• Journal of the Korean Applied Science and Technology
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• v.33 no.4
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• pp.667-675
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• 2016

Nanoemulsions are actively used in several applications for pharmaceutical, cosmetic and chemical industries. In this study, we propose the use of microfluidizer known as high pressure homogenizer to prepare lipid nanoemulsion as a potent cosmetic delivery carrier. The lipid nanoemulsions were prepared by O/W emulsion with hydrogenated lecithin and different type of oils. Effects of oil type on the stability of the lipid nanoemulsion were investigated with Dynamic Light Scattering (DLS) and Zeta-potential. Arbutin was used as model drug for transdermal administration through hairless mouse skin. Transdermal arbutin delivery using the lipid nanoemulsions was studied with HPLC method.

• Journal of the Korea Convergence Society
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• v.12 no.8
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• pp.179-186
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• 2021

Among the Covid-19 vaccine platforms, mRNA-platform vaccines are summarized qualitatively in this paper. Manufacturing mRNA vaccines consist of serial processes; the preparation process of DNA template, the transcription of mRNA, nanoemulsion process, and the fill and finish unit combined with formulation stages. It is noticeable that major players are collaborated for producing mRNA vaccines. In particular, the nanoemulsion process is recognized to the key process requiring formulated lipid materials to protect modified mRNA until they arrive in intracellular cytosol. It is known that the nanoemulsion process adapts well-designed microfluidic devices. We expect that the nanoemulsion process will stimulate pharmaceutical industries to develop diverse applications.

• Proceedings of the SCSK Conference
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• 2003.09a
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• pp.61-72
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• 2003

In cosmetic area, retinol is prominent ingredient for anti-wrinkle but unstable against light, heat, oxygen and so on. Therefore the stabilization of retinol is required. Here, we capsulated doubly retinol in the SLM(Skin Lipid Matrix) that makes three dimensional lamellar structure similar to skin, after formation of primary liposome (retinol-nanoemulsion). First, we make primary liposome from retinol / hydrogenated lecithin / polysorbate20 / caprylic ＆ capric triglyceride / ethanol / and so on, and the mean diameter to 70 nm, using microfluidizer passed three times at 800 Bar, repeatedly. Then we produce DC-liposome (doubly capsulated-liposome) that was encapsulated primary liposome with SLM made of hydrogenated phosphatidyl choline / caprylic ＆ capric triglyceride / 1, 3-butylene glycol / ceramide3 / cholesterol /etc. We measured for color stability against light and heat with chromameter. As a result of this experiment, we observed DC-liposome was more than from 1.5 to 3 times as stable as general liposome. Livability of retinol has improved from 2 to 6 times when we analyzed it by HPLC. Also, penetration effect of DC-liposome has improved.

• Journal of the Society of Cosmetic Scientists of Korea
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• v.44 no.1
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• pp.31-37
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• 2018

Oil/water (O/W) nanoemulsions are effective vehicles to change the permeability of the skin. In this study, we focused on the preparation and characterization of nanoemulsion which serve as colloidal carriers for the dermal application of ceramide IIIB (CIIIB) and stratum corneum (SC) lipids such as cholesterol, and palmitic acid. In order to optimize the nanoemulsions, emulsification process conditions were conducted with regard to droplet size, nanoemulsion stability, and solubility of CIIIB. A decrease in droplet size was observed through emulsification temperature of $80^{\circ}C$ and phase inversion composition (PIC) method. CIIIB has low solubility in oil and water. When the concentration of CIIIB was increased, the droplet size of nanoemulsion was increased. When Lipoid S75-3 was added to the oil phase, the solubility of CIIIB increased, indicating some interactions shown in DSC measurements. CIIIB and SC lipids could be successfully incorporated in nanoemulsions without crystallization or physical instability. In conclusion, a stable nanoemulsion containing the SC lipids could be effective as an efficient moisturizing system for skin.

• Proceedings of the SCSK Conference
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• 2003.09a
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• pp.258-267
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• 2003

Recently inside nano liposome particles or nano-emulsions which contain tough-melting physiology activity materials or the coefficient of low organism utilization promote the coefficient of organism utilization, so this part has been studied a lot because they can absorb selectly cosmetics, specially physiology activity materials, into the skin. Also, in particle size, cells interstitial lipid interval are 30~50nm, so nano-emulsions that the size is similar to 30~50 nm are made to study for absorbing quickly into the skin. And transparent skin which contains oils in common skin lotion dosage form has become the center of public interest. The used nano-emulsions in this study were unsaturated lecithin/co-surfactant! ethanol/ oil / water. And polysorbate 20/ polysorbate 80/ Dicetyl phosphate/hydrogenated .caster oil/ isoceteth-20/SLS were used in co-surfactant. The used oils were cyclomethicone and caprylic/capric triglyceride. The manufacturing process was that microfluidizer was fixed in 1000bar and transit times were changed from 1 to 10 times. From transparency and particle size, the transparency sequence was SLS> polysorbate 20= polysorbate 80> isoceteth-20> dicetyl phosphate >hydrogenated caster oil and the particle size was small. Specially cyclomethicone nano-emulsions, when we made unsaturated lecithin /SLS /ethanol/water/cyclomethicone, cyclomethicone 5％ was good for transparency. And 20％ of this was used for making transparent skin toner in common skin dosage form.

• Applied Chemistry for Engineering
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• v.23 no.5
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• pp.467-473
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• 2012

Coenzyme Q10 (CoQ10) is a natural lipid cofactor with antioxidant and anti-aging properties as cosmetic and food ingredients, involved in cellular energy metabolism. Here, nano-emulsions with CoQ10 were fabricated with lecithin, ethanol, oil, and sorbitan monostearate (Arlacel 60), as major components. Phase inversion emulsion method with ultrasonicator was utilized in producing CoQ10 solution, and stabilization effects from lecithin and ethanol and other diverse perturbation factors were evaluated over time. Physical properties of the emulsion were characterized such as its size, surface charges by zeta-potential, and the overall structures. Optimal concentrations of CoQ10 and Arlacel 60 were 0.8% and 3%, respectively, for producing the smallest sizes of nanoemersions in a 100 nm diameter with best morphology. No notable changes in the size were observed over 7 days from Ostwald ripening, when the concentration of Arlacel 60 was higher than 2%. Even after 270 days at room temperature, the size of nanoemulsions maintained as 115 nm in diameter, revealing only a 10% increase with high degrees of long termed stability and substantiality. In addition, changes in the surface potential occurred possible due to the flocculation effect on the nanoparticles.