Proceedings of the PSK Conference (대한약학회:학술대회논문집)

The Pharmaceutical Society of Korea (대한약학회)
권호 표지

$MPP^{+}-induced$ cytotoxicity is attenuated by induction of heme oxygenase

  • Park, Ha-Young (Lab. of Pharmacology College of Pharmacy. Sungkyunkwan University) ;
  • Lee, Seung-Jin (Lab. of Pharmacology College of Pharmacy. Sungkyunkwan University) ;
  • Yang, Sang-In (Lab. of Pharmacology College of Pharmacy. Sungkyunkwan University) ;
  • Jang, Choon-Gon (Lab. of Pharmacology College of Pharmacy. Sungkyunkwan University) ;
  • Lee, Seok-Yong (Lab. of Pharmacology College of Pharmacy. Sungkyunkwan University)
  • Published : 2002.10.01
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Abstract

MPP$\^$＋/ is known to be a neurotoxic substance that induces the degeneration of dopaminergic neurons and a Parkinsonism-like syndrome. MPP$\^$＋/ is retained intracellularly or accumulated in dopaminergic neurons via the dopamine-reuptake system. It inhibits mitochondrial electron transport in dopaminergic neurons. In addition. it generates hydroxyl radicals. which cause the peroxidation of membrane lipid or damage DNA. (omitted)

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