• The Journal of Korean Medicine Ophthalmology and Otolaryngology and Dermatology
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• v.35 no.2
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• pp.13-27
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• 2022

목적 : 본 연구는 인간피부각질형성세포(HaCaT keratinocytes) 모델을 TNF-α와 IFN-γ로 자극하여 내복자(萊菔子)의 피부염증 감소 및 만성 염증성 질환에 미치는 영향을 알아보고자 하였다. 방법 : 내복자(萊菔子) 에탄올 추출물(RSE)이 세포생존율에 미치는 영향을 확인하기 위하여 MTT assay를 시행하였다. 또한 RSE가 TNF-α와 IFN-γ로 자극한 HaCaT 세포에서 p-IκBα, p-ERK, p-JAK2, p-STAT1, p-STAT6의 발현과 periostin, TSLP 단백질 발현에 미치는 영향을 확인하였다. 결과 : RSE는 200㎍/㎖ 이하에서 세포 독성을 보이지 않았고, HaCaT keratinocytes에서 TNF-α와 IFN-γ자극에 의하여 증가된 IκBα, ERK의 인산화를 억제하였다. 또한 JAK2와 STAT1, STAT6의 인산화를 억제하였으며, periostin과 TSLP의 발현을 감소시켰다. 결론 : RSE는 HaCaT keratinocytes에서 pro-inflammatory cytokines 및 transcription factors의 발현을 감소시켜 피부염증 감소 효능을 보였고, 만성 염증성 질환에서 내복자(萊菔子)의 사용 가능성을 확인하였다.

• The Journal of Korean Medicine Ophthalmology and Otolaryngology and Dermatology
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• v.35 no.2
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• pp.1-12
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• 2022

Objectives : This study was conducted to verify the anti-inflammatory effects of Aster glehni water extracts in HaCaT keratinocytes. Methods : In this study, cell viability was confirmed by MTT assay. Production of TNF-α and IL-6 was determined by ELISA. mRNA expression of TARC and MDC were measusred by qRT-PCR. Also, expressions of p-JNK, JNK, p-ERK, ERK, p-p38, and p-38 were investigated by using western blot assay. Results : Aster glehni water extracts were not shown any significant cytotoxicity at 15.625-500㎍/㎖ in HaCaT keratinocytes. Aster glehni extracts inhibited the TNF-α and IL-6 production in HaCaT keratinocytes treated with TNF-α and IFN-γ. Also, expression of TARC, MDC, p-ERK, and p-STAT1 was decreased. Conclusions : These results suggest that Aster glehni water extracts have anti-inflammatory effects in HaCaT keratinocytes and can be applied to the development of anti-inflammatory treatment substances.

• Archives of Plastic Surgery
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• v.49 no.1
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• pp.43-49
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• 2022

Background Cleft lip and cleft palate are the most frequent congenital craniofacial deformities, with an incidence of approximately 1 per 700 people. Postoperative palatal fistula is one of the most significant long-term complications. This study investigated the incidence of postoperative palatal fistula and its predictive factors based on 25 years of experience at our hospital. Methods We retrospectively reviewed 636 consecutive palatal repairs performed between January 1996 and October 2020 by a single surgeon. Data from patients' medical records regarding cleft palate repair were analyzed. The preoperative extent of the cleft was evaluated using the Veau classification system, and the cleft palate repair technique was chosen according to the extent of the cleft. SPSS version 25.0 was used for all statistical analyses, and exploratory univariate associations were investigated using the t-test. Results Fistulas occurred in 20 of the 636 patients; thus, the incidence of palatal fistula was 3.1%. The most common fistula location was the hard palate (9/20, 45%), followed by the junction of the hard and soft palate (6/20, 30%) and the soft palate (5/20, 25%). The cleft palate repair technique significantly predicted the incidence of palatal fistula following cleft palate repair (P=0.042). Fistula incidence was significantly higher in patients who underwent surgery using the Furlow double-opposing Z-plasty technique (12.1%) than in cases where the Busan modification (3.0%) or two-flap technique (2.0%) was used. Conclusions The overall incidence of palatal fistulas was 3.1% in this study. Moreover, the technique of cleft palate repair predicted fistula incidence.

• Herbal Formula Science
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• v.30 no.4
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• pp.351-361
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• 2022

Objectives : The purpose of this study is to report the clinical effect of herbal medicine decoction on COVID-19 symptoms remaining after administering Western medicine and worsening eczema during the COVID-19 prevalence period in patients with chronic eczema. Methods : The two chronic eczema patients suffering from COVID-19 symptoms and worsening eczema received a series of herbal medicine decoction for treatment. The effectiveness of treatment was evaluated by VAS, NRS, EASI, PASI, DLQI, photography and subjective evaluation of the patient's improvement of symptoms. Results : After treatment, all symptoms of COVID-19 disappered and aggravated eczema lesions were remarkably improved in both cases. Compared to its peak, the first case shows that PASI improved by 88% and DLQI by 44%. According to photo and symptom changes, the size of the affected area of facial acne and lip eczema was decreased. The second case shows that EASI improved by 43% and DLQI by 65%. According to photo and symptom changes, redness, rash were stopped and pruritus was decreased. Conclusion : This study suggests that herbal medicine could induce effectiveness on both COVID-19 symptoms as well as chronic eczema.

• Journal of Broadcast Engineering
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• v.27 no.6
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• pp.914-922
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• 2022

In this paper, we construct a commercial 4K UHD(Ultra High Definition) streaming device that utilizes a 5G mobile communication network as a transport channel and conduct a streaming performance test. It uses RTP(Realtime Transport Protocol) which has transmission quality monitoring capability as a transmission protocol to apply adaptive streaming. In addition, it provides the function to adjust the encoding rate of the video signal so that encoding can be optimized for the change in the bandwidth of the transmission channel. Through the performance test, it is confirmed that the H.265 encoding rate for 4K UHD signal is 48.69Mbps, the average glass-to-glass delay time is 293.60ms, and the average time difference between video and audio for lip sync is 120ms. With the result of performance test, it is shown that the streaming device is applied to 4K UHD Streaming device over 5G mobile communication network.

• Proceedings of the SCSK Conference
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• 2003.09a
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• pp.162-177
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• 2003

It has been known that the color of skin reflects the blood flow within. In lips, the capillaries close to the skin surface are numerous; hence lips are redder than the rest of face. However, dermatological research on lips is not as advanced as research on facial or body skin, and little was known about the relationship between relatively dull-colored lips and skin blood flow. The physiological differences between colorful and dull-colored lips were studied by a two-dimensional laser Doppler blood flow analyzer, a spectrometer for the measurement of the degree of oxygen saturation, and a confocal microscope for observing inside lips non-invasively. Dull-colored lips and the corner of lips (dull-colored compared to the center) showed relatively poor blood flow and lower oxygenated hemoglobin. It was found that colorful lips (generally the young) had a blood flow that tended to run straight in parallel with the skin surface. This unique blood-capillary structure can express clear red blood. Those with dull-colored lips had lost this unique structure. Their blood ran perpendicularly from the deep of the skin and down back again into the deep part as like the blood circulation patterns of facial skin. Therefore, the lips of the latter group had fewer blood capillaries near skin surface in the lips than that of the colorful-lips group. A lipstick containing a-glucosyl-hesperidin, which is derived from certain citrus fruits and can enhance blood circulation, was applied for evaluating its effects. Blood flow was increased 30 min after the application. After two weeks of daily application, the lips' condition became noticeably less dull. These findings suggest that the decrease of blood flow in dull-colored lips is caused by the loss of the unique capillary structure and the use of the lipstick to increase blood flow can give a vivid color to lips.

• Journal of Oral Medicine and Pain
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• v.22 no.1
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• pp.23-29
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• 1997

A 49 years old male patient was referred from the Department of Medicine, KNUH for the management of painful oral lesions. The patient had disability of food and drug intake due to multiple intraoral ulcers. Extraoral findings showed upper and lower lip swelling, crust formation on the lips. The lesions were diagnosed as Stevens-Johnson syndrome based on clinical and hematologic findings. The patient was treated with saline irrigation and pulsed Nd:YAG laser irradiation. After 5 daily treatment, the lesions decreased in size and severity, and the patient became more comfortable for food intake and speeching. It was suggested from the results of this clinical trial that a pulsed Nd:YAG laser therapy would be helpful for the symptoms associated with Stevens-Johnson syndrome.

• Nuclear Engineering and Technology
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• v.54 no.11
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• pp.4072-4083
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• 2022

Ultrasonic impact treatment (UIT) is carried out on the Ni-based alloy stainless steel pipe gas tungsten arc welding (GTAW) girth weld, the differences of microstructure, microhardness and shear strength distribution of the joint before and after ultrasonic shock are studied by microhardness test and shear punch test. The results show that after UIT, the plastic deformation layer is formed on the outside surface of the Ni-based alloy overlayer, single-phase austenite and γ type precipitates are formed in the overlayer, and a large number of columnar crystals are formed on the bottom side of the overlayer. The average microhardness of the overlayer increased from 221 H V to 254 H V by 14.9%, the shear strength increased from 696 MPa to 882 MPa with an increase of 26.7% and the transverse average residual stress decreased from 102.71 MPa (tensile stress) to -18.33 MPa (compressive stress), the longitudinal average residual stress decreased from 114.87 MPa (tensile stress) to -84.64 MPa (compressive stress). The fracture surface has been appeared obvious shear lip marks and a few dimples. The element migrates at the fusion boundary between the Ni-based alloy overlayer and the austenitic stainless steel joint, which is leaded to form a local martensite zone and appear hot cracks. The welded joint is cooled by FA solidification mode, which is forming a large number of late and skeleton ferrite phase with an average microhardness of 190 H V and no obvious change in shear strength. The base metal is all austenitic phase with an average microhardness of 206 H V and shear strength of 696 MPa.

• Journal of the Korea Society of Computer and Information
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• v.14 no.4
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• pp.19-30
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• 2009

In this paper, We propose a method with which we can detect facial components and face in input image. We use eye map and mouth map to detect facial components using eyes and mouth. First, We find out eye zone, and second, We find out color value distribution of skin region using the color around the eye zone. Skin region have characteristic distribution in YCbCr color space. By using it, we separate the skin region and background area. We find out the color value distribution of the extracted skin region and extract around the region. Then, detect mouth using mouthmap from extracted skin region. Proposed method is better than traditional method the reason for it comes good result with accurate mouth region.

• Proceedings of the Korea Water Resources Association Conference
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• 2020.06a
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• pp.387-387
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• 2020

본 연구에서는 LIP에 의한 극한강우로부터 발생되는 극한홍수량을 산정한다. Huff 형 강우시간 분포를 기후변화 시나리오별로 적용하고, 원전주변지역에서의 상세한 토지이용조건의 변화를 고려하여 빈도별 홍수량을 산정한다. 외부침수해석의 정교화를 위한 상세 지형자료를 구축하고, 원자력발전소 부지의 상세 DEM 자료를 생성한다. 이를 위해서 원자력발전소 부지에서 건물, 연석, 도로 등의 영향을 분석하고 토지이용상황에 따른 조도계수를 산정한다. 또한 원전지역에서의 외부침수재해도 분석을 위해서 국립해양조사원에서 검토한 기후변화를 고려한 조위분석 자료를 외부경계조건으로 설정한 후 부지에 대한 2차원 수리분석을 실시한다. 침수심, 침수유속, 침수시간, 침수동압력 분석 등 2차원 침수해석결과를 바탕으로 발생빈도별 침수심, 침수강도 등의 정량적인 분석을 통해서 빈도별 재해도 곡선을 개발한다. 그리고 원전지역에서의 외부 침수에 대한 대표적인 재해도 곡선을 산정하기 위하여 재현기간별 지속시간에 따른 침수심을 분석하고 정리한다. 재현기간별 침수심에 대해 확률 분포형을 적용하기 위해서 AIC검증을 통한 분포형의 적합성을 분석을 실시한다. 또한 재현기간별 지속시간에 따른 침수심들 간의 상관관계를 분석하여 분포형에 적용한다. 적용된 분포형을 몬테칼로 시뮬레이션을 통한 대표적인 확률론적 외부 침수 재해도 곡선을 산정한다. 본 연구를 바탕으로 원전 부지 및 그 부속 시설물(SSC)의 홍수방지 기능과 홍수 대비 시설물에 대한 적용 절차의 신뢰성, 홍수 저감 및 대응 전략에 대한 정량화가 가능하여 원전 홍수 위험에 대한 정량적인 평가 지원이 가능하겠다. 고려할 외부 홍수와 관련된 원전 내부시설 및 장비에 대한 상세한 모델링 절차, 특정 시나리오에 대한 홍수 방지 및 예방과 관련한 SSC의 정량화, 홍수저감 활동과 관련된 통제실 외부 시설물에 대한 수동 조작에 대한 평가가 이루어질 수 있겠다.