• Molecules and Cells
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• v.45 no.7
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• pp.444-453
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• 2022

Multivalent macromolecular interactions underlie dynamic regulation of diverse biological processes in ever-changing cellular states. These interactions often involve binding of multiple proteins to a linear lattice including intrinsically disordered proteins and the chromosomal DNA with many repeating recognition motifs. Quantitative understanding of such multivalent interactions on a linear lattice is crucial for exploring their unique regulatory potentials in the cellular processes. In this review, the distinctive molecular features of the linear lattice system are first discussed with a particular focus on the overlapping nature of potential protein binding sites within a lattice. Then, we introduce two general quantitative frameworks, combinatorial and conditional probability models, dealing with the overlap problem and relating the binding parameters to the experimentally measurable properties of the linear lattice-protein interactions. To this end, we present two specific examples where the quantitative models have been applied and further extended to provide biological insights into specific cellular processes. In the first case, the conditional probability model was extended to highlight the significant impact of nonspecific binding of transcription factors to the chromosomal DNA on gene-specific transcriptional activities. The second case presents the recently developed combinatorial models to unravel the complex organization of target protein binding sites within an intrinsically disordered region (IDR) of a nucleoporin. In particular, these models have suggested a unique function of IDRs as a molecular switch coupling distinct cellular processes. The quantitative models reviewed here are envisioned to further advance for dissection and functional studies of more complex systems including phase-separated biomolecular condensates.

• Smart Structures and Systems
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• v.2 no.1
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• pp.47-60
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• 2006

Bi-spectrum is a tool in the signal processing for identification of non-linear dynamic behvaiour in systems, and well-known for stationary system where components are non-linearly interacting. Breathing of a crack during shaft rotation is also exhibits a non-linear behaviour. The crack is known to generate 2X (twice the machine RPM) and higher harmonics in addition to 1X component in the shaft response during its rotation. Misaligned shaft also shows similar such feature as a crack in a shaft. The bi-spectrum method has now been applied on a small rotating rig to observe its features. The bi-spectrum results are found to be encouraging to distinguish these faults based on few experiments conducted on a small rig. The results are presented here.

• Journal of Ocean Engineering and Technology
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• v.30 no.2
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• pp.134-140
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• 2016

An envelope protection system is a control system that allows a submarine to operate freely using its own operational envelope without exceeding the structural limit, dynamic limit, and control input limit. In this paper, an envelope protection system for the pitch angle of a submarine is designed using a dynamic trim algorithm. A linear quadratic regulator and artificial neural network are used for the true dynamics approximation. A submarine maneuvering simulation program developed using experimental data is used to validate the designed envelope protection system. Simulation results show the effectiveness of the designed envelope protection system.

• Transactions of the Korean Society of Mechanical Engineers A
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• v.21 no.8
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• pp.1188-1194
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• 1997

In this paper, we design output feedback nonlinear dynamic control law by using state feedback nonlinear dynamic compensator and PI observer and show that the controller can stabilize globally and asymptotically a class of nonlinear systems with mismatched uncertainties. We also show that it is possible for a nonlinear system to use the output of PI observer in place of state variables in case that the nonlinear dynamic control law is used, similarly as in the linear system. The effectiveness of the proposed control law is demonstrated by a numerical simulation.

• Transactions of the Korean Society of Mechanical Engineers A
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• v.21 no.8
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• pp.1184-1184
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• 1997

In this paper, we design output feedback nonlinear dynamic control law by using state feedback nonlinear dynamic compensator and PI observer and show that the controller can stabilized globally and asymptotically a class of nonlinear systems with mismatched uncertainties. We also show that it is possible for a nonlinear system to use the output of PI observer in place of state variables in case that the nonlinear dynamic control law is used, similarly as in the linear system. The effectiveness of the proposed control law is demonstrated by a numerical simulation.

• Journal of the Korean Society for Precision Engineering
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• v.24 no.12
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• pp.57-64
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• 2007

There have been many researches for optimal controllers in multivariable systems, and they generally use accurate linear models of the plant dynamics. Real systems, however, contain nonlinearities and high-order dynamics that may be difficult to model using conventional techniques. Therefore, it is necessary a PID gain tuning method without explicit modeling for the multivariable plant dynamics. The PID tuning method utilizes the sign of Jacobian and gradient descent techniques to iteratively reduce the error-related objective function. This paper, especially, focuses on the role of I-controller when there is a steady state error. However, it is not easy to tune I-gain unlike P- and D-gain because I-controller is mainly operated in the steady state. Simulations for an overhead crane system with dynamic friction show that the proposed PID-LC algorithm improves controller performance, even in the steady state error.

• Journal of Ocean Engineering and Technology
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• v.5 no.2
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• pp.16-30
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• 1991

A numerical procedure is described for predicting the dynamic responses of combined systems of floating breakwaters and huge offshore structures supported by a large numer of the floating bodies in waves. The hydrodynamic interactins among tatal floating bodies are taken into account in their exact form within the context of linear potential theory. Wave control effects are discussed with both hydrodynamic interactions and hydrodynamic-structure interaction effects. The method presented is applicalbe to combined systems of floating breakwaters and huge structures for ocean space utilization for which a number of practical uses are seen in the future.

• Journal of Ocean Engineering and Technology
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• v.5 no.2
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• pp.156-156
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• 1991

A numerical procedure is described for predicting the dynamic responses of combined systems of floating breakwaters and huge offshore structures supported by a large numer of the floating bodies in waves. The hydrodynamic interactins among tatal floating bodies are taken into account in their exact form within the context of linear potential theory. Wave control effects are discussed with both hydrodynamic interactions and hydrodynamic-structure interaction effects. The method presented is applicalbe to combined systems of floating breakwaters and huge structures for ocean space utilization for which a number of practical uses are seen in the future.

• 제어로봇시스템학회:학술대회논문집
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• 2005.06a
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• pp.1871-1876
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• 2005

In this paper, We present a new nonlinear adaptive control law using a disturbance accommodating control (DAC) observer for a Japanese automatic landing flight experiment vehicle called ALFLEX. A future spaceplane must have ability to deal with greater fluctuations in the stability and control derivatives of flight dynamics, because its flight region is much wider than that of conventional aircraft. In our previous studies, digital adaptive flight control systems have been developed based on a linear-parameter-varying (LPV) model depending on dynamic pressure, and obtained good simulation results. However, under previous control laws, it is difficult to accommodate uncertainties represented by disturbance and nonlinearity, and to design a stable flight control system. Therefore, in this study, we attempted to design a nonlinear adaptive control law using the DAC Observer and inverse dynamic methods. A good tracking property of the obtained system was confirmed in numerical simulation.

• Journal of Institute of Control, Robotics and Systems
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• v.10 no.10
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• pp.947-955
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• 2004

This paper is concerned with a mixed control with aerodynamic fin and side thrust control applied to an agile missile using a dynamic inversion and a time-varying control technique. The nonlinear dynamic inversion method with the weighting function allocates the desired control inputs(aerodynamic fin and side thrust control) to achieve a reference command, and the time-varying control technique plays the role to guarantee the robustness for the uncertainties. The proposed schemes are validated by nonlinear simulations with aerodynamic data.