• Journal of Biomedical Engineering Research
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• v.38 no.1
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• pp.43-48
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• 2017

Chemotherapy, radiation therapy, and surgery are major methods to treat cancer. However, current cancer treatments report severe side effects and high recurrences. Recent studies about engineering nanoparticles as a drug carrier suggest possibilities in terms of specific targeting and spatiotemporal release of drugs. While many nanoparticles demonstrate lower toxicity and better targeting results than free drugs, they still need to improve their performance dramatically in terms of targeting accuracy, immune responses, and non-specific accumulation at organs. One possible way to overcome the challenges is to make precisely controlled nanoparticles with respect to size, shape, surface properties, and mechanical stiffness. Here, we demonstrate $500{\times}200nm$ discoidal polymeric nanoconstructs (DPNs) as a drug delivery carrier. DPNs were prepared by using a top-down fabrication method that we previously reported to control shape as well as size. Moreover, DPNs have multiple payloads, poly lactic-co-glycolic acid (PLGA), polyethylene glycol (PEG), lipid-Rhodamine B dye (RhB) and Salinomycin. In this study, we demonstrated a potential of DPNs as a drug carrier to treat cancer.

• Journal of Korean Society of Steel Construction
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• v.29 no.4
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• pp.269-280
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• 2017

In this study, seismic performance was evaluated for the exposed column-base plate weak-axis connections of small size steel structures through cyclic loading tests. The primary test parameters are the thickness of base plate, the presence of rib plates, the number of anchor bolts and embedment length of anchor bolts. To investigate the effect of bond performance of anchor bolts on the seismic performance of column-base plate connections, L-shaped round bars and thread bars were used as the hooked anchor bolts in the test specimens. Test results showed that bond performance of anchor bolts and the thickness of base plate significantly affect the structural performance and energy dissipation capacity. In particular, it was found that even if the requirements for minimum thickness of the base plate that is satisfied, the base plate can yield before the capacity of steel column reaches the plastic moment resulting in decreasing the structural performance of the connections. However, the proposed details of the connections might be considered as the partially restrained, that is semi-rigid connections. Consequently, the L-shaped thread anchor bolts is applicable in the exposed column-base plate weak-axis connections of small-size steel structures.

• Journal of Korean Association for Spatial Structures
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• v.8 no.4
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• pp.47-55
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• 2008

This paper deals with basic theories and some numerical results on structural optimization for geodesic dome. First of all, the space efficiency of geodesic dome is investigated by using the ratio of icosahedron's surface area to the internal volume enclosed by it. The procedure how to create the geodesic dome is also provided in systematic way and implemented and utilized into the design optimization code ISADO-OPT. The mathematical programming technique is introduced to find out the optimum pattern of member size of geodesic dome against a point load. In this study, total weight of structure is considered as the objective function to be minimized and the displacement occurred at loading point and member stresses of geodesic dome are used as the constraint functions. The finite difference method is used to calculate the design sensitivity of objective function with respect to design variables. The SLP, SQP and MFDM available in the optimizer DoT is used to search optimum member size patterns of geodesic dome. It is found to be that the optimum member size pattern can be efficiently obtained by using the proposed design optimization technique and numerical results can be used as benchmark test as a basic reference solution for design optimization of dome structures.

• Korean Journal of Environmental Biology
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• v.20 no.1
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• pp.91-99
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• 2002

With physico-chemical environmental factors such as temperature, DO, pH, conductivity and nutrients, size fractionated of phytoplankton standing crops and chlorophyll a concentrations $(>8\mu{m},\;3-8\mu{m},\;<3\mu{m})$ and their relationships were investigated at each station of Kyungan Stream and Togyo Reservoir from April to November in 1997. The two sampling sites showed different nutrient status: Kyungan Stream was eutrophic, while Togyo Reservoir was mesotrophic. Large sizes of phytoplankton and chl. a were higher in Kyungan Stream, opposite to those of Togyo Reservoir; Standing crops of phytoplankton $(>8\mu{m)$ and chl. a $(3-8\mu{m)}$ were high in Kyung-an Stream, while phytoplankton $(3-8\mu{m)}$and chi. a $(<3\mu{m)$ were abundant in Togyo Reservoir. These results imply that phytoplankton community in the highly eutrophicated water mainly comprised the large filamentous and/or colonial algae, such as Microcystis spp. and Aphanizomenon flos-aquae, which easily enriched by nutrients loading.

• Applied Chemistry for Engineering
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• v.24 no.6
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• pp.639-644
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• 2013

In this study, ethosomes loaded with Eucommia ulmoides extracts that have anti-inflammatory and anti-aging activities on the skin were prepared as cosmetic materials. The particle size, physical property, and entrapment efficiency of ethosomes to identify their stabilities during 4 weeks were measured. Ethosomes containing 0.01~0.05% E. ulmoides extracts did not show either precipitation or separation. The mean particle size of these ethosomes was 136.4 nm, and monodisperse. The particle size of ethosome containing 0.05% E. ulmoides extracts was 151.15 nm and the entrapment efficiency was 81.79%. Therefore, in vitro skin permeation experiment was performed with ethosome containing 0.05% E. ulmoides extracts that showed the high loading efficiency and stability during 4 weeks. The order of skin permeation of E. ulmoides extracts was ethosome (77.16%) > liposome (62.80%) > ethanolic solutoin (41.59%). These results suggest that ethosomes containing 0.05% E. ulmoides extracts are effective for the skin permeation and may be used as a cosmetic formulation containing plant extracts.

• KSCE Journal of Civil and Environmental Engineering Research
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• v.29 no.5A
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• pp.519-529
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• 2009

Fiber reinforced composite materials have various advantages in mechanical and chemical aspects. Not only high fatigue and chemical resistance, but also high specific strength and stiffness are attained, and therefore, damping characteristics are beneficial to marine piles. Since piles used for marine structures are subjected to compression and bending as well, detailed research is necessary. Current study examine the mechanical behavior under flexural and/or compressive loads using concrete filled fiber reinforced plastic composite piles, which include large size diameter. 25 pile specimens which have various size of diameters and lengths were fabricated using hand lay-up or filament winding method to see the effect of fabrication method. The inner diameters of test specimens ranged from 165 mm to 600 mm, and the lengths of test specimens ranged from 1,350 mm to 8,000 mm. The strengths of the fill-in concrete were 27 and 40 MPa. Fiber volumes used in circumferential and axial directions are varied in order to see the difference. For some tubes, spiral inner grooves were fabricated to reduce shear deformation between concrete and tube. It was observed that the piles made using filament winding method showed higher flexural stiffness than those made using hand lay-up. The flexural stiffness of piles decreases from the early loading stage, and this phenomenon does not disappear even when the inner spiral grooves were introduced. It means that the relative shear deformation between the concrete and tube wasn't able to be removed.

• Journal of Korean Society of Steel Construction
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• v.25 no.1
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• pp.61-70
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• 2013

A turn-buckle is capable of adjusting the tensile force by left-hand threads and right-hand threads between tension members. There are different types of turn-buckles according to tension member and connection form but the practical and existing turn-buckles are incapable of measuring the tensile force. A turn-buckle for adjusting and measuring tensile force has therefore been developed. This study shows the ultimate strength and reliability for measurement of the new turn-buckles through finite element analysis of the developed ones. From analytic results of the new turn-buckles which have the measurement limit loads of 100kN, 200kN and 300kN, the ultimate strength is approximately five times stronger than the measurement limit capacity. Additionally, a review of the new turn-buckle, which has the measurement limit load of over 300kN, shows that there is a tendency for the size of turn-buckle to become larger. So the connection devices were designed and the loading test was conducted from the concept that the parallel connection of turn-buckle with 300kN capacity can measure the tensile force of 600kN. The results of parallel loading test show the sufficient possibility. Furthermore, the mock-up test was constructed to investigate the release of initial load and corrosion when the new turn-buckle is installed at the outdoor and exposed to rain and atmosphere.

• Journal of Hydrogen and New Energy
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• v.31 no.1
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• pp.57-64
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• 2020

The water-gas shift reaction for the compact reformer was carried out at a gas hourly space velocity of 72,152 h^-1 over the Cu-Nb-CeO₂ catalysts prepared by co-precipitation method. In order to investigate the effect of Nb₂O₅ promotion over a Cu-CeO₂ catalyst, the Nb₂O₅ loading amount was systematically changed from 0 to 5 wt.%. Among the prepared catalysts, the Cu-Nb-CeO₂ (1%) catalyst showed the highest catalytic activity (CO conversion=61% at 400℃) as well as 100% CO₂ selectivity. The high activity and stability of Cu-Nb-CeO₂ (1%) catalyst are correlated to high Brunauer-Emmett-Teller surface area, small metallic Cu crystallite size, and enhanced redox property.

• Economic and Environmental Geology
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• v.36 no.3
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• pp.171-176
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• 2003

The fate and behavior of polycyclic aromatic hydrocarbons(PAHs) and heavy metals in the environment are mainly controlled by their interactions with various components of soils and sediments. Due to their large surface area and abundance in many soils, smectites may greatly influence the fate and transport of the contaminants. In our experiment, PAH sorption by hexadecyltimethylammonium(HDTMA)-modified smectite linearly increased in proportion to the amount of HDTMA added on the clay. However, trimethylammonium(TMA)-modified smectite did not show superiority in its sorption of PAH compared with the HDTMA-smectite or dodecyltrimethylammonium(DTMA)- smectite. Meanwhile, the smectites modified with the same cationic surfactants adsorbed Cd$^{2＋}$(heavy metal) significantly from water at low surfactant loading level, but the Cd$^{2＋}$ adsorption linearly decreased as the loading of surfactant increased. The result shows that the sorption tendency of organoclays for organic or inorganic contaminants was significantly influenced by the amount and size of the surfactants added on the clay. This reveals that the stabilization and configuration of cationic surfactant formed on the clay interlayer of different sizes may be an important factor in controlling the sorptive capacity of each pollutant in the environment.

• Applied Chemistry for Engineering
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• v.7 no.5
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• pp.999-1005
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• 1996

Pt catalyst on carbon black was prepared by colloidal method, ion exchanging method and methanol reducing method. The colloidal method has been used generally. At ion exchanging method, $H^+$ of functional group on carbon surface made by oxidation treatment was exchanged with Pt ion. At methanol reducing method, Pt was impregnated on carbon to reduce by methanol contained with surfactants. With TEM and XRD, Pt particle size impregnated on carbon by various methods was $30{\sim}50{\AA}$. Loading yield was about 100%, loading yield of ion exchanging method was 99.92% by DCP analysis and 99.87% by combustion method. Within 60 hour, current density of oxygen reduction was $460mA/cm^2$ at 0.7V(vs. RHE) at colloidal method. It was the better performance than catalyst prepared by ion exchanging, methanol reducing method. But, it was shown some decrease of performance for long operation time(after 100hour), catalyst prepared by methanol reducing method was shown stable performance.