• Journal of Nutrition and Health
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• 제26권9호
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• pp.1049-1070
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• 1993

The purpose of this study is to investigate dietary factors which influence the conditions of Korean fatty liver patients. The subjects were 83 fatty liver patients living in city, ages of 10 to 60 yrs old, and they were the same patients studied 9 months ago in previous study. The patients were groupsed into 3 groups(improved, similar, worsened groups) according to the changes in disease condition. Nutrient and alcohol intakes and health status were investigated. In improved group, the patients tended to lose weight, the number of exercising patients was increased, the consumptions of calorie, carbohydrate, calcium, phosphorus were decreased. And alcohol intake was decreased markedly and serum total amino acids(AA), EAA, NEAA, BCAA and AMAA contents, EAA/NEAA and BCAA/AMAA ratios were increased. In worsened group, patients tended to gain weight, the number of exercising patients decreased, the consumptions of calorie, protein, carbohydrate, calcium, phosphorus and niacin decreased but vitamin. A intake increased. And also, in this group, alcohol intake of male patients decreased and that of female slightly increased, and serum EAA, BCAA and AMAA contents, EAA/NEAA and BCAA/AMAA ratios, and total fatty acid contents increased and total AA and NEAA contents decreased. In conclusion, it is desirable to reduced weight, stress, alcohol, salt and animal fat consumptions, and to exercise, and to take adequate amount and quality of protein to improve conditions of fatty liver patients.

• 한국환경보건학회지
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• 제17권1호
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• pp.79-88
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• 1991

These studies were carried out to find out some characteristic responses of biological samples under the exposure of trace metals. In animal experiment, six rats per week were killed for 6 weeks under Cd exposures and the concentrations of Cd, Cu and Zn in their organs and blood were determined by flame atomic absorption spectrophotometry.The results were summarized as follows: In animal experiments, the concentrations of Cd in the liver and kidney of Cd exposure groups were increased, however, the values of hematocrit and hemoglobin in blood were decreased remarkably. The body weight of the Cd exposure groups showed lower trend than that of control group. The concentrations of Cd in heart, lung and testes were increased slowly during the first 2 weeks. The concentrations of Cd in their organs decreased while the rapid increase of the concentration of Cd in the liver and kidney was observed. While rapid increase of the concentra~ion of Cd in the liver and kidney was observed, the concentrations of Cd in the organs were decreased afterward and increased again while the low increase of the concentration of Cd in the liver and kidney was observed. The concentrations Cu and Zn were increased remarkably in all the organs for first 2 and 3 weeks. In the exposure groups of Cd+Cu and Cd+Zn, the liver and kidney didn't show lower concentration of Cd than that of Cd group.

• 한국환경보건학회지
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• 제29권2호
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• pp.23-28
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• 2003

To evaluate the effect of cyclohexane(CH) treatment on the liver cytochrome P-450 dependent aniline hydroxylase(CYPdAH) activity in alcohol-pretreated animals, CH(1.56 g/kg body weight) was intraperitoneally administered to Sprague-Dawley male rats, which had been drunk 15％ alcohol in distilled water for 1,3 and 6 weeks. CH was injected to rats 4 times every other day and the animals were sacrificed at 24 hours after injection of CH. In the alcohol-pretreated rats, liver injuries were not demonstrated on the basis of the liver weight per body weight, the levels of serum alanine aminotransferase and hepatic microsomal glucose-6-phosphatase activities. By the CH treatment, alcohol-pretreated animals showed the significantly increased activity of hepatic microsomal CYPdAH. Concomitantly $V_{max}$ value in CYPdAH was more increased, whereas $K_{M}$ value more decreased in alcohol-pretreated animals by the treatment of CH. In conclusion, the increasing cause of microsomal CYPdAH in CH-treated rats pretreated with alcohol may be due to induction of enzyme protein in rat liver.r.r.

• 근관절건강학회지
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• 제22권3호
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• pp.219-227
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• 2015

Purpose: The purpose of this study was to investigate the degree of dietary compliance, nutritional status, and stages of disease in patients with liver cirrhosis and to identify the relationships among those variables. Methods: This study used a cross-sectional design and conducted a survey of 100 patients who were treated at D-university hospital in Busan. For data analysis, descriptive statistics and Pearson's correlation coefficients were performed using SPSS/WINdow 20.0 program. Results: The mean score of dietary compliance was 3.50 in the a 5-point scale. Stage of disease was significantly correlated with dietary compliance (r=.20, p=.048), and protein as one of nutritional status (r=-.44, p<.001). Conclusion: These findings suggest that dietary compliance of patients with liver cirrhosis can have an influence on prognosis of disease. Therefore, patients should be encouraged to improve dietary compliance from the early stage of liver cirrhosis.

• 근관절건강학회지
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• 제23권3호
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• pp.179-186
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• 2016

Purpose: The purpose of this study was to identify factors that influence dietary compliance in patients with liver cirrhosis. Methods: This study used a cross-sectional design and was conducted with a survey of 141 patients in liver cirrhosis who were treated at D-university hospital in Busan. For data analysis, descriptive statistics, Pearson's correlation coefficients, and a multiple regression were performed using SPSS/WIN 20.0 Program for windows. Results: The mean score was 3.47 in dietary compliance. Dietary compliance had a positive correlation with self-efficacy, perceived-benefit medical staff support, age, drink or not but had a negative correlation with perceived barrier. As a result of multiple regression analysis, self-efficacy and perceived-benefits explained 30.1% (F=7.69, p<.001) of the variance of dietary compliance. Conclusion: Dietary compliance was suggested to consider self-efficacy and perceived-benefits when developing a nutritional education programs for patients with liver cirrhosis.

• 성인간호학회지
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• 제14권4호
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• pp.501-509
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• 2002

Purpose: This study was performed to identify the illness intrusiveness, quality of life, and their relationships in patients with chronic liver disease. Method: Data was collected using scales of illness intrusiveness developed by Devins et al and Korean health related quality of life (KoQoLS) developed by Shim et al to measure the illness intrusiveness and quality of life from 141 chronic liver disease patients. Result: The total mean score of illness intrusiveness was $38.85{\pm}18.45$. The domain of illness intrusiveness which showed the highest mean score was health ($4.60{\pm}2.02$), and the lowest mean score domain was relationship with spouse ($20.4{\pm}1.69$). The subcategory of KoQoLS which showed the highest mean score was bodily pain ($6.96{\pm}2.98$), and the lowest mean score subcategory was vitality ($2.75{\pm}1.20$). There were negative relationships between illness intrusiveness and KoQoLS in all subcategories. Abovel all, Illness intrusiveness had the strongest negative relationship with role limitation (r=-0.641) among the KoQoLS subcategories. Conclusion: Because the illness intrusiveness had negative influence on the quality of life in patients with chronic liver disease, further research will need to specify detailed illness intrusiveness and to explore influencing factors on quality of life in them.

• 한국환경보건학회지
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• 제18권1호
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• pp.95-104
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• 1992

The influence of selenium to several toxic effects of cadmum, including lethality has been shown following pretreatment with cadmium, zinc and seleniurm Five groups of rats, each consisting of 16 rats, were studied and each group was divided into four subgroups, 4 rats for each subgroup. After subcutaneous pretreatment during 5 days with saline, CdCl$_{2}$ (0.5mg/kg, ZnCl$_{2}$ (13.0mg/kg) and $Na_{2}SeO_{3}$(1.0mg/kg), rats were given intraperitioneal administration of various dosage of or cadium of cadmium and selenium. After giving the challenge dose, cadmium and metallothionein(MT) concentrations were determined in liver and kidney The concentration of cadmium in liver and kideny increased proportionally to the increase of challenge dosage. The simultaneous administration of cadmium and selenium significantly more decrease cadmium concentrations in liver and kidney than those of the administration of cadmium only. However, MT concentrations in liver and kideny were increased by the pretreatment of cacmium, zinc and selenium. Our results suggest that increasing cadmium concentrations, gradully accumulating in the tissues of liver and kidney as a result of the pretreatment, served to induced the synthesis of MT, thus making them resistant to the challenge from cadmium.

• 약학회지
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• 제51권1호
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• pp.1-6
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• 2007

The aim of this study was to examine whether administration of glutamine are able to prevent the methotrexate induced gut barrier damage, bacterial translocation, and weight changes. The animals with glutamine were fed with L-glutamine (1.2 and 2.4 mg/kg/day) for 7 days before methotrexate administration (20 mg/kg orally). 48 hour after methotrexate administration, intestinal permeability were measured for an assessment of the gut barrier dysfunction. Also, enteric aerobic bacterial counts, number of gram-negatives in mesenteric lymph node (MLN), liver spleen, kidney and heart were measured for an assessment of the enteric bacterial number and bacterial translocation. Amounts of food intake, body weight changes and organ weight changes of liver spleen, kidney and heart were measured. Methotrexate administration caused body and liver weight loss regardless amounts of food intakes. Methotrexate induced increasing intestinal permeability, enteric bacterial undergrowth and bacterial translocation to MLN, liver and spleen, but not kidney and heart. The supplements with glutamine reduced the intestinal permeability bacterial translocation, and not influences enteric bacterial number, and body and liver weight changes. This study suggested that glutamine might effectively reduce methotrexate induced intestinal damage and bacterial translocation, but not influence body and organ weight loss.

• Asian Pacific Journal of Cancer Prevention
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• 제14권6호
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• pp.3855-3859
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• 2013

Purpose: Liver cancer, one of the most common cancers in China, is reported to feature relatively high morbidity and mortality. Curcumin (Cum) is considered as a drug possessing anti-angiogenic, anti-inflammation and anti-oxidation effect. Previous research has demonstrated antitumor effects in a series of cancers. Materials and Methods: In this study the in vitro cytotoxicity of Cum was measured by MTT assay and pro-apoptotic effects were assessed by DAPI staining and measurement of caspase-3 activity. In vivo anti-hepatoma efficacy of Cum was assessed with HepG2 xenografts. Results: It is found that Cum dose-dependently inhibited cell growth in HepG2 cells with activation of apoptosis. Moreover, Cum delayed the growth of liver cancer in a dose-dependent manner in nude mice. Conclusions: Cum might be a promising phytomedicine in cancer therapy and further efforts are needed to explore this therapeutic strategy.

• 셀메드
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• 제2권4호
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• pp.34.1-34.5
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• 2012

The present study aimed to determine the hepatoprotective activity of the chloroform extract of D. linearis leaves (CEDL) using the paracetamol (PCM)- and carbon tetrachloride ($CCl_4$)-induced liver injury models in rats. The rats received $dH_2O$ (negative control), 200 mg/kg of silymarin (positive control) or CEDL (50, 250 and 500 mg/kg) orally once daily for 7 days and then were subjected to the hepatotoxic induction on the $7^{th}$ day. The samples (i.e. blood and liver) were collected and underwent biochemical and microscopical analysis, respectively. From the data obtained, both inducers caused significant (p < 0.05) increase in the levels of AST and ALT when compared to the control group, which were significantly (p < 0.05) reduced by CEDL in a generally dose-dependent manner. These biochemical findings were supported by the histopathological analysis and histological scoring. In conclusion, CEDL possesses potential hepatoprotective activity, which could be associated with its flavonoid and tannin contents with the mechanisms of hepatoprotection linked to either its antioxidant or anti-inflammtory/immunomodulating activities. Further in-depth studies are required to identify the responsible bioactive compound.