• Journal of Pharmaceutical Investigation
• /
• 제39권5호
• /
• pp.339-343
• /
• 2009

Recently, co-delivery of drug and gene has been attempted for higher therapeutic effects of anticancer agents. In this study, cationic liposomes were prepared using 1,2-dioleoyl-3-trimethylammoniopropane (DOTAP) as a cationic lipid to investigate the effect of drug loading on the physicochemical characteristics of cationic liposomes/DNA complexes. The complex formation between cationic liposomes and negatively charged plasmid DNA was confirmed and the protection from DNase was observed. Particle size of complexes was reduced not by drug loading, but by the increased ratio of cationic lipid to plasmid DNA. Meanwhile, zeta potential of complex was increased by the addition of cationic liposomes to complexes and the effect of drug loading on the zeta potential was not much higher than on particle size. Gel retardation of complexes was indicated when the complexation weight ratios of cationic lipid to plasmid DNA were higher than 24:1 for drug free complexes and 20:1 for drug loaded ones, respectively. Agarose gel retardation showed the similar complexation between plasmid DNA and drug free liposomes or drug loaded liposomes. Both complexes protected plasmid DNA from DNase independent of complexation temperature. From the results, drug loading may affect not the complex formation of cationic liposomes and plasmid DNA, but the particle size of complex.

• 한국지진공학회:학술대회논문집
• /
• 한국지진공학회 2000년도 춘계 학술발표회 논문집 Proceedings of EESK Conference-Spring
• /
• pp.298-307
• /
• 2000

The behavior of a unreinforced cement brick building structure subjected to earthquake loading was experimentally investigated. for this four full size wall specimens were tested under quasi-static in-plane cyclic loading. Experimental observations indicate that the failure modes of unreinforced masonry walls are principally governed by sliding or/and rocking depending on the aspect ration and magnitude of axial loading. Also found was the flexure or shear mode resulting from the degraded strength of brick and/or mortar due to the cyclic loading effect.

• Advances in materials Research
• /
• 제8권3호
• /
• pp.219-235
• /
• 2019

This research is devoted to analyzing mechanical-thermal post-buckling behavior of a micro-size beam reinforced with graphene platelets (GPLs) based on geometric imperfection effects. Graphene platelets have three types of dispersion within the structure including uniform-type, linear-type and nonlinear-type. The micro-size beam is considered to be perfect (ideal) or imperfect. Buckling mode shape of the micro-size beam has been assumed as geometric imperfection. Modified couple stress theory has been used for describing scale-dependent character of the beam having micro dimension. Via an analytical procedure, post-buckling path of the micro-size beam has been derived. It will be demonstrated that nonlinear buckling characteristics of the micro-size beam are dependent on geometric imperfection amplitude, thermal loading, graphene distribution and couple stress effects.

• 상하수도학회지
• /
• 제17권4호
• /
• pp.528-533
• /
• 2003

Bubble size is one of the most important parameters affecting DAF (Dissolved-Air-Flotation) process. It is generally known that small bubbles are preferred. However, the fact seems to be based on the particle removal efficiency at contact zone only, without considering separation zone. Besides, the effect of bubble size on the overall DAF process has not been fully investigated yet. Therefore, the effect of bubble size on collision efficiency, collision chances, and surface loading rate is calculated using theoretical models, and the results are discussed in this paper.

• Advances in concrete construction
• /
• 제5권6호
• /
• pp.613-624
• /
• 2017

In this paper, an experimental investigation was carried out to study the effect of volume fraction of fiber and maximum aggregate size on mode-I fracture parameters of high strength concrete. Total of 108 beams were tested on loading frame with three point loading, the variables in the high strength concrete beams are aggregate size (20 mm, 16 mm and 10 mm) and volume fraction of fibers (0%, 0.5%, 1% and 1.5%). The fracture parameters like fracture energy, brittleness number and fracture process zone were analyzed by the size effect method (SEM). It was found that fracture energy (Gf) increases with increasing the Maximum aggregate size and also increasing the volume of fibers, brittleness number (${\beta}$) decreases and fracture process zone (CF) increases.

• 환경위생공학
• /
• 제17권2호
• /
• pp.11-17
• /
• 2002

Diesel particulate matter (DPM) is known to be one of the major harmful emissions produced by diesel engines. The majority of diesel particles are in the range of smaller than $I{\mu}\textrm{m}$. Because of their tiny volume, ultrafine diesel particles contribute very little to the total mass concentration which is currently regulated for automobile emissions. Diesel particles are known to have deleterious effects upon human health because they penetrate human respiratory tract and have negative effects on the health. The measurement of the number distribution of nanometer size particles (nanoparticles) in the diesel exhaust emission is important in order to evaluate their environmental and health impact, and to develop new types of diesel particulate filters. In this study, we directly sampled particulate matters emitted from a diesel truck mounted on the chassis dynamometer by a flow separator and dilution system, and measured the nanoparticles using two types of differential mobility analyzers combined with a Faraday cup electrometer (FCE) and a condensation particle counter (CPC). The particle size distributions were analyzed by changing engine operation condition, i.e. ratio of engine loading. The total number concentration of particles were increased with the engine loading ratio and the nanoparticles (less than 50nm) were affected by hydrocarbon (HC) concentration in the diesel exhaust.

• 대한토목학회논문집
• /
• 제10권1호
• /
• pp.71-80
• /
• 1990

본(本) 논문(論文)에서는 동적하중(動的荷重)을 받는 콘크리트의 파괴특성을 규명하고, 동적하중하(動的荷重下)에서의 변화특성을 연구하였다. 이를 위하여 포괄적인 실험연구가 수행되었으며 부재크기의 영향을 분석하기 위하여 몇가지 시리즈로 분류하여 실험하였다. 본 실험으로부터 최대파괴하중(最大破壞荷重), 정적(靜的) 및 동적(動的) 파괴(破壞)에너지 그리고 공칭파괴응력이 계산되었다. 본(本) 연구결과(硏究結果) 변형속도(變形速度)가 증가함에 따라 콘크리트의 파괴에너지가 증가하는 것으로 나타났다. 또한, 부재의 크기가 커짐에 따라 파괴에너지 값이 상당히 변화되는 것으로 타나났다. 본(本) 연구(硏究)에서는 부재 크기에 따른 콘크리트의 정적(靜的) 및 동적(動的) 파괴에너지를 예측할 수 있는 예측공식을 도출하여 제시하였다. 본(本) 연구(硏究)는 콘크리트의 동적파괴거동해석에 유용한 기초자료가 될 것으로 사료된다.

• Advances in nano research
• /
• 제4권3호
• /
• pp.197-228
• /
• 2016

In the present study, thermo-electro-mechanical vibration characteristics of functionally graded piezoelectric (FGP) Timoshenko nanobeams subjected to in-plane thermal loads and applied electric voltage are carried out by presenting a Navier type solution for the first time. Three kinds of thermal loading, namely, uniform, linear and non-linear temperature rises through the thickness direction are considered. Thermo-electro-mechanical properties of FGP nanobeam are supposed to vary smoothly and continuously throughout the thickness based on power-law model. Eringen's nonlocal elasticity theory is exploited to describe the size dependency of nanobeam. Using Hamilton's principle, the nonlocal equations of motion together with corresponding boundary conditions based on Timoshenko beam theory are obtained for the free vibration analysis of graded piezoelectric nanobeams including size effect and they are solved applying analytical solution. According to the numerical results, it is revealed that the proposed modeling can provide accurate frequency results of the FGP nanobeams as compared to some cases in the literature. In following a parametric study is accompanied to examine the effects of several parameters such as various temperature distributions, external electric voltage, power-law index, nonlocal parameter and mode number on the natural frequencies of the size-dependent FGP nanobeams in detail. It is found that the small scale effect and thermo-electrical loading have a significant effect on natural frequencies of FGP nanobeams.

• 약학회지
• /
• 제45권6호
• /
• pp.623-633
• /
• 2001

Various bupivacaine-loaded microspheres were prepared using poly(d,1-lactide) (PLA) and poly(d,1-lactic-co-glycolide) (PLGA) by a solvent evaporation method for the sustained release of drug. The effects of process conditions such as drug loading, polymer type and solvent type on the characteristics of microspheres were investigated. The prepared microspheres were characterized for their drug loading, size distribution, surface morphology and release kinetics. Drug loading efficiency and yield of PLGA micro- spheres were higher than those of PLA microspheres. The prepared microspheres had an average particle size below 5${\mu}{\textrm}{m}$. The particle size range of microspheres was 1.65~2.24${\mu}{\textrm}{m}$. As a result of SEM, the particle size of PLA microspheres was smaller than that of PLGA microspheres. In morphology studies, microspheres showed a spherical shape and smooth surface in all process conditions. In thermal analysis, bupivacaine-loaded microspheres showed no peaks originating from bupivacaine. This suggested that bupivacaine base was molecular-dispersed in the polymer matrix of microspheres. The release pattern of the drug from microspheres was evaluated for 96 hours. The initial burst release of bupivacaine base decreased with increasing the molecular weight of PLGA, and the drug from microspheres released slowly. In conclusion, bupivacaine-loaded microspheres were successfully prepared from poly(d,1-lactide) and poly (d,1- lactic-co-glycolide) polymers with different molecular weights allowing control of the release rate.

• Structural Engineering and Mechanics
• /
• 제23권2호
• /
• pp.147-161
• /
• 2006

Recent developments in fractal theory suggest that fractal may provide a more realistic representation of characteristics of cementitious materials. In this paper, the roughness of fracture surfaces in cementitious material has been characterized by fractal theory. A systematic experimental investigation was carried out to examine the dependency of fracture parameters on the aggregate sizes as well as the loading rates. Three maximum aggregate sizes (4.76 mm, 12.7 mm, and 19.1 mm) and two loading rates (slow and fast loading rate) were used. A total of 25 compression tests and 25 tension tests were performed. All fracture parameters exhibited an increase, to varying degrees, when aggregates were added to the mortar matrix. The fracture surfaces of the specimens were digitized and analyzed. Results of the fractal analysis suggested that concrete fracture surfaces exhibit fractal characteristics, and the fractal geometry provide a useful tool for characterizing nonlinear fracture behavior of concrete. Fractal dimension D was monotonically increased as maximum aggregate sizes increase. A new fractal fracture model was developed which considers the size and shape of aggregate, and the crack paths in the constituent phases. Detailed analyses were given for four different types of fracture paths. The fractal fracture model can estimate fractal dimension for multiphase composites.