• 제목/요약/키워드: Linkage model

검색결과 622건 처리시간 0.031초

Genome wide association study of fatty acid composition in Duroc swine

  • Viterbo, Vanessa S.;Lopez, Bryan Irvine M.;Kang, Hyunsung;Kim, Hoonseop;Song, Choul-won;Seo, Kang Seok
    • Asian-Australasian Journal of Animal Sciences
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    • 제31권8호
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    • pp.1127-1133
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    • 2018
  • Objective: Genome wide association study was conducted to identify and validate candidate genes associated with fatty acid composition of pork. Methods: A total of 480 purebreed Duroc pigs were genotyped using IlluminaPorcine60k bead chips while the association test was implemented following genome-wide rapid association using Mixed Model and Regression-Genomic Control (GRAMMAR-GC) approach. Results: A total of 25, 29, and 16 single nucleotide polymorphisms (SNPs) were significantly associated with stearic (18:0), oleic (18:1) and saturated fatty acids (SFA), respectively. Genome wide significant variants were located on the same region of swine chromosome 14 (SSC14) that spanned from 120 to 124 Mb. Top SNP ALGA008191 was located at 5 kb near the stearoyl-CoA desaturase (SCD) gene. This gene is directly involved in desaturation of stearic acid into oleic acid. General relationship of significant SNPs showed high linkage disequilibrium thus genome-wide signals was attributed to SCD gene. However, understanding the role of other genes like elongation of very long chain fatty acids-3 (ELOVL3) located on this chromosomal segment might help in further understanding of metabolism and biosynthesis of fatty acids. Conclusion: Overall, this study provides evidence that validates SCD gene as strong candidate gene associated with fatty acid composition in Duroc pigs. Moreover, this study confirms significant SNPs near ELOVL3 gene.

Typology of ROII Patterns on Cluster Analysis in Korean Enterprises

  • Kim, Young Sun;Kwon, Oh Jun;Kim, Ki Sik;Rhee, Kyung Yong
    • Safety and Health at Work
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    • 제3권4호
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    • pp.278-286
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    • 2012
  • Objectives: Authors investigated the pattern of the rate of occupational injuries and illnesses (ROII) at the level of enterprises in order to build a network for exchange of experience and knowledge, which would contribute to workers' safety and health through safety climate of workplace. Methods: Occupational accidents were analyzed at the manufacturing work site unit. A two step clustering process for the past patterns regarding the ROII from 2001 to 2009 was investigated. The ROII patterns were categorized based on regression analysis and the patterns were further divided according to the subtle changes with Mahalanobis distance and Ward's linkage. Results: The first clustering of ROII through regression analysis showed 5 different functions; 29 work sites of the linear function, 50 sites of the quadratic function, 95 sites of the logarithm function, 62 sites of the exponential function, and 54 sites of the sine function. Fourteen clusters were created in the second clustering. There were 3 clusters in each function categorized in the first clustering except for sine function. Each cluster consisted of the work sites with similar ROII patterns, which had unique characteristics. Conclusion: The five different patterns of ROII suggest that tailored management activities should be applied to every work site. Based on these differences, the authors selected exemplary work sites and built a network to help the work sites to share information on safety climate and accident prevention measures. The causes of different patterns of ROII, building network and evaluation of this management model should be evaluated as future researches.

Frustration of Rod-Disc Molecule in Reorientation under Vertical Electric Field

  • Jung, Jun-Ho;Ha, Kyung-Su;Chae, Mi-Na;Park, Seul-Ki;Song, Eun-Gyoung;Lee, Myong-Hoon;Jeong, Kwang-Un;Lee, Seung-Hee
    • 한국정보디스플레이학회:학술대회논문집
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    • 한국정보디스플레이학회 2009년도 9th International Meeting on Information Display
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    • pp.610-613
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    • 2009
  • New rod-disc liquid crystal (LC) molecule RD12 (12 is the number of carbon atoms between the rod and disc mesogenic liquid crystals) was synthesized via the chemical attachment of six cyanobiphenly calamitic mesogens linked to the triphenyl discotic mesogen with six alkyl chain linkage. Aligning characteristics associated with homogenous alignment is investigated at first and then field-dependent molecular reorientation under a vertical electric field is studied. Interestingly, they show abnormal slow molecular transition from initiate state (no electric field condition) to certain voltage. In this condition, we observe the molecular competition during reorientation. However, once a tilting direction of disk molecules are defined, the frustration is not observed anymore. The origin of this phenomenon is explained with a suggested model for the first time.

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국내 V커머스 2.0 콘텐츠와 MCN 연계 전략 (Korean V-Commerce 2.0 Content and MCN Connected Strategy)

  • 정원식
    • 디지털콘텐츠학회 논문지
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    • 제18권3호
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    • pp.599-606
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    • 2017
  • 동영상을 이용한 콘텐츠에 커머스를 접목한 'V커머스'가 크게 성장하며, 이른바 V커머스 2.0시대를 맞이하고 있다. 본 연구는 이러한 배경을 바탕으로, V커머스 2.0 콘텐츠와 MCN의 연계점과 시너지 창출 가능성에 주목하여, 그 특성을 감안한 연계 전략에 대해 고찰하였다. 결론적으로 첫째, V커머스는 1.0 시대를 넘어, 재미와 공감을 지향하는 콘텐츠로서의 특성이 중심이 되는 2.0시대로 진화하고 있으며, 이는 스마트폰의 대중화와 SNS의 일상화에 따른 웹콘텐츠 전반의 변화에 부합한다. 둘째, V커머스 2.0 콘텐츠는 SNS의 네트워크성을 기반으로 한 공유와 추천을 홍보와 구매 제고로 치환하여 활용하는 특성을 갖는다. 따라서 '커머스' 이전에 '콘텐츠'로서의 경쟁력이 상대적으로 중요하다. 셋째, V커머스 2.0과 MCN산업은 핵심 경쟁력 확보와 새로운 수익모델 창출의 돌파구라는 차원에서, 서로에게 강력한 연계의 필요성을 가지고 있다. 이에 V커머스 2.0과 MCN의 시너지를 창출하기 위한 연계 전략으로 빅데이터의 활용을 통한 V커머스 2.0 맞춤형 콘텐츠 경쟁력 강화, 스토리텔링 마케팅 구축과 브랜드화, 라이브성과 쌍방향 소통성의 강화를 제시하였다.

사용성 평가 전용 인체모델 선정 소프트웨어 개발 및 자동차 적용사례 (Development Software to Select Boundary Manikins for Product Evaluation: Applied to an Automobile Case)

  • 임영재;박성준;박우진;박준수;정의승;임익성
    • 대한인간공학회지
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    • 제29권6호
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    • pp.831-841
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    • 2010
  • Usability evaluation of physical products involves characterizing complex physical interactions between humans and products. Human models known as manikins have been widely utilized as usability evaluation tools for automobile interior package design. When combined with computer-aided design software programs, such manikins can be used to simulate driving postures and evaluate driver-interior fits early in the design process, and therefore, may greatly facilitate achieving high-quality design in a cost-efficient manner. The purpose of this study was to define a set of manikins for designing automobile interior packages for the South Korean male population. These manikins were conceptualized as "boundary" manikins, which represent individuals lacking in certain physical capacities or having usability-related issues (e.g., an individual with the 5th percentile forward reach capability, an individual with the 95th percentile shoulder width). Such boundary manikins can serve as an efficient tool for determining if an automobile interior design accommodates the majority of the population. The boundary manikins were selected from the large sample of Korean males whose anthropometric dimensions were described in the recent Size Korea anthropometric database. For each male in the database, his comfortable driving posture was represented using a kinematic body linkage model and various physical capacity measured and usability-related characteristics relevant to driver accommodation were evaluated. For each such measure, a boundary manikin was selected among the Korean males. The manikins defined in this study are expected to serve as tools for ergonomic design of automobile interior packages. The manikin selection method developed in this study was implemented as a generic software program useful for various product design applications.

무관한 산업에 대한 정벌적 관세부과 (Tariffs on Irrelevant Industries)

  • 이병채
    • 통상정보연구
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    • 제13권4호
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    • pp.399-410
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    • 2011
  • 전통적으로 자국 산업의 이익보호를 위해 관세는 널리 사용되어 왔다. 개발도상의 단계에 있는 나라들은 자국의 유치산업을 보호할 목적으로 관세를 사용하는 반면, 선진국들은 자국의 상품이 타국의 시장에 진출할 수 있도록 타국을 압박하는 수단으로 사용되는 경우가 많다. 본 논문에서는 선진국이 자국의 특정 수출품을 개발도상국 시장에 일정한 비율 이상 진출시키기 위해 개발도상국의 제3의 생산품에 관세를 부과하겠다는 위협을 하는 경우 그 경제적 효과를 간단한 게임이론 모형을 통해 살펴본다. 만약 관세가 부과된 제3의 생산품이 주력 수출품인 경우 개발도상국 정부는-주력 수출품 생산자들의 로비 등을 통해-문제가 된 상품에 일정한 제재를 부과함으로써 선진국과의 마찰을 자발적으로 해소하려는 유인을 갖게 됨을 보인다. 이러한 결과는 최근 FTA로 대변되는 양자 간 무역협정의 체결에서 나타나는 산업 간 이해득실의 차이를 개별 산업의 협상력 차이로 설명할 수 있다는 의미를 지닌다.

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Electromagnetic Forming Process Analysis Based on Coupled Simulations of Electromagnetic Analysis and Structural Analysis

  • Lee, Man Gi;Lee, Seung Hwan;Kim, Sunwoo;Kim, Jin Ho
    • Journal of Magnetics
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    • 제21권2호
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    • pp.215-221
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    • 2016
  • We conducted a phased electromagnetic forming process analysis (EFPA) over time through a coupling of electromagnetic analysis and structural analysis. The analysis is conducted through a direct linkage between electromagnetic analysis and structural analysis. The analysis process is repeated until the electric current is completely discharged by a formed coil. We calculate the forming force that affects the workpiece using MAXWELL, a commercial electromagnetic finite element analysis program. Then, we simulate plastic behavior by using the calculated forming force data as the forming force input to ANSYS, a commercial structure finite element analysis program. We calculate the forming force data by using the model shape in MAXWELL, a commercial electromagnetic finite element analysis program. We repeat the process until the current is fully discharged by the formed coil. Our results can be used to reduce the error in data transformation with a reduced number of data transformations, because the proposed approach directly links the electromagnetic analysis and the structural analysis after removing the step of the numerical analysis of a graph describing the forming force, unlike the existing electromagnetic forming process. Second, it is possible to simulate a more realistic forming force by keeping a certain distance between nodes using the re-mesh function during the repeated analysis until the current is completely discharged by the formed coil, based on the MAXWELL results. We compare and review the results of the EFPA using the peak value of the forming force that acts on the workpiece (which is the existing analysis method), and the proposed phased EFPA over time approach.

점포동일시의 매개효과를 통한 점포환경, 점포개성의 점포충성도에 대한 영향력에 관한 연구 - 패션제품 관련 점포를 중심으로 - (Study on the Impact on Store Loyalty of Store Environment and Store Personality, through the Mediating Effects of Store Benevolence - Focused on Stores Involved with Fashion Products -)

  • 장경혜
    • 한국의상디자인학회지
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    • 제15권1호
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    • pp.75-89
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    • 2013
  • The purpose of this study is to verify the mediating effect of store benevolence for impact on store loyalty of store environment and store personality. For this study, data were collected through questionnaires. The survey ran from March to May, 2011, the total of 330 respondents was used in analysis. The subjects consisted of adults living in the Daegu and Gyeongsangbuk-do region, and convenience sampling. For statistical analysis, SPSS 19.0 were used to verify the study model. The major results of the study show that store benevolence may play a linkage role of store environment, store personality on store loyalty. The store benevolence variable has the effect of partial mediation. The analysis of relationship between the variables of store environment (convenience, information service accessibility, accessibility, variation) and the store type show significant differences store environment (convenience, information service and the store type). The analysis of relationship between the variables of store personality(warm, fun, sophisticated, forward-looking) and the store type show significant differences store personality (warm, fun, sophisticated, forward-looking) and store type. The analysis of relationship between the variables of store environment(convenience, information service accessibility, accessibility, variation), and the demographic variables show significant differences in store environment (information service accessibility) regarding only age. The analysis of relationship between the variables of store personality(warm, fun, sophisticated, forward-looking) and the demographic variable show significant differences in store personality(warm) regarding only age (accessibility, accessibility, variation).

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객체 기반의 임베디드 실물 및 가상 프로토타입 통합 기법 (The Integrated Mechanism based on Object between Virtual Prototyping and Physical prototyping)

  • 김종일;이정배;양재수;이영란;정영진;한강우;강신관;김대응
    • 정보처리학회논문지A
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    • 제14A권4호
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    • pp.227-234
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    • 2007
  • 가상 프로토타이핑 환경에서는 다양한 컴포넌트와 라이브러리를 제공함으로써 정밀한 단위까지의 목표 모델의 시뮬레이션이 가능하다. 그리고 실물 프로토타이핑 환경에서는 목표 모델의 임베디드 구동 환경에 가까운 시뮬레이션 환경을 제공한다. 하지만, 가상 프로토타이핑 환경에서는 실제 목표 모델의 구동 환경 요소까지의 시뮬레이션이 어렵고, 실물 프로토타이핑 환경에서는 다양하고 정밀한 제품까지의 시뮬레이션이 어려운 실정이다. 이런 가상과 실물 프로토타이핑 환경의 단점을 보완하기 위한 통합 프로토타이핑 시스템을 위한 연동 기법이 개발되었으며, 본 논문에서는 기존의 실물/가상 프로토타이핑 연동 기법을 개선해서 객체 기반의 임베디드 시스템 통합 프로토타이핑 개발 환경을 구축하였다. 이러한 새로운 임베디드 시스템 개발 환경을 구축함으로써, 재사용성, 유연성, 확장성 그리고 편리성을 가질 수 있다.

의무기록의 다각적 활용을 통한 충실도 높은 병원 암등록 체계의 구축: 서울아산병원의 경험 (Construction and Validation of Hospital-Based Cancer Registry Using Various Health Records to Detect Patients with Newly Diagnosed Cancer: Experience at Asan Medical Center)

  • 김화정;조진희;유용만;이선혜;황경하;이무송
    • Journal of Preventive Medicine and Public Health
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    • 제43권3호
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    • pp.257-264
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    • 2010
  • Objectives: An accurate estimation of cancer patients is the basis of epidemiological studies and health services. However in Korea, cancer patients visiting out-patient clinics are usually ruled out of such studies and so these studies are suspected of underestimating the cancer patient population. The purpose of this study is to construct a more complete, hospital-based cancer patient registry using multiple sources of medical information. Methods: We constructed a cancer patient detection algorithm using records from various sources that were obtained from both the in-patients and out-patients seen at Asan Medical Center (AMC) for any reason. The medical data from the potentially incident cancer patients was reviewed four months after first being detected by the algorithm to determine whether these patients actually did or did not have cancer. Results: Besides the traditional practice of reviewing the charts of in-patients upon their discharge, five more sources of information were added for this algorithm, i.e., pathology reports, the national severe disease registry, the reason for treatment, prescriptions of chemotherapeutic agents and radiation therapy reports. The constructed algorithm was observed to have a PPV of 87.04%. Compared to the results of traditional practice, 36.8% of registry failures were avoided using the AMC algorithm. Conclusions: To minimize loss in the cancer registry, various data sources should be utilized, and the AMC algorithm can be a successful model for this. Further research will be required in order to apply novel and innovative technology to the electronic medical records system in order to generate new signals from data that has not been previously used.