• Journal of Ginseng Research
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• v.19 no.1
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• pp.39-44
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• 1995

Total saponin from Korean red ginseng changed thermodynamic parameters of membranes from dipalmitoylphosphatidylcholine (DPPC) and ghost erythrocytes of human. In liposomes from DPPC, temperature of the main transition (Lb'-La) in liquid-crystalline phase increases by 0.2$^{\circ}C$ in average, but enthalpy does not change. Total saponin at a concentration of smaller than $10^5$% "stabilizes" the timid bilayers. At larger than 0.07 of saponin/DPPC ratio, saponin leads to an exclusion of the bound lipid molecules from the main phase transition into lamella liquid crystalline La-phase. Total saponin influences specifically all erythrocyte membrane transitions in a concentration-dependent manner, i.e. on the structures of all the main membrane skeleton proteins. A high structural specificity of saponin with membrane proteins, could be a base of specificity of physiological response of not only erythrocytes, but also other cells.her cells.

• Journal of Photoscience
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• v.3 no.1
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• pp.33-38
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• 1996

The effect of vesicular L-$\alpha$-phosphatidylcholine on the rate of formation of all-trans-N-retinylidene-n-butylamine (3) and on the regeneration kinetics of bacteriorhodopsin pigment from retinal and bacterio-opsin have been studied. An estimate of the relative positions of retinal and n-butylamine in the vesicles has been made by fluoresence quenching experiments. Partition coefficient of retinal and microviscosity of the retinal-binding region have also been determined. The results are discussed in terms of the nature of chemical interaction between retinal and amine in a lipid environment.

• 대한예방의학회:학술대회논문집
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• 2004.10a
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• pp.53.1-53.1
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• 2004

• Toxicological Research
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• v.4 no.2
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• pp.95-105
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• 1988

The effects of polyacetylenes on living membrances, rat erythrocyte and murine leukemic L1210 cell as well as artificial lipid bilayer were determined to investigate the cytotoxic mechanism of polyacetylenes against cancer cell lines. As results, panaxydol and panaxynol caused erythrocyte hemolysis dose-dependently while panaxytriol had no lysis. For liposomes composed of phosphatidyl choline (PC) and phosphatidic acid(PA), all three polyacetylenes supressed the osmotic behavior at the same degree.

• Proceedings of the Korean Biophysical Society Conference
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• 1996.07a
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• pp.34-34
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• 1996

Previously we showed that $Ba^{2+}$ block of large conductance $Ca^{2+}$-activated $K^{+}$ (BK) channel was larger in the planar lipid bilayer formed with negatively-charged phosphatidylserine (PS) than neutral phosphatidylethanolamine (PE). In this work, have studied the blocking effect of two $K^{+}$ channel blockers with different mechanisms of action, $Ba^{2+}$ and tetraethylammonium (TEA), on BK channels of rat skeletal muscle. (omitted)itted)

• Bulletin of the Korean Chemical Society
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• v.10 no.1
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• pp.69-71
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• 1989

Effects of SDS and temperature on the conformational changes of bacteriorhodopsin were studied using a, b, c bands of bacteriorhodopsin. In the SDS denaturation, bacteriorhodopsin in purple membrane was more labile than bacteriorhodopsin reconstituted into PC vesicles. These rather interesting results may be understood by effective SDS concentration in lipid layer.

• Journal of Plant Biology
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• v.33 no.1
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• pp.25-30
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• 1990

Effects of dimethipin on the senescence of excised barley first leaves were investigated. Dimethipin markedly inhibited chlorophyll and protein loss and reduced peroxidase activity relevant to senescence phenomena in th excised leaves. Dimethipin decreased hydrogen peroxide content, later malondialdehyde content, and increased the activities of superoxide dismutase and catalase. The antisenescence effects of dimethipin may result from the stabilization of membrane structure through inhibiting the peroxidation of unsaturated lipid and the accumulation of free radicals during senescence.

• Proceedings of the PSK Conference
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• 2003.04a
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• pp.295.1-295.1
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• 2003

A suitable model for the estimation of the drug release from nanoparticles has been varied and problematic, especially for the release from lipid nanoparticles containing water-insoluble drugs, due to the difficult particle collection from the release medium. Dialysis membrane has been widely used for the release test from colloidal carrier systems. The amount of drug from the carriers in normal dialysis diffusion technique was very low typically. (omitted)

• Proceedings of the PSK Conference
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• 2002.10a
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• pp.267.2-267.2
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• 2002

MPP$\^$＋/ is known to be a neurotoxic substance that induces the degeneration of dopaminergic neurons and a Parkinsonism-like syndrome. MPP$\^$＋/ is retained intracellularly or accumulated in dopaminergic neurons via the dopamine-reuptake system. It inhibits mitochondrial electron transport in dopaminergic neurons. In addition. it generates hydroxyl radicals. which cause the peroxidation of membrane lipid or damage DNA. (omitted)

• Proceedings of the PSK Conference
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• 2002.10a
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• pp.328.1-328.1
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• 2002

A major lipid-signaling pathway in mammalian cells implicated the activation of sphingomyelinase (SMase), which hydrolyses sphingomyeline to generate ceramide and phosphocholine. Sphingomyelinase is divided into many isoform groups dependent on optimal pH, and essential cation especially magnesium in their activation. Such as acidic sphingomyelinase, neutral sphingomyelinase and alkaline sphingomyelinase. Ceramide is known as a crucial second messenger in cell responses like cell proliferation. cell cycle arrest. cellular senescence, and apoptosis. (omitted)