• Mycobiology
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• v.39 no.1
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• pp.45-51
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• 2011

This work was conducted to investigate dietary supplementation of oyster mushroom fruiting bodies on biochemical and histological changes in hyper and normocholesterolemic rats. Six-week old female Sprague-Dawley albino rats were divided into three groups of 10 rats each. Feeding a diet containing a 5% powder of Pleurotus ostreatus fruiting bodies to hypercholesterolemic rats reduced plasma total cholesterol, triglyceride, low-density lipoprotein (LDL), total lipid, phospholipids, and LDL/high-density lipoprotein ratio by 30.18, 52.75, 59.62, 34.15, 23.89, and 50%, respectively. Feeding oyster mushrooms also significantly reduced body weight in hypercholesterolemic rats. However, it had no adverse effects on plasma albumin, total bilirubin, direct bilirubin, creatinin, blood urea nitrogen, uric acid, glucose, total protein, calcium, sodium, potassium, chloride, inorganic phosphate, magnesium, or enzyme profiles. Feeding mushroom increased total lipid and cholesterol excretion in feces. The plasma lipoprotein fraction, separated by agarose gel electrophoresis, indicated that P. ostreatus significantly reduced plasma ${\beta}$ and pre-${\beta}$-lipoprotein but increased ${\alpha}$-lipoprotein. A histological study of hepatic cells by conventional hematoxylin-eosin and oil red O staining revealed normal findings for mushroom-fed hypercholesterolemic rats. These results suggest that a 5% P. ostreatus diet supplement provided health benefits by acting on the atherogenic lipid profile in hypercholesterolemic rats.

• International journal of advanced smart convergence
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• v.11 no.3
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• pp.170-178
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• 2022

Purpose: Gardening has been reported to have positive emotional and physical effects in older adults. However, limited studies have assessed this relationship in Korea. Therefore, in this pilot study of densely populated urban dwellers, we aimed to investigate whether temporary but repeated experiences of the natural environment could positively change metabolism-related blood indicators. Methods: This study used pre- and post-interventional designs to investigate the effects of 16 weeks of gardening on lipid profiles in an urban adult population and investigate their relationships. This study was conducted 30 times at the H Botanical Garden in Yongin City from August 16, 2021 to November 30, 2021 (16 weeks, twice a week, 3 hours each time). Before and after the gardening program, a clinical pathologist collected blood samples from the participants. Results: High-density lipoprotein levels increased, low-density lipoprotein levels decreased, and total cholesterol levels decreased after the gardening activity. Conclusions: Our findings suggest that gardening has potential for clinical application as it has good control over the lipid profile through physical activity. These findings can be used as basic data for studying the relationship between urban populations and their living environment and for various studies in the future as experiencing the natural environment provides many health benefits.

• Journal of Ginseng Research
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• v.10 no.1
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• pp.114-121
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• 1986

Effect of saponin fraction of ginseng C.A. Meyer on blood serum lipoprotein distribution of high cholesterol fed rabbits for two to four weeks was investigated. A. significant increase of very low density lipoprotein(VLDL) and low density lipoprotein(LDL) occured while high density lipoprotein(HDL) were decreased in the blood of both groups which were fed high cholesterol diet with (test group) and/or without ginseng saponin(control group) for 2-4 weeks. However the degrees of VLDL and LDL increase and HDL decrease were relatively small in ginseng administered group compared with control group. This suggests that the hypocholesterolemic action of the saponin might be brought about by decreasing the raised VLDL and LDL level and increasing the lowered HDL level.

• Journal of Pharmaceutical Investigation
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• v.1 no.1
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• pp.13-21
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• 1971

The effects of alcohol. extract of acacia on total cholesterol, ${\beta}-lipoprotein$ content and S-GOT activity in serum of rabbit were examined. Rabbits were divided into four groups. A : Control group B : Cholesterol group C : Cholesterol+aca. alc. ex. (A) group D : Cholesterol+aca. alc. ex. (B) group Each group had four rabbits. A Group was fed with the stock diet only for the experimental period of 28 days. B Group was fed with the stock diet containing 500mg of cholesterol. C Group was fed with the stock diet containing 500mg of cholesterol and 300mg of acacia alcohol extract. D Group was fed with the stock diet containing 500mg of cholesterol and 500mg of acacia aocohol extract. Total cholesterol ${\beta}-lipoprotein$ content and S-GOT activity in serum was determined with spectrophotometer, spectronic 20. It was confirmed that the extract of acacia alcohol inhibits the increase of total cholesterol, ${\beta}-lipoprotein$ content and S-GOT activity in serum but the statistical probability was not significant.

• Journal of Nutrition and Health
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• v.28 no.8
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• pp.697-705
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• 1995

This study was conducted to investigate the effect of increasing dietary fat on plasma lipoprotein in young Korean women. During the three weeks of experimental periods, 8 healthy college women consumed a regular diet, a medium fat diet and a high fat diet for one week, consecutively. The percentages of fat from energy intake in the subjects on the regular, medium, and high fat diets were 20, 29 and 38%, respectively. Our data showed that the dietary intakes of fat and cholesterol had an influence on the plasma lipoprotein. The medium fat diet enhanced the blood glucose concentration and the plasma HDL, and the high fat diet resulted in increases in the blood glucose concentration and the plasma LDL as well as HDL. Also the type of diets led to changes in the composition of lipoprotein. When on the medium fat diet, HDL and LDL had higher phospholipid content. On the high fat diet, LDL had higher phospholipid, cholesterol and triglyceride contents, and HDL included higher cholesterol content.

• Journal of Life Science
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• v.8 no.4
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• pp.353-359
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• 1998

This study was initiated to antioxidant activity of silybin on oxidation of human low density lipoproteins(LDL). Siltbin was extracted from Silybum marianum by the combination of fractionation and it was futher purified by silica gel column chromatography, and isolated active substances were identified silybin by IR, NMR and GC-MS. siltbin inhibited the ozidation of human low density lipoprotein(LDL) mediated by 5$^{\mu}$m CU $^{2+}$ ion in a dose dependent manner. LDL oxidation by congugated dines formation was completely inhibited by silybin at a concentration of 5$^{\mu}$M. The results provide a possibility that silybin might protect LDL against oxidation in atherosclerotic lessions.

• Journal of Nutrition and Health
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• v.5 no.2
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• pp.75-82
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• 1972

Fifteen cases of primiparas and their offsprings (fetal cord) were investigated with regard their serum total, free and esterified cholesterol by means of Liberman Buchard reaction. The serum ${\alpha}-and\;{\beta}-lipoprotein$ were analyzed by cellulose acetate electrophoresis, and the serum atherolipid numbers were calculated on the bases of the serum total cholesterol and ${\beta}-/{\alpha}-$ lipoprotein ratio, with the following conclusion. 1.Total, free and esterified cholesterol are $178.9{\pm}25.3$, $45.1{\pm}12.6$ and $133.7{\pm}20.6\;mg.%$ in the normal control women, $201.5{\pm}29.5,\;58.7{\pm}42.1$ and $157.1{\pm}26.2\;mg.%$ in the maternal blood, showing hypercholesterolemia in the latter as compared to the former. 2. The serum total, free and esterified cholesterol in the cord blood are $94.5{\pm}20.4$, $32.9{\pm}1.5$ and $61.2{\pm}18.9mg.%$, showing hypocholesterolemia as compared to the control women and maternal blood. 3. The serum ${\alpha}-$, $pre-{\beta}$, ${\beta}-lipoprotein$ and chylomicron are $24.2{\pm}4.2$, $17.3{\pm}3.4$, $51.8{\pm}4.8$ and $6.0{\pm}1.6%$ in the normal women, whereas $14.9{\pm}2.1$, $22.2{\pm}5.1$, $58.7{\pm}3.3 and 3.1{\pm}1.2%$ in the maternal serum, $32.4{\pm}8.1$, $28.8{\pm}2.4$, $25.8{\pm}7.0$ and $3.1{\pm}0.9%$ in the cord serum, showing $hyper-{\beta}-lipoproteinemia$ in the former and $hypo-{\beta}-lipoproteinemia$ in the latter. 4. The serum atherolipid number of the normal control women, maternal cord blood are $4.21{\pm}1.24$, $8.02{\pm}1.42$ and $1.12{\pm}0.37$, showing hyperlipemia in the former and hypolipemia in latter. 5. The relative ratio of the serum free and esterified cholestrol of both normal control women and maternal blood is about 1 : 3, while that of the fetal blood about 1 : 2. 6. The relative ratioes of the serum ${\alpha}-and$ ${\beta}-lipoprotein$ in the control women is about 1 : 2, that of materna blood about 1 : 3 and that of the fetal blood about equal magnitude. 7. The serum esterified cholesterol, ${\alpha}-lipoprotein,\;{\beta}-/{\alpha}-lipoprotein$ ratio and atherolipid number fluctuates are proportionally between the maternal and fetal blood, while the serum free, total cholesterol and ${\beta}-lipoprotein$ between the two vary inversely with statistically significant corelations. 8. It is apparent from the above results that the fetal nutritional demand for lipids resulted from hypocholesterolemia and hypo ${\beta}-lipoproteinemia$ seems to be met satisfactorily by maternal hypercholesterolemia and hyper ${\beta}-lipoproteinemia$, which seems to pose a significant maternal-infant nutritional relationship. A brief ciscussion was made on these conciusion in the light of biochemistry and endocrinology.

• Proceedings of the KIEE Conference
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• 1987.07b
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• pp.1296-1300
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• 1987

NMR spectrum analysis is performed to obtain the preliminary data for cancer detection. As NMR spectrum of plasma is dominated by the resonances of water, the resonances of plasma lipoprotein lipid is obscured by the water resonance. Thus, we can obtain the signal of plasma lipoprotein lipid using Ultracentrifugation. we analyzed the spectrum measuring the mean line widths of the methyl and methylene resonances for normal control group. As a result, the line width was Hz To obtain a potentially valuable approach to the detection of cancer, the performance of additional clinical trials in larger populations will be made.

• BMB Reports
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• v.45 no.10
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• pp.565-570
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• 2012

We recently reported that a water extract of laurel or turmeric, 1,8-cineole enriched fractions, showed hypolipidemic activity in the zebrafish model. Therefore, the present study investigated the cineole's anti-oxidant and anti-inflammatory activities in lipoprotein metabolism in vitro and in vivo. Cineole had inhibitory effects on cupric ion-mediated oxidation of lipoproteins in general, while simultaneously enhancing ferric ion removal ability in high-density lipoprotein (HDL). Hypercholesterolemia was induced in zebrafish using cholesterol-feeding treatment, 4% cholesterol, for 3 weeks. After feeding with or without the addition of cineole, the results revealed that cineole possessed lipid-lowering and anti-inflammatory activities in hypercholesterolemic zebrafish. In addition, serum amyloid A and interleukin-6 levels were lowered and lipid accumulation was decreased in the liver. Conclusively, 1,8-cineole was found to have anti-oxidant activities in lipoprotein metabolism both in vitro and in vivo with simultaneous reduction of lipid accumulation in the liver of zebrafish.

• Journal of Acupuncture Research
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• v.40 no.4
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• pp.351-355
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• 2023

Background: Wet cupping (WC) is an efficient and cost-effective technique for removing metabolic waste from the bloodstream via the skin. The study aimed to examine the effect of WC on cholesterol levels including total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C), and low-density lipoprotein cholesterol (LDL-C) in a Sudanese population. Methods: In this prospective cross-sectional study, 30 participants undergoing regular WC therapy were enrolled. Blood samples collected twice: pre-WC therapy (case group) and 10-14 days afterward (controls). Results: Of the participants, 56.67% were male and 43.33% were female, aged 24-69. Pre-WC TC and LDL-C levels were significantly higher than the post-WC control group (p = 0.001). Conversely, HDL-C levels decreased significantly in the pre-WC cases compared to controls (p = 0.001). No significant sex-based difference in mean cholesterol levels (p > 0.05). Conclusions: After WC, males and females experienced significant reductions in TC and LDL-C, and significant increase in HDL-C.