 방화벽, ISP, 사용자 프라이버시, 쿠키 등과 같은 많은 문제들이 있지만, 이 문제를 해결하기 위한 명확한 방법은 아직 없다. 특히, 로컬캐시 문제는 웹 마이닝 시스템의 입력으로 사용되는 사용자 세션을 구분하는데 가장 어려운 문제이다 본 연구에서는 참조 로그와 에이전트 로그, 그리고 액세스 로그 둥의 서버측 클릭스트림 데이타만을 이용하여 로컬캐시 문제를 해결하고, 사용자 세션을 구분하고 세션을 보정하는 휴리스틱 방법을 제안한다.

• 천문학회보
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• 제40권2호
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• pp.32.3-33
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• 2015

There exist scaling relations that link the mass of supermassive black holes with both the velocity dispersion and the mass of the central stellar cusp of their host galaxies. This implies that these two components grow in tandem. Feedback from actively accreting supermassive black holes (AGN), in the form of multi-phase gas outflows, has been argued to be the agent of this co-evolution. Here we employ the powerful GMOS integral field spectroscopy unit on the 8.2m Gemini-North telescope to investigate ionized gas outflows of luminous Type 2 AGN in the local Universe (z<0.1). Our sample of 6 galaxies is drawn from the Sloan Digital Sky Survey (SDSS) and was selected based on their [OIII] dust-corrected luminosity (>1042 erg/s) and signatures of outflows in the [OIII] line profile of their spatially integrated SDSS spectra. These are arguably the best candidates to explore AGN feedback in action since they are < 1% of a large local type 2 AGN SDSS sample selected based on their [OIII] kinematics. We combine a careful spectral decomposition of the [OIII] and $H{\alpha}$ line profiles with spatial information on ~0.5kpc scales to understand the outflow kinematics and energetics in these objects. We find clear evidence for strong outflows in [OIII] and occasionally $H{\alpha}$ that are clearly driven by the ionizing radiation of the AGN. We kinematically and spatially decompose outflowing and rotating ionized gas components. We find [OIII] to be a better tracer of AGN outflows, while $H{\alpha}$ appears to be strongly affected by both stellar rotation and outflows induced by ongoing star formation. The observed kinematics and spatial distribution of the ionized gas imply a large opening angle for the outflow. Finally, we find the projected outflow velocity to decrease as a function of distance, while its dispersion shows a more complex structure with a potentially initially increasing trend (out to 0.5-1kpc distances).

• The Journal of Korean Physical Therapy
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• 제18권4호
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• pp.41-50
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• 2006

Purpose: The purpose of this study was to determined that the efficacy and comfort of iontophoretic transdermal delivery of lidocaine by comparison of local anesthetic duration, sensory threshold, pain threshold and pain tolerance levels according to four different cleansing regimes. Methods: Forty healthy volunteers were randomly assigned to four groups; oil cleansing group, lotion cleansing group, solution cleansing group and alcohol cleansing group. All subjects were received lidocaine iontophoresis on the forearm using direct current with 4 mA for 10 minutes. All subjects were measured the duration of local anesthesia after lidocaine iontophoresis, also evaluated the sensory threshold, pain threshold and pain tolerance level during iontophoresis. For comparisons of the efficacy and the sensory characteristics of iontophoresis within the groups, an one-way ANOVA was used. Results: The duration of local anesthesia were found significant difference between groups (p<0.001). The anesthetic duration in solution and alcohol cleansing groups were significantly longer than oil and lotion cleansing group by post hoc (p<0.05). Statistically significant difference were noted in respect to all sensory characteristics such as sensory threshold, pain threshold and pain tolerance between groups (p<0.001). The sensory threshold in solution and alcohol cleansing group were significantly lower than oil and lotion cleansing group by post hoc using Duncan multiple range test (p<0.05). The pain threshold and pain tolerance in solution and alcohol cleansing group were significantly higher than oil and lotion cleansing group by post hoc (p<0.05). Conclusion: These results demonstrated that cleansing regimes have affected the efficacy and discomfort of iontophoretic transdermal delivery of lidocaine. These findings indicate that cleansing agents without oil ingredient contributed to more comfort, and more successful achievement of the iontophoretic transdermal delivery.

• The Korean Journal of Pain
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• 제25권4호
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• pp.221-227
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• 2012

Background: It has been reported that curcumin, the main active compound of Curcuma longa, also known as turmeric, exhibits antinociceptive properties. The aim of this study was to examine the participation of ATP-sensitive potassium channels ($K_{ATP}$ channels) and, in particular, that of the L-arginine-nitric oxide-cyclic GMP-$K_{ATP}$ channel pathway, in the antinociceptive effect of curcumin. Methods: Pain was induced by the intraplantar injection of 1% formalin in the right hind paw of Wistar rats. Formalin-induced flinching behavior was interpreted as an expression of nociception. The antinociceptive effect of oral curcumin was explored in the presence and absence of local pretreatment with L-NAME, an inhibitor of nitric oxide synthase, ODQ, an inhibitor of soluble guanylyl cyclase, and glibenclamide, a blocker of $K_{ATP}$ channels. Results: Oral curcumin produced a dose-dependent antinociceptive effect in the 1% formalin test. Curcumin-induced antinociception was not altered by local L-NAME or ODQ, but was significantly impaired by glibenclamide. Conclusions: Our results confirm that curcumin is an effective antinociceptive agent. Curcumin-induced antinociception appears to involve the participation of $K_{ATP}$ channels at the peripheral level, as local injection of glibenclamide prevented its effect. Activation of $K_{ATP}$ channels, however, does not occur by activation of the L-arginine-nitric oxide-cGMP-$K_{ATP}$ channel pathway.

• 대한지리학회지
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• 제39권3호
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• pp.360-373
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• 2004

본 연구는 석유제품 유통기관의 판매권역을 설정하기 위한 방법론을 제시하고 설정된 판매권역별 특성을 살피고자 하였다. 이를 위해 공간적 상호작용 모델과 입지-배분모델을 적용하여 효과적으로 정유회사 하부의 지역본부 및 지사와 직영 주유소의 판매권역을 설정하는 방법론을 선정하고 판매권역별 특성을 고찰하는 것을 목적으로 한다. 정유회사의 지역본부 및 지사의 판매권역을 설정해 본 결과 경기지역본부와 같이 타 본부에 비해 유인력이 큰 공급지가 입지한 수도권의 경우 거리에 기초하여 수요지를 배분하는 입지-배분모델을 적용하고, 나머지 지역의 경우 수요지의 유출력과 공급지의 유인력을 현실적으로 반영할 수 있는 공간적 상호작용 모델을 적용하여 판매권역을 설정하는 것이 가장 합리적이었다. 또한 설정된 각 판매권역의 특성을 분석해 본 결과 판매권역 내에 포함되는 자동차대수와 인구수에 있어서 상당한 격차를 보이고 있었다. 이는 판매권역이 잠재적 수요를 기초로 하여 설정되므로, 휘발유 소비 수준의 격차가 이와 같은 판매권역간에 편차를 야기시키고 있다고 풀이할 수 있다.