• Korean Journal of Clinical Pharmacy
• /
• v.31 no.3
• /
• pp.237-246
• /
• 2021

Background: Pembrolizumab, an anti-cancer drug, is known to increase the activity of the immune system, leading to side effects called immune-related adverse events (irAE), including type 1 diabetes. This study analyzed the correlation between blood glucose level and pembrolizumab administration and investigated the covariates that affect those changes in cancer treatment. Methods: The information of 133 adult cancer patients was obtained from the electronic medical record (EMR) to identify the changes in random blood glucose (RBG) levels during the pembrolizumab treatment. Subjects were classified into subgroups according to their baseline RBG level, history of diabetes, and the use of steroids, and linear regression analysis was conducted. In addition, a secondary analysis was performed within the group of subjects having a strong correlation to glycemic change, which was based on the Pearson correlation coefficient being less than -0.7 or greater than +0.7. Univariate and multivariate logistic regressions were conducted to identify the risk factors to glycemic increase. Results: The RBG level tended to descend without significant differences in total patients during the administration period of pembrolizumab. Despite the insignificance, the logistic regression analysis presents that the odds ratios of baseline RBG less than 130 mg/dL, prophylactic steroid use, and higher dose of pembrolizumab per cycle (mg/kg/cycle) were greater than 1. Conclusions: Prophylactic administration of steroids and a higher dose of pembrolizumab per cycle may increase the blood glucose level as irAE in cancer patients with a strong tendency to glycemic change.

• Journal of Convergence for Information Technology
• /
• v.11 no.7
• /
• pp.104-110
• /
• 2021

A novel selective oxidation process has been developed for low source/drain (S/D) series resistance of the fin channel metal oxide semiconductor field effect transistor (MOSFET). Using this technique, the selective oxidation fin-channel MOSFET (SoxFET) has the gate-all-around structure and gradually enhanced S/D extension regions. The SoxFET demonstrated over 70% reduction in S/D series resistance compared to the control device. Moreover, it was found that the SoxFET behaved better in performance, not only a higher drive current but also higher transconductances with suppressing subthreshold swing and drain induced barrier lowering (DIBL) characteristics, than the control device. The saturation current, threshold voltage, peak linear transconductance, peak saturation transconductance, subthreshold swing, and DIBL for the fabricated SoxFET are 305 ㎂/㎛, 0.33 V, 13.5 𝜇S, 76.4 𝜇S, 78 mV/dec, and 62 mV/V, respectively.

• Journal of Korean society of Dental Hygiene
• /
• v.19 no.5
• /
• pp.743-752
• /
• 2019

Objectives: Grip strength is a measure for assessing overall muscle strength, muscle mass, and nutritional status, and is a useful tool for early examination of a person's general health. Thus, this study analyzed the association between oral health-related factors and grip strength, using the 6th Korea National Health and Nutrition Examination Survey (KNHANES) data. Methods: Data were analyzed using the IBM SPSS version 25.0 (IBM Co., Armonk, NY, USA) software with a complex sampling analysis of stratified and clustered variables, all with weighted values, applied for every analysis conducted. From the 6th KNHANES data, a total of 26,101 people were selected as the study population. A complex sample generalized linear model analysis was performed for participants' sociodemographic characteristics, health status, use of oral care products, and factors such as adult mastication and speaking habits. Results: Grip strength was found to be higher among men compared to women. Grip strength was the highest in the 20-39 year old group. Furthermore, grip strength was statistically significantly higher among married and employed individuals, and in the right hand (p<0.001). Grip strength was statistically significantly higher among people who perceived themselves to have good health and among those who did not have health-related problems in the past two weeks (p<0.001). It was also higher among those who used interdental brushes and electronic toothbrushes (p<0.001), but decreased with greater discomfort in mastication and speaking among adults (p<0.05). Conclusions: Grip strength was found to be associated with oral health-related factors and therefore, these could be helpful tools in evaluating both general and subjective health statuses. In general, oral care products are small in size with oral care involving the use of hands and certain precise motions and actions to remove foreign substances in the oral cavity. As shown in the findings, grip strength declines with increased age and as a result, the use of oral care products should be strongly recommended in order to promote better general health.

• The Journal of Korea Institute of Information, Electronics, and Communication Technology
• /
• v.13 no.6
• /
• pp.483-488
• /
• 2020

In recent years, the demand for wireless devices incorporating several wireless communication systems into one has been increasing in order to provide services that meet the diverse needs of consumers. Wireless devices consisting of various wireless communication systems require many frequency fixed filters. A frequency tunable filter can replace a number of frequency fixed filters in the wireless devices. If a frequency tunable filter is used in wireless systems, the system can be configured more efficiently. In this paper, a 3-pole frequency tunable BPF(bandpass filter) operating in the frequency band of 800 ~ 2400MHz is designed. In order to widen the operating frequency band, a tuning screw is designed to have a step and a linear motor is used to facilitate the adjustment of the tuning screw. The implemented frequency tunable BPF operates in the designed frequency range and has the maximum insertion loss of 2.82dB in the channel band and the minimum attenuation of 18.7dB at ± 50MHz frequency offset from the center frequency of the band.

• Clinical and Experimental Reproductive Medicine
• /
• v.48 no.2
• /
• pp.163-173
• /
• 2021

Objective: This study aimed to characterize a validated model for predicting oocyte retrieval in controlled ovarian stimulation (COS) and to construct model-based nomograms for assistance in clinical decision-making regarding the gonadotropin protocol and dose. Methods: This observational, retrospective, cohort study included 636 women with primary unexplained infertility and a normal menstrual cycle who were attempting assisted reproductive therapy for the first time. The enrolled women were split into an index group (n=497) for model building and a validation group (n=139). The primary outcome was absolute oocyte count. The dose-response relationship was tested using modified Poisson, negative binomial, hybrid Poisson-E_max, and linear models. The validation group was similarly analyzed, and its results were compared to that of the index group. Results: The Poisson model with the log-link function demonstrated superior predictive performance and precision (Akaike information criterion, 2,704; λ=8.27; relative standard error (λ)=2.02%). The covariate analysis included women's age (p<0.001), antral follicle count (p<0.001), basal follicle-stimulating hormone level (p<0.001), gonadotropin dose (p=0.042), and protocol type (p=0.002 and p<0.001 for short and antagonist protocols, respectively). The estimates from 500 bootstrap samples were close to those of the original model. The validation group showed model assessment metrics comparable to the index model. Based on the fitted model, a static nomogram was built to improve visualization. In addition, a dynamic electronic tool was created for convenience of use. Conclusion: Based on our validated model, nomograms were constructed to help clinicians individualize the stimulation protocol and gonadotropin doses in COS cycles.

• Journal of Advanced Navigation Technology
• /
• v.24 no.6
• /
• pp.607-612
• /
• 2020

In this paper, we deal with the stability of linear discrete systems with time-varying delays and unstructured uncertainty. Stability conditions are derived based on Lyapunov stability theory, and can include the effect of uncertainty. The unstructured uncertainty in the papaer which can not be figured out its exact characteristics and only can be expreesed by its magnitude is considered. Compared with the previous results on the stability, the new results can expand the applicable systems and alleviate the stability conditions which are more effective and powerful. The proposed stability condition is expressed in the form of an simple inequality, and includes the both effects of the uncertainties and time-varying delay. We present the results comparing the new stability condition with the existing results, and verify the effectiveness and the superiority of the proposed results through numerical example.

• Journal of Distribution Science
• /
• v.20 no.8
• /
• pp.93-103
• /
• 2022

Purpose: Online shopping festivals have quickly become the newest trend in online shopping worldwide due to the COVID-19 pandemic. This has led to marketing distribution channels that traditionally emphasized traditional techniques having turned to electronic commerce platforms. Although the pandemic scenario encourages online purchasing, other factors, such as the influence of participation intention to shop during the Online Shopping Festival, must also be considered. Research design, data and methodology: Multiple linear regression analysis was used to test the hypothesis based on data from 121 respondents who are actively involved with online shopping activities in Klang Valley, Selangor. Results: The results of this study show that promotion categories and the perceived influence of mass participation have a significant influence on participation intention. Meanwhile, the perceived temptation of price promotion and perceived fun promotional activities did not significantly influence participation intention. Conclusions: Theoretically, this study contributes to the literature by using the Theory of Planned Behavior and Stimulus-Response models to explain the factors that drive participation intention for online shopping. In practice, this study attracts and encourages customers to shop during the festival day because various attractive promotions are offered by sellers in Malaysia.

• Journal of the Korea Institute of Information and Communication Engineering
• /
• v.25 no.11
• /
• pp.1635-1641
• /
• 2021

Portable systems with built-in active noise control is required low power operation. Excessive anti noise search operation can lead to rapid battery consumption. A method that can adaptively cancel noise according to the operating conditions of the system is required and the methods of reducing power are becoming very important key feature in today's portable systems. In this paper, we propose the method of active noise control(ANC) using binary search algorithm in noisy systems. The implemented architecture detects a frequency component considered as noise from the input signal and by using the binary search algorithm, the system find out an appropriate amplitude value for anti-noise in a much faster time than the general linear search algorithm. Through the experimental results, it was confirmed that the proposed algorithm performs a successful functional operation.

• Progress in Medical Physics
• /
• v.32 no.4
• /
• pp.116-121
• /
• 2021

Purpose: To investigate the effects of dose rate on intensity-modulated radiation therapy (IMRT) quality assurance (QA). Methods: We performed gamma tests using portal dose image prediction and log files of a multileaf collimator. Thirty treatment plans were randomly selected for the IMRT QA plan, and three verification plans for each treatment plan were generated with different dose rates (200, 400, and 600 monitor units [MU]/min). These verification plans were delivered to an electronic portal imager attached to a Varian medical linear accelerator, which recorded and compared with the planned dose. Root-mean-square (RMS) error values of the log files were also compared. Results: With an increase in dose rate, the 2%/2-mm gamma passing rate decreased from 90.9% to 85.5%, indicating that a higher dose rate was associated with lower radiation delivery accuracy. Accordingly, the average RMS error value increased from 0.0170 to 0.0381 cm as dose rate increased. In contrast, the radiation delivery time reduced from 3.83 to 1.49 minutes as the dose rate increased from 200 to 600 MU/min. Conclusions: Our results indicated that radiation delivery accuracy was lower at higher dose rates; however, the accuracy was still clinically acceptable at dose rates of up to 600 MU/min.

• Journal of the Korean Society of Safety
• /
• v.38 no.3
• /
• pp.35-42
• /
• 2023

This study analyzed the current and temperature characteristics of major components of an induction motor during normal and abnormal operations as functions of the difference in the rated capacities of medium and large-sized motors widely used in industrial settings. The temperature rise equation of the induction motor winding was derived through locked-rotor operation experiments and linear regression analysis. When the ambient temperature is 40 ℃, the time to reach 155 ℃, the temperature limit of the insulation class (F class) of the winding of the induction motor, was confirmed to be 48 seconds for the 2.2 kW induction motor and 39 seconds for the 3.7 kW induction motor. This means that when the rated capacity is large or the installation environment is high temperature, the time to reach the temperature limit of the insulation class during locked-rotor operation is short, and the risk of insulation deterioration and fire is high. In addition, even if the EOCR (Electronic Over Current Relay) is installed, if the setting time is excessively set, the EOCR does not operate even if the normal and locked-rotor operation of the induction motor is repeated, and the temperature limit of the insulation grade of the winding of the induction motor is exceeded. The results of this study can be used for preventive measures such as the promotion of electrical and mechanical measures for the failure of induction motors and fire prevention in industrial sites, or the installation of fire alarm systems.